01 septiembre 2014

JACC. Effect of Aspiration Thrombectomy on Microvascular Obstruction in NSTEMI Patients

Holger Thiele, MD∗; Suzanne de Waha, MD∗; Uwe Zeymer, MD§; Steffen Desch, MD∗; Bruno Scheller, MD‖; Bernward Lauer, MD¶; Tobias Geisler, MD#; Meinrad Gawaz, MD#; Oliver Gunkel, MD∗∗; Leonhard Bruch, MD††; Norbert Klein, MD‡‡; Dietrich Pfeiffer, MD‡‡; Gerhard Schuler, MD∗; Ingo Eitel, MD∗

Background: Aspiration thrombectomy in ST-segment elevation myocardial infarction is recommended by current guidelines based on several randomized trials. There are no trials assessing thrombectomy in non–ST-segment elevation myocardial infarction (NSTEMI) patients.

01 septiembre 2014

JACC. Aspirin Treatment and Outcomes After Percutaneous Coronary Intervention

Katharina Mayer, MD∗; Isabell Bernlochner, MD†; Siegmund Braun, MD∗; Stefanie Schulz, MD∗; Martin Orban, MD‡; Tanja Morath, MD∗; Lisena Cala, MS∗; Petra Hoppmann, MD†; Heribert Schunkert, MD∗; Karl-Ludwig Laugwitz, MD†; Adnan Kastrati, MD∗; Dirk Sibbing, MD‡

Background_ Aspirin administration, as part of a dual antiplatelet treatment regimen, is essential for patients undergoing percutaneous coronary intervention (PCI). Although the correlation between high on-clopidogrel treatment platelet reactivity (HCPR) and clinical outcome is well established, data for high on-aspirin treatment platelet reactivity (HAPR) are conflicting.

01 septiembre 2014

JACC. Percutaneous Mitral Valve Edge-to-Edge Repair. In-Hospital Results and 1-Year Follow-Up of 628 Patients of the 2011–2012 Pilot European Sentinel Registry

Georg Nickenig, MD, PhD∗; Rodrigo Estevez-Loureiro, MD, PhD†; Olaf Franzen, MD‡; Corrado Tamburino, MD, PhD§; Marc Vanderheyden, MD‖; Thomas F. Lüscher, MD¶; Neil Moat, MS#; Susanna Price, MD, PhD∗∗; Gianni Dall’Ara, MD†; Reidar Winter, MD, PhD††; Roberto Corti, MD¶; Carmelo Grasso, MD§; Thomas M. Snow, MD†; Raban Jeger, MD‡‡; Stefan Blankenberg, MD§§; Magnus Settergren, MD, PhD††; Klaus Tiroch, MD‖‖; Jan Balzer, MD¶¶; Anna Sonia Petronio, MD##; Heinz-Joachim Büttner, MD∗∗∗; Federica Ettori, MD†††; Horst Sievert, MD‡‡‡; Maria Giovanna Fiorino, MD§§§; Marc Claeys, MD, PhD‖‖‖; Gian Paolo Ussia, MD¶¶¶; Helmut Baumgartner, MD###; Salvatore Scandura, MD§; Farqad Alamgir, MD∗∗∗∗; Freidoon Keshavarzi, MD∗∗∗∗; Antonio Colombo, MD††††; Francesco Maisano, MD, PhD‡‡‡‡; Henning Ebelt, MD§§§§; Patrizia Aruta, MD§; Edith Lubos, MD§§; Björn Plicht, MD‖‖‖‖; Robert Schueler, MD∗; Michele Pighi, MD†; Carlo Di Mario, MD, PhD†

Background: The use of transcatheter mitral valve repair (TMVR) has gained widespread acceptance in Europe, but data on immediate success, safety, and long-term echocardiographic follow-up in real-world patients are still limited.

01 agosto 2014

JACC. Accuracy of Coronary CT Angiography Using a Submillisievert Fraction of Radiation Exposure

Julia Stehli, MD∗; Tobias A. Fuchs, MD∗; Sacha Bull, MD∗; Olivier F. Clerc, MD∗; Mathias Possner, MD∗; Ronny R. Buechel, MD∗; Oliver Gaemperli, MD∗; Philipp A. Kaufmann, MD∗

Background: Coronary computed tomography angiography (CTA) is increasingly being used for evaluation of coronary artery disease (CAD). As a result of the widely reported potential of carcinogenic risk from x-ray based examinations, many strategies have been developed for dose reduction with CTA.

