01 septiembre 2014

AMERICAN HEART JOURNAL. Randomized comparison of biodegradable polymer sirolimus-eluting stents versus durable polymer everolimus-eluting stents for percutaneous coronary revascularization: Rationale and design of the BIOSCIENCE trial

Thomas Pilgrim, MD, Marco Roffi, MD, David Tüller, MD, Olivier Muller, MD, André Vuilliomenet, MD, Stéphane Cook, MD, Daniel Weilenmann, MD, Christoph Kaiser, MD, Peiman Jamshidi, MD, Dik Heg, PhD, Peter Jüni, MD, Stephan Windecker, MD

Background: Biodegradable polymers for release of antiproliferative drugs from metallic drug-eluting stents aim to improve long-term vascular healing and efficacy. We designed a large scale clinical trial to compare a novel thin strut, cobalt-chromium drug-eluting stent with silicon carbide–coating releasing sirolimus from a biodegradable polymer (O-SES, Orsiro; Biotronik, Bülach, Switzerland) with the durable polymer-based Xience Prime/Xpedition everolimus-eluting stent (EES) (Xience Prime/Xpedition stent, Abbott Vascular, IL) in an all-comers patient population.

01 septiembre 2014

AMERICAN HEART JOURNAL. Diagnostic accuracy of multidetector computed tomography coronary angiography in 325 consecutive patients referred for transcatheter aortic valve replacement

Daniele Andreini, MD, PhD, Gianluca Pontone, MD, Saima Mushtaq, MD, Antonio L. Bartorelli, MD, Giovanni Ballerini, MD, Erika Bertella, MD, Chiara Segurini, MD, Edoardo Conte, MD, Andrea Annoni, MD, Andrea Baggiano, MD, Alberto Formenti, MD, Laura Fusini, MS, Gloria Tamborini, MD, Francesco Alamanni, MD, Cesare Fiorentini, MD, Mauro Pepi, MD

Background: Multidetector computed tomography (MDCT) provides detailed assessment of valve annulus and iliofemoral vessels in transcatheter aortic valve replacement (TAVR) patients. However, data on diagnostic performance of MDCT coronary angiography (MDCT-CA) are scarce. The aim of the study is to assess diagnostic performance of MDCT for coronary artery evaluation before TAVR.

14 agosto 2014

STROKE. Clinical Sciences. Twelve–Single Nucleotide Polymorphism Genetic Risk Score Identifies Individuals at Increased Risk for Future Atrial Fibrillation and Stroke

Hayato Tada, MD*; Dov Shiffman, PhD*; J. Gustav Smith, MD, PhD; Marketa Sjögren, PhD; Steven A. Lubitz, MD, MPH; Patrick T. Ellinor, MD, PhD; Judy Z. Louie, MSc; Joseph J. Catanese, MSc; Gunnar Engström, MD, PhD; James J. Devlin, PhD; Sekar Kathiresan, MD*; Olle Melander, MD, PhD*

Background and Purpose: Atrial fibrillation (AF) is prevalent and there is a clinical need for biomarkers to identify individuals at higher risk for AF. Fixed throughout a life course and assayable early in life, genetic biomarkers may meet this need. Here, we investigate whether multiple single nucleotide polymorphisms together as an AF genetic risk score (AF-GRS) can improve prediction of one’s risk for AF.

31 julio 2014

STROKE. Brief Report. Characteristics of Intracerebral Hemorrhage During Rivaroxaban Treatment

Joji Hagii, MD; Hirofumi Tomita, MD; Norifumi Metoki, MD; Shin Saito, MD; Hiroshi Shiroto, MD; Hiroyasu Hitomi, MD; Takaatsu Kamada, MD; Satoshi Seino, MD; Koki Takahashi, MD; Yoshiko Baba, MD; Satoko Sasaki, MD; Takamitsu Uchizawa, MD; Manabu Iwata, MD; Shigeo Matsumoto, MD; Tomohiro Osanai, MD; Minoru Yasujima, MD; Ken Okumura, MD

Background and Purpose: Neuroradiological characteristics and functional outcomes of patients with intracerebral hemorrhage (ICH) during novel oral anticoagulant treatment were not well defined. We examined these in comparison with those during warfarin treatment.

