01 marzo 2013

NEUROSURGERY. Infection Risk in Neurointervention and Cerebral Angiography

Kelkar, Prashant S. DO; Fleming, J. Brett MD; Walters, Beverly C. MD, MSc; Harrigan, Mark R. MD

Background: The risk of infection with cerebral angiography and neurointerventional procedures has not been defined. Likewise, although the use of routine prophylactic antibiotics has been advocated by some neurointerventionalists, the utility of prophylactic antibiotics in this setting has not been determined.

01 marzo 2013

NEUROSURGERY. Continued Concern About Parent Vessel Steno-Occlusive Progression With Onyx HD-500 and the Utility of Quantitative Magnetic Resonance Imaging in Serial Assessment

Carlson, Andrew P. MD; Alaraj, Ali MD; Amin-Hanjani, Sepideh MD; Charbel, Fady T. MD; Aletich, Victor A. MD

Background: Onyx HD-500 is a liquid embolic used to treat intracranial aneurysms.

01 marzo 2013

NEUROSURGERY. Frequency and Factors Associated With Unsuccessful Lead (First) Coil Placement in Patients Undergoing Coil Embolization of Intracranial Aneurysms

Khatri, Rakesh MD; Chaudhry, Saqib A. MD; Rodriguez, Gustavo J. MD; Suri, M. Fareed K. MD; Cordina, Steve M. MD; Qureshi, Adnan I. MD

Background: There is limited knowledge about associated rates, aneurysm characteristics, technical factors, and immediate impact of unsuccessful placement of the lead (first) coil during endovascular embolization of intracranial aneurysms.

01 marzo 2013

NEUROSURGERY. In-Stent Stenosis After Stent-Assisted Coiling: Incidence, Predictors and Clinical Outcomes of 435 Cases

Chalouhi, Nohra MD*; Drueding, Ross BA*; Starke, Robert M. MD*,‡; Jabbour, Pascal MD*; Dumont, Aaron S. MD*; Gonzalez, L. Fernando MD*; Rosenwasser, Robert MD*; Tjoumakaris, Stavropoula MD

Background: Neuroform and Enterprise are widely used self-expanding stents designed to treat wide-necked intracranial aneurysms.

01 marzo 2014

JACC. Off-Pump Transapical Implantation of Artificial Neo-Chordae to Correct Mitral Regurgitation. The TACT Trial (Transapical Artificial Chordae Tendinae) Proof of Concept

Joerg Seeburger, MD, PhD∗; Mauro Rinaldi, MD, PhD†; Sten Lyager Nielsen, MD‡; Stefano Salizzoni, MD†; Ruediger Lange, MD, PhD§; Markus Schoenburg, MD‖; Ottavio Alfieri, MD, PhD¶; Michael Andrew Borger, MD, PhD∗; Friedrich Wilhelm Mohr, MD, PhD∗; Audrius Aidietis, MD, PhD#

Objectives: The goal of this study was to evaluate the safety and performance of the NeoChord DS1000 system (NeoChord, Inc., Minneapolis, Minnesota).

28 febrero 2014

THE LANCET NEUROLOGY. Acute post-stroke blood pressure relative to premorbid levels in intracerebral haemorrhage versus major ischaemic stroke: a population-based study

Urs Fischer MD a †, Marie Therese Cooney PhD a †, Linda M Bull RN a, Louise E Silver DPhil a, Prof John Chalmers MD b, Prof Craig S Anderson MD b, Ziyah Mehta DPhil a, Prof Peter M Rothwell FMedSci a

Background: It is often assumed that blood pressure increases acutely after major stroke, resulting in so-called post-stroke hypertension. In view of evidence that the risks and benefits of blood pressure-lowering treatment in acute stroke might differ between patients with major ischaemic stroke and those with primary intracerebral haemorrhage, we compared acute-phase and premorbid blood pressure levels in these two disorders.

05 marzo 2014

THE LANCET NEUROLOGY. Long-term, serial screening for intracranial aneurysms in individuals with a family history of aneurysmal subarachnoid haemorrhage: a cohort study

Dr A Stijntje E Bor MD a, Prof Gabriel J E Rinkel MD a, Jeroen van Norden BSc a, Marieke J H Wermer MD b

Background: Individuals with two or more first-degree relatives who have had aneurysmal subarachnoid haemorrhage (aSAH) have an increased risk of aneurysms and aSAH. We investigated the yield of long-term serial screening for intracranial aneurysms in these individuals.

13 febrero 2014

THE LANCET NEUROLOGY. Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial

Lisa Manning MBChB a b *, Yoichiro Hirakawa MD c *, Hisatomi Arima PhD c, Xia Wang MMed c, Prof John Chalmers MD c d, Prof Jiguang Wang PhD e, Prof Richard Lindley MD c, Emma Heeley PhD c, Candice Delcourt MD c d, Prof Bruce Neal MD c, Prof Pablo Lavados MD f g, Prof Stephen M Davis MD h i, Prof Christophe Tzourio MD j k, Prof Yining Huang MD l, Prof Christian Stapf MD m n o, Prof Mark Woodward PhD c, Prof Peter M Rothwell FMedSci p, Prof Thompson G Robinson MD a b, Prof Craig S Anderson MD c d, for the INTERACT2 investigators†

Background: High blood pressure is a prognostic factor for acute stroke, but blood pressure variability might also independently predict outcome. We assessed the prognostic value of blood pressure variability in participants of INTERACT2, an open-label randomised controlled trial

30 enero 2014

STROKE. Clinical Sciences. Prevalence and Outcomes of Symptomatic Intracranial Large Artery Stenoses and Occlusions in China. The Chinese Intracranial Atherosclerosis (CICAS) Study

Yongjun Wang, MD; Xingquan Zhao, MD; Liping Liu, MD; Yannie O.Y. Soo, MD; Yuehua Pu, MD; Yuesong Pan, MD; Yilong Wang, MD; Xinying Zou, MD; Thomas W.H. Leung, MD; Yefeng Cai, MD; Qingke Bai, MD; Yiping Wu, MD; Chunxue Wang, MD; Xiaoping Pan, MD; Benyan Luo, MD; Ka Sing Lawrence Wong, MD; for the CICAS Study Group

Background and Purpose: We aimed to establish the prevalence, characteristics, and outcomes of intracranial atherosclerosis (ICAS) in China by a large, prospective, multicenter study.