01 agosto 2014

JACC. Anatomic Assessment of Sympathetic Peri-Arterial Renal Nerves in Man

Kenichi Sakakura, MD∗; Elena Ladich, MD∗; Qi Cheng, MD∗; Fumiyuki Otsuka, MD∗; Kazuyuki Yahagi, MD∗; David R. Fowler, MD†; Frank D. Kolodgie, PhD∗; Renu Virmani, MD∗; Michael Joner, MD∗

Background: Although renal sympathetic denervation therapy has shown promising results in patients with resistant hypertension, the human anatomy of peri-arterial renal nerves is poorly understood.

01 agosto 2014

JACC. Prevalence and Characteristics of TCFA and Degree of Coronary Artery Stenosis

Jinwei Tian, MD, PhD∗; Harold Dauerman, MD‡; Catalin Toma, MD§; Habib Samady, MD‖; Tomonori Itoh, MD¶; Shoichi Kuramitsu, MD#; Takenori Domei, MD#; Haibo Jia, MD, PhD∗; Rocco Vergallo, MD†; Tsunenari Soeda, MD, PhD†; Sining Hu, MD∗; Yoshiyasu Minami, MD†; Hang Lee, PhD∗∗; Bo Yu, MD, PhD∗; Ik-Kyung Jang, MD, PhD†

Background: The relationship between features of vulnerable plaque and angiographic coronary stenosis is unknown.

01 agosto 2014

JACC. High-Risk Plaque Detected on Coronary CT Angiography Predicts Acute Coronary Syndromes Independent of Significant Stenosis in Acute Chest Pain

Stefan B. Puchner, MD∗; Ting Liu, MD∗; Thomas Mayrhofer, PhD∗; Quynh A. Truong, MD, MPH∗; Hang Lee, PhD§; Jerome L. Fleg, MD‖; John T. Nagurney, MD, MPH¶; James E. Udelson, MD#; Udo Hoffmann, MD, MPH∗; Maros Ferencik, MD, PhD∗

Background: It is not known whether high-risk plaque, as detected by coronary computed tomography angiography (CTA), permits improved early diagnosis of acute coronary syndromes (ACS) independently to the presence of significant coronary artery disease (CAD) in patients with acute chest pain.

01 agosto 2014

JACC. Early Safety and Efficacy of Percutaneous Left Atrial Appendage Suture Ligation

Matthew J. Price, MD∗; Douglas N. Gibson, MD∗; Steven J. Yakubov, MD†; Jason C. Schultz, MD∗; Luigi Di Biase, MD, PhD‡; Andrea Natale, MD‡; J. David Burkhardt, MD‡; Ashish Pershad, MD§; Timothy J. Byrne, DO§; Brett Gidney, MD‖; Joseph R. Aragon, MD¶; Jeffrey Goldstein, MD#; Kriegh Moulton, MD#; Taral Patel, MD∗∗; Bradley Knight, MD∗∗; Albert C. Lin, MD∗∗; Miguel Valderrábano, MD††

Background: Transcatheter left atrial appendage (LAA) ligation may represent an alternative to oral anticoagulation for stroke prevention in atrial fibrillation.

01 agosto 2014

JACC. Prognostic Value of Site SYNTAX Score and Rationale for Combining Anatomic and Clinical Factors in Decision Making

Yao-Jun Zhang, PhD∗; Javaid Iqbal, MRCP, PhD∗; Carlos M. Campos, MD∗; David V. Klaveren, MSc‡; Christos V. Bourantas, MD∗; Keith D. Dawkins, MD§; Adrian P. Banning, MD‖; Javier Escaned, MD, PhD¶; Ton de Vries, MSc#; Marie-Angèle Morel, BSc#; Vasim Farooq, MD∗; Yoshinobu Onuma, MD∗; Hector M. Garcia-Garcia, MD, PhD∗; Gregg W. Stone, MD∗∗; Ewout W. Steyerberg, PhD‡; Friedrich W. Mohr, MD††; Patrick W. Serruys, MD, PhD∗

Background: The results of SYNTAX trial have been reported based on “corelab” calculated SS (cSS). It has been shown that reproducibility of SS is better among the core laboratory technicians than interventional cardiologists. Thus, the prognostic value and clinical implication of the “site” SYNTAX SS (sSS) remain unknown.

01 julio 2014

JACC. Detection of Myocardial Injury by CMR After Transcatheter Aortic Valve Replacement

Won-Keun Kim, MD∗; Andreas Rolf, MD∗; Christoph Liebetrau, MD∗; Arnaud Van Linden, MD∗; Johannes Blumenstein, MD∗; Jörg Kempfert, MD†; Georg Bachmann, MD§; Holger Nef, MD‡; Christian Hamm, MD∗; Thomas Walther, MD†; Helge Möllmann, MD∗

Background: Myocardial injury after transcatheter aortic valve replacement (TAVR) is common, but its cause and relationship to the extent of myocardial tissue loss remain unclear.

