07 diciembre 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Etiology, Frequency, and Clinical Outcomes of Myocardial Infarction After Successful Drug-Eluting Stent Implantation

Tomotaka Dohi, MD, PhD, Akiko Maehara, MD, Bernhard Witzenbichler, MD, Michael J. Rinaldi, MD, Ernest L. Mazzaferri Jr, MD, Peter L. Duffy, MD, MMM, Giora Weisz, MD, Franz-Josef Neumann, MD, Timothy D. Henry, MD, David A. Cox, MD, Thomas D. Stuckey, MD, Bruce R. Brodie, MD, Claire Litherland, MS, Sorin J. Brener, MD, Ajay J. Kirtane, MD, SM, Gary S. Mintz, MD and Gregg W. Stone, MD

Background: The frequency, causes, and impact of myocardial infarction (MI) after successful percutaneous coronary intervention have not been well studied.

01 agosto 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Comparison of Right and Left Upper Limb Arterial Variants in Patients Undergoing Bilateral Transradial Procedures

Francesco Burzotta, MD, PhD, Marta Francesca Brancati, MD, Italo Porto, MD, PhD, Silvia Saffioti, MD, Cristina Aurigemma, MD, PhD, Giampaolo Niccoli, MD, PhD, Antonio Maria Leone, MD, PhD, Valentina Coluccia, MD, Filippo Crea, MD and Carlo Trani, MD

Background: Transradial approach (TRA), when compared with transfemoral, improves the safety of percutaneous coronary procedures. Arterial axis variants are known to hinder the performance of transradial approach percutaneous coronary procedures. Data on the occurrence of arterial axis variants in the right and left arm arterial axes of individual patients are lacking.

01 enero 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. The Rotterdam Radial Access Research. Ultrasound-Based Radial Artery Evaluation for Diagnostic and Therapeutic Coronary Procedures

Francesco Costa, MD, Maarten A.H. van Leeuwen, MD, Joost Daemen, MD, PhD, Roberto Diletti, MD, Floris Kauer, MD, Robert-Jan van Geuns, MD, PhD, Jurgen Ligthart, RT, Karen Witberg, CCRN, Felix Zijlstra, MD, PhD, Marco Valgimigli, MD, PhD and Nicolas M. Van Mieghem, MD, PhD

Background: Radial artery wall might be damaged after cannulation for cardiac catheterization. We investigated structural changes of the radial artery wall after catheterization to understand whether these might predict radial pulsation loss or occlusion and local pain or functional impairment of the upper extremity.

01 enero 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Safety and Efficacy of New-Generation Drug-Eluting Stents in Women at High Risk for Atherothrombosis. From the Women in Innovation and Drug-Eluting Stents Collaborative Patient-Level Pooled Analysis

Gennaro Giustino, MD, Usman Baber, MD, MSc, Olga Salianski, Samantha Sartori, PhD, Gregg W. Stone, MD, Martin B. Leon, MD, Melissa Aquino, MSc, Giulio G. Stefanini, MD, PhD, P. Gabriel Steg, MD, PhD, Stephan Windecker, MD, PhD, Monica O’ Donoghue, William Wijns, MD, Patrick W. Serruys, MD, PhD, Marco Valgimigli, MD, PhD, Marie-Claude Morice, MD, Edoardo Camenzind, MD, Giora Weisz, MD, Pieter C. Smits, MD, David Kandzari, MD, Clemens Von Birgelen, MD, George D. Dangas, MD, PhD, Jin Y. Cha, Soren Galatius, MD, Raban V. Jeger, MD, Takeshi Kimura, MD, Ghada W. Mikhail, MD, Dipti Itchhaporia, MD, Laxmi Mehta, MD, Rebecca Ortega, MD, Hyo-Soo Kim, MD, Adnan Kastrati, MD, Philippe Genereux, MD, Alaide Chieffo, MD and Roxana Mehran, MD

Background: The safety and efficacy of new-generation drug-eluting stents (DES) in women with multiple atherothrombotic risk (ATR) factors is unclear.