14 enero 2014

STROKE. Clinical Sciences. Patient Phenotypes Associated With Outcomes After Aneurysmal Subarachnoid Hemorrhage

George M. Ibrahim, MD; Benjamin R. Morgan, MESc; R. Loch Macdonald, MD, PhD

Background and Purpose: Predictors of outcome after aneurysmal subarachnoid hemorrhage have been determined previously through hypothesis-driven methods that often exclude putative covariates and require a priori knowledge of potential confounders. Here, we apply a data-driven approach, principal component analysis, to identify baseline patient phenotypes that may predict neurological outcomes.

14 enero 2014

STROKE. Clinical Sciences. Impaired Cerebral Autoregulation Is Associated With Vasospasm and Delayed Cerebral Ischemia in Subarachnoid Hemorrhage

Fadar Otite, MD, MSc*; Susanne Mink, MD*; Can Ozan Tan, PhD; Ajit Puri, MD; Amir A. Zamani, MD; Aujan Mehregan; Sherry Chou, MD, MSc; Susannah Orzell, BS; Sushmita Purkayastha, PhD; Rose Du, MD, PhD; Farzaneh A. Sorond, MD, PhD

Background and Purpose: Cerebral autoregulation may be impaired in the early days after subarachnoid hemorrhage (SAH). The purpose of this study was to examine the relationship between cerebral autoregulation and angiographic vasospasm (aVSP) and radiographic delayed cerebral ischemia (DCI) in patients with SAH.

28 julio 2011

STROKE. Clinical Sciences. Progression Rate and Ipsilateral Neurological Events in Asymptomatic Carotid Stenosis

Liam S. Hirt, MBBS, MRCP

Background and Purpose: Progression of asymptomatic carotid stenoses with >50% luminal narrowing is associated with an increased risk of stroke. The significance of the progression rate in these patients is unknown. The main aim of this study was to evaluate the rate of change of carotid luminal narrowing over 1 year, as a risk factor for ipsilateral ischemic events, in patients with a >50% asymptomatic carotid stenosis. Secondary aims were to establish the incidence of changes in carotid luminal narrowing and establish additional risk factors for ipsilateral neurological events.

23 enero 2014

STROKE. Clinical Sciences. Association Between Arterial Calcifications and Nonlacunar and Lacunar Ischemic Strokes

Anouk C. van Dijk, MD; Susanne Fonville, MD; Taihra Zadi, BSc; Antonius M.G. van Hattem, BSc; Ghesrouw Saiedie, BSc; Peter J. Koudstaal, MD, PhD; Aad van der Lugt, MD, PhD

Background and Purpose: Nonlacunar cerebral infarcts are presumed to be caused by thromboembolism from the heart or extracranial arteries, whereas lacunar infarcts are thought to be caused by small vessel disease. We investigated to what extent arterial calcifications differ between nonlacunar and lacunar ischemic strokes.

06 febrero 2014

STROKE. Clinical Sciences. Impact of Pretreatment Noncontrast CT Alberta Stroke Program Early CT Score on Clinical Outcome After Intra-Arterial Stroke Therapy

Albert J. Yoo, MD; Osama O. Zaidat, MD, MS; Zeshan A. Chaudhry, MD; Olvert A. Berkhemer, MD; R. Gilberto González, MD, PhD; Mayank Goyal, MD; Andrew M. Demchuk, MD; Bijoy K. Menon, MD; Elan Mualem, BA; Dawn Ueda, MD; Hope Buell, MS; Siu Po Sit, PhD; Arani Bose, MD on behalf of the Penumbra Pivotal and Penumbra Imaging Collaborative Study (PICS) Investigators

Background and Purpose: The efficacy of intra-arterial treatment remains uncertain. Because most centers performing IAT use noncontrast CT (NCCT) imaging, it is critical to understand the impact of NCCT findings on treatment outcomes. This study aimed to compare functional independence and safety among patients undergoing intra-arterial treatment stratified by the extent of ischemic change on pretreatment NCCT.

28 enero 2014

STROKE. Clinical Sciences. Symptomatic Intracranial Hemorrhage After Stroke Thrombolysis

Daniel Strbian, MD, PhD, MSc (Stroke Med); Patrik Michel, MD; David J. Seiffge, MD; Jeffrey L. Saver, MD, FAHA; Heikki Numminen, MD, PhD; Atte Meretoja, MD, PhD, MSc (Stroke Med); Kei Murao, MD; Bruno Weder, MD; Nina Forss, MD, PhD; Anna-Kaisa Parkkila, MD, PhD; Ashraf Eskandari, RN; Charlotte Cordonnier, MD, PhD; Stephen M. Davis, MD, PhD; Stefan T. Engelter, MD, PhD; Turgut Tatlisumak, MD, PhD

Background and Purpose: Several prognostic scores have been developed to predict the risk of symptomatic intracranial hemorrhage (sICH) after ischemic stroke thrombolysis. We compared the performance of these scores in a multicenter cohort.