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ESTUDIOS


01 febrero 2014

WORLD JOURNAL OF HEPATOLOGY. Portal vein thrombosis in liver cirrhosis

Nao Kinjo, Hirofumi Kawanaka, Tomohiko Akahoshi, Yoshihiro Matsumoto, Masahiro Kamori, Yoshihiro Nagao, Naotaka Hashimoto, Hideo Uehara, Morimasa Tomikawa, Ken Shirabe and Yoshihiko Maehara.

Portal vein thrombosis (PVT) is considered to be a frequent complication of liver cirrhosis. However, unlike PVT in patients without cirrhosis, very few data are available on the natural history and management of PVT in cirrhosis, despite its association with potentially life-threatening conditions, such as gastroesophageal bleeding and acute intestinal ischemia. Moreover, no consensus regarding PVT in cirrhosis exists. Suggested causes of PVT in cirrhosis include reduced portal blood flow velocity, multiple congenital or acquired thrombophilic factors, inherited or acquired conditions, and derangement of liver architecture. However, the understanding of PVT in cirrhosis is incomplete. In addition, information on the management of PVT in cirrhosis is inadequate. The aims of this review are to: (1) assemble data on the physiopathological mechanism, clinical findings, diagnosis and management of PVT in cirrhosis; (2) describe the principal factors most frequently involved in PVT development; and (3) summarize the recent knowledge concerning diagnostic and therapeutic procedures.

01 marzo 2014

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY. mRECIST criteria and contrast-enhanced US for the assessment of the response of hepatocellular carcinoma to transarterial chemoembolization

Hippocrates Moschouris, Katerina Malagari, Marina G. Papadaki, Ioannis Kornezos, Konstantinos Stamatiou, Antonios Anagnostopoulos, Katerina Chatzimichael, Nikolaos Kelekis

PURPOSE: We aimed to evaluate the combination of the modified Response Evaluation Criteria In Solid Tumors (mRECIST) and contrast-enhanced ultrasonography (CEUS) as a tool for the assessment of hepatocellular carcinoma treated with transarterial chemoembolization.

01 marzo 2014

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY. Applications of the Amplatzer Vascular Plug to various vascular lesions

Serkan Güneyli, Celal Çınar, Halil Bozkaya, Mustafa Parıldar, İsmail Oran

The Amplatzer® Vascular Plug (AVP) can be used to embolize medium-to-large high-flow vessels in various locations. Between 2009 and 2012, 41 AVPs (device size, 6–22 mm in diameter) were used to achieve occlusion in 31 patients (24 males, seven females) aged 9–92 years (mean age, 54.5 years). The locations and indications for embolotherapy were as follows: internal iliac artery embolization before stent-graft repair for aorto-iliac (n=6) and common iliac artery (n=3) aneurysms, subclavian artery embolization before stent-graft repair for thoracic aorta (n=3) and arcus aorta (n=1) aneurysms, brachiocephalic trunk embolization before stent-graft repair for a thoracic aorta aneurysm (n=1), embolization of aneurysms and pseudoaneurysms (n=5), embolization for carotid blow-out syndrome (n=3), closure of arteriovenous fistula (n=8), and closure of a portosystemic fistula (n=1). Of the 41 AVPs, 30 were AVP 2 and 11 were AVP 4. The mean follow-up duration was 4.7 months (range, 1–24 months). During follow-up, there was one migration, one insufficient embolization, and one recanalization. The remaining vascular lesions were successfully excluded from the circulation. The AVP, which can be used in a wide spectrum of pathologies, is easy to use and causes few complications. This essay presents our experience with the AVP.

01 marzo 2014

DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY. Feasibility of using vessel-detection software for the endovascular treatment of visceral arterial bleeding

Jin Iwazawa, Shoichi Ohue, Naoko Hashimoto, Takashi Mitani

We aimed to investigate the feasibility of using vessel-detection software to identify damaged arteries during endovascular embolization in five patients with visceral arterial hemorrhages. We used a software program originally developed to detect tumor feeder vessels in liver tumor embolization with C-arm computed tomography datasets to detect the vessels responsible for the arterial hemorrhages in patients with splenic artery pseudoaneurysms (n=2), lower gastrointestinal bleeding (n=2), and bladder tumor bleeding (n=1). In all cases, the injured vessel was identified accurately on a three-dimensional vascular map at the optimal working angle with a relatively short mean processing time of 118 s (range, 107–136 s). The operating angiographers used this information to direct the catheter into the damaged artery without sequential angiographic runs. The software analysis was also used to plan coil delivery to the most appropriate site in the injured artery. The results suggest that the vessel-detection software for liver tumor embolization can also be used to detect damaged vessels and to plan treatment strategies in endovascular embolization of visceral arterial hemorrhage.

