01 abril 2015

JACC. Association of Spontaneous Bleeding and Myocardial Infarction With Long-Term Mortality After Percutaneous Coronary Intervention

Dhruv S. Kazi, MD, MSc∗; Thomas K. Leong, MPH§; Tara I. Chang, MD, MS‖; Matthew D. Solomon, MD, PhD§; Mark A. Hlatky, MD‖; Alan S. Go, MD‡

Background: Platelet inhibition after percutaneous coronary intervention (PCI) reduces the risk of myocardial infarction (MI) but increases the risk of bleeding. MIs and bleeds during the index hospitalization for PCI are known to negatively affect long-term outcomes. The impact of spontaneous bleeding occurring after discharge on long-term mortality is unknown.

01 abril 2015

JACC. Duration of Triple Therapy in Patients Requiring Oral Anticoagulation After Drug-Eluting Stent Implantation. The ISAR-TRIPLE Trial

Katrin A. Fiedler, MD∗; Michael Maeng, MD†; Julinda Mehilli, MD‡; Stefanie Schulz-Schüpke, MD∗; Robert A. Byrne, MB, BCh, PhD∗; Dirk Sibbing, MD‡; Petra Hoppmann, MD‖; Simon Schneider, MD‖; Massimiliano Fusaro, MD∗; Ilka Ott, MD∗; Steen D. Kristensen, MD†; Tareq Ibrahim, MD‖; Steffen Massberg, MD‡; Heribert Schunkert, MD∗; Karl-Ludwig Laugwitz, MD§; Adnan Kastrati, MD∗; Nikolaus Sarafoff, MD‡

Background: Patients receiving oral anticoagulation (OAC) who undergo drug-eluting stent (DES) implantation require additional dual antiplatelet therapy with aspirin and clopidogrel. Such triple therapy confers an elevated bleeding risk, and its optimal duration is not known.

20 febrero 2015

CIRCULATION. Coronary Heart Disease. Invasive Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease

Bong-Ki Lee, MD, PhD; Hong-Seok Lim, MD, PhD; William F. Fearon, MD; Andy S. Yong, MBBS, PhD; Ryotaro Yamada, MD; Shigemitsu Tanaka, MD; David P. Lee, MD; Alan C. Yeung, MD; Jennifer A. Tremmel, MD, MS

Background: More than 20% of patients presenting to the cardiac catheterization laboratory with angina have no angiographic evidence of coronary artery disease. Despite a “normal” angiogram, these patients often have persistent symptoms, recurrent hospitalizations, a poor functional status, and adverse cardiovascular outcomes, without a clear diagnosis.

30 enero 2015

CIRCULATION. Valvular Heart Disease. Transcatheter Aortic Valve Implantation in the United Kingdom Temporal Trends, Predictors of Outcome, and 6-Year Follow-Up: A Report From the UK Transcatheter Aortic Valve Implantation (TAVI) Registry, 2007 to 2012

Peter F. Ludman, MA, MD, FRCP; Neil Moat, MD, FRCS; Mark A. de Belder, MA, MD, FRCP; Daniel J. Blackman, MD; Alison Duncan, MBBS, BSc, MRCP, PhD; Winston Banya, MSc; Philip A. MacCarthy, BSc, MBChB, PhD, FRCP; David Cunningham, BSc, PhD; Olaf Wendler, MD, PhD, FRCS; Damian Marlee, PhD; David Hildick-Smith, MD, FRCP; Christopher P. Young, MD, FRCS; Jan Kovac, MUDr; Neal G. Uren, MD, FRCP; Tomasz Spyt, MD, FRCS, CTh, FECTS; Uday Trivedi, MD, FRCS; Jonathan Howell, MBBS, MA (Oxon), MFPHM; Huon Gray, MD, FRCP; on behalf of the UK TAVI Steering Committee and the National Institute for Cardiovascular Outcomes Research*

Background: We assessed trends in the performance of transcatheter aortic valve implantation in the United Kingdom from the first case in 2007 to the end of 2012. We analyzed changes in case mix, complications, outcomes to 6 years, and predictors of mortality.

24 febrero 2015

CIRCULATION. Interventional Cardiology. Optimal Medical Therapy Improves Clinical Outcomes in Patients Undergoing Revascularization With Percutaneous Coronary Intervention or Coronary Artery Bypass Grafting

Javaid Iqbal, MRCP, PhD*; Yao-Jun Zhang, MD*; David R. Holmes, MD; Marie-Claude Morice, MD; Michael J. Mack, MD; Arie Pieter Kappetein, MD, PhD; Ted Feldman, MD; Elizabeth Stahle, MD; Javier Escaned, MD, PhD; Adrian P. Banning, MD, FRCP; Julian P. Gunn, MD, MRCP; Antonio Colombo, MD; Ewout W. Steyerberg, PhD; Friedrich W. Mohr, MD; Patrick W. Serruys, MD, PhD

Background: There is a paucity of data on the use of optimal medical therapy (OMT) in patients with complex coronary artery disease undergoing revascularization with percutaneous coronary intervention or coronary artery bypass grafting (CABG) and its long-term prognostic significance.

