01 junio 2013

CIRCULATION. Impact of Onset-to-Reperfusion Time on Stroke Mortality. A Collaborative Pooled Analysis

Mikael Mazighi, MD, PhD; Saqib A. Chaudhry, MD; Marc Ribo, MD; Pooja Khatri, MD, MSc; David Skoloudik, MD; Maxim Mokin, MD; Julien Labreuche, BST; Elena Meseguer, MD; Sharon D. Yeatts, PhD; Adnan H. Siddiqui, MD; Joseph Broderick, MD; Carlos A. Molina, MD; Adnan I. Qureshi, MD; Pierre Amarenco, MD

Background—Onset-to-reperfusion time has been reported to be associated with clinical prognosis. However, its impact on mortality remained to be assessed. Using a collaborative pooled analysis, we examined whether early mortality after successful endovascular treatment is time dependent.

01 junio 2013

AMERICAN JOURNAL OF ROENTGENOLOGY. Improved Image Quality and Detection of Small Cerebral Infarctions With Diffusion-Tensor Trace Imaging

Keith A. Cauley, Senthur Thangasamy and Sathish K. Dundamadappa

OBJECTIVE. The purpose of this study was to test a hypothesis that routinely performed diffusion-tensor trace imaging is of sufficient image quality and sensitivity for infarct detection to safely and routinely replace standard diffusion-weighted imaging (DWI) in the clinical setting.

01 junio 2013

AMERICAN JOURNAL OF ROENTGENOLOGY. Endovascular Diagnosis and Management of Chronic Cerebrospinal Venous Insufficiency: Retrospective Analysis of 30-Day Morbidity and Mortality in 95 Consecutive Patients

Hector Ferral, George Behrens, Yanki Tumer and Magdalene Riemenschneider

OBJECTIVE. The purpose of this study is to report the 30-day morbidity and mortality associated with the endovascular diagnosis and management of chronic cerebrospinal venous insufficiency.

01 junio 2013

JOURNAL OF ENDOVASCULAR THERAPY. Intracranial Hemodynamic Stabilization Patterns After Stenting of Severe Stenosis in the Proximal Internal Carotid Artery

Jong Wook Shin , MD; Hye Seon Jeong , MD; Hee-Jung Song , MD, PhD; Jae-Hwan Lee , MD, PhD; Si Wan Choi , MD, PhD; Suk Hoon Lee , PhD; Jieun Shin , PhD; and Jei Kim , MD

Purpose: To evaluate intracranial hemodynamic stabilization patterns after carotid artery stenting (CAS) in patients having variable collateral developments before CAS.

01 junio 2013

RADIOLOGY. Pipeline for Uncoilable or Failed Aneurysms: Results from a Multicenter Clinical Trial

Tibor Becske, MD, David F. Kallmes, MD, Isil Saatci, MD, Cameron G. McDougall, MD, István Szikora, MD, PhD, Giuseppe Lanzino, MD, Christopher J. Moran, MD, Henry H. Woo, MD, Demetrius K. Lopes, MD, Aaron L. Berez, MD, Daniel J. Cher, MD, Adnan H. Siddiqui, MD, PhD, Elad I. Levy, MD, Felipe C. Albuquerque, MD, David J. Fiorella, MD, PhD, Zsolt Berentei, MD, Miklós Marősfoi, MD, Saruhan H. Cekirge, MD and Peter K. Nelson, MD

Purpose: To evaluate the safety and effectiveness of the Pipeline Embolization Device (PED; ev3/Covidien, Irvine, Calif) in the treatment of complex intracranial aneurysms.

01 junio 2013

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Changes of Cine Cerebrospinal Fluid Dynamics in Patients with Multiple Sclerosis Treated with Percutaneous Transluminal Angioplasty: A Case-control Study

Robert Zivadinov, MD, PhD , Christopher Magnano, MS , Roberto Galeotti, MD , Claudiu Schirda, PhD , Erica Menegatti, PhD , Bianca Weinstock-Guttman, MD , Karen Marr, RVT, RDMS , Ilaria Bartolomei, MD , Jesper Hagemeier, MS , Anna Maria Malagoni, MD, PhD , David Hojnacki, MD , Cheryl Kennedy, LMSW, MPH , Ellen Carl, PhD , Clive Beggs, PhD , Fabrizio Salvi, MD , Paolo Zamboni, MD

Purpose: To investigate characteristics of cine phase contrast-calculated cerebrospinal fluid (CSF) flow and velocity measures in patients with relapsing-remitting (RR) multiple sclerosis (MS) receiving standard medical treatment who had been diagnosed with chronic cerebrospinal venous insufficiency (CCSVI) and underwent percutaneous transluminal angioplasty (PTA).

01 junio 2013

JOURNAL OF VASCULAR SURGERY. The effect of postoperative stroke and myocardial infarction on long-term survival after carotid revascularization

Jessica P. Simons, MD, MPH , Philip P. Goodney, MD, MS , Donald T. Baril, MD , Brian W. Nolan, MD, MS , Nathanael D. Hevelone, MPH , Jack L. Cronenwett, MD , Louis M. Messina, MD , Andres Schanzer, MD , Vascular Study Group of New England

Introduction: The largest randomized controlled trial that compared the efficacy of carotid endarterectomy (CEA) with carotid artery stenting (CAS) showed equivalent outcomes for the composite end point of postoperative stroke, myocardial infarction (MI), or death. However, CAS had a higher risk of postoperative stroke, and CEA had a higher risk of MI. We hypothesize that there is a differential association of postoperative stroke, compared with that of postoperative MI, with reduced long-term survival after carotid revascularization when compared with neither complication.

