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ABSTRACT


01 marzo 2015

JACC. Evaluation and Treatment of Patients With Lower Extremity Peripheral Artery Disease. Consensus Definitions From Peripheral Academic Research Consortium (PARC)

Manesh R. Patel, MD∗; Michael S. Conte, MD†; Donald E. Cutlip, MD‡; Nabil Dib, MD‖; Patrick Geraghty, MD¶; William Gray, MD#; William R. Hiatt, MD††; Mami Ho, MD, PhD‡‡; Koji Ikeda, PhD§§; Fumiaki Ikeno, MD‖‖; Michael R. Jaff, DO¶¶; W. Schuyler Jones, MD∗; Masayuki Kawahara, MD‡‡; Robert A. Lookstein, MD##; Roxana Mehran, MD#; Sanjay Misra, MD∗∗∗; Lars Norgren, MD†††; Jeffrey W. Olin, MD##; Thomas J. Povsic, MD, PhD∗; Kenneth Rosenfield, MD‡‡‡; John Rundback, MD§§§; Fadi Shamoun, MD‖‖‖; James Tcheng, MD∗; Thomas T. Tsai, MD¶¶¶; Yuka Suzuki, PhD###; Pascal Vranckx, MD∗∗∗∗; Bret N. Wiechmann, MD††††; Christopher J. White, MD‡‡‡‡; Hiroyoshi Yokoi, MD§§§§; Mitchell W. Krucoff, MD∗

Abstract: The lack of consistent definitions and nomenclature across clinical trials of novel devices, drugs, or biologics poses a significant barrier to accrual of knowledge in and across peripheral artery disease therapies and technologies. Recognizing this problem, the Peripheral Academic Research Consortium, together with the U.S. Food and Drug Administration and the Japanese Pharmaceuticals and Medical Devices Agency, has developed a series of pragmatic consensus definitions for patients being treated for peripheral artery disease affecting the lower extremities. These consensus definitions include the clinical presentation, anatomic depiction, interventional outcomes, surrogate imaging and physiological follow-up, and clinical outcomes of patients with lower-extremity peripheral artery disease. Consistent application of these definitions in clinical trials evaluating novel revascularization technologies should result in more efficient regulatory evaluation and best practice guidelines to inform clinical decisions in patients with lower extremity peripheral artery disease.

01 abril 2015

JOURNAL OF VASCULAR SURGERY. Subsequent arterial ischemic events in patients receiving anticoagulant therapy for venous thromboembolism

Olga Madridano, MD, PhD, Jorge del Toro, MD, Alicia Lorenzo, MD, PhD, Mar Martín, MD, PhD, Jorge Gómez Cerezo, MD, PhD, Luis Hernández, MD, PhD, Paolo Prandoni, MD, PhD, Manuel Monreal, MD, PhD on behalf of the RIETE Investigators( J.I. Arcelus, M. Arroyo, A. Ballaz, R. Barba, M. Barrón, B. Barrón-Andrés, J. Bascuñana, P. Bedate, A. Blanco-Molina, T. Bueso, I. Casado, F. del Molino, J. del Toro, C. Falgá, C. Fernández-Capitán, C. Font, M.I. Fuentes, P. Gallego, F. García-Bragado, O. Gavín, V. Gómez, J. González, E. González-Bachs, E. Grau, M. Guil, R. Guijarro, J. Gutiérrez, L. Hernández, S. Hernández-Huerta, L. Jara-Palomares, M.J. Jaras, D. Jiménez, R. Lecumberri, J.L. Lobo, L. López-Jiménez, J.B. López-Sáez, M.A. Lorente, A. Lorenzo, J.M. Luque, O. Madridano, M. Macià, A. Maestre, P.J. Marchena, M. Martín, J.J. Martín-Villasclaras, M. Monreal, J.M. Mora, D. Mosquera, F.J. Muñoz, M.D. Nauffal, J.A. Nieto, M.J. Núñez, J.L. Ogea, R. Otero, J.M. Pedrajas, M.L. Peris, A. Riera-Mestre, A. Rivas, M.A. Rodríguez-Dávila, P. Román, V. Rosa, J. Ruiz, A. Ruiz-Gamietea, N. Ruiz-Giménez, J.C. Sahuquillo, A. Samperiz, J.F. Sánchez Muñoz-Torrero, S. Soler, J.M. Suriñach, G. Tiberio, R.M. Tilvan, C. Tolosa, J. Trujillo, F. Uresandi, M. Valdés, B. Valero, R. Valle, J. Vela, G. Vidal, C. Vilar, A. Villalobos, J. Villalta, R. Malý, J. Hirmerova, M. Miklo sová, E. Salgado, L. Bertoletti, A. Bura-Riviere, D. Farge-Bancel, I. Mahe, A. Merah, I. Quere, S. Schellong, D. Babalis, M. Papadakis, I. Tzinieris, A. Braester, B. Brenner, I. Tzoran, D. Zeltser, G. Barillari, M. Ciammaichella, P. Di Micco, R. Duce, R. Maida, F. Dalla Valle, C. Piovella, R. Poggio, P. Prandoni, R. Quintavalla, L. Rota, A. Schenone, E. Tiraferri, D. Tonello, A. Tufano, A. Visonà, B. Zalunardo, M. Fernandes, F. Gonçalves, M. Santos, M. Saraiva, R. Sousa, M. Bosevski, D. Kovacevic, A. Alatri, D. Aujeski, H. Bounameaux, L. Calanca, L. Mazzolai)

