01 abril 2014

JACC. Transcatheter Implantation of Homologous “Off-the-Shelf” Tissue-Engineered Heart Valves With Self-Repair Capacity. Long-Term Functionality and Rapid In Vivo Remodeling in Sheep

Anita Driessen-Mol, PhD∗; Maximilian Y. Emmert, MD, PhD†; Petra E. Dijkman, PhD†; Laura Frese, PhD†; Bart Sanders, MSc∗; Benedikt Weber, PhD†; Nikola Cesarovic, PhD‡; Michele Sidler, MD||; Jori Leenders, MSc∗; Rolf Jenni, MD, MSEE§; Jürg Grünenfelder, MD§; Volkmar Falk, MD§; Frank P.T. Baaijens, PhD∗; Simon P. Hoerstrup, MD, PhD∗

Objectives: This study sought to evaluate long-term in vivo functionality, host cell repopulation, and remodeling of “off-the-shelf” tissue engineered transcatheter homologous heart valves.

01 abril 2014

JACC. Diagnostic Performance of Noninvasive Fractional Flow Reserve Derived From Coronary Computed Tomography Angiography in Suspected Coronary Artery Disease. The NXT Trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)

Bjarne L. Nørgaard, MD, PhD∗; Jonathon Leipsic, MD, PhD†; Sara Gaur, MD∗; Sujith Seneviratne, MBBS‡; Brian S. Ko, MBBS, PhD‡; Hiroshi Ito, MD, PhD§; Jesper M. Jensen, MD, PhD∗; Laura Mauri, MD, PhD‖; Bernard De Bruyne, MD, PhD¶; Hiram Bezerra, MD, PhD#; Kazuhiro Osawa, MD§; Mohamed Marwan, MD, PhD∗∗; Christoph Naber, MD, PhD††; Andrejs Erglis, MD, PhD‡‡; Seung-Jung Park, MD, PhD§§; Evald H. Christiansen, MD, PhD∗; Anne Kaltoft, MD, PhD∗; Jens F. Lassen, MD, PhD∗; Hans Erik Bøtker, MD, DMSci∗; Stephan Achenbach, MD, PhD∗∗

Objectives: The goal of this study was to determine the diagnostic performance of noninvasive fractional flow reserve (FFR) derived from standard acquired coronary computed tomography angiography (CTA) datasets (FFRCT) for the diagnosis of myocardial ischemia in patients with suspected stable coronary artery disease (CAD).

01 abril 2014

JACC. Transcatheter Versus Surgical Closure of Perimembranous Ventricular Septal Defects in Children. A Randomized Controlled Trial

Jian Yang, MD, PhD∗; Lifang Yang, MD∗; Shiqiang Yu, MD, PhD∗; Jincheng Liu, MD, PhD∗; Jian Zuo, MD∗; Wensheng Chen, MD, PhD∗; Weixun Duan, MD∗; Qijun Zheng, MD∗; Xuezeng Xu, MD∗; Jun Li, MD∗; Jun Zhang, MD, PhD∗; Jian Xu, MD∗; Lijun Sun, MD, PhD∗; Xiuling Yang, MD∗; Lize Xiong, MD, PhD∗; Dinghua Yi, MD, PhD∗; Lei Wang, MD†; Qingchun Liu, MD‡; Shuping Ge, MD∗; Jun Ren, MD, PhD∗

Objectives: The objective of this study was to evaluate the safety and efficacy of the surgical versus transcatheter approach to correct perimembranous ventricular septal defects (pmVSDs) in a prospective, randomized, controlled clinical trial.

01 mayo 2014

JACC. Transradial Coronary Catheterization and Intervention Across the Whole Spectrum of Allen Test Results

Marco Valgimigli, MD, PhD∗; Gianluca Campo, MD†; Carlo Penzo, MD‡; Matteo Tebaldi, MD†; Simone Biscaglia, MD†; Roberto Ferrari, MD, PhD†

Objectives: The aim of this study was to investigate the safety and feasibility of transradial coronary catheterization across the whole spectrum of Allen test (AT) results.

01 mayo 2014

JACC. Ischemic Outcomes After Coronary Intervention of Calcified Vessels in Acute Coronary Syndromes. Pooled Analysis From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trials

Philippe Généreux, MD∗; Mahesh V. Madhavan, BA∗; Gary S. Mintz, MD∗; Akiko Maehara, MD∗; Tullio Palmerini, MD§; Laura LaSalle, BA†; Ke Xu, PhD†; Tom McAndrew, MS†; Ajay Kirtane, MD, SM∗; Alexandra J. Lansky, MD‖; Sorin J. Brener, MD†; Roxana Mehran, MD†; Gregg W. Stone, MD∗

Objectives: This study sought to determine the frequency and impact of coronary calcification among patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS).

