01 septiembre 2013

AMERICAN HEART JOURNAL. A multicenter randomized comparison of paclitaxel-coated balloon catheter with conventional balloon angioplasty in patients with bare-metal stent restenosis and drug-eluting stent restenosis

Seiji Habara, MD, Masashi Iwabuchi, MD, Naoto Inoue, MD, Shigeru Nakamura, MD, Ryuta Asano, MD, Shinsuke Nanto, MD, Yasuhiko Hayashi, MD, Nobuo Shiode, MD, Shigeru Saito, MD, Yuji Ikari, MD, Takeshi Kimura, MD, Joji Hosokawa, MD, Masato Nakamura, MD, Jun-ichi Kotani, MD, Ken Kozuma, MD, Kazuaki Mitsudo, MD

Background: The aim of this study was to investigate the efficacy and safety of paclitaxel-coated balloon (PCB) for the treatment of the bare-metal stent restenosis (BMS-ISR) and drug-eluting stent restenosis (DES-ISR).

01 septiembre 2013

AMERICAN HEART JOURNAL. Bleeding after percutaneous coronary intervention in women and men matched for age, body mass index, and type of antithrombotic therapy

Gjin Ndrepepa, MD, Stefanie Schulz, MD, Franz-Josef Neumann, MD, Robert A. Byrne, MBBCh, Petra Hoppmann, MD, Salvatore Cassese, MD, Ilka Ott, MD, Massimiliano Fusaro, MD, Tareq Ibrahim, MD, Tomohisa Tada, MD, Gert Richardt, MD, Karl-Ludwig Laugwitz, MD, Heribert Schunkert, MD, Adnan Kastrati, MD

Background: Factors underlying the increased risk of bleeding after percutaneous coronary intervention (PCI) in women compared with men remain incompletely understood.

01 agosto 2013

AMERICAN HEART JOURNAL. Racial disparity with on-treatment platelet reactivity in patients undergoing percutaneous coronary intervention

Lakshmana K. Pendyala, MD, Rebecca Torguson, MPH, Joshua P. Loh, MBBS, Joseph M. Devaney, PhD, Fang Chen, PhD, Hironori Kitabata, MD, Sa’ar Minha, MD, Israel M. Barbash, MD, William O. Suddath, MD, Lowell F. Satler, MD, Augusto D. Pichard, MD, Ron Waksman, MD

Background: On-treatment platelet reactivity to clopidogrel is variable and in part genetic dependent. In African American (AA) patients, the relation between on-treatment platelet reactivity to clopidogrel and the factors that influence this interaction is unknown. The present study aims to evaluate on-treatment platelet reactivity to clopidogrel in AA patients and its interaction to race and CYP2C19*2 loss of function mutation.

01 agosto 2013

AMERICAN HEART JOURNAL. The impact of industry representative´s visits on utilization of coronary stents

Doron Sudarsky, MD, Jahangir Charania, MD, Alexandra Inman, MD, Sabrina D´Alfonso, MSc, Shahar Lavi, MD

Background: The interaction between physicians and industry is complex and essential for improvement of medical care. However, conflict of interests may affect decision process. Our aim was to test if promotional visits by industry representatives affect treatment patterns and the use of various stents during percutaneous coronary interventions.

01 septiembre 2014

JACC. Incidence and Sequelae of Prosthesis-Patient Mismatch in Transcatheter Versus Surgical Valve Replacement in High-Risk Patients With Severe Aortic Stenosis

Philippe Pibarot, DVM, PhD∗; Neil J. Weissman, MD†; William J. Stewart, MD‡; Rebecca T. Hahn, MD§; Brian R. Lindman, MD, MSCI¶; Thomas McAndrew, MS‖; Susheel K. Kodali, MD§; Michael J. Mack, MD#; Vinod H. Thourani, MD∗∗; D. Craig Miller, MD††; Lars G. Svensson, MD, PhD‡‡; Howard C. Herrmann, MD§§; Craig R. Smith, MD§; Josep Rodés-Cabau, MD∗; John Webb, MD‖‖; Scott Lim, MD¶¶; Ke Xu, PhD‖; Irene Hueter, PhD§; Pamela S. Douglas, MD##; Martin B. Leon, MD§

Background: Little is known about the incidence of prosthesis-patient mismatch (PPM) and its impact on outcomes after transcatheter aortic valve replacement (TAVR).