09 marzo 2015

CIRCULATION. Valvular Heart Disease. Infective Endocarditis After Transcatheter Aortic Valve Implantation

Ignacio J. Amat-Santos, MD; David Messika-Zeitoun, MD, PhD; Helene Eltchaninoff, MD; Samir Kapadia, MD; Stamatios Lerakis, MD; Asim N. Cheema, MD; Enrique Gutiérrez-Ibanes, MD; Antonio J. Munoz-Garcia, MD, PhD; Manuel Pan, MD; John G. Webb, MD; Howard C. Herrmann, MD; Susheel Kodali, MD; Luis Nombela-Franco, MD; Corrado Tamburino, MD; Hasan Jilaihawi, MD; Jean-Bernard Masson, MD; Fabio Sandoli de Brito Jr, MD; Maria Cristina Ferreira, MD; Valter Correa Lima, MD; José Armando Mangione, MD; Bernard Iung, MD; Alec Vahanian, MD; Eric Durand, MD; E. Murat Tuzcu, MD; Salim S. Hayek, MD; Rocio Angulo-Llanos, MD; Juan J. Gómez-Doblas, MD; Juan Carlos Castillo, MD; Danny Dvir, MD; Martin B. Leon, MD; Eulogio Garcia, MD; Javier Cobiella, MD; Isidre Vilacosta, MD; Marco Barbanti, MD; Raj R. Makkar, MD; Henrique Barbosa Ribeiro, MD; Marina Urena, MD; Eric Dumont, MD; Philippe Pibarot, PhD; Javier Lopez, MD; Alberto San Roman, MD; Josep Rodés-Cabau, MD

Background: We aimed to determine the incidence, predictors, clinical characteristics, management, and outcomes of infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI).

13 abril 2015

CIRCULATION. Congenital Heart Disease. Intermediate Outcomes in the Prospective, Multicenter Coarctation of the Aorta Stent Trial (COAST)

Jeffery Meadows, MD; Matthew Minahan, BS; Doff B. McElhinney, MD; Kerry McEnaney, BS; Richard Ringel, MD; on behalf of the COAST Investigators*

Background: The Coarctation of the Aorta Stent Trial (COAST) was designed to assess the safety and efficacy of the Cheatham Platinum stent when used in children and adults with native or recurrent coarctation. Acute outcomes have been reported. We report here follow-up to 2 years.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Fractional Flow Reserve and Coronary Bifurcation Anatomy. A Novel Quantitative Model to Assess and Report the Stenosis Severity of Bifurcation Lesions

Shengxian Tu, PhD∗; Mauro Echavarria-Pinto, MD‡; Clemens von Birgelen, MD, PhD§; Niels R. Holm, MD¶; Stylianos A. Pyxaras, MD#; Indulis Kumsars, MD∗∗; Ming Kai Lam, MD§; Ilona Valkenburg, BSc§; Gabor G. Toth, MD#; Yingguang Li, MSc†; Javier Escaned, MD, PhD‡; William Wijns, MD, PhD#; Johan H.C. Reiber, PhD†

Objectives: The aim of this study was to develop a new model for assessment of stenosis severity in a bifurcation lesion including its core. The diagnostic performance of this model, powered by 3-dimensional quantitative coronary angiography to predict the functional significance of obstructive bifurcation stenoses, was evaluated using fractional flow reserve (FFR) as the reference standard.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Randomized Comparisons Between Different Stenting Approaches for Bifurcation Coronary Lesions With or Without Side Branch Stenosis

Young-Hak Kim, MD∗; Jae-Hwan Lee, MD†; Jae-Hyung Roh, MD∗; Jung-Min Ahn, MD∗; Sung-Han Yoon, MD∗; Duk-Woo Park, MD∗; Jong-Young Lee, MD∗; Sung-Cheol Yun, PhD‡; Soo-Jin Kang, MD∗; Seung-Whan Lee, MD∗; Cheol Whan Lee, MD∗; Ki Bae Seung, MD§; Won-Yong Shin, MD‖; Nae-Hee Lee, MD¶; Bong-Ki Lee, MD#; Sang-Gon Lee, MD∗∗; Chang-Wook Nam, MD††; Junghan Yoon, MD‡‡; Joo-Young Yang, MD§§; Min-Su Hyon, MD‖‖; Keun Lee, MD¶¶; Jae-Sik Jang, MD##; Hyun-Sook Kim, MD∗∗∗; Seong-Wook Park, MD∗; Seung-Jung Park, MD∗