01 mayo 2014

JACC. Rapid Endovascular Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction. The CHILL-MI Trial: A Randomized Controlled Study of the Use of Central Venous Catheter Core Cooling Combined With Cold Saline as an Adjunct to Percutaneous Coronary Intervention for the Treatment of Acute Myocardial Infarction

David Erlinge, MD, PhD∗; Matthias Götberg, MD, PhD∗; Irene Lang, MD, PhD†; Michael Holzer, MD, PhD†; Marko Noc, MD, PhD‡; Peter Clemmensen, MD, PhD§; Ulf Jensen, MD, PhD‖; Bernhard Metzler, MD, PhD¶; Stefan James, MD, PhD#; Hans Erik Bötker, MD, PhD††; Elmir Omerovic, MD, PhD††; Henrik Engblom, MD, PhD‡‡; Marcus Carlsson, MD, PhD‡‡; Håkan Arheden, MD, PhD‡‡; Ollie Östlund, MSc#; Lars Wallentin, MD, PhD#; Jan Harnek, MD, PhD∗; Göran K. Olivecrona, MD, PhD∗

Objectives: The aim of this study was to confirm the cardioprotective effects of hypothermia using a combination of cold saline and endovascular cooling.

01 mayo 2014

JACC. Comparison of Diagnostic Accuracy of Combined Assessment Using Adenosine Stress Computed Tomography Perfusion + Computed Tomography Angiography With Transluminal Attenuation Gradient + Computed Tomography Angiography Against Invasive Fractional Flow Reserve

Dennis T.L. Wong, MBBS (Hons), PhD∗; Brian S. Ko, MBBS (Hons), PhD∗; James D. Cameron, MBBS, MD∗; Darryl P. Leong, MBBS (Hons), MPH, PhD†; Michael C.H. Leung, MBBS (Hons), PhD∗; Yuvaraj Malaiapan, MBBS∗; Nitesh Nerlekar, MBBS∗; Marcus Crossett, Ba App Sc‡; John Troupis, MBBS∗; Ian T. Meredith, MBBS (Hons), PhD∗; Sujith K. Seneviratne, MBBS∗

Objectives: The goal of this study was to compare the diagnostic accuracy of combined computed tomography perfusion (CTP) + computed tomography angiography (CTA), transluminal attenuation gradient by 320-detector row computed tomography (TAG320) + CTA, and CTP + TAG320 + CTA (multidetector computed tomography–integrated protocol [MDCT-IP]) assessment in predicting significant fractional flow reserve (FFR).

01 mayo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Intimal hyperplasia and vascular remodeling after everolimus-eluting and sirolimus-eluting stent implantation in diabetic patients: The randomized diabetes and drug-eluting stent (DiabeDES) IV intravascular ultrasound trial

Lisbeth Antonsen MD1,*, Michael Maeng MD,PhD2, Per Thayssen MD,DMSci1, Evald Høj Christiansen MD,PhD2, Knud Nørregaard Hansen MD1, Anne Kaltoft MD,PhD2, Henrik Steen Hansen MD,DMSci1, Leif Thuesen MD,DMSci2, Jens Flensted Lassen MD,PhD2 andLisette Okkels Jensen MD,DMSci,PhD1

Objective: To evaluate the effects of the everolimus-eluting Xience™/Promus™ stent (EES) and the sirolimus-eluting Cypher™ stent (SES) on intimal hyperplasia (IH) in diabetic patients.

01 mayo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Transcatheter therapies for mitral regurgitation: A professional society overview from the american college of cardiology, the american association for thoracic surgery, society for cardiovascular angiography and interventions foundation, and the society of thoracic surgeons

Patrick T. O´Gara MD, FACC, Co-Chair Writing Committee Members1, John H. Calhoon MD, Co-Chair2, Marc R. Moon MD, FACC3 andCarl L. Tommaso MD, FACC, FSCAI4

The document was approved by the American College of Cardiology Board of Trustees, the American Association for Thoracic Surgery Council, the Society for Cardiovascular Angiography and Interventions Foundation Board of Directors, and The Society of Thoracic Surgeons Board of Directors in November 2013. For the purpose of transparency, disclosure information for the ACC Board of Trustees, the board of the convening organization of this document

01 mayo 2014

AMERICAN HEART JOURNAL. Prognosis of elderly patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention in 2001 to 2011: A report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) registry

Matthijs A. Velders, MD, Stefan K. James, MD, PhD, Berglind Libungan, MD, Giovanna Sarno, MD, PhD, Ole Fröbert, MD, PhD, Jörg Carlsson, MD, PhD, Martin J. Schalij, MD, PhD, Per Albertsson, MD, PhD, Bo Lagerqvist, MD, PhD

Background: Elderly patients constitute a growing part of the population presenting with ST-elevation myocardial infarction (STEMI). The use of primary percutaneous coronary intervention (PCI) in this high-risk population remains poorly investigated.

01 mayo 2014

AMERICAN HEART JOURNAL. Sex difference in clinical outcomes after percutaneous coronary intervention in Korean population

Duk-Woo Park, MD, Young-Hak Kim, MD, Sung-Cheol Yun, PhD, Jung-Min Ahn, MD, Jong-Young Lee, MD, Soo-Jin Kang, MD, Seung-Whan Lee, MD, Cheol Whan Lee, MD, Seong-Wook Park, MD, Seung-Jung Park, MD

Background: Conflicting data on sex-based differences in outcomes after percutaneous coronary intervention (PCI) among Western population exist. Little is known about the nature of sex-specific PCI outcomes in an Asian population.

