01 abril 2015

THE LANCET. Neurology. Diagnosis of atrial fibrillation after stroke and transient ischaemic attack: a systematic review and meta-analysis

Dr Luciano A Sposato, MD, Lauren E Cipriano, PhD, Gustavo Saposnik, MD, Estefanía Ruíz Vargas, PhD, Patricia M Riccio, MD, Prof Vladimir Hachinski, MD

Background: Among patients with atrial fibrillation, the risk of stroke is highest for those with a history of stroke; however, oral anticoagulants can lower the risk of recurrent stroke by two-thirds. No consensus has been reached about how atrial fibrillation should be investigated in patients with stroke, and its prevalence after a stroke remains uncertain. We did a systematic review and meta-analysis to estimate the proportion of patients newly diagnosed with atrial fibrillation after four sequential phases of cardiac monitoring after a stroke or transient ischaemic attack.

02 julio 2015

STROKE. Clinical Sciences. Impact of General Anesthesia on Safety and Outcomes in the Endovascular Arm of Interventional Management of Stroke (IMS) III Trial

Alex Abou-Chebl, MD; Sharon D. Yeatts, PhD; Bernard Yan, MD; Kevin Cockroft, MD; Mayank Goyal, MD; Tudor Jovin, MD; Pooja Khatri, MD; Phillip Meyers, MD; Judith Spilker, BSN; Rebecca Sugg, MD; Katja E. Wartenberg, MD; Tom Tomsick, MD; Joe Broderick, MD; Michael D. Hill, MD

Background and Purpose: General anesthesia (GA) for endovascular therapy (EVT) of acute ischemic stroke may be associated with worse outcomes.

14 julio 2015

STROKE. Clinical Sciences. Temporal Changes in Periprocedural Events in the Carotid Revascularization Endarterectomy Versus Stenting Trial

George Howard, DrPH; L. Nelson Hopkins, MD; Wesley S. Moore, MD; Barry T. Katzen, MD; Elie Chakhtoura, MD; William F. Morrish, MD; Robert D. Ferguson, MD; Robert J. Hye, MD; Fayaz A. Shawl, MD; Mark R. Harrigan, MD; Jenifer H. Voeks, PhD; Virginia J. Howard, PhD; Brajesh K. Lal, MD; James F. Meschia, MD; Thomas G. Brott, MD

Background and Purpose: Post-hoc, we hypothesized that over the recruitment period of the Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST), increasing experience and improved patient selection with carotid stenting, and to a lesser extent, carotid endarterectomy would contribute to lower periprocedural event rates.

16 junio 2015

STROKE. Clinical Sciences. Carotid Plaque Morphological Classification Compared With Biomechanical Cap Stress

Frank J.H. Gijsen, PhD; Harm A. Nieuwstadt, PhD; Jolanda J. Wentzel, PhD; Hence J.M. Verhagen, MD, PhD; Aad van der Lugt, MD, PhD; Antonius F.W. van der Steen, PhD

Background and Purpose: Two approaches to target plaque vulnerability—a histopathologic classification scheme and a biomechanical analysis—were compared and the implications for noninvasive risk stratification of carotid plaques using magnetic resonance imaging were assessed.

11 junio 2015

STROKE. Clinical Sciences. Predictive Factors for Rebleeding After Aneurysmal Subarachnoid Hemorrhage

Carlina E. van Donkelaar, MSc*; Nicolaas A. Bakker, MD, PhD*; Nic J.G.M. Veeger, PhD; Maarten Uyttenboogaart, MD, PhD; Jan D.M. Metzemaekers, MD, PhD; Gert-Jan Luijckx, MD, PhD; Rob J.M. Groen, MD, PhD; J. Marc C. van Dijk, MD, PhD

Background and Purpose: Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating type of stroke associated with high morbidity and mortality. One of the most feared complications is an early rebleeding before aneurysm repair. Predictors for such an often fatal rebleeding are largely unknown. We therefore aimed to determine predictors for an early rebleeding after aSAH in relation with time after ictus.

30 junio 2015

STROKE. Brief Report. Five-Year Outcome in Stroke Patients Submitted to Thrombolysis

Célia Machado, MD; João Pinho, MD; José Nuno Alves, MD; Ana Filipa Santos, MD; Maria do Céu Ferreira, MD; Maria João Abreu, MD; Liliana Oliveira, MD; João Mota, MD; João Ramalho Fontes, MD; Carla Ferreira, MD

Background and Purpose: Little is known on long-term follow-up after thrombolysis in ischemic stroke patients because the majority of studies evaluated outcome at 3 to 12 months. We aimed to assess 5-year outcome after intravenous thrombolysis (IVT).

14 mayo 2015

STROKE. Clinical Sciences. The VASOGRADE. A Simple Grading Scale for Prediction of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage

Airton Leonardo de Oliveira Manoel, MD; Blessing N. Jaja, MD, PhD; Menno R. Germans, MD, PhD; Han Yan, BSc; Winnie Qian, BA; Ekaterina Kouzmina, BSc; Tom R. Marotta, MD; David Turkel-Parrella, MD; Tom A. Schweizer, PhD; R. Loch Macdonald, MD, PhD, and the SAHIT collaborators

Background and Purpose: Patients are classically at risk of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage. We validated a grading scale—the VASOGRADE—for prediction of DCI.