01 febrero 2014

RADIOLOGY. Unresectable Hepatocellular Carcinoma: Randomized Controlled Trial of Transarterial Ethanol Ablation versus Transcatheter Arterial Chemoembolization

Simon Chun Ho Yu, FRCR, Joyce Wai Yi Hui, FRCR, Edwin Pun Hui, FRCP, Stephen Lam Chan, FRCP, Kit Fai Lee, FRCS, Frankie Mo, PhD, John Wong, FRCS, Brigette Ma, FRCP, Paul Lai, FRCS, Tony Mok, FRCP, Winnie Yeo, FRCP

Hepatocellular carcinoma (HCC) is one of the most common solid malignancies globally and has tripled in incidence in the past 2 decades in the United States (1). While it remains endemic in Asia and Africa (2), it is now diagnosed in approximately half a million people annually worldwide (3). Transarterial therapy has been playing an important role in the treatment algorithm for patients with multifocal or large intrahepatic lesions who are not eligible for surgical resection, transplantation, or local ablative therapy (4). Among the various options for transarterial therapy, which include transcatheter arterial chemoembolization (TACE), bland embolization (5), radioembolization (6), and transarterial ethanol ablation (TEA) (7–9), TACE is the only one that has been proved to be of survival benefit, as opposed to best supportive care, in randomized controlled trials (RCTs) (10–12).

01 febrero 2014

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. Radiological Diagnosis and Management of Epistaxis

Antonín Krajina, Viktor Chrobok

The majority of episodes of spontaneous posterior epistaxis treated with embolisation are idiopathic in nature. The angiographic findings are typically normal. Specific angiographic signs are rare and may include the following: a tumour blush, telangiectasia, aneurysm, and/or extravasation. Selective internal carotid artery (ICA) angiography may show rare causes of epistaxis, such as traumatic or mycotic aneurysms, which require different treatment approaches. Complete bilateral selective external and internal carotid angiograms are essential to evaluation. The images should be analysed for detection of central retinal blush in the external carotid artery (ECA) and anastomoses between the branches of the ECA and ICA. Monocular blindness and stroke are two of the most severe complications. Embolisation aims to decrease flow to the bleeding nasal mucosa while avoiding necrosis of the nasal skin and palate mucosa. Embolisation is routinely performed with a microcatheter positioned in the internal maxillary artery distal to the origin of the meningeal arteries. A guiding catheter should be placed in the proximal portion of the ECA to avoid vasospasm. Embolisation with microparticles is halted when the peripheral branches of the sphenopalatine artery are occluded. The use of coils is not recommended because recurrent epistaxis may occur due to proximal embolization; moreover, the option of repeat distal embolisation is lost. The success rate of embolisation therapy (accounting for late recurrence of bleeding) varies between 71 and 94 %. Results from endoscopic surgery are quite comparable. When epistaxis is refractory to nasal packing or endoscopic surgery, embolisation is the treatment of choice in some centres.

01 febrero 2014

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY. Chemoembolization of Hepatocellular Carcinoma with Hepasphere 30–60 μm. Safety and Efficacy Study

Katerina Malagari, Maria Pomoni, Hippokratis Moschouris, Alexios Kelekis, Angelos Charokopakis, Evanthia Bouma, Themistoklis Spyridopoulos, Achilles Chatziioannou, Vlasios Sotirchos, Theodoros Karampelas, Constantin Tamvakopoulos, Dimitrios Filippiadis, Enangelos Karagiannis, Athanasios Marinis, John Koskinas, Dimitrios A. Kelekis

Background: This study examined the safety, pharmacokinetics, and efficacy of transarterial chemoembolization of hepatocellular carcinoma (HCC) using a newly developed size of a superabsorbent polymer drug-eluting embolic material.

01 enero 2014

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Peripherally Inserted Central Catheter Thrombosis—Reverse Tapered versus Nontapered Catheters: A Randomized Controlled Study

Maxim Itkin, MD , Jeffrey I. Mondshein, MD , S. William Stavropoulos, MD , Richard D. Shlansky-Goldberg, MD , Michael C. Soulen, MD , Scott O. Trerotola, MD

Purpose: To compare the thrombosis rate, ease of insertion, bleeding rate, and complications of a nontapered peripherally inserted central catheter (PICC) versus a reverse tapered PICC.

01 enero 2014

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Percutaneous Microwave Ablation of Hepatic Tumors: Prospective Evaluation of Postablation Syndrome and Postprocedural Pain

Anita Andreano, MD , Stefania Galimberti, PhD , Elvira Franza, MD , Erica M. Knavel, MD , Sandro Sironi, MD , Fred T. Lee, MD , Maria Franca Meloni, MD

Purpose: To prospectively investigate the frequency and severity of postablation syndrome (PAS) and postprocedural pain in a cohort of patients undergoing hepatic microwave ablation.

01 enero 2014

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Percutaneous Ablation of Peribiliary Tumors with Irreversible Electroporation

Mikhail T. Silk, BS , Thomas Wimmer, MD , Kyungmouk S. Lee, MD , Govindarajan Srimathveeravalli, PhD , Karren T. Brown, MD , Peter T. Kingham, MD , Yuman Fong, MD , Jeremy C. Durack, MD , Constantinos T. Sofocleous, MD , Stephen B. Solomon, MD

Purpose: To assess biliary complications after irreversible electroporation (IRE) ablation of hepatic tumors located < 1 cm from major bile ducts.

01 enero 2014

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY. Effect of Real-Time Radiation Dose Feedback on Pediatric Interventional Radiology Staff Radiation Exposure

John Racadio, MD , Rami Nachabe, PhD , Bart Carelsen, PhD , Judy Racadio, MD , Nicole Hilvert, RT(R) , Neil Johnson, MBBS , Kamlesh Kukreja, MD , Manish Patel, DO

Purpose: To measure and compare individual staff radiation dose levels during interventional radiologic (IR) procedures with and without real-time feedback to evaluate whether it has any impact on staff radiation dose.

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