01 abril 2014

AMERICAN HEART JOURNAL. Distribution of coronary calcifications in patients with suspected coronary heart disease

Franz von Ziegler, MD, Martin Greif, MD, Janine Tittus, MD, Jan Schenzle, MD, Christoph Becker, MD, Alexander Becker, MD

Background: Coronary calcifications are a marker of coronary atherosclerosis. The role of coronary calcium scoring (CS) as part of the initial evaluation of patients with suspected coronary heart disease (CHD) is controversially discussed. The primary goal of this study was to characterize the coronary calcium distribution in this particular patient population. In a second step, we aimed to establish a possible clinical implication using CS for the diagnosis of CHD.

01 abril 2014

AMERICAN HEART JOURNAL. Clinical outcomes after hybrid coronary revascularization versus coronary artery bypass surgery: a meta-analysis of 1,190 patients

Ralf E. Harskamp, MD, Akshay Bagai, MD, MHS, Michael E. Halkos, MD, MSc, Sunil V. Rao, MD, MHS, William B. Bachinsky, MD, Manesh R. Patel, MD, Robbert J. de Winter, MD, PhD, Eric D. Peterson, MD, MPH, John H. Alexander, MD, MHS, Renato D. Lopes, MD, PhD, MHS

Background: Hybrid coronary revascularization (HCR) represents a minimally invasive revascularization strategy in which the durability of the internal mammary artery to left anterior descending artery graft is combined with percutaneous coronary intervention to treat remaining lesions. We performed a systematic review and meta-analysis to compare clinical outcomes after HCR with conventional coronary artery bypass graft (CABG) surgery.

01 abril 2014

JACC: CARDIOVASCULAR INTERVENTIONS. Current Status of Rotational Atherectomy

Matthew I. Tomey, MD; Annapoorna S. Kini, MD; Samin K. Sharma, MD

Rotational atherectomy facilitates percutaneous coronary intervention for complex de novo lesions with severe calcification. A strategy of routine rotational atherectomy has not, however, conferred reduction in restenosis or major adverse cardiac events. As it is technically demanding, rotational atherectomy is also uncommon. At this 25-year anniversary since the introduction of rotational atherectomy, we sought to review the current state-of-the-art in rotational atherectomy technique, safety, and efficacy data in the modern era of drug-eluting stents, strategies to prevent and manage complications, including slow-flow/no-reflow and burr entrapment, and appropriate use in the context of the broader evolution in the management of stable ischemic heart disease. Fundamental elements of optimal technique include use of a single burr with burr-to-artery ratio of 0.5 to 0.6-rotational speed of 140,000 to 150,000 rpm, gradual burr advancement using a pecking motion, short ablation runs of 15 to 20 s, and avoidance of decelerations >5,000 rpm. Combined with meticulous technique, optimal antiplatelet therapy, vasodilators, flush solution, and provisional use of atropine, temporary pacing, vasopressors, and mechanical support may prevent slow-flow/no-reflow, which in contemporary series is reported in 0.0% to 2.6% of cases. On the basis of the results of recent large clinical trials, a subset of patients with complex coronary artery disease previously assigned to rotational atherectomy may be directed instead to medical therapy alone or bypass surgery. For patients with de novo severely calcified lesions for which rotational atherectomy remains appropriate, referral centers of excellence are required.

01 abril 2014

JACC: CARDIOVASCULAR INTERVENTIONS. Long-Term Clinical Outcomes After Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Ostial/Midshaft Lesions in Unprotected Left Main Coronary Artery From the DELTA Registry. A Multicenter Registry Evaluating Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Left Main Treatment

Toru Naganuma, MD∗; Alaide Chieffo, MD∗; Emanuele Meliga, MD†; Davide Capodanno, MD, PhD‡; Seung-Jung Park, MD§; Yoshinobu Onuma, MD‖; Marco Valgimigli, MD¶; Sanda Jegere, MD#; Raj R. Makkar, MD††; Igor F. Palacios, MD‡‡; Charis Costopoulos, MD∗; Young-Hak Kim, MD§; Piotr P. Buszman, MD, PhD§§; Tarun Chakravarty, MD††; Imad Sheiban, MD‖‖; Roxana Mehran, MD¶¶; Christoph Naber, MD∗∗∗; Ronan Margey, MD‡‡; Arvind Agnihotri, MD‡‡; Sebastiano Marra, MD‖‖; Piera Capranzano, MD‡; Martin B. Leon, MD##; Jeffrey W. Moses, MD##; Jean Fajadet, MD∗∗∗; Thierry Lefevre, MD†††; Marie-Claude Morice, MD†††; Andrejs Erglis, MD#; Corrado Tamburino, MD, PhD‡; Ottavio Alfieri, MD∗; Patrick W. Serruys, MD, PhD‖; Antonio Colombo, MD∗

Objectives: The aim of this study was to report the long-term clinical outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents (DES) versus coronary artery bypass grafting (CABG) for ostial/midshaft lesions in an unprotected left main coronary artery (ULMCA).