03 junio 2016

JOURNAL OF NEUROSURGERY. Efficacy of a coaxial system with a compliant balloon catheter for navigation of the Penumbra reperfusion catheter in tortuous arteries: technique and case experience

Kazuki Takahira, MD1, Taketo Kataoka, MD2, Tatsuya Ogino, MD1, Hideki Endo, MD1, and Hirohiko Nakamura, MD, PhD1

OBJECTIVE: The authors describe a method by which they easily and atraumatically navigate a large-bore reperfusion catheter of the Penumbra system to an embolus by using a coaxial system with a compliant balloon catheter in patients with tortuous arteries.

03 junio 2016

JOURNAL OF NEUROSURGERY. Impact of subclinical coronary artery disease on the clinical outcomes of carotid endarterectomy

Hyunwook Kwon, MD1, Dae Hyuk Moon, MD, PhD2, Youngjin Han, MD1, Jong-Young Lee, MD, PhD3, Sun U Kwon, MD, PhD4, Dong-Wha Kang, MD, PhD4, Suk Jung Choo, MD, PhD5, Tae-Won Kwon, MD, PhD1, Min-Ju Kim, MSc6, and Yong-Pil Cho, MD, PhD1

OBJECTIVE: Controversy persists regarding the optimal management of subclinical coronary artery disease (CAD) prior to carotid endarterectomy (CEA) and the impact of CAD on clinical outcomes after CEA. This study aimed to evaluate the short-term surgical risks and long-term outcomes of patients with subclinical CAD who underwent CEA.

01 junio 2015

JOURNAL OF NEUROSURGERY. Ultrasound-induced opening of the blood-brain barrier to enhance temozolomide and irinotecan delivery: an experimental study in rabbits

Kevin Beccaria, MD1,2, Michael Canney, PhD1, Lauriane Goldwirt, PharmD, PhD3, Christine Fernandez, PharmD, PhD3, Julie Piquet, MS4, Marie-Cécile Perier, MSc5, Cyril Lafon, PhD6, Jean-Yves Chapelon, PhD6, and Alexandre Carpentier, MD, PhD7,8

OBJECT: The blood-brain barrier (BBB) limits the intracerebral penetration of drugs and brain tumor treatment efficacy. The effect of ultrasound-induced BBB opening on the intracerebral concentration of temozolomide (TMZ) and irinotecan (CPT-11) was assessed.

01 junio 2016

JOURNAL OF NEUROSURGERY. Age-related outcomes following intracranial aneurysm treatment with the Pipeline Embolization Device: a subgroup analysis of the IntrePED registry

Waleed Brinjikji, MD1, David F. Kallmes, MD1,2, Harry J. Cloft, MD, PhD1,2, and Giuseppe Lanzino, MD1,2

OBJECT: The association between age and outcomes following aneurysm treatment with flow diverters such as the Pipeline Embolization Device (PED) have not been well established. Using the International Retrospective Study of the Pipeline Embolization Device (IntrePED) registry, the authors assessed the age-related clinical outcomes of patients undergoing aneurysm embolization with the PED.

01 junio 2016

JOURNAL OF NEUROSURGERY. Initial experience with dual-lumen balloon catheter injection for preoperative Onyx embolization of skull base paragangliomas

Travis R. Ladner, BA1, Lucy He, MD2, Brandon J. Davis, MD, PhD2, George L. Yang, BA1, George B. Wanna, MD2,3, and J Mocco, MD, MS2

OBJECT: Paragangliomas are highly vascular head and neck tumors for which preoperative embolization is often considered to facilitate resection. The authors evaluated their initial experience using a dual-lumen balloon to facilitate preoperative embolization in 5 consecutive patients who underwent preoperative transarterial Onyx embolization assisted by the Scepter dual-lumen balloon catheter between 2012 and 2014.