17 junio 2014

STROKE. Clinical Sciences. Diagnostic Yield of Pelvic Magnetic Resonance Venography in Patients With Cryptogenic Stroke and Patent Foramen Ovale

Ava L. Liberman, MD; Vistasp J. Daruwalla, MBBS; Jeremy D. Collins, MD; Matthew B. Maas, MD; Marcos Paulo Ferreira Botelho, MD; Jad Bou Ayache, MD; James Carr, MD; Ilana Ruff, MD; Richard A. Bernstein, MD, PhD; Marc J. Alberts, MD; Shyam Prabhakaran, MD, MS

Background and Purpose: Paradoxical embolization is frequently posited as a mechanism of ischemic stroke in patients with patent foramen ovale. Several studies have suggested that the deep lower extremity and pelvic veins might be an embolic source in cryptogenic stroke (CS) patients with patent foramen ovale.

17 abril 2014

CIRCULATION. Arrhythmia/Electrophysiology. Periprocedural Stroke and Bleeding Complications in Patients Undergoing Catheter Ablation of Atrial Fibrillation With Different Anticoagulation Management

Luigi Di Biase, MD, PhD; J. David Burkhardt, MD; Pasquale Santangeli, MD; Prasant Mohanty, MPH, MBBS; Javier E. Sanchez, MD; Rodney Horton, MD; G. Joseph Gallinghouse, MD; Sakis Themistoclakis, MD; Antonio Rossillo, MD; Dhanunjaya Lakkireddy, MD; Madhu Reddy, MD; Steven Hao, MD; Richard Hongo, MD; Salwa Beheiry, RN; Jason Zagrodzky, MD; Bai Rong, MD; Sanghamitra Mohanty, MD; Claude S. Elayi, MD; Giovanni Forleo, MD; Gemma Pelargonio, MD; Maria Lucia Narducci, MD; Antonio Dello Russo, MD; Michela Casella, MD; Gaetano Fassini, MD; Claudio Tondo, MD; Robert A. Schweikert, MD; Andrea Natale, MD

Background: Periprocedural thromboembolic and hemorrhagic events are worrisome complications of catheter ablation for atrial fibrillation (AF). The periprocedural anticoagulation management could play a role in the incidence of these complications. Although ablation procedures performed without warfarin discontinuation seem to be associated with lower thromboembolic risk, no randomized study exists.

22 julio 2014

CIRCULATION. Congenital Heart Disease. Fetal Aortic Valvuloplasty for Evolving Hypoplastic Left Heart Syndrome

Lindsay R. Freud, MD; Doff B. McElhinney, MD; Audrey C. Marshall, MD; Gerald R. Marx, MD; Kevin G. Friedman, MD; Pedro J. del Nido, MD; Sitaram M. Emani, MD; Terra Lafranchi, NP-C; Virginia Silva, RN; Louise E. Wilkins-Haug, MD, PhD; Carol B. Benson, MD; James E. Lock, MD; Wayne Tworetzky, MD

Background: Fetal aortic valvuloplasty can be performed for severe midgestation aortic stenosis in an attempt to prevent progression to hypoplastic left heart syndrome (HLHS). A subset of patients has achieved a biventricular (BV) circulation after fetal aortic valvuloplasty. The postnatal outcomes and survival of the BV patients, in comparison with those managed as HLHS, have not been reported.

26 junio 2014

CIRCULATION. Epidemiology and Prevention. 30-Year Mortality After Venous Thromboembolism. A Population-Based Cohort Study

Kirstine Kobberøe Søgaard, MD; Morten Schmidt, MD; Lars Pedersen, PhD; Erzsébet Horváth–Puhó, PhD; Henrik Toft Sørensen, DMSc

Background: Studies on long-term mortality after venous thromboembolism (VTE) are sparse.

29 julio 2014

CIRCULATION. Arrhythmia/Electrophysiology. Evolution of Left Ventricular Ejection Fraction After Acute Myocardial Infarction

Johanna Sjöblom, MD, PhD; Josephine Muhrbeck, MD; Nils Witt, MD, PhD; Mahbubul Alam, MD, PhD; Viveka Frykman-Kull, MD, PhD

Background: Implantable cardioverter-defibrillator therapy improves survival in patients with reduced left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI). Although the risk of sudden cardiac death is highest in the first month after AMI, there is no survival benefit of early implantable cardioverter-defibrillator implantation, and the optimal time frame has yet to be established. Thus, the aim of this study was to investigate what proportion of post-AMI patients had improved LV function to such an extent that the indication for implantable cardioverter-defibrillator was no longer present.

30 septiembre 2014

CIRCULATION. Clinical Outcomes After Implantation of a Centrifugal Flow Left Ventricular Assist Device and Concurrent Cardiac Valve Procedures

Carmelo Milano, MD; Francis D. Pagani, MD, PhD; Mark S. Slaughter, MD; Duc Thinh Pham, MD; David R. Hathaway, MD; Mary V. Jacoski, MS; Kevin B. Najarian, MS; Keith D. Aaronson, MD, MS; for the ADVANCE Investigators

Background: Cardiac valve procedures are commonly performed concurrently during implantation of left ventricular assist devices, but the added procedural risk has not been studied in detail.

