12 agosto 2014

STROKE. Clinical Sciences. Number of Cerebral Microbleeds and Risk of Intracerebral Hemorrhage After Intravenous Thrombolysis

Steffen Dannenberg*; Jan F. Scheitz, MD*; Michal Rozanski, MD; Hebun Erdur, MD; Peter Brunecker, Dr rer medic; David J. Werring, PhD; Jochen B. Fiebach, MD; Christian H. Nolte, MD

Background and Purpose: Cerebral microbleeds (CMBs) are found in a substantial proportion of patients with ischemic stroke eligible for treatment with intravenous thrombolysis. Until now, there is limited data on the impact of multiple CMBs on occurrence of intracerebral hemorrhage (ICH) after intravenous thrombolysis.

28 agosto 2014

STROKE. Clinical Sciences. Morphological, Hemodynamic, and Clinical Independent Risk Factors for Anterior Communicating Artery Aneurysms

Wojciech Kaspera, MD; Piotr Ładziński, MD, PhD; Patrycja Larysz, MD; Anna Hebda, MS; Krzysztof Ptaszkiewicz, MD; Marek Kopera, MD; Dawid Larysz, MD, PhD

Background and Purpose: The pathogenesis of cerebral aneurysms still raises some controversies. The aim of this study was to identify morphological, hemodynamic, and clinical independent risk factors for anterior communicating artery (ACoA) aneurysm development.

22 julio 2014

STROKE. Clinical Sciences. Flow Diversion Versus Conventional Treatment for Carotid Cavernous Aneurysms

Mario Zanaty, MD; Nohra Chalouhi, MD; Robert M. Starke, MD; Guilherme Barros, BS; Mark Philip Saigh, BA; Eric Winthrop Schwartz, BS; Norman Ajiboye, MD; Stavropoula I. Tjoumakaris, MD; David Hasan, MD; Robert H. Rosenwasser, MD; Pascal Jabbour, MD

Background and Purpose: Several endovascular treatment options are available for cavernous carotid aneurysms. We compared pipeline embolization device (PED) versus conventional endovascular treatment in terms of evolution of mass effect, complications, recurrence, and retreatment rate.

31 julio 2014

STROKE. Clinical Sciences. Long-Term Follow-Up Study of Endarterectomy Versus Angioplasty in Patients With Symptomatic Severe Carotid Stenosis Trial

Jean-Louis Mas, MD; Caroline Arquizan, MD; David Calvet, PhD; Alain Viguier, MD; Jean-François Albucher, MD; Philippe Piquet, MD; Pierre Garnier, MD; Fausto Viader, MD; Maurice Giroud, MD; Hassan Hosseini, PhD; Grégoire Hinzelin, MD; Pascal Favrole, MD; Hilde Hénon, MD; Jean-Philippe Neau, MD; Xavier Ducrocq, MD; Raymond Padovani, MD; Loic Milandre, MD†; François Rouanet, MD; Valérie Wolff, MD; Denis Saudeau, MD; Marie-Hélène Mahagne, MD; Denis Sablot, MD; Pierre Amarenco, MD; Vincent Larrue, MD; Bernard Beyssen, MD; Didier Leys, PhD; Thierry Moulin, MD; Michel Lièvre, MD; Gilles Chatellier, MD; on behalf of the EVA-3S Investigators

Background and Purpose: We aimed at comparing the long-term benefit–risk balance of carotid stenting versus endarterectomy for symptomatic carotid stenosis.

01 agosto 2014

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Endovascular Procedures versus Intravenous Thrombolysis in Stroke with Tandem Occlusion of the Anterior Circulation

Serdar Tütüncü, MD, Jan F. Scheitz, MD , Georg Bohner, MD , Jochen B. Fiebach, MD , Matthias Endres, MD , Christian H. Nolte, MD

Purpose: Stroke with tandem occlusion within the anterior circulation presents a lower probability of recanalization and good clinical outcome after intravenous (IV) thrombolysis than stroke with single occlusion. The present study describes the impact of endovascular procedures (EPs) compared with IV thrombolysis alone on recanalization and clinical outcome.

01 mayo 2014

STROKE. Clinical Sciences. Activities of Daily Living Is a Critical Factor in Predicting Outcome After Carotid Endarterectomy in Asymptomatic Patients

Anand Dayama, MD; Pratik Pimple, MBBS, MPH; Barath Badrinathan, MD; Richard Lee, MD; James G. Reeves, MD

Background and Purpose: Ability to perform basic daily activity represented by functional status (FNS) before surgery can be assessed in the clinic for determining health status of the patient. We sought to study the effect of FNS on postoperative outcomes after carotid endarterectomy (CEA) in a national data set.

29 abril 2014

STROKE. Clinical Sciences. Intravenous Thrombolysis of Basilar Artery Occlusion. Thrombus Length Versus Recanalization Success

Daniel Strbian, MD, PhD, MSc (Stroke Med), FESO; Tiina Sairanen, MD, PhD, MSc (Stroke Med); Heli Silvennoinen, MD, PhD; Oili Salonen, MD, PhD; Perttu J. Lindsberg, MD, PhD, FESO

Background and Purpose: In middle cerebral artery occlusion, probability of recanalization after intravenous tissue-type plasminogen activator thrombolysis (IVT) was reported to drop <1% for thrombi exceeding 8 mm. We aimed to evaluate the effect of thrombus length and location on success of recanalization after IVT in basilar artery occlusion.