01 julio 2016

JOURNAL OF NEUROSURGERY. The safety of Pipeline flow diversion in fusiform vertebrobasilar aneurysms: a consecutive case series with longer-term follow-up from a single US center

Sabareesh K. Natarajan, MD, MS1,2, Ning Lin, MD1,2,3, Ashish Sonig, MD, MS, MCh1,2, Ansaar T. Rai, MD4, Jeffrey S. Carpenter, MD4, Elad I. Levy, MD, MBA1,2,5,6, and Adnan H. Siddiqui, MD, PhD1,2,5,6,7

OBJECT: Pessimism exists regarding flow diversion for posterior circulation aneurysms because of reports of perforator territory infarcts and delayed ruptures. The authors report the results of patients who underwent Pipeline Embolization Device (PED) flow diversion using novel strategies for treatment of fusiform posterior circulation aneurysms, and compare these results with those from previously reported series.

01 julio 2016

JOURNAL OF NEUROSURGERY. Treatment of ruptured complex and large/giant ruptured cerebral aneurysms by acute coiling followed by staged flow diversion

Waleed Brinjikji, MD1, Mariangela Piano, MD4, Shanna Fang, MD2, Guglielmo Pero, MD4, David F. Kallmes, MD1,3, Luca Quilici, MD4, Luca Valvassori, MD4, Emilio Lozupone, MD5, Harry J. Cloft, MD, PhD1,3, Edoardo Boccardi, MD4, and Giuseppe Lanzino, MD1,3

OBJECT: Flow-diversion treatment has been shown to be associated with high rates of angiographic obliteration; however, the treatment is relatively contraindicated in the acute phase following subarachnoid hemorrhage (SAH) as these patients require periprocedural dual antiplatelet therapy. Acute coiling followed by flow diversion has emerged as an intriguing and feasible treatment option for ruptured complex and giant aneurysms. In this study the authors report outcomes and complications of patients with ruptured aneurysms undergoing coiling in the acute phase followed by planned delayed flow diversion.

01 julio 2016

JOURNAL OF NEUROSURGERY. Re-treatment rates after treatment with the Pipeline Embolization Device alone versus Pipeline and coil embolization of cerebral aneurysms: a single-center experience

Min S. Park, MD1, Michael Nanaszko, MD2, Matthew R. Sanborn, MD2, Karam Moon, MD2, Felipe C. Albuquerque, MD2, and Cameron G. McDougall, MD, FRCSC2

OBJECT: The optimal strategy for use of the Pipeline Embolization Device (PED, ev3 Neurovascular) has not been clearly defined. The authors examined re-treatment rates after treatment with PED alone versus PED and adjunctive coil embolization (PED/coil).

01 julio 2016

JOURNAL OF NEUROSURGERY. Management of arteriovenous malformations in the elderly: a single-center case series and analysis of outcomes

Aqueel H. Pabaney, MD, Kevin A. Reinard, MD, Max K. Kole, MD, Donald M. Seyfried, MD, and Ghaus M. Malik, MD

OBJECT: Treatment of brain arteriovenous malformations (bAVMs) in the elderly remains a challenge for cerebrovascular surgeons. In this study the authors reviewed the patient characteristics, treatments, angiographic results, and clinical outcomes in 28 patients over 65 years of age who were treated at Henry Ford Hospital between 1990 and 2014.

01 julio 2016

JOURNAL OF NEUROSURGERY. Intraarterial administration of norcantharidin attenuates ischemic stroke damage in rodents when given at the time of reperfusion: novel uses of endovascular capabilities

Imad S. Khan, MD1,2, Mitchell Odom, BS3, Moneeb Ehtesham, MD3, Daniel Colvin, PhD4, C. Chad Quarles, PhD4, BethAnn McLaughlin, PhD5, and Robert J. Singer, MD1,2

OBJECT: Matrix metalloprotease-9 (MMP-9) plays a critical role in infarct progression, blood-brain barrier (BBB) disruption, and vasogenic edema. While systemic administration of MMP-9 inhibitors has shown neuroprotective promise in ischemic stroke, there has been little effort to incorporate these drugs into endovascular modalities. By modifying the rodent middle cerebral artery occlusion (MCAO) model to allow local intraarterial delivery of drugs, one has the ability to mimic endovascular delivery of therapeutics. Using this model, the authors sought to maximize the protective potential of MMP-9 inhibition by intraarterial administration of an MMP-9 inhibitor, norcantharidin (NCTD).