01 julio 2014

JACC: CARDIOVASCULAR INTERVENTIONS. Comparative Outcomes After Unprotected Left Main Stem Percutaneous Coronary Intervention

Sami S. Almudarra, MBBS, MSc∗; Chris P. Gale, BSc(Hons), MBBS, PhD, Dip MEd, MSc∗; Paul D. Baxter, BSc, PhD, CStat∗; Sarah J. Fleming, BSc, MSc, PhD∗; Richard A. Brogan, BSc(Hons), MB ChB∗; Peter F. Ludman, MA, MD‡; Mark A. de Belder, MA, MD§; Nick P. Curzen, BM(Hons), PhD‖

Objectives: The goal of this study was to report outcomes from percutaneous coronary intervention (PCI) to an unprotected left main stem (UPLMS) stenosis according to presenting syndrome, including ST-segment elevation myocardial infarction (STEMI), non–ST-segment elevation acute coronary syndrome (NSTEACS), and chronic stable angina (CSA).

01 julio 2014

JACC. Long-Term Follow-Up of Elective Chronic Total Coronary Occlusion Angioplasty

Sudhakar George, MD∗; James Cockburn, MD∗; Tim C. Clayton, MSc†; Peter Ludman, MD‡; James Cotton, MD§; James Spratt, MA‖; Simon Redwood, MD#; Mark de Belder, MD¶; Adam de Belder, MD∗; Jonathan Hill, MA∗∗; Angela Hoye, MBChB, PhD††; Nick Palmer, MD‡‡; Sudhir Rathore, MD§§; Anthony Gershlick, MB BS‖‖; Carlo Di Mario, MD, PhD##; David Hildick-Smith, MD∗

Background: Chronic total occlusion (CTO) is common, being reported in 18% to 30% of patients undergoing coronary angiography. Percutaneous coronary intervention (PCI) is usually performed to relieve anginal symptoms, but data are emerging to suggest that there may also be a mortality benefit.

01 septiembre 2014

AMERICAN HEART JOURNAL. Assessment of side branch predilation before a provisional T-stent strategy for bifurcation lesions. A randomized trial

Manuel Pan, MD, PhD, Alfonso Medina, MD, PhD, Miguel Romero, MD, PhD, Soledad Ojeda, MD, PhD, Pedro Martin, MD, PhD, Javier Suarez de Lezo, MD, PhD, Jose Segura, MD, PhD, Francisco Mazuelos, MD, PhD, Jose Novoa, MD, PhD, Jose Suarez de Lezo, MD, PhD

Background: A simple approach is the predominant strategy for the percutaneous coronary intervention of bifurcation lesions. Performing side branch (SB) predilation in this context is currently a matter of controversy. In this study, we assess the efficacy of SB predilatation before a provisional T-stent strategy for bifurcation lesions.

01 septiembre 2013

AMERICAN HEART JOURNAL. Change in enrollment patterns, patient selection, and clinical outcomes with the availability of drug-eluting stents in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trial

Binita Shah, MD, MSi, Vankeepuram S. Srinivas, MBBS, MSi, Jiang Lu, MSi, Maria M. Brooks, PhDi, Eric R. Bates, MDi, Zoran S. Nedeljkovic, MDi, Jorge Escobedo, MDi, Gladwin S. Das, MDi, John J. Lopez, MDi, Frederick Feit, MDi iFor the BARI 2D Study Group.

Background: In the BARI 2D trial, patients with type 2 diabetes and stable coronary artery disease were randomized to prompt revascularization versus intensive medical therapy (IMT). This analysis sought to evaluate how the availability of drug-eluting stents (DESs) has changed practice and outcomes.

01 septiembre 2013

AMERICAN HEART JOURNAL. Differences in the outcome of patients undergoing percutaneous coronary interventions at teaching versus non-teaching hospitals

Amneet Sandhu, MD, Mauro Moscucci, MD, MBA, Simon Dixon, MD, David H. Wohns, MD, David Share, MD, MPH, Thomas LaLonde, MD, Dean Smith, PhD, Hitinder S. Gurm, MBBS

Background: Teaching hospitals have superior outcomes for major medical conditions including cardiovascular disease compared to non-teaching hospitals. This may not be applicable to invasive cardiac procedures given a potential increase in complications due to trainee participation.