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ESTUDIOS


15 mayo 2014

STROKE. Clinical Sciences. Optimal Workflow and Process-Based Performance Measures for Endovascular Therapy in Acute Ischemic Stroke

Bijoy K. Menon, MD; Mohammed A. Almekhlafi, MD, MSc; Vitor Mendes Pereira, MD, MSc; Jan Gralla, MD; Alain Bonafe, MD; Antoni Davalos, MD; Rene Chapot, MD; Mayank Goyal, MD; on behalf of the STAR Study Investigators

Background and Purpose: We report on workflow and process-based performance measures and their effect on clinical outcome in Solitaire FR Thrombectomy for Acute Revascularization (STAR), a multicenter, prospective, single-arm study of Solitaire FR thrombectomy in large vessel anterior circulation stroke patients.

22 mayo 2014

STROKE. Clinical Sciences. Capillary Index Score in the Interventional Management of Stroke Trials I and II

Firas Al-Ali, MD; Thomas A. Tomsick, MD; John J. Connors III, MD; James M. Gebel, MD; John J. Elias, PhD; Georges Z. Markarian, MD; Zein Al-Ali; Joseph P. Broderick, MD

Background and Purpose: The Capillary Index Score (CIS) is a simple angiography-based scale for assessing viable tissue in the ischemic territory. We retrospectively applied it to Interventional Management of Stroke (IMS) trials I and II to evaluate the predictive value for good outcomes.

12 junio 2014

STROKE. Clinical Sciences. Impact of Diffusion-Weighted Imaging Alberta Stroke Program Early Computed Tomography Score on the Success of Endovascular Reperfusion Therapy

Manabu Inoue, MD, PhD*; Jean-Marc Olivot, MD, PhD*; Julien Labreuche, BST; Michael Mlynash, MD, MS; Waimea Tai, MD; Jean-François Albucher, MD; Elena Meseguer, MD; Pierre Amarenco, MD; Mikael Mazighi, MD, PhD

Background and Purpose: In acute ischemic stroke patients treated by intravenous thrombolysis, a diffusion-weighted imaging (DWI) Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is an independent factor of functional outcomes. Our aim was to assess the impact of pretreatment DWI-ASPECTS on outcomes after endovascular therapy, with a specific emphasis on recanalization.

29 mayo 2014

STROKE. Clinical Sciences. Predictors of Functional Dependence Despite Successful Revascularization in Large-Vessel Occlusion Strokes

Zhong-Song Shi, MD; David S. Liebeskind, MD; Bin Xiang, PhD; Sijian Grace Ge, MS; Lei Feng, MD; Gregory W. Albers, MD; Ronald Budzik, MD; Thomas Devlin, MD; Rishi Gupta, MD; Olav Jansen, MD; Tudor G. Jovin, MD; Monika Killer-Oberpfalzer, MD; Helmi L. Lutsep, MD; Juan Macho, MD; Raul G. Nogueira, MD; Marilyn Rymer, MD; Wade S. Smith, MD; Nils Wahlgren, MD; Gary R. Duckwiler, MD; for the Multi MERCI, TREVO, and TREVO 2 Investigators

Background and Purpose: High revascularization rates in large-vessel occlusion strokes treated by mechanical thrombectomy are not always associated with good clinical outcomes. We evaluated predictors of functional dependence despite successful revascularization among patients with acute ischemic stroke treated with thrombectomy.

01 junio 2015

NEUROSURGERY. Long-term Outcomes of the International Randomized Clinical Trial of Stenting Versus Endarterectomy for Symptomatic Carotid Artery Stenosis

Starke, Robert M. MD; Komotar, Ricardo J. MD; Ahmad, Faiz MD; Connolly, E. Sander MD

Atherosclerotic stenosis of the internal carotid artery accounts for 10% to 15% of all strokes. For symptomatic patients with significant extracranial carotid stenosis, prior trials have found better outcomes after carotid endarterectomy (CEA) compared with best medical therapy.1-5 Numerous studies have assessed endovascular treatment (angioplasty with or without stenting) as an alternative to CEA.6-10 More recently, randomized trials comparing stenting with CEA for symptomatic carotid stenosis found that stenting was associated with a higher risk of stroke but lower rates of myocardial infarction, access site hematoma, and cranial nerve palsy.

01 junio 2015

NEUROSURGERY. Clinical Features and Prognosis of Intracranial Artery Dissection

Sikkema, Tineke MD*; Uyttenboogaart, Maarten MD, PhD*; van Dijk, J. Marc C. MD, PhD‡; Groen, Rob J.M. MD, PhD‡; Metzemaekers, Jan D.M. MD, PhD‡; Eshghi, Omid MD§; Mazuri, Aryan MD§; Bakker, Nicolaas A. MD, PhD‡; Luijckx, Gert-Jan MD, PhD*

BACKGROUND: Intracranial artery dissections (IADs) are an important cause of stroke or subarachnoid hemorrhage (SAH). Outcome of IAD in the anterior circulation or presentation without SAH is rarely investigated and might be different.

