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ABSTRACT


04 febrero 2016

STROKE. Clinical Sciences. Thrombus Permeability Is Associated With Improved Functional Outcome and Recanalization in Patients With Ischemic Stroke

Emilie M.M. Santos, MSc*; Henk A. Marquering, PhD*; Mark D. den Blanken, MSc; Olvert A. Berkhemer, MD, MSc; Anna M.M. Boers, MSc; Albert J. Yoo, MD; Ludo F. Beenen, MD; Kilian M. Treurniet, MD, MSc; Carrie Wismans, BSc; Kim van Noort, BSc; Hester F. Lingsma, PhD; Diederik W.J. Dippel, MD, PhD; Aad van der Lugt, MD; Wim H. van Zwam, MD, PhD; Yvo B.W.E.M. Roos, MD, PhD; Robert J. van Oostenbrugge, MD; Wiro J. Niessen, PhD; Charles B. Majoie, MD, PhD, on behalf of the MR CLEAN Investigators

Background and Purpose: Preclinical studies showed that thrombi can be permeable and may, therefore, allow for residual blood flow in occluded arteries of patients having acute ischemic stroke. This perviousness may increase tissue oxygenation, improve thrombus dissolution, and augment intra-arterial treatment success. We hypothesize that the combination of computed tomographic angiography and noncontrast computed tomography imaging allows measurement of contrast agent penetrating a permeable thrombus, and it is associated with improved outcome.

01 abril 2016

JOURNAL OF NEUROSURGERY. Long-term treatment outcome of venous-predominant arteriovenous malformation

Jin Pyeong Jeon, MD1, Jeong Eun Kim, MD2, Jun Hyong Ahn, MD1, Won-Sang Cho, MD2, Young Dae Cho, MD3, Young-Je Son, MD2, Jae Seung Bang, MD2, Hyun-Seung Kang, MD2, Chul-Ho Sohn, MD3, Hyun-Tai Chung, PhD2, Chang Wan Oh, MD2, and Dong Gyu Kim, MD2

OBJECT: Treatment strategies for venous-predominant arteriovenous malformation (vp-AVM) remain unclear due to the limited number of cases and a lack of long-term outcomes. The purpose of this study was to report the authors’ experience with treatment outcomes with a review of the pertinent literature in patients with vp-AVM.

01 abril 2016

JOURNAL OF NEUROSURGERY. Correlation between angiographic transit times and neurological status on admission in patients with aneurysmal subarachnoid hemorrhage

Alexander Ivanov, MD1, Andreas Linninger, PhD1,2, Chih-Yang Hsu, BS2, Sepideh Amin-Hanjani, MD1, Victor A. Aletich, MD1, Fady T. Charbel, MD1, and Ali Alaraj, MD1

OBJECT: The use of digital subtraction angiography (DSA) for semiquantitative cerebral blood flow(CBF) assessment is a new technique. The aim of this study was to determine whether patients with aneurysmal subarachnoid hemorrhage (aSAH) with higher Hunt and Hess grades also had higher angiographic contrast transit times (TTs) than patients with lower grades.

05 noviembre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Radiation Doses in Patient Eye Lenses during Interventional Neuroradiology Procedures

R.M. Sánchez, E. Vañó, J.M. Fernández, S. Rosati and L. López-Ibor

BACKGROUND AND PURPOSE: Eye lenses are among the most sensitive organs to x-ray radiation and may be considered at risk during neurointerventional radiology procedures. The threshold dose to produce eye lens opacities has been recently reduced to 500 mGy by the International Commission on Radiologic Protection. In this article, the authors investigated the radiation doses delivered to patients´ eyes during interventional neuroradiology procedures at a university hospital.

