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ESTUDIOS


01 marzo 2012

JOURNAL OF CEREBROVASCULAR AND ENDOVASCULAR NEUROSURGERY. Coil Embolization of a Ruptured Basilar Tip Aneurysm Associated with Bilateral Cervical Internal Carotid Artery Occlusion: A Case Report and Literature Review

Sang-Shin Kim, MD1, Dong-Hyuk Park, MD, PhD1, Nam-Jun Lee, MD, PhD2, Shin-Hyuk Kang, MD, PhD1, Dong-Jun Lim, MD, PhD3, Yong-Gu Chung, MD, PhD1

We report here on a rare case of a ruptured basilar tip aneurysm that was successfully treated with coil embolization in the bilateral cervical internal carotid artery (ICA) occlusions with abnormal vascular networks from the posterior circulation. A 43-year old man with a familial history of moyamoya disease presented with subarachnoid hemorrhage. Digital subtraction angiography demonstrated complete occlusion of the bilateral ICAs at the proximal portion and a ruptured aneurysm at the basilar artery bifurcation. Each meningeal artery supplied the anterior cranial base, but most of both hemispheres were supplied with blood from the basilar artery and the posterior cerebral arteries through a large number of collateral vessels to the ICA bifurcation as well as the anterior cerebral and middle cerebral arteries. The perfusion computed tomography (CT) scans with acetazolamide (ACZ) injection revealed no reduction of cerebral blood flow and normal cerebrovascular reactivity to ACZ. An abdominal CT aortogram showed no other extracranial vessel abnormalities. A ruptured basilar tip aneurysm was successfully treated with coil embolization without complications. Endovascular embolization may be a good treatment option with excellent safety for a ruptured basilar tip aneurysm that accompanies proximal ICA occlusion with vulnerable collateral flow. (J Cerebrovasc Endovasc Neurosurg. 2012 Mar;14(1):44~49)

01 septiembre 2012

JOURNAL OF CEREBROVASCULAR AND ENDOVASCULAR NEUROSURGERY. Effect of Premedication Method and Drug Resistance of Antiplatelet Agent on Periprocedural Thromboembolic Events During Coil Embolization of an Unruptured Intracranial Aneurysm

Se Hwan Park, MD, Yong Bae Kim, MD, PhD, Seung Kon Huh, MD, PhD

Objective: A retrospective review of premedication method and drug resistance of aspirin and clopidogrel in association with thromboembolic events during and after coil embolization of an unruptured intracranial aneurysm was conducted. Methods:Our premedication policy for coil embolization of an unruptured intracranial aneurysm has changed from administration of the loading dose before the procedure (i.e. loading group) to repeated administration of the maintenance dose for several days (i.e. preparation group). The loading group (27 patients with 29 aneurysms) and the preparation group (30 patients with 35 aneurysms) were compared for identification of the effect of premedication method on periprocedural thromboembolic events. The results of drug response assays of the preparation group were analyzed with respect to periprocedural thromboembolic events. Results:No statistically significant difference in incidence of thromboembolic events was observed between the loading group and the preparation group. Analysis of the results of the drug response assay showed high prevalence (56.7%, 73.3%) of clopidogrel resistance and relatively low prevalence (6.7%) of aspirin resistance. Patients who had thromboembolic events tended to have lower responsiveness to both aspirin and clopidogrel than patients without it. Conclusion:The method of antiplatelet premedication does not affect the rate of periprocedural thromboembolic events in coil embolization for treatment of an unruptured intracranial aneurysm. Nevertheless, considering the high prevalence of drug resistance, it is reasonable to premedicate antiplatelet agents in the preparation method for the drug response assay. Use of a higher dose of aspirin and clopidogrel or addition of an alternative drug (cilostazol or triflusal) can be applied against antiplatelet agent resistance. However, because the hemorrhagic risk associated with this supplementary use of antiplatelet agent has not been well-documented, the hemorrhagic risk and the preventive benefit must be weighed.

17 octubre 2011

FRONTIERS IN ENDOVASCULAR AND INTERVENTIONAL NEUROLOGY. Endovascular embolization of head and neck tumors

Marc A. Lazzaro, Aamir Badruddin, Osama O. Zaidat, Ziad Darkhabani, Dhruvil J. Pandya and John R. Lynch

Endovascular tumor embolization as adjunctive therapy for head and neck cancers is evolving and has become an important part of the tools available for their treatment. Careful study of tumor vascular anatomy and adhering to general principles of intra-arterial therapy can prove this approach to be effective and safe. Various embolic materials are available and can be suited for a given tumor and its vascular supply. This article aims to summarize current methods and agents used in endovascular head and neck tumor embolization and discuss important angiographic and treatment characteristics of selected common head and neck tumors.