01 junio 2013

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. Does Mechanical Thrombectomy in Acute Embolic Stroke Have Long-term Side Effects on Intracranial Vessels? An Angiographic Follow-up Study

Wiebke Kurre, Marta Aguilar Pérez, Diana Horvath, Elisabeth Schmid, Hansjörg Bäzner, Hans Henkes

Purpose: Mechanical thrombectomy (mTE) proved to be effective treating acute vessel occlusions with an acceptable rate of procedural complications. Potential long-term side effects of the vessel wall trauma caused by mechanical irritation of the endothelium are unknown up to now.

01 junio 2013

LANCET. Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials

Dr William N Whiteley PhD , Harold P Adams MD , Philip MW Bath FRCP , Eivind Berge MD , Per Morten Sandset MD , Martin Dennis MD , Gordon D Murray PhD , Ka-Sing Lawrence Wong MD , Peter AG Sandercock MD

Background: Many international guidelines on the prevention of venous thromboembolism recommend targeting heparin treatment at patients with stroke who have a high risk of venous thrombotic events or a low risk of haemorrhagic events. We sought to identify reliable methods to target anticoagulant treatment and so improve the chance of avoiding death or dependence after stroke.

01 mayo 2013

STROKE. Association of Hypertension With Stroke Recurrence Depends on Ischemic Stroke Subtype

Yilong Wang, MD, PhD; Jie Xu, MD, PhD; Xingquan Zhao, MD, PhD; David Wang, DO, FAHA, FAAN; Chunxue Wang, MD, PhD; Liping Liu, MD, PhD; Anxin Wang, MD; Xia Meng, MD, PhD; Hao Li, PhD; Yongjun Wang, MD

Background and Purpose—The association between hypertension (HTN) and stroke recurrence is unclear, but may be influenced by different subtypes of stroke. This study aims to explore whether HTN contributes to the recurrence of certain subtypes of ischemic stroke (IS).

01 mayo 2013

STROKE. Chronic Pain Syndromes After Ischemic Stroke. PRoFESS Trial

Martin J. O’Donnell, MB, PhD; Hans-Christoph Diener, MD; Ralph L. Sacco, MD; Akbar A. Panju, MD; Richard Vinisko, MA; Salim Yusuf, MD, Dphil On Behalf of PRoFESS Investigators

Background and Purpose—Chronic pain syndromes are reported to be common after stroke, but most previous epidemiological studies have generally included small cohorts of patients with relatively short-term follow-up. In a large cohort with ischemic stroke (Prevention Regimen for Effectively avoiding Second Stroke [PRoFESS] trial), we determined the prevalence, risk factors, and clinical consequence of new poststroke pain syndromes.

01 mayo 2013

STROKE. Risk of Rupture of an Intracranial Aneurysm Based on Patient Characteristics

Monique H.M. Vlak, MD; Gabriel J.E. Rinkel, MD; Paut Greebe, RN, PhD; Ale Algra, MD

Background and Purpose—Knowledge about risk factors contributes to understanding the pathophysiological mechanisms that cause intracranial aneurysm rupture and helps to develop possible treatment strategies. We aimed to study lifestyle and personal characteristics as risk factors for the rupture of intracranial aneurysms.

01 mayo 2013

STROKE. Early Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. Development and Validation of a Practical Risk Chart

Nicolien K. de Rooij, MD; Jacoba P. Greving, PhD; Gabriel J.E. Rinkel, MD; Catharina J.M. Frijns, MD

Background and Purpose—To develop and validate a risk chart for prediction of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage based on admission characteristics.

01 mayo 2013

STROKE. Rescue Treatment of Thromboembolic Complications During Endovascular Treatment of Cerebral Aneurysms

Waleed Brinjikji, MD; Jennifer S. McDonald, PhD; David F. Kallmes, MD; Harry J. Cloft, MD, PhD

Background and Purpose—Acute intraprocedural thrombus formation complicating endovascular cerebral aneurysm treatment is often treated with intra-arterial or intravenous administration of thrombolytic agents or glycoprotein IIb/IIIa (GpIIb/IIIa) inhibitors. We sought to evaluate the morbidity and mortality associated with such treatments using a large multihospital database.

01 junio 2013

LANCET. Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial

Prof P David Adelson MD, Prof Stephen R Wisniewski PhD , John Beca MD , S Danielle Brown MS, Michael Bell MD , Prof J Paul Muizelaar , Pamela Okada MD , Sue R Beers PhD , Goundappa K Balasubramani PhD , Deborah Hirtz MD , for the Paediatric Traumatic Brain Injury Consortium

Background: On the basis of mixed results from previous trials, we assessed whether therapeutic hypothermia for 48—72 h with slow rewarming improved mortality in children after brain injury.