01 septiembre 2014

JACC. Transcatheter Aortic Valve Replacement for Severe Symptomatic Aortic Stenosis Using a Repositionable Valve System

Ian T. Meredith AM, MBBS, PhD∗; Darren L. Walters, MBBS, MPhil†; Nicolas Dumonteil, MD‡; Stephen G. Worthley, MD§; Didier Tchétché, MD‖; Ganesh Manoharan, MD¶; Daniel J. Blackman, MD#; Gilles Rioufol, MD, PhD∗∗; David Hildick-Smith, MD††; Robert J. Whitbourn, MBBS‡‡; Thierry Lefèvre, MD§§; Rüdiger Lange, MD‖‖; Ralf Müller, MD¶¶; Simon Redwood, MD##; Dominic J. Allocco, MD∗∗∗; Keith D. Dawkins, MD∗∗∗

Background: Transcatheter aortic valve replacement provides results comparable to those of surgery in patients at high surgical risk, but complications can impact long-term outcomes. The Lotus valve, designed to improve upon earlier devices, is fully repositionable and retrievable, with a unique seal to minimize paravalvular regurgitation (PVR).

01 julio 2014

JACC. Improved Functional Status and Quality of Life in Prohibitive Surgical Risk Patients With Degenerative Mitral Regurgitation After Transcatheter Mitral Valve Repair

D. Scott Lim, MD∗; Matthew R. Reynolds, MD, MSc†; Ted Feldman, MD§; Saibal Kar, MD‖; Howard C. Herrmann, MD¶; Andrew Wang, MD#; Patrick L. Whitlow, MD∗∗; William A. Gray, MD††; Paul Grayburn, MD‡‡; Michael J. Mack, MD‡‡; Donald D. Glower, MD#

Background: Surgical mitral valve repair (SMVR) remains the gold standard for severe degenerative mitral regurgitation (DMR). However, the results with transcatheter mitral valve repair (TMVR) in prohibitive-risk DMR patients have not been previously reported.

08 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Clinical Outcomes and Safety of Transfemoral Aortic Valve Implantation Under General Versus Local Anesthesia

Atsushi Oguri, MD, Masanori Yamamoto, MD, Gauthier Mouillet, MD, Martine Gilard, MD, Marc Laskar, MD, Helene Eltchaninoff, MD, Jean Fajadet, MD, Bernard Iung, MD, Patrick Donzeau-Gouge, MD, Pascal Leprince, MD, Alain Leguerrier, MD, Alain Prat, MD, Michel Lievre, PhD, Karine Chevreul, MD, Jean-Luc Dubois-Rande, MD, Romain Chopard, MD, Eric Van Belle, MD, Toshiaki Otsuka, MD and Emmanuel Teiger, MD; on behalf of FRANCE 2 Registry Investigators

Background: Transcatheter aortic valve implantation (TAVI) performed under local anesthesia (LA) is becoming increasingly common. We aimed to compare the clinical outcomes in patients who underwent transfemoral-TAVI under general anesthesia (GA) and LA.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Open Transapical Approach to Transcatheter Paravalvular Leakage Closure

Vincent J. Nijenhuis, MD, Martin J. Swaans, MD, Martijn C. Post, MD, PhD, Robin H. Heijmen, MD, PhD, Thomas L. de Kroon, MD and Jurrien M. ten Berg, MD, PhD

Background: Significant prosthetic paravalvular leakage (PVL) could have serious clinical consequences and impairs survival. Reoperation is associated with a high mortality rate, and transcatheter closure is a new treatment modality for high-risk patients. The goal of this study was to determine safety and midterm clinical efficacy of transcatheter PVL closure using an open transapical approach.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Congenital Heart Disease. Trial Occlusion to Assess the Risk of Persistent Pulmonary Arterial Hypertension After Closure of a Large Patent Ductus Arteriosus in Adolescents and Adults With Elevated Pulmonary Artery Pressure