29 octubre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Retrospective Analysis of Delayed Intraparenchymal Hemorrhage after Flow-Diverter Treatment: Presentation of a Retrospective Multicenter Trial

A. Benaissa, C. Tomas, F. Clarençon, N. Sourour, D. Herbreteau, L. Spelle, S. Gallas, A.-C. Januel, A.L. Gaultier and L. Pierot

BACKGROUND AND PURPOSE: Intracranial aneurysm treatment with flow diverters has shown satisfying results in terms of aneurysm occlusion, and while some cases of delayed intraparenchymal hemorrhage have been described, no systematic analysis of the risk factors affecting its occurrence has been conducted in a large series of patients. This retrospective analysis of delayed intraparenchymal hemorrhage after flow-diverter treatment is a multicenter, retrospective study using a large series of treated patients to analyze factors affecting the occurrence of delayed intraparenchymal hemorrhage.

19 noviembre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Intravenous C-Arm Conebeam CT Angiography following Long-Term Flow-Diverter Implantation: Technologic Evaluation and Preliminary Results

S.C.H. Yu, K.T. Lee, T.W.W. Lau, G.K.C. Wong, V.K.Y. Pang and K.Y. Chan

BACKGROUND AND PURPOSE: A noninvasive investigation with high spatial resolution and without metal artifacts is necessary for long-term imaging follow-up after flow-diverter implantation. We aimed to evaluate the diagnostic value of conebeam CT angiography with intravenous contrast enhancement in the assessment of vascular status following implantation of the Pipeline Embolization Device and to analyze the preliminary results of vascular status following long-term Pipeline Embolization Device implantation.

01 octubre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Posterior Inferior Cerebellar Artery Patency after Flow-Diverting Stent Treatment

M.R. Levitt, M.S. Park, F.C. Albuquerque, K. Moon, M.Y.S. Kalani and C.G. McDougall

BACKGROUND AND PURPOSE: The rate of PICA occlusion after flow-diverting stent placement for vertebral and vertebrobasilar artery aneurysms is not known. The purpose of this study is to determine the medium-term rate of PICA patency and risk factors for occlusion after such aneurysm treatment.

24 septiembre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Stent-Assisted Coil Embolization of Intracranial Aneurysms: Complications in Acutely Ruptured versus Unruptured Aneurysms

R.S. Bechan, M.E. Sprengers, C.B. Majoie, J.P. Peluso, M. Sluzewski and W.J. van Rooij

BACKGROUND AND PURPOSE: The use of stents in the setting of SAH is controversial because of concerns about the efficacy and risk of dual antiplatelet therapy. We compare complications of stent-assisted coil embolization in patients with acutely ruptured aneurysms with complications in patients with unruptured aneurysms.

15 octubre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Safety and Efficacy of Intravenous Tirofiban as Antiplatelet Premedication for Stent-Assisted Coiling in Acutely Ruptured Intracranial Aneurysms

S. Kim, J.-H. Choi, M. Kang, J.-K. Cha and J.-T. Huh

BACKGROUND AND PURPOSE: Stent-assisted coiling of intracranial aneurysms requires antiplatelet therapy, typically aspirin and clopidogrel to prevent thromboembolic complications. There is a substantial concern that tirofiban may increase the risk of hemorrhage when used as an antiplatelet premedication in ruptured intracranial aneurysms. Our aim was to evaluate the safety and efficacy of intravenous tirofiban administration, instead of oral dual antiplatelet agents, as an antiplatelet premedication for stent-assisted coiling in patients with acutely ruptured intracranial aneurysms.

26 noviembre 2015

AMERICAN JOURNAL OF NEURORADIOLOGY. Normal Venous Phase Documented during Angiography in Patients with Spinal Vascular Malformations: Incidence and Clinical Implications

D. Eckart Sorte, M. Obrzut, E. Wyse and P. Gailloud

BACKGROUND AND PURPOSE: A key angiographic sign observed in patients with spinal vascular malformations is the absence of a normal venous phase. While this finding alone is often believed to rule out a lesion impacting the perimedullary venous drainage, the observation of a venous phase in several patients with vascular malformations led us to reconsider the validity of that sign.