29 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Pharmacology. Aspirin Reload Before Elective Percutaneous Coronary Intervention

Stefania Basili, MD*, Gaetano Tanzilli, MD*, Valeria Raparelli, MD, Camilla Calvieri, MD, Pasquale Pignatelli, MD, Roberto Carnevale, PhD, Marcello Dominici, MD, Attilio Placanica, MD, Alessio Arrivi, MD, Alessio Farcomeni, PhD, Francesco Barillà, MD, Enrico Mangieri, MD and Francesco Violi, MD

Background: Microvascular obstruction seems to predict poor outcome in patients undergoing elective percutaneous coronary intervention (PCI), but the underlying mechanism is still unclear. We analyzed whether serum thromboxane B2, a stable metabolite of thromboxane A2, may be implicated in post-PCI microvascular obstruction.

01 octubre 2014

RADIOLOGY. Left Ventricular Function and Volume with Coronary CT Angiography Improves Risk Stratification and Identification of Patients at Risk for Incident Mortality: Results from 7758 Patients in the Prospective Multinational CONFIRM Observational Cohort Study

Reza Arsanjani, MD, Daniel S. Berman, MD, Heidi Gransar, MS, Victor Y. Cheng, MD, Allison Dunning, MS, Fay Y. Lin, MD, Stephan Achenbach, MD, Mouaz Al-Mallah, MD, Matthew J. Budoff, MD, Tracy Q. Callister, MD, Hyuk-Jae Chang, MD, Filippo Cademartiri, MD, Kavitha M. Chinnaiyan, MD, Benjamin J. W. Chow, MD, Augustin DeLago, MD, Martin Hadamitzky, MD, Joerg Hausleiter, MD, Philipp Kaufmann, MD, Troy M. LaBounty, MD, Jonathon Leipsic, MD, Gilbert Raff, MD, Leslee J. Shaw, PhD, Todd C. Villines, MD, Ricardo C. Cury, MD, Gudrun Feuchtner, MD, Yong-Jin Kim, MD, James K. Min, MD, For the CONFIRM Investigators

To assess whether gradations of left ventricular (LV) ejection fraction (LVEF) and volumes measured with coronary computed tomography (CT) would augment risk stratification and discrimination for incident mortality.

01 junio 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Cardioprotective effect of high-dose intragraft adenosine infusion on microvascular function and prevention of no-reflow during saphenous vein grafts intervention

Nikhil Kapoor MD1, Venkata Yalamanchili MD1, Tariq Siddiqui MD1, Syed Raza MD1 andMassoud A. Leesar MD2,*

Background: Despite the use of embolic protection devices, no-reflow can still occur during saphenous vein grafts (SVGs) intervention. High-dose intracoronary adenosine infusion preconditions the myocardium, improves coronary flow, and prevents no-reflow. The role of high-dose intragraft adenosine infusion on protection of microvascular function and prevention of no-reflow has not been investigated

01 junio 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Optimizing rotational atherectomy in high-risk percutaneous coronary interventions: Insights from the PROTECT ΙΙ study

Mauricio G. Cohen MD1,*, Abhijit Ghatak MD1, Neal S. Kleiman MD2, Srihari S. Naidu MD3, Joseph M. Massaro PHD4, Ajay J. Kirtane MD, SM5, Jeffrey Moses MD5, E. Magnus Ohman MD6, Vladimír Džavík MD7, Igor F. Palacios MD8, Alan W. Heldman MD1, Jeffrey J. Popma MD9 andWilliam W. O´Neill MD10

Objective: To study rotational atherectomy (RA) outcomes in patients undergoing high-risk PCI randomized to receive hemodynamic support using either IABP or Impella 2.5 in the PROTECT II trial.

01 junio 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Working through complexities of radial and brachial vasculature during transradial approach

Tejas Patel MD, FACC, FSCAI1,2,*, Sanjay Shah MD1,2, Samir Pancholy MD, FACC, FSCAI3, Rajnikant Radadiya MBBS1, Surender Deora MD1, Chirayu Vyas MD1, Martial Hamon MD, FESC4 andIan C. Gilchrist MD, FACC, FSCAI5

Objectives: The aim of this review is to discuss different methods of working through radial artery (RA) and brachial artery (BA) vascular complexities to increase the success rate of transradial approach (TRA).