01 abril 2016

EUROPEAN JOURNAL OF NEUROLOGY. Frequency and temporal profile of recanalization after cerebral vein and sinus thrombosis

C. Herweh1, M. Griebe2, C. Geisbüsch3, K. Szabo2, E. Neumaier-Probst4, M. G. Hennerici2, M. Bendszus1, P. A. Ringleb3 andS. Nagel3,*

Background and purpose: The temporal course of recanalization and its association with clinical outcome were analysed in our patients with cerebral sinus and/or venous thrombosis (CSVT) and follow-up magnetic resonance imaging (MRI).

01 febrero 2016

EUROPEAN JOURNAL OF NEUROLOGY. A collaborative system for endovascular treatment of acute ischaemic stroke: the Madrid Stroke Network experience

M. Alonso de Leciñana1,†,*, B. Fuentes2,†, Á. Ximénez-Carrillo3,†, J. Vivancos3, J. Masjuan1, A. Gil-Nuñez4, P. Martínez-Sánchez2, G. Zapata-Wainberg3, A. Cruz-Culebras1, A. García-Pastor4, F. Díaz-Otero4, E. Fandiño1, R. Frutos1, J.-L. Caniego3, J.-C. Méndez1, A. Fernández-Prieto2, E. Bárcena-Ruiz3, E. Díez-Tejedor2 andon behalf of the Madrid Stroke Network

Background and purpose: The complexity and expense of endovascular treatment (EVT) for acute ischaemic stroke (AIS) can present difficulties in bringing this approach closer to the patients. A collaborative node was implemented involving three stroke centres (SCs) within the Madrid Stroke Network to provide round-the-clock access to EVT for AIS.

26 marzo 2016

THE LANCET. A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre, open-label, single-arm, phase 1 trial

Prof Gerd Hasenfuß, MD, Prof Chris Hayward, MD, Dan Burkhoff, MD, Frank E Silvestry, MD, Scott McKenzie, MD, Finn Gustafsson, MD, Filip Malek, MD, Jan Van der Heyden, MD, Prof Irene Lang, MD, Prof Mark C Petrie, MD, Prof John G F Cleland, MD, Prof Martin Leon, MD, Prof David M Kaye, MD on behalf of the REDUCE LAP-HF study investigators†

Background: Heart failure with preserved ejection fraction (HFPEF) is a common, globally recognised, form of heart failure for which no treatment has yet been shown to improve symptoms or prognosis. The pathophysiology of HFPEF is complex but characterised by increased left atrial pressure, especially during exertion, which might be a key therapeutic target. The rationale for the present study was that a mechanical approach to reducing left atrial pressure might be effective in HFPEF.

26 marzo 2016

THE LANCET. Unidirectional left-to-right interatrial shunting for treatment of patients with heart failure with reduced ejection fraction: a safety and proof-of-principle cohort study

Maria Del Trigo, MD, Sebastien Bergeron, MD, Mathieu Bernier, MD, Ignacio J Amat-Santos, MD, Rishi Puri, PhD, Francisco Campelo-Parada, MD, Omar Abdul-Jawad Altisent, MD, Ander Regueiro, MD, Neal Eigler, MD, Erez Rozenfeld, Prof Philippe Pibarot, PhD, Prof William T Abraham, MD, Dr Josep Rodés-Cabau, MD

Background: In patients with heart failure, interventions to reduce elevated left atrial pressure improve symptoms and reduce the risk of hospital admission. We aimed to assess the safety and potential efficacy of therapeutic left-to-right interatrial shunting in patients with heart failure with reduced ejection fraction.

26 marzo 2016

THE LANCET. 1-year outcomes with the Absorb bioresorbable scaffold in patients with coronary artery disease: a patient-level, pooled meta-analysis

Prof Gregg W Stone, MD, Prof Runlin Gao, MD, Takeshi Kimura, MD, Dean J Kereiakes, MD, Prof Stephen G Ellis, MD, Yoshinobu Onuma, PhD, Wai-Fung Cheong, PhD, Jennifer Jones-McMeans, PhD, Xiaolu Su, MS, Zhen Zhang, PhD, Prof Patrick W Serruys, PhD

Background: Compared with metallic drug-eluting stents, bioresorbable vascular scaffolds (BVS) offer the potential to improve long-term outcomes of percutaneous coronary intervention. Whether or not these devices are as safe and effective as drug-eluting stents within the first year after implantation is unknown.