31 marzo 2016

STROKE. Brief Report. Access to Endovascular Treatment in Remote Areas. Analysis of the Reperfusion Treatment Registry of Catalonia

Natalia Pérez de la Ossa, PhD; Sònia Abilleira, PhD; Laura Dorado, PhD; Xabier Urra, PhD; Marc Ribó, PhD; Pere Cardona, PhD; Eva Giralt, MD; Joan Martí-Fàbregas, PhD; Francisco Purroy, PhD; Joaquín Serena, PhD; David Cánovas, MD; Moisés Garcés, MD; Jurek Krupinski, PhD; Anna Pellisé, MD; Júlia Saura, MD; Carlos Molina, PhD; Antoni Dávalos, PhD; Miquel Gallofré, PhD, on behalf of the Catalan Stroke Code and Reperfusion Consortium*

Background and Purpose: Since demonstration of the benefit of endovascular treatment (EVT) in acute ischemic stroke patients with proximal arterial occlusion, stroke care systems need to be reorganized to deliver EVT in a timely and equitable way. We analyzed differences in the access to EVT by geographical areas in Catalonia, a territory with a highly decentralized stroke model.

17 marzo 2016

STROKE. Brief Report. Determining the Number of Ischemic Strokes Potentially Eligible for Endovascular Thrombectomy. A Population-Based Study

Nicholas H. Chia, MBBS; James M. Leyden, MBBS; Jonathan Newbury, BMBS, PhD; Jim Jannes, MBBS, PhD; Timothy J. Kleinig, MBBS, PhD

Background and Purpose: Endovascular thrombectomy (ET) is standard-of-care for ischemic stroke patients with large vessel occlusion, but estimates of potentially eligible patients from population-based studies have not been published. Such data are urgently needed to rationally plan hyperacute services. Retrospective analysis determined the incidence of ET-eligible ischemic strokes in a comprehensive population-based stroke study (Adelaide, Australia 2009–2010).

07 abril 2016

STROKE. Brief Report. Cannabis Use and Outcomes in Patients With Aneurysmal Subarachnoid Hemorrhage

Réza Behrouz, DO; Lee Birnbaum, MD; Ramesh Grandhi, MD; Jeremiah Johnson, MD; Vivek Misra, MD; Santiago Palacio, MD; Ali Seifi, MD; Christopher Topel, DO; Rachel Garvin, MD; Jean-Louis Caron, MD

Background and Purpose: The incidence of cannabis use in patients with aneurysmal subarachnoid hemorrhage (aSAH) and its impact on morbidity, mortality, and outcomes are unknown. Our objective was to evaluate the relationship between cannabis use and outcomes in patients with aSAH.

31 marzo 2016

STROKE. Brief Report. Silent Brain Infarction in Patients With Asymptomatic Carotid Artery Atherosclerotic Disease

Hediyeh Baradaran, MD; Gino Gialdini, MD; Edward Mtui, MD; Gulce Askin, MPH; Hooman Kamel, MD; Ajay Gupta, MD

Background and Purpose: The relationship between carotid atherosclerosis and ipsilateral silent brain infarction (SBI) is unclear. We tested the hypothesis that extracranial internal carotid artery (ICA) stenosis is associated with a greater prevalence of SBI in the cerebral hemisphere ipsilateral to ICA disease compared with the unaffected, contralateral side.

05 abril 2016

STROKE. Basic Sciences. Microbubble-Mediated Sonothrombolysis Improves Outcome After Thrombotic Microembolism-Induced Acute Ischemic Stroke

Yongkang Lu, MD, PhD*; Junfen Wang, MD, PhD*; Ruizhu Huang, MD; Gangbin Chen, MD; Lintao Zhong, MD; Shuxin Shen, MD, PhD; Chuanxi Zhang, MD; Xinzhong Li, MD; Shiping Cao, MD, PhD; Wangjun Liao, MD, PhD; Yulin Liao, MD, PhD; Jianping Bin, MD, PhD

Background and Purpose: Microthrombi originating from disintegrated clots or formed in situ may account for the poor clinical improvement of acute ischemic stroke after recanalization therapy. We attempted to determine whether microbubble-mediated sonothrombolysis could dissolve platelet-rich and erythrocyte-rich microthrombi, thereby reducing their brain injury-causing potential.

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