09 diciembre 2011

FRONTIERS IN ENDOVASCULAR AND INTERVENTIONAL NEUROLOGY. Stenting in the treatment of acute ischemic stroke: literature review

Edgar A. Samaniego, Guilherme Dabus and Italo Linfante

Recanalization of acute large artery occlusions is a strong predictor of good outcome. The development of thrombectomy devices resulted in a significant improvement in recanalization rates compared to thrombolytics alone. However, clinical trials and registries with these thrombectomy devices in acute ischemic stroke (AIS) have shown recanalization rates in the range of 40–81%. The last decade has seen the development of nickel titanium self-expandable stents (SES). These stents, in contrast to balloon-mounted stents, allow better navigability and deployment in tortuous vessels and therefore are optimal for the cerebral circulation. SES were initially used for stent-assisted coil embolization of intracranial aneurysms and for treatment of intracranial stenosis. However, a few authors have recently reported feasibility of deployment of SES in AIS. The use of these devices yielded higher recanalization rates compared to traditional thrombectomy devices. Encouraged by these results, retrievable SES systems have been recently used in AIS. These devices offer the advantage of resheathing and retrieving of the stent even after full deployment. Some of these stents can also be detached in case permanent stent placement is needed. Retrievable SES are being used in Europe and currently tested in clinical trials in the United States. We review the recent literature in the use of stents for the treatment of AIS secondary to large vessel occlusion.

17 octubre 2011

INTERVENTIONAL NEURORADIOLOGY. Treatment of Intracranial Aneurysms Using Flow-Diverting Silk Stents (BALT): a Single Centre Experience

M. Leonardi, L. Cirillo, F. Toni, M. Dall’Olio, C. Princiotta, A. Stafa, L. Simonetti, and R. Agati

The Silk stent (Balt, Montmorency, France) is a retractable device designed to achieve curative reconstruction of the parent artery associated with an intracranial aneurysm. We present our initial experience with the Silk flow-diverting stent in the management and follow-up of 25 patients presenting with intracranial aneurysms.

16 marzo 2012

INTERVENTIONAL NEURORADIOLOGY. Treatment of Progressive Cerebral Sinuses Thrombosis with Local Thrombolysis

R. Mohammadian, B. Sohrabi, R. Mansourizadeh, F. Mohammadian, A. Nazempour, M. Farhoudi, A. Pashapour, A.A. Taher Aghdam, A. Hashemzadeh, and M. Pourkakrodi

Cerebral venous thrombosis (CVT) is a potentially serious disease, with nonspecific clinical symptoms and an unpredictable outcome. Despite adequate anticoagulation, a patient’s clinical condition can rapidly deteriorate. The aim of this study was to evaluate the efficacy of local thrombolysis in these patients.

01 octubre 2010

STROKE. Flow-Diverter Stent for the Endovascular Treatment of Intracranial Aneurysms. A Prospective Study in 29 Patients With 34 Aneurysms

Boris Lubicz, MD, PhD; Laurent Collignon, MD; Gaï Raphaeli, MD; Jean-Pierre Pruvo, MD, PhD; Michaël Bruneau, MD; Olivier De Witte, MD, PhD; Xavier Leclerc, MD, PhD

Background and Purpose—The purpose of this study is to report our preliminary experience with the flow-diverter Silk stent for the endovascular treatment of intracranial aneurysms.

18 agosto 2011

AMERICAN JOURNAL OF NEURORADIOLOGY. Comparison of 2-Year Angiographic Outcomes of Stent- and Nonstent-Assisted Coil Embolization in Unruptured Aneurysms with an Unfavorable Configuration for Coiling

G. Hwang, H. Park, J.S. Bang, S.-C. Jin, B.C. Kim, C.W. Oh, H.S. Kang, M.H. Han and O.-K. Kwon

BACKGROUND AND PURPOSE: Stents are known to have hemodynamic and biologic effects in addition to their mechanical scaffold effect. To determine whether stents affect long-term outcomes after coiling of unruptured aneurysms, we compared angiographic outcomes at 2 years postembolization for stent- and nonstent-assisted coiled unruptured aneurysms.