01 enero 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model

Smita Sihag, MD*, Michael S. Haas, PhD*, Karen M. Kim, MD, J. Luis Guerrero, BS, Jonathan Beaudoin, MD, Elisabeth M. Alicot, PharmD, Franziska Schuerpf, BS, James D. Gottschall, BS, Robyn J. Puro, PhD, Joren C. Madsen, MD, David H. Sachs, MD, Walter Newman, PhD, Michael C. Carroll, PhD and James S. Allan, MD

Background: Acute coronary syndrome is the leading cause of mortality worldwide. However, treatment of acute coronary occlusion inevitably results in ischemia-reperfusion injury. Circulating natural IgM has been shown to play a significant role in mouse models of ischemia-reperfusion injury. A highly conserved self-antigen, nonmuscle myosin heavy chain II, has been identified as a target of pathogenic IgM. We hypothesized that a monoclonal antibody (m21G6) directed against nonmuscle myosin heavy chain II may inhibit IgM binding and reduce injury in a preclinical model of myocardial infarction. Thus, our objective was to evaluate the efficacy of intravenous m21G6 treatment in limiting infarct expansion, troponin release, and left ventricular dysfunction in a swine myocardial infarction model.

01 enero 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Atrial Fibrillation Is Associated With Increased Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement

Angelo B. Biviano, MD, MPH, Tamim Nazif, MD, Jose Dizon, MD, Hasan Garan, MD, Jessica Fleitman, MD, Dua Hassan, MD, Samir Kapadia, MD, Vasilis Babaliaros, MD, Ke Xu, PhD, Rupa Parvataneni, MS, Josep Rodes-Cabau, MD, Wilson Y. Szeto, MD, William F. Fearon, MD, Danny Dvir, MD, Todd Dewey, MD, Mathew Williams, MD, Michael J. Mack, MD, John G. Webb, MD, D. Craig Miller, MD, Craig R. Smith, MD, Martin B. Leon, MD and Susheel Kodali, MD

Background: This study sought to evaluate the impact of atrial fibrillation (AF) on clinical outcomes in patients undergoing transcatheter aortic valve replacement.

01 enero 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Pharmacology. Efficacy and Safety of Available Protocols for Aspirin Hypersensitivity for Patients Undergoing Percutaneous Coronary Intervention. A Survey and Systematic Review

Matteo Bianco, MD, Alessandro Bernardi, MD, Fabrizio D’Ascenzo, MD, Enrico Cerrato, MD, Pierluigi Omedè, MD, Antonio Montefusco, MD, James J. DiNicolantonio, PharmD, Giuseppe Biondi Zoccai, MD, Ferdinando Varbella, MD, Giovanni Carini, MD, Claudio Moretti, MD, Roberto Pozzi, MD and Fiorenzo Gaita, PhD

Background: The most suitable approach for patients with aspirin hypersensitivity undergoing percutaneous coronary intervention remains to be assessed.

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Thrombus Aspiration in Patients With ST-Segment Elevation Myocardial Infarction Presenting Late After Symptom Onset

Steffen Desch, MD∗,†; Thomas Stiermaier, MD∗,†; Suzanne de Waha, MD∗,†; Philipp Lurz, MD, PhD‡; Matthias Gutberlet, MD§; Marcus Sandri, MD‡; Norman Mangner, MD‡; Enno Boudriot, MD‡; Michael Woinke, MD‡; Sandra Erbs, MD‡; Gerhard Schuler, MD‡; Georg Fuernau, MD∗,†; Ingo Eitel, MD∗,†; Holger Thiele, MD∗,†

Objectives: The aim of this study was to examine whether manual thrombus aspiration reduces microvascular obstruction assessed by cardiac magnetic resonance imaging in patients with ST-segment elevation myocardial infarction (STEMI) presenting late after symptom onset.

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Outcomes From Selective Use of Thrombectomy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. An Analysis of the British Cardiovascular Intervention Society/National Institute for Cardiovascular Outcomes Research (BCIS-NICOR) Registry, 2006–2013

Alex Sirker, MB BChir∗; Mamas Mamas, BM BChir†; Chun Shing Kwok, MB BS†; Evangelos Kontopantelis, PhD‡; Peter Ludman, MD§; David Hildick-Smith, MD‖

Objectives: This study used a large national cohort to examine patterns of thrombectomy use in ST-segment elevation myocardial infarction (STEMI) and the relationship to mortality.

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Benefits and Risks of Extended Dual Antiplatelet Therapy After Everolimus-Eluting Stents

James B. Hermiller, MD∗; Mitchell W. Krucoff, MD†; Dean J. Kereiakes, MD‡; Stephan Windecker, MD§; P. Gabriel Steg, MD‖,¶; Robert W. Yeh, MD, MSc#,∗∗,††; David J. Cohen, MD, MSc‡‡; Donald E. Cutlip, MD∗∗,††,§§; Joseph M. Massaro, PhD††,‖‖; Wen-Hua Hsieh, PhD††; Laura Mauri, MD, MSc∗∗,††,¶¶

Objectives: The purpose of this study was to characterize outcomes for everolimus-eluting stent (EES)–treated subjects according to treatment with continued thienopyridine plus aspirin versus aspirin alone 12 to 30 months after stenting.