Objectives: This study sought to evaluate the optimal percutaneous coronary intervention techniques using drug-eluting stents for bifurcation coronary lesions.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Randomized Comparison of FFR-Guided and Angiography-Guided Provisional Stenting of True Coronary Bifurcation Lesions. The DKCRUSH-VI Trial (Double Kissing Crush Versus Provisional Stenting Technique for Treatment of Coronary Bifurcation Lesions VI)

Shao-Liang Chen, MD∗; Fei Ye, MD∗; Jun-Jie Zhang, PhD∗; Tian Xu, MBBS‡; Nai-Liang Tian, MD‡; Zhi-Zhong Liu, PhD‡; Song Lin, MD§; Shou-Jie Shan, MD∗; Zhen Ge, MD∗; Wei You, MD‡; Yue-Qiang Liu, MD§; Xue-Song Qian, MD‖; Feng Li, MD¶; Song Yang, MD#; Tak W. Kwan, MD∗∗; Bo Xu, MBBS††; Gregg W. Stone, MD‡‡

Objectives: This study sought to compare the outcomes of fractional flow reserve (FFR)–guided and angiography (Angio)–guided provisional side-branch (SB) stenting for true coronary bifurcation lesions.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Fractional Flow Reserve in the Transradial Era: Will Hand Vein Adenosine Infusion Suffice? A Comparative Study of the Extent, Rapidity, and Stability of Hyperemia From Hand and Femoral Venous Routes of Adenosine Administration

Peter Scott, MD∗; Alex Sirker, PhD∗; Rafal Dworakowski, MD, PhD∗; Gideon Paul, MD†; Luciano Candilio, MD∗; Nishat Jahagirdar, BSc∗; Narbeh Melikian, MD∗; Jonathan Byrne, PhD∗

Objectives: The aim of this study was to assess adenosine infusion via a cannula in the back of the hand compared with central venous access to achieve peak hyperemia during fractional flow reserve (FFR).

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. The Effect of Transradial Coronary Catheterization on Upper Limb Function

Maarten A.H. van Leeuwen, MD∗; Nicolas M. van Mieghem, MD, PhD†; Mattie J. Lenzen, PhD†; Ruud W. Selles, PhD‡; Mirjam F. Hoefkens, MD§; Felix Zijlstra, MD, PhD†; Niels van Royen, MD, PhD∗

Objectives: The aim of this study was to analyze the change of upper limb function when percutaneous coronary procedures were performed through the radial artery.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Radial Versus Femoral Access for Coronary Angiography/Intervention in Women With Acute Coronary Syndromes

Shaheen Pandie, MB ChB, MMed∗; Shamir R. Mehta, MD, MSc∗; Warren J. Cantor, MD†; Asim N. Cheema, MD, PhD‡; Peggy Gao, MSc∗; Mina Madan, MD§; Kari Niemela, MD, PhD‖; Sunil V. Rao, MD¶; Jon David Schwalm, MD∗; Vicent Valentin, MD#; James L. Velianou, MD∗; Sanjit S. Jolly, MD, MSc∗

Objectives: The purpose of this study was to determine the efficacy and safety of radial versus femoral access in women undergoing coronary angiography/intervention.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Assessment of the Geometric Interaction Between the Lotus Transcatheter Aortic Valve Prosthesis and the Native Ventricular Aortic Interface by 320-Multidetector Computed Tomography

Robert P. Gooley, MD; James D. Cameron, MD; Ian T. Meredith, AM, MD

Objectives: This study sought to assess the geometric interaction between the Lotus Valve System transcatheter aortic prosthesis (Boston Scientific, Natick, Massachusetts) and the native aortoventricular interface using multidetector computed tomography (MDCT).

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Thrombus Formation Following Transcatheter Aortic Valve Replacement

Eduardo De Marchena, MD∗; Julian Mesa, MD∗; Sydney Pomenti, BS∗; Christian Marin y Kall, MD∗; Ximena Marincic, BS∗; Kazuyuki Yahagi, MD†; Elena Ladich, MD†; Robert Kutys, MS†; Yaar Aga, BS∗; Michael Ragosta, MD‡; Atul Chawla, MD§; Michael E. Ring, MD||; Renu Virmani, MD†

Objectives: This paper reviews the published data and reports 3 cases of thrombosis involving CoreValve (Medtronic, Minneapolis, Minnesota) and 1 involving Edward Sapien (Edwards Lifesciences, Irvine, California) devices. Three of these cases had pathological findings at autopsy.