Duan-zhen Zhang, MD, Xian-yang Zhu, MD, Bei Lv, MD, Chun-sheng Cui, MD, Xiu-min Han, MD, Xiao-tang Sheng, MD, Qi-guang Wang, MD and Po Zhang, MD

Background: No method is available to predict whether patients with patent ductus arteriosus (PDA) and severe pulmonary arterial hypertension (PAH) will show persistent postprocedural PAH (PP-PAH) after PDA closure. This study evaluated the usefulness of trial occlusion for predicting PP-PAH after transcatheter PDA closure in patients with severe PAH.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Association of Glycemic Control With Mortality in Patients With Diabetes Mellitus Undergoing Percutaneous Coronary Intervention

Praneet K. Sharma, MD, Shikhar Agarwal, MD, MPH, Stephen G. Ellis, MD, Sachin S. Goel, MD, Leslie Cho, MD, E. Murat Tuzcu, MD, A. Michael Lincoff, MD and Samir R. Kapadia, MD

Background: Diabetes mellitus adversely affects outcomes in patients undergoing percutaneous coronary intervention. The association of baseline hemoglobin A1c (HbA1c) at the time of percutaneous coronary intervention with long-term mortality is unknown.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Geometrical and Stress Analysis of Factors Associated With Stent Fracture After Melody Percutaneous Pulmonary Valve Implantation

Daria Cosentino, PhD, Michael A. Quail, MBChB, MRCPCH, MSc, Giancarlo Pennati, PhD, Claudio Capelli, PhD, Philipp Bonhoeffer, MD, Vanessa Díaz-Zuccarini, PhD, Andrew M. Taylor, MD, FRCP, FRCR and Silvia Schievano, PhD

Background: Patients treated with the Melody device (Medtronic) for percutaneous pulmonary valve implantation experience stent fractures in ≈25% of the cases. The aim of this study is to identify the risk factors associated with fracture using 3-dimensional (3D) analyses.

10 junio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Everolimus-Eluting Stents Improve Vascular Response in a Diabetic Animal Model

Anwer Habib, MD, Vinit Karmali, MA, Michael C. John, MPH, Rohini Polavarapu, BA, Gaku Nakazawa, MD, Kim Pachura, BS, Talina Davis, Frank D. Kolodgie, PhD, Renu Virmani, MD and Aloke V. Finn, MD

Background: Preclinical evaluation of the vascular response of drug-eluting stents is limited especially in the setting of diabetes mellitus preventing the evaluation of changes in drug-eluting stent design and eluted drugs after clinical use.

17 junio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Incidence, Predictors, and Implications of Reinfarction After Primary Percutaneous Coronary Intervention in ST-Segment–Elevation Myocardial Infarction

Samantha G. Stone, Gregory W. Serrao, MD, Roxana Mehran, MD, Matthew I. Tomey, MD, Bernhard Witzenbichler, MD, Giulio Guagliumi, MD, Jan Z. Peruga, MD, Bruce R. Brodie, MD, Dariusz Dudek, MD, Martin Möckel, MD, Sorin J. Brener, MD, George Dangas, MD, PhD and Gregg W. Stone, MD

Background: Reinfarction after primary percutaneous coronary intervention in patients with ST-segment–elevation myocardial infarction has negative consequences. Little is known about reinfarction after drug-eluting stents and bivalirudin anticoagulation. We, therefore, sought to determine the incidence, predictors, and implications of reinfarction after primary percutaneous coronary intervention in the contemporary era.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. New Techniques. Effects of Transendocardial CD34+ Cell Transplantation in Patients With Ischemic Cardiomyopathy

Gregor Poglajen, MD, PhD, Matjaz Sever, MD, PhD, Marko Cukjati, MD, Peter Cernelc, MD, PhD, Ivan Knezevic, MD, Gregor Zemljic, MD, François Haddad, MD, Joseph C. Wu, MD, PhD and Bojan Vrtovec, MD, PhD

Background: We investigated the effects of transendocardial CD34+ cell transplantation in patients with ischemic cardiomyopathy.