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Effects of Mechanical Ventilation on Heart Geometry and Mitral Valve Leaflet Coaptation During Percutaneous Edge-to-Edge Mitral Valve Repair

Johannes Patzelt, MD∗; Yingying Zhang, MD∗; Peter Seizer, MD∗; Harry Magunia, MD†; Andreas Henning, MD∗; Veronika Riemlova, MD∗; Tara A.E. Patzelt, Dr Oec Publ‡; Marc Hansen, Dipl Ing§; Michael Haap, MD‖; Reimer Riessen, MD‖; Henning Lausberg, MD¶; Tobias Walker, MD¶; Joerg Reutershan, MD†; Christian Schlensak, MD¶; Christian Grasshoff, MD†; Dan I. Simon, MD#; Peter Rosenberger, MD†; Juergen Schreieck, MD∗; Meinrad Gawaz, MD∗; Harald F. Langer, MD∗

Objectives: This study sought to evaluate a ventilation maneuver to facilitate percutaneous edge-to-edge mitral valve repair (PMVR) and its effects on heart geometry.

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Incidence, Predictive Factors, and Effect of Delirium After Transcatheter Aortic Valve Replacement

Masieh Abawi, BSc∗; Freek Nijhoff, MD∗; Pierfrancesco Agostoni, MD, PhD∗; Marielle H. Emmelot-Vonk, MD, PhD†; Rehana de Vries, MSc†; Pieter A. Doevendans, MD, PhD∗; Pieter R. Stella, MD, PhD∗

Objectives: The purpose of this study was to investigate the incidence, predictive factors, and effect of post-operative delirium (POD) among patients treated by transcatheter aortic valve replacement (TAVR).

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Cerebral Protection During MitraClip Implantation. Initial Experience at 2 Centers

Christian Frerker, MD∗; Michael Schlüter, PhD†; Oscar D. Sanchez, MD‡; Sebastian Reith, MD§; Maria E. Romero, MD‡; Elena Ladich, MD‡; Jörg Schröder, MD§; Tobias Schmidt, MD∗; Felix Kreidel, MD∗; Michael Joner, MD‡; Renu Virmani, MD‡; Karl-Heinz Kuck, MD∗

Objectives: This study sought to assess the feasibility and safety of using a filter-based cerebral protection system (CPS) during MitraClip implantation and to report on the histopathologic analysis of the captured debris.

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Severe Prinzmetal-Type Coronary Artery Spasm Causing Recurrent ST-Segment Elevation and Reversible Obstruction of a Bioresorbable Scaffold

Tommaso Gori, MD, PhD∗; Udo Sechtem, MD†; Thomas Münzel, MD†

A 38-year-old man with a history of smoking and hyperlipidemia was admitted for sudden-onset chest pain. The pre-admission electrocardiogram (ECG) showed ST-segment elevation in leads V4 through V6. After administration of 5000 IU heparin and 250 mg aspirin intravenously, the patient underwent urgent coronary angiography that showed an occluded intermediate branch and a stenosis of the circumflex coronary artery

01 enero 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Prospective Multicenter Evaluation of the Direct Flow Medical Transcatheter Aortic Valve System. 12-Month Outcomes of the Evaluation of the Direct Flow Medical Percutaneous Aortic Valve 18F System for the Treatment of Patients With Severe Aortic Stenosis (DISCOVER) Study

Thierry Lefèvre, MD∗; Antonio Colombo, MD†; Didier Tchétché, MD‡; Azeem Latib, MD†; Silvio Klugmann, MD§; Jean Fajadet, MD‡; Federico De Marco, MD§; Francesco Maisano, MD†; Giuseppe Bruschi, MD§; Klaudija Bijuklic, MD‖; Stefano Nava, MD§; Neil Weissman, MD¶; Reginald Low, MD#; Martyn Thomas, MD∗∗; Christopher Young, MD∗∗; Simon Redwood, MD∗∗; Michael Mullen, MD††; John Yap, MD††; Eberhard Grube, MD‡‡; Georg Nickenig, MD‡‡; Jan-Malte Sinning, MD‡‡; Karl Eugen Hauptmann, MD§§; Ivar Friedrich, MD§§; Michael Lauterbach, MD§§; Michael Schmoeckel, MD‖‖; Charles Davidson, MD¶¶; Joachim Schofer, MD‖

Objectives: The aim of this study was to assess the 1-year outcome after transcatheter aortic valve replacement (TAVR) of the Direct Flow Medical (DFM) valve in patients with severe symptomatic aortic stenosis who were contraindicated or high risk for surgery.