01 agosto 2015

NEUROSURGERY. Clinical Prediction and Decision Rules in Neurosurgery: A Critical Review

Stein, Sherman C. MD; Attiah, Mark A. BA

Abstract: Clinical prediction and decision rules use evidence-based medicine to assist clinicians in diagnosing and treating illness. Although widespread in modern medical practice, there are relatively few clinical rules for neurosurgical conditions. This article reviews the background of how clinical prediction and decision rules are derived, validated, evaluated, and used in practice. It also summarizes a list of clinical rules published for neurosurgical illnesses and analyzes each rule for how it was derived and whether it was validated and/or evaluated compared with similar rules. It reports on whether the implementation of each rule was studied and grades the overall quality of each report.

01 agosto 2015

NEUROSURGERY. Chronic Traumatic Encephalopathy: Is It Real? The Relationship Between Neurotrauma and Neurodegeneration

Bailes, Julian E. MD*; Turner, Ryan C. PhD§,¶; Lucke-Wold, Brandon P. BS§,¶; Patel, Vimal PhD*; Lee, John M. MD, PhD‡

Case series identifying chronic traumatic encephalopathy (CTE) in former athletes and military veterans have been, and continue to be, reported. Recently, there have also been substantial descriptions of the neuropathological similarities and differences between CTE and other neurodegenerative diseases such as Alzheimer disease (AD). Finally, there is growing evidence that neurodegenerative diseases, including Parkinson disease (PD), afflict those with a history of head trauma and blast exposure at higher rates than the general population.

01 agosto 2015

NEUROSURGERY. Flow Diversion for the Treatment of Intracranial Aneurysms: Current State and Expanding Indications

Munich, Stephan A. MD*,§; Cress, Marshall C. MD*,§; Levy, Elad I. MD, MBA

The concept of flow diversion seems intuitive for the treatment of vascular disease. Flow diversion is stenting in a way that truly reconstructs the parent vessel, encouraging flow within the true vessel lumen and restricting it from surrounding pathology. This technique is possible because of the tightly braided nature of flow-diverting stents (30%-35% metal surface area coverage).

01 agosto 2015

NEUROSURGERY. Microsurgical Management of Residual and Recurrent Aneurysms After Coiling and Clipping: An Experience With 97 Patients

Owen, Christopher M. MD; Montemurro, Nicola MD; Lawton, Michael T. MD

Residual and recurrent aneurysms are difficult quandaries for patients and clinicians because curative occlusion is not achieved and a decision about retreatment must be made, weighing the risks of rupture from a partially treated aneurysm against the risks of further intervention, which can be exponentially more challenging than an untreated aneurysm.

01 agosto 2015

NEUROSURGERY. Aneurysm Remnants After Coiling and Clipping: Considerations in Surgical and Endovascular Treatment Options

Binning, Mandy J. MD; Veznedaroglu, Erol MD

The clinical significance of remnants or recurrences of treated intracranial aneurysms is not a new concern for vascular neurosurgeons. However, in the endovascular era of aneurysm treatment, there has been more focus on this problem. It should be noted, first and foremost, that not all aneurysm remnants are created equally.

01 agosto 2015

NEUROSURGERY. Modern Paradigms for the Treatment of Ruptured Anterior Communicating Artery Aneurysms

Moon, Karam MD; Nakaji, Peter MD; Albuquerque, Felipe C. MD; McDougall, Cameron G. MD; Spetzler, Robert F. MD

The anterior communicating artery (ACoA) is a common location for both ruptured and unruptured aneurysms. As with the treatment of all intracranial aneurysms, microsurgical clip occlusion has long represented the traditional and time-tested method of treatment. However, with the evolution of endovascular technology and improvements in catheter design that allowed easier access to the ACoA complex, coiling for lesions in this location became safer, with early series demonstrating good results.

01 agosto 2015

JOURNAL OF NEUROSURGERY. The long-term outcomes of radiosurgery for arteriovenous malformations in pediatric and adolescent populations

Shunya Hanakita, MD1, Tomoyuki Koga, MD, PhD1, Masahiro Shin, MD, PhD1, Hiroshi Igaki, MD, PhD2, and Nobuhito Saito, MD, PhD1

OBJECT: Although stereotactic radiosurgery (SRS) has been accepted as a therapeutic option for arteriovenous malformations (AVMs) in children and adolescents, substantial data are still lacking regarding the outcomes of SRS for AVMs in this age group, especially long-term complications. This study aimed to clarify the long-term outcomes of SRS for the treatment of AVM in pediatric patients aged ≤ 18 years.

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