04 junio 2015

STROKE. Clinical Sciences. Long-Term Excess Mortality After Aneurysmal Subarachnoid Hemorrhage

Justiina Huhtakangas, MD; Hanna Lehto, MD; Karri Seppä, MSc, PhD; Riku Kivisaari, MD, PhD; Mika Niemelä, MD, PhD; Juha Hernesniemi, MD, PhD; Martin Lehecka, MD, PhD

Background and Purpose: There is high case-fatality rate and loss of productive life-years related to aneurysmal subarachnoid hemorrhage (aSAH) but data on long-term survival of patients with aSAH are scarce. We aim to evaluate long-term excess mortality and related risk factors after an aSAH event.

28 abril 2015

STROKE. Clinical Sciences. Recovery to Preinterventional Functioning, Return-to-Work, and Life Satisfaction After Treatment of Unruptured Aneurysms

Daan Backes, MD; Gabriel J.E. Rinkel, MD, FRCPE; Irene C. van der Schaaf, MD, PhD; Jenny A. Nij Bijvank, MD; Bon H. Verweij, MD, PhD; Johanna M.A. Visser-Meily, MD, PhD; Marcel W. Post, PhD; Ale Algra, MD, PhD; Mervyn D.I. Vergouwen, MD, PhD

Background and Purpose: The eventual goal of preventive treatment of unruptured intracranial aneurysms is to increase the number of life years with high life satisfaction. Insight in the time with reduced functioning, working capacity, and life satisfaction after aneurysm treatment is pivotal to balance the pros and cons of preventive aneurysm occlusion.

07 mayo 2015

STROKE. Clinical Sciences. Relative Influence of Capillary Index Score, Revascularization, and Time on Stroke Outcomes From the Interventional Management of Stroke III Trial

Firas Al-Ali, MD; John J. Elias, PhD; Thomas A. Tomsick, MD; David S. Liebeskind, MD; Joseph P. Broderick, MD; on behalf of the IMS Study Groups

Background and Purpose: Until recently, acute ischemic stroke (AIS) trials have failed to show a benefit of endovascular therapy compared with standard therapy, leading some authors to recommend decreasing the time from ictus to revascularization to improve outcomes. We hypothesize that improving patient selection using the capillary index score (CIS) may also be a useful strategy.

23 abril 2015

STROKE. Clinical Sciences. Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome

Tae-Hee Cho, PhD; Norbert Nighoghossian, PhD; Irene Klærke Mikkelsen, PhD; Laurent Derex, PhD; Marc Hermier, PhD; Salvador Pedraza, MD; Jens Fiehler, MD; Leif Østergaard, PhD; Yves Berthezène, PhD; Jean-Claude Baron, ScD

Background and Purpose: The relative merits of reperfusion versus recanalization to predict tissue and clinical outcomes in anterior circulation stroke have been previously assessed using data acquired >12 hours postonset. To avoid late-occurring confounders such as non-nutritional reperfusion, futile recanalization and no-reflow phenomenon, we performed ultraearly assessment of reperfusion and recanalization.

05 mayo 2015

STROKE. Clinical Sciences. Is Visual Evaluation of Aneurysm Coiling a Reliable Study End Point?

Marielle Ernst, MD; Albert J. Yoo, MD; Levente Kriston, PhD; Michael H. Schönfeld, MD; Eik Vettorazzi, MSc; Jens Fiehler, MD

Background and Purpose: Angiographic occlusion as a surrogate marker of satisfactory aneurysm treatment is commonly used in clinical trials although some pitfalls have to be considered. To investigate the inter-rater reliability of visual rating of aneurysm occlusion as study end point, we performed a systematic review and meta-analysis.

01 agosto 2015

RSNA: Radiology. Stent-assisted Coil Placement for the Treatment of 211 Acutely Ruptured Wide-necked Intracranial Aneurysms: A Single-Center 11-Year Experience

Pengfei Yang, MD Kaijun Zhao, MD Yu Zhou, MD Rui Zhao, MD Lei Zhang, MD Wenyuan Zhao, MD Bo Hong, MD Yi Xu, MD Qinghai Huang, MD Timo Krings, MD Jianmin Liu, MD

Purpose: To evaluate the safety and angiographic and clinical outcome of stent-assisted coil placement (SACP) for acutely ruptured wide-necked intracranial aneurysms treated in a single center during an 11-year period.

02 abril 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Degree of Collaterals and Not Time Is the Determining Factor of Core Infarct Volume within 6 Hours of Stroke Onset

E. Cheng-Ching, J.A. Frontera, S. Mana, J. Aoki, Y. Tateishi, F.K. Hui, D. Wisco, P. Ruggieri, M.S. Hussain and K. Uchino

BACKGROUND AND PURPOSE: Growth of the core infarct during the first hours of ischemia onset is not well-understood. We hypothesized that factors other than time from onset of ischemia contribute to core infarct volume as measured by MR imaging.

07 mayo 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Deconstructive and Reconstructive Techniques in Treatment of Vertebrobasilar Dissecting Aneurysms: A Systematic Review and Meta-Analysis

Ö. Sönmez, W. Brinjikji, M.H. Murad and G. Lanzino

BACKGROUND AND PURPOSE: Various endovascular techniques have been applied to the treatment of vertebrobasilar dissecting aneurysms, including parent artery preservation with coiling, stent placement or flow diverter placement, and trapping and proximal occlusion. We performed a systematic review and meta-analysis to study clinical and angiographic outcomes of patients undergoing endovascular treatment of vertebrobasilar dissecting aneurysms.