Objective: Patients with acute venous thromboembolism (VTE) are at increased risk for the development of subsequent arterial ischemic events unrelated to the diagnosis of VTE. Accurate identification of VTE patients at increased risk for ischemic events during the course of anticoagulation may help to select those who would potentially benefit from concomitant therapy with anticoagulants and antiplatelets.

01 abril 2015

JOURNAL OF VASCULAR SURGERY. Superficial venous reflux duration and cessation with two concurrent duplex probes

Christopher R. Lattimer, MBBS, FRCS, MS, FdIT, PhD, Erika Mendoza, MD, PhD

Background: Venous reflux is the principal hemodynamic disorder and therapeutic target in patients with superficial venous insufficiency. To date, no studies have identified where or when it stops, anatomically or regionally, along the course of the refluxive conduit. Duplex measurements of reflux are performed invariably with a single probe. Because many anatomic locations are studied, repeated provocation maneuvers are required. However, this fails to appreciate reflux as a circulation. The use of two probes placed concurrently in different regions may address this limitation. The study compared venous reflux duration and cessation, above the knee and below the knee simultaneously, with two duplex probes

01 abril 2015

JOURNAL OF VASCULAR SURGERY. Relative importance of iliac vein obstruction in patients with post-thrombotic femoral vein occlusion

Seshadri Raju, MD, FACS, Mark Ward Jr., MS, Micah Davis, BS

Background: Patients with femoral vein occlusion rapidly develop collateral flow through the deep femoral vein, an embryonic collateral. In contrast, iliac vein collateralization is sparser and functionally poorer. It is not uncommon to have femoral vein occlusions associated with iliac vein obstruction, even though the femoral vein occlusion is often more readily apparent on venograms and duplex scans, whereas the iliac vein obstruction may remain occult. We examined whether percutaneous stent correction of iliac vein obstruction associated with femoral vein occlusions would yield symptomatic relief.

01 abril 2015

JOURNAL OF VASCULAR SURGERY. Venous duplex and pathologic differences in thrombus characteristics between de novo deep vein thrombi and endovenous heat-induced thrombi

Brian J. Santin, MD, Joanne M. Lohr, MD, Thomas W. Panke, MD, Patrick M. Neville, MD, Melissa M. Felinski, DO, Brian A. Kuhn, MD, Matthew H. Recht, MD, Patrick E. Muck, MD

Objective: Superficial venous reflux disease has been treated with endovenous ablation techniques for more than 15 years. Thrombi discovered in the postoperative period are referred to as endovenous heat-induced thrombi (EHIT). In spite of the few studies of the ultrasound differentiation between EHIT and deep vein thrombi (DVT), there remains a paucity of literature regarding the evaluation of ultrasound examination and pathologic differentiation.

01 abril 2015

JOURNAL OF VASCULAR SURGERY. The soluble urokinase plasminogen activator receptor and its fragments in venous ulcers

Anwar Ahmad, MD, MRCS, Prakash Saha, PhD, MRCS, Colin Evans, PhD, Tine Thurison, Gunilla Hoyer-Hansen, PhD, Ashish Patel, PhD, MRCS, Bijan Modarai, PhD, FRCS, Alberto Smith, PhD

Objective: Activation of proteolytic mechanisms at the cell surface through the activity of urokinase-type plasminogen activator (uPA) bound to its receptor, uPAR, is an important process in wound healing. The soluble forms of uPAR (suPAR and its fragments I, II, and III) have nonproteolytic functions that include chemotaxis, adhesion, and proliferation, which also have a role in wound healing. The aim of this study was to determine whether suPAR and its cleaved fragments are present in venous ulcers and whether their levels are associated with healing.

