01 mayo 2013

STROKE. Association of Hypertension With Stroke Recurrence Depends on Ischemic Stroke Subtype

Yilong Wang, MD, PhD; Jie Xu, MD, PhD; Xingquan Zhao, MD, PhD; David Wang, DO, FAHA, FAAN; Chunxue Wang, MD, PhD; Liping Liu, MD, PhD; Anxin Wang, MD; Xia Meng, MD, PhD; Hao Li, PhD; Yongjun Wang, MD

Background and Purpose—The association between hypertension (HTN) and stroke recurrence is unclear, but may be influenced by different subtypes of stroke. This study aims to explore whether HTN contributes to the recurrence of certain subtypes of ischemic stroke (IS).

01 mayo 2013

STROKE. Chronic Pain Syndromes After Ischemic Stroke. PRoFESS Trial

Martin J. O’Donnell, MB, PhD; Hans-Christoph Diener, MD; Ralph L. Sacco, MD; Akbar A. Panju, MD; Richard Vinisko, MA; Salim Yusuf, MD, Dphil On Behalf of PRoFESS Investigators

Background and Purpose—Chronic pain syndromes are reported to be common after stroke, but most previous epidemiological studies have generally included small cohorts of patients with relatively short-term follow-up. In a large cohort with ischemic stroke (Prevention Regimen for Effectively avoiding Second Stroke [PRoFESS] trial), we determined the prevalence, risk factors, and clinical consequence of new poststroke pain syndromes.

01 mayo 2013

STROKE. Risk of Rupture of an Intracranial Aneurysm Based on Patient Characteristics

Monique H.M. Vlak, MD; Gabriel J.E. Rinkel, MD; Paut Greebe, RN, PhD; Ale Algra, MD

Background and Purpose—Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies. We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.

01 mayo 2013

STROKE. Early Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Development and Validation of a Practical Risk Chart

Nicolien K. de Rooij, MD; Jacoba P. Greving, PhD; Gabriel J.E. Rinkel, MD; Catharina J.M. Frijns, MD

Background and Purpose—To develop and validate a risk chart for prediction of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage based on admission characteristics.

01 mayo 2013

STROKE. Rescue Treatment of Thromboembolic Complications During Endovascular Treatment of Cerebral Aneurysms

Waleed Brinjikji, MD; Jennifer S. McDonald, PhD; David F. Kallmes, MD; Harry J. Cloft, MD, PhD

Background and Purpose—Acute intraprocedural thrombus formation complicating endovascular cerebral aneurysm treatment is often treated with intra-arterial or intravenous administration of thrombolytic agents or glycoprotein IIb/IIIa (GpIIb/IIIa) inhibitors. We sought to evaluate the morbidity and mortality associated with such treatments using a large multihospital database.

01 junio 2013

LANCET. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial

Prof P David Adelson MD, Prof Stephen R Wisniewski PhD , John Beca MD , S Danielle Brown MS, Michael Bell MD , Prof J Paul Muizelaar , Pamela Okada MD , Sue R Beers PhD , Goundappa K Balasubramani PhD , Deborah Hirtz MD , for the Paediatric Traumatic Brain Injury Consortium

Background: On the basis of mixed results from previous trials, we assessed whether therapeutic hypothermia for 48—72 h with slow rewarming improved mortality in children after brain injury.

01 mayo 2013

STROKE. Stent-Assisted Coiling of Intracranial Aneurysms. Predictors of Complications, Recanalization, and Outcome in 508 Cases

Nohra Chalouhi, MD; Pascal Jabbour, MD; Saurabh Singhal, MD; Ross Drueding, BA; Robert M. Starke, MD; Richard T. Dalyai, MD; Stavropoula Tjoumakaris, MD; L. Fernando Gonzalez, MD; Aaron S. Dumont, MD; Robert Rosenwasser, MD; Ciro G. Randazzo, MD

Background and Purpose—Self-expanding stents are increasingly used for treatment of complex intracranial aneurysms. We assess the safety and the efficacy of intracranial stenting and determine predictors of treatment outcomes.

01 mayo 2013

LANCET. Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study

Faisal Mohammad Amin MD , Mohammad Sohail Asghar MD , Anders Hougaard MD , Adam Espe Hansen PhD , Vibeke Andrée Larsen MD , Patrick JH de Koning MS, Prof Henrik BW Larsson MD , Prof Jes Olesen MD , Dr Messoud Ashina MD

Extracranial arterial dilatation has been hypothesised to be the cause of pain in patients who have migraine without aura. To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura.

01 mayo 2013

STROKE. De Novo and Recurrent Aneurysms in Pediatric Patients With Cerebral Aneurysms

Päivi Koroknay-Pál, MD, PhD; Mika Niemelä, MD, PhD; Hanna Lehto, MD; Riku Kivisaari, MD, PhD; Jussi Numminen, MD, PhD; Aki Laakso, MD, PhD; Juha Hernesniemi, MD, PhD

Background and Purpose—Long-term angiographic follow-up studies on pediatric aneurysm patients are scarce.