29 abril 2014

STROKE. Clinical Sciences. Age of Collagen in Intracranial Saccular Aneurysms

Nima Etminan, MD; Rita Dreier, PhD; Bruce A. Buchholz, PhD; Kerim Beseoglu, MD; Peter Bruckner, PhD; Christian Matzenauer, MD; James C. Torner, PhD; Robert D. Brown Jr, MD; Hans-Jakob Steiger, MD; Daniel Hänggi, MD; R. Loch Macdonald, MD, PhD

Background and Purpose: The chronological development and natural history of cerebral aneurysms (CAs) remain incompletely understood. We used 14C birth dating of a main constituent of CAs, that is, collagen type I, as an indicator for biosynthesis and turnover of collagen in CAs in relation to human cerebral arteries to investigate this further.

17 abril 2014

STROKE. Isolated Cortical Vein Thrombosis. Systematic Review of Case Reports and Case Series

Jonathan M. Coutinho, MD, PhD; Jorn J. Gerritsma, MSc; Susanna M. Zuurbier, MD; Jan Stam, MD, PhD

Background and Purpose: Isolated cortical vein thrombosis is a distinct subtype of cerebral venous and sinus thrombosis. Because of the rarity of isolated cortical vein thrombosis, limited knowledge on its clinical and radiological manifestations is available.

01 mayo 2014

STROKE. Safety of Thrombolysis in Patients With Acute Ischemic Stroke and Cerebral Cavernous Malformations

Hebun Erdur, MD; Jan F. Scheitz, MD; Serdar Tütüncü, MD; Jochen B. Fiebach, MD; Matthias Endres, MD; David J. Werring, FRCP, PhD; Christian H. Nolte, MD

Background and Purpose: Data on safety of intravenous thrombolysis with recombinant tissue-type plasminogen activator for acute ischemic stroke in patients with coexisting cerebral cavernous malformations (CCMs) are scarce. We assessed the risk of thrombolysis-associated hemorrhage in these patients.

01 junio 2014

NEUROSURGERY. Contrast-Enhanced Angiographic Computed Tomography for Detection of Aneurysm Remnants After Clipping: A Comparison With Digital Subtraction Angiography in 112 Clipped Aneurysms

Gölitz, Philipp MD*; Struffert, Tobias MD, PhD*; Ganslandt, Oliver MD, PhD‡; Lang, Stefan*; Knossalla, Frauke MD§; Doerfler, Arnd MD, PhD*

Background: For preclusion of remnants after aneurysm clipping, a reliable, noninvasive imaging technique is desirable.

01 junio 2014

NEUROSURGERY. High-Resolution 3-Dimensional T2*-Weighted Angiography (HR 3-D SWAN): An Optimized 3-T Magnetic Resonance Imaging Sequence for Targeting the Subthalamic Nucleus

Lefranc, Michel MD*; Derrey, Stéphane MD, PhD#; Merle, Philippe MD‡; Tir, Mélissa MD, PhD§; Constans, Jean-Marc MD, PhD¶; Montpellier, Dominique MD‖; Macron, Jean Michel MD, PhD‡; Le Gars, Daniel MD, PhD*; Peltier, Johan MD, PhD*; Baledentt, Olivier PhD¶; Krystkowiak, Pierre MD, PhD§

Background: Subthalamic nucleus deep brain stimulation (STN-DBS) is an established treatment for Parkinson´s disease.

01 junio 2014

NEUROSURGERY. Magnetic Resonance-Guided Laser Ablation Improves Local Control for Postradiosurgery Recurrence and/or Radiation Necrosis

Rao, Malay S. MD, PharmD*; Hargreaves, Eric L. PhD‡; Khan, Atif J. MD*; Haffty, Bruce G. MD*; Danish, Shabbar F. MD‡

Background: Enhancing lesions that progress after stereotactic radiosurgery are often tumor recurrence or radiation necrosis. Magnetic resonance-guided laser-induced thermal therapy (LITT) is currently being explored for minimally invasive treatment of intracranial neoplasms.

01 junio 2014

NEUROSURGERY. Use of Cone-Beam Computed Tomography Angiography in Planning for Gamma Knife Radiosurgery for Arteriovenous Malformations: A Case Series and Early Report

Safain, Mina G. MD*; Rahal, Jason P. MD*; Raval, Ami MD*; Rivard, Mark J. PhD‡,§; Mignano, John E. MD, PhD‡,§; Wu, Julian K. MD*,§; Malek, Adel M. MD, PhD*,§

Background: The effectiveness of Gamma Knife radiosurgery (GKR) for cerebral arteriovenous malformations (AVMs) is predicated on inclusion of the entire nidus while excluding normal tissue. As such, GKR may be limited by the resolution and accuracy of the imaging modality used in targeting.

01 julio 2013

NEUROSURGERY. Differences in the Basilar Artery Bifurcation Angle Among Patients Who Present With a Ruptured Aneurysm at the Top of the Basilar Artery and Patients With Perimesencephalic Subarachnoid Hemorrhage: A Retrospective Cross-sectional Study

Jagadeesan, Bharathi D. MD*,‡; Kadkhodayan, Yasha MD§; Delgado Almandoz, Josser E. MD§; Wallace, Adam MD¶; Cross, Dewitte T. III MD¶,‖; Derdeyn, Colin P. MD¶,‖,#; Zipfel, Gregory J. MD‖,#; Dacey, Ralph G. Jr MD‖; Moran, Christopher J. MD¶,‖

Background: The angle of the basilar artery bifurcation of (BAB angle) is thought to influence the risk of the development and rupture of aneurysms at this site. It is, however, unknown whether the BAB angle also influences the incidence of angiographically negative perimesencephalic subarachnoid hemorrhage (PMSAH).