01 abril 2015

JOURNAL OF VASCULAR SURGERY. Inferior vena cava filter retrieval provides no advantage in the average patient

Courtney J. Warner, MD, MS, Elizabeth A. Richey, MD, MPH, Dyane E. Tower, DPM, MPH, Anna E. Condino, MD, MPH, Stephanie J. Tapp, PhD, Anna N.A. Tosteson, ScD, Daniel B. Walsh, MD

Background: Inferior vena cava (IVC) filter placement is performed to mitigate the risk of pulmonary embolism (PE) when anticoagulation is contraindicated or ineffective. Technical advances now allow catheter-based filter retrieval. Many believe the benefits of retrieval are self-evident, yet retrieval carries an inherent complication risk and cost. The purpose of this study was to quantitatively weigh the risks and benefits of IVC filter retrieval using formal decision analysis.

01 mayo 2015

JOURNAL OF VASCULAR SURGERY. Predictive factors for limb occlusions after endovascular aneurysm repair

Elsa M. Faure, MD, Jean-Pierre Becquemin, MD, Frédéric Cochennec, MD on behalf of ENGAGE collaborators( Ricardo Garcia Monaco, Mariano Ferreira, Rob Fitridge, Nick Boyne, Steve Dubenec, Michael Grigg, Patrice Mwipatayi, Thomas Rand, Patrick Peeters, Marc Bosiers, Jeroen Hendriks, Frank Vermassen, Min Lee, Tom Forbes, Oren Steinmetz, Yvan Douville, Leonard Tse, Wei Guo, Jichun Zhao, Jianfang Luo, Jaime Camacho, Jiri Novotny, Dominique Midy, Jean-Pierre Becquemin, Emmanuel Choukroun, Dittmar Bockler, G. Torsello, Gerhard Hoffmann, Kostantinos Papazoglou, Dimitris Kiskinis, Stephen Cheng, Yehuda Wolf, Andrea Stella, Carlo Pratesi, Carlo Setacci, Jae Kyu Kim, Do Yun Lee, Valdas Bilkis, Steven van Sterkenburg, Joep Teijink, Rob Welten, Jean-Paul de Vries, Hence Verhagen, Jan Heijligers, Andrew Hill, Thodur Vasudevan, Guttorm Jenssen, Eric Dorenberg, Rolf Busund, Piotr Gutowski, Walerian Staszkiewicz, Joao Albuquerque e Castro, Ivan Vulev, Phillip Matley, Corstiaan Leendert Punt, Jacobus Van Marle, V. Riambau, Eduardo Ros, Aurelio Garcia de la Torre, Francisco Gomez Palons, Carlos Vaquero Puerta, Hakan Roos, Thomas Larzon, Martin Delle, Do Dai-Do, Juerg Schmidli, Boonprasit Kritpracha, Furuzan Numan, Yigit Goktay, Levent Oguzkurt, Paul Hayes, Richard McWilliams, Matt Thompson, Ray Ashleigh, John Rose, Carmelo Gastambide)

Objective: Greater flexibility and smaller sizes for introducer sheaths in the newest stent grafts increase the feasibility of endovascular aneurysm repair but raise concerns about long-term limb patency. The aim of the study was to determine the incidence of and predictive factors for limb occlusion after use of the Endurant stent graft (Medtronic Inc, Minneapolis, Minn) for abdominal aortic aneurysm.

01 mayo 2015

JOURNAL OF VASCULAR SURGERY. Results of transcaval embolization for sac expansion from type II endoleaks after endovascular aneurysm repair

Kristina A. Giles, MD, Mark F. Fillinger, MD, Randall R. De Martino, MD, MPH, Andrew W. Hoel, MD, Richard J. Powell, MD, Daniel B. Walsh, MD

Objective: Management of type II endoleaks after endovascular aneurysm repair can be problematic. This study reports our experience with a relatively novel strategy to treat this complication, transcaval coil embolization (TCCE) of the aneurysm sac.

01 mayo 2015

JOURNAL OF VASCULAR SURGERY. Results of transcaval embolization for sac expansion from type II endoleaks after endovascular aneurysm repair

Kristina A. Giles, MD, Mark F. Fillinger, MD, Randall R. De Martino, MD, MPH, Andrew W. Hoel, MD, Richard J. Powell, MD, Daniel B. Walsh, MD

Objective: Management of type II endoleaks after endovascular aneurysm repair can be problematic. This study reports our experience with a relatively novel strategy to treat this complication, transcaval coil embolization (TCCE) of the aneurysm sac.

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