01 abril 2013

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Hemorrhagic and Ischemic Outcomes After Bivalirudin Versus Unfractionated Heparin During Carotid Artery Stenting

Siddharth A. Wayangankar, MD, MPH, Mazen S. Abu-Fadel, MD, Herbert D. Aronow, MD, MPH, Kevin F. Kennedy, MS, Raghav Gupta, MD, Robert W. Yeh, MD, William A. Gray, MD, Kenneth Rosenfield, MD and Thomas A. Hennebry, MD

Background—The direct thrombin inhibitor, bivalirudin, is associated with similar efficacy and superior safety in patients undergoing percutaneous coronary intervention. However, the role of direct thrombin inhibitors in carotid artery stenting is not well defined. The objective of this study was to compare the safety and effectiveness of bivalirudin and unfractionated heparin (UFH) for carotid artery stenting. We hypothesized that bivalirudin would be associated with less in-hospital postprocedure bleeding than UFH but similar rates of in-hospital and 30-day ischemic outcomes.

01 abril 2013

AMERICAN JOURNAL OF ROENTGENOLOGY. Comparison of Enterprise With Neuroform Stent-Assisted Coiling of Intracranial Aneurysms

Yasha Kadkhodayan, Nicholas Rhodes, Spiros Blackburn, Colin P. Derdeyn, DeWitte T. Cross, III and Christopher J. Moran

OBJECTIVE. The Enterprise stent is the first closed-cell stent designed to treat wide-necked intracranial aneurysms. Advantages of the design can include improvement in keeping coils within an aneurysm and the ability of the stent to be recaptured. We compared the technical and clinical complications of the Enterprise stent with the open-cell Neuroform stent, its primary alternative.

01 abril 2013

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Assessment of Reverse Flow as a Means of Cerebral Protection during Carotid Artery Stent Placement with Diffusion-weighted and Transcranial Doppler Imaging

Stephen D. Goode, MRCS, FRCR, PhD , Nigel Hoggard, MD, MRCP, FRCR , Sumaira Macdonald, FRCR, PhD , David H. Evans, PhD, DSc , Trevor J. Cleveland, FRCS, FRCR , Peter A. Gaines, FRCP, FRCR

Purpose: To assess the effectiveness of flow reversal as an alternative means of cerebral protection by using transcranial Doppler recordings and diffusion-weighted imaging (DWI) as surrogate markers of brain injury.

01 marzo 2013

STROKE. MR-DWI–Positive Lesions and Symptomatic Ischemic Complications After Coiling of Unruptured Intracranial Aneurysms

Dong-Hun Kang, MD; Byung Moon Kim, MD; Dong Joon Kim, MD; Sang Hyun Suh, MD; Dong Ik Kim, MD; Yong-Sun Kim, MD; Seung Kon Huh, MD; Jaechan Park, MD; Jae Whan Lee, MD; Yong Bae Kim, MD

Background and Purpose—The aims of this study are to evaluate the risk factors for symptomatic ischemic complication (symptomatic ischemic complication [SIC], transient ischemic attack, or stroke) and microembolisms detected as MR diffusion-weighted imaging (MR-DWI)–positive (DWI(+)) lesions, and the relationship between DWI(+) and SIC after coiling of unruptured intracranial aneurysm.

01 marzo 2013

NEUROSURGERY. Continued Concern About Parent Vessel Steno-Occlusive Progression With Onyx HD-500 and the Utility of Quantitative Magnetic Resonance Imaging in Serial Assessment

Carlson, Andrew P. MD; Alaraj, Ali MD; Amin-Hanjani, Sepideh MD; Charbel, Fady T. MD; Aletich, Victor A. MD

BACKGROUND: Onyx HD-500 is a liquid embolic used to treat intracranial aneurysms. OBJECTIVE: To determine the incidence of parent vessel stenosis and the management strategy for these patients.

01 marzo 2013

STROKE. Is Intracerebral Hemorrhage a Time-Dependent Phenomenon After Successful Combined Intravenous and Intra-Arterial Therapy?

Pascal J. Mosimann, MD; Gaia Sirimarco, MD; Elena Meseguer, MD; Jean-Michel Serfaty, MD; Jean-Pierre Laissy, MD; Julien Labreuche, BST; Bertrand Lapergue, MD; Jaime Gonzalez-Valcarcel, MD; Philippa C. Lavallée, MD; Lucie Cabrejo, MD; Celine Guidoux, MD; Isabelle F. Klein, MD, PhD; Jean-Marc Olivot, MD, PhD; Elisabeth Schouman-Claeys, MD; Pierre Amarenco, MD; Mikael Mazighi, MD, PhD

Background and Purpose—Onset-to-reperfusion time (ORT) has recently emerged as an essential prognostic factor in acute ischemic stroke therapy. Although favorable outcome is associated with reduced ORT, it remains unclear whether intracranial bleeding depends on ORT. We therefore sought to determine whether ORT influenced the risk and volume of intracerebral hemorrhage (ICH) after combined intravenous and intra-arterial therapy.