01 septiembre 2012

JOURNAL OF CEREBROVASCULAR AND ENDOVASCULAR NEUROSURGERY. Clinical and Angiographic Outcomes of Wingspan Stent Placement for Treatment of Symptomatic Intracranial Stenosis: Single Center Experience with 19 Cases

Jun Hyoung Lee, MD, Ji Kwang Yun, MD, Dae Won Kim, MD, Sung Don Kang, MD

Objective:The limitations of medical management of symptomatic intracranial arterial stenosis (ICS) have prompted development of new strategies, including endovascular treatment. However, stenting of symptomatic ICS remains investigational. Here, we have reported and analyzed a series of 19 endovascular procedures involving placement of a Wingspan stent. Methods:We conducted a retrospective review of a series of ICS in which patients were treated with percutaneous transarterial balloon angioplasty and stent placement (PTAS). Patients included in the study were diagnosed as symptomatic ICS between May 2010 and September 2011. Results:Nineteen patients (median age, 65 years; 12 males, seven women) were treated with the Wingspan stent system for symptomatic ICS ranging from 50% to 99%. The technical success rate was 100%. The location of ICS included the internal carotid (n = 5; 1 petrous, 3 cavernous, and 1 clinoid segments), vertebral (n = 1; V4 segment), basilar (n = 1), and middle cerebral (n = 12; 9 M1, 3 M2) arteries. There was no occurrence of procedure-related mortality. Periprocedural morbidity occurred in two cases (10.5%), including carotid-cavernous fistula (n = 1) and subarachnoid hemorrhage (n = 1). No ipsilateral stroke was recorded beyond 30 days during a mean follow-up period of 13.2 months (range 9–19 months). Restenosis (> 50%) was observed in one patient (6.3%), who was asymptomatic, on follow-up imaging. Conclusion:Wingspan stent for symptomatic ICS can be performed with a high rate of technical success and acceptable periprocedural morbidity rates. Our initial experience indicates that this procedure represents a viable treatment option for this patient population.

01 abril 2013

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. Prevention of Intracranial In-stent Restenoses: Predilatation with a Drug Eluting Balloon, Followed by the Deployment of a Self-Expanding Stent

Zsolt Vajda, Thomas Güthe, Marta Aguilar Perez, Wiebke Kurre, Elisabeth Schmid, Hansjörg Bäzner, Hans Henkes

Purpose: Stenting in intracranial atherosclerotic disease (ICAD) is increasingly debated, due to issues of procedural safety, technical efficacy, and in-stent recurrent stenoses (ISR). In the present study, feasibility, safety, and efficacy of angioplasty using a drug-eluting balloon (DEB) followed by the implantation of a self-expanding stent (Enterprise) were evaluated for the treatment of ICAD lesions.

22 septiembre 2011

PLOS. Comparison of Devices Used for Stent-Assisted Coiling of Intracranial Aneurysms

Benjamin Izar, Ansaar Rai, Karthikram Raghuram, Jill Rotruck, and Jeffrey Carpenter

Introduction; Two self-expandable stents, the Neuroform and the Enterprise stent, are widely used for stent-assisted coiling (SAC) of complex shaped intracranial aneurysms. However, comparative knowledge about technical feasibility, peri- and post-procedural morbidity and mortality, packing densities as well as follow-up data is limited.

01 marzo 2012

TECHNIQUES IN VASCULAR AND INTERVENTIONAL RADIOLOGY. Past, Present, and Future Perspectives on the Endovascular Treatment of Acute Ischemic Stroke

Omar M. Arnaout, MD , Rudy J. Rahme, MD , Tarek Y. El Ahmadieh, MD , Salah G. Aoun, MD , H. Hunt Batjer, MD, FACS, FAANS , Bernard R. Bendok, MD, FACS, FAANS

Interventional neuroradiology plays a continuously expanding and exciting role in the treatment of acute stroke, as evidenced by the development of several important advances, including the advent of multiple new devices and therapies. Furthermore, guidelines regarding endovascular interventions in the setting of acute stroke have been developed and used. In addition to technological advances, the field of pharmacology in the setting of acute stroke is constantly evolving. In a rapidly expanding field, we aim to review significant recent advances related to the endovascular treatment of stroke as well as provide perspective for future directions.

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