01 septiembre 2013

RADIOLOGY. Coronary Artery Imaging with Single-Source Rapid Kilovolt Peak–Switching Dual-Energy CT

Jonathan A. Scheske, MD, Julie M. O’Brien, MD, James P. Earls, MD, James K. Min, MD, Troy M. LaBounty, MD, Ricardo C. Cury, MD, Ting-Yim Lee, PhD, Aaron So, PhD, Cameron J. Hague, MD, Donya Al-Hassan, MD, Sachio Kuriyabashi, MD, David A. Dowe, MD and Jonathon A. Leipsic, MD

Purpose: To evaluate beam-hardening (BH) artifact reduction in coronary computed tomography (CT) angiography with dual-energy CT, to define the optimal monochromatic-energy levels for coronary and myocardial signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in dual-energy CT, and to compare these levels with single-energy CT.

01 septiembre 2013

RADIOLOGY. CT-based Diagnosis of Diffuse Coronary Artery Disease on the Basis of Scaling Power Laws

Yunlong Huo, PhD, Thomas Wischgoll, PhD, Jenny Susana Choy, MD, Srikanth Sola, MD1, Jose L. Navia, MD, Shawn D. Teague, MD, Deepak L. Bhatt, MD and Ghassan S. Kassab, PhD

Purpose: To provide proof of concept for a diagnostic method to assess diffuse coronary artery disease (CAD) on the basis of coronary computed tomography (CT) angiography.

01 agosto 2013

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Bloodstream Infections Occurring in Patients With Percutaneously Implanted Bioprosthetic Pulmonary Valve A Single-center Experience

Jonathan Buber, MD, Lisa Bergersen, MD, MPH, James E. Lock, MD, Kimberlee Gauvreau, ScD, Jesse J. Esch, MD, Michael J. Landzberg, MD, Anne Marie Valente, MD, Thomas J. Sandora, MD, MPH and Audrey C. Marshall, MD

Background—Percutaneous pulmonary valve implantation using a stent-based bioprosthetic valve provides an alternative to surgery in select patients. Systemic infections in Melody valve–implanted patients with and without identified valve involvement have been reported, yet the incidence is unknown, and risk factors remain unidentified.

01 agosto 2013

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Infective Endocarditis After Transcatheter Pulmonary Valve Replacement Using the Melody Valve. Combined Results of 3 Prospective North American and European Studies

Doff B. McElhinney, MD, Lee N. Benson, MD, Andreas Eicken, MD, PhD, Jacqueline Kreutzer, MD, Robert F. Padera, MD, PhD and Evan M. Zahn, MD

Background—Transcatheter (percutaneous) pulmonary valve (TPV) replacement has emerged as a viable therapy for right ventricular outflow tract conduit dysfunction. Little is known about the incidence, clinical course, and outcome of infective endocarditis (IE) after TPV implant. We reviewed combined data from 3 ongoing prospective multicenter trials to evaluate the experience with IE among patients undergoing TPV replacement using the Melody valve.

01 julio 2013

CIRCULATION. Quantification of Incomplete Revascularization and its Association With Five-Year Mortality in the Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Trial Validation of the Residual SYNTAX Score

Vasim Farooq, MBChB, MRCP; Patrick W. Serruys, MD, PhD; Christos V. Bourantas, MD; Yaojun Zhang, MD; Takashi Muramatsu, MD; Ted Feldman, MD; David R. Holmes, MD; Michael Mack, MD; Marie Claude Morice, MD; Elisabeth Ståhle, MD; Antonio Colombo, MD; Ton de Vries, MSc; Marie-angèle Morel, BSc; Keith D. Dawkins, MD; Arie-Pieter Kappetein, MD, PhD; Friedrich W. Mohr, MD

Background—The residual Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery (SYNTAX) Score is an objective measure of the degree and complexity of residual stenosis after percutaneous coronary intervention (PCI).

01 julio 2013

JACC: CARDIVASCULAR INTERVENTIONS. Prediction of 1-Year Mortality in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention. Validation of the Logistic Clinical SYNTAX (Synergy Between Percutaneous Coronary Interventions With Taxus and Cardiac Surgery) Score

Vasim Farooq, MBChB; Yvonne Vergouwe, PhD; Philippe Généreux, MD; Christos V. Bourantas, MD, PhD; Tullio Palmerini, MD; Adriano Caixeta, MD; Hector M. Garcìa-Garcìa, MD, PhD; Roberto Diletti, MD; Marie-angèle Morel, BSc; Thomas C. McAndrew, MS; Arie Pieter Kappetein, MD, PhD; Marco Valgimigli, MD; Stephan Windecker, MD; Keith D. Dawkins, MD; Ewout W. Steyerberg, PhD; Patrick W. Serruys, MD, PhD; Gregg W. Stone, MD

Objectives This study sought to validate the Logistic Clinical SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score in patients with non–ST-segment elevation acute coronary syndromes (ACS), in order to further legitimize its clinical application.

01 julio 2013

CIRCULATION. Prognostic Value of the Index of Microcirculatory Resistance Measured After Primary Percutaneous Coronary Intervention

William F. Fearon, MD; Adrian F. Low, MBBS; Andy S. Yong, MBBS, PhD; Ross McGeoch, MBChB; Colin Berry, MBChB, MD; Maulik G. Shah, MD; Michael Y. Ho, MD; Hyun-Sook Kim, MD; Joshua P. Loh, MBBS; Keith G. Oldroyd, MBChB, MD

Background—Most methods for assessing microvascular function are not readily available in the cardiac catheterization laboratory. The aim of this study is to determine whether the Index of Microcirculatory Resistance (IMR), measured at the time of primary percutaneous coronary intervention, is predictive of death and rehospitalization for heart failure.

01 julio 2013

JACC: CARDIVASCULAR INTERVENTIONS. Impact of Cholesterol Metabolism on Coronary Plaque Vulnerability of Target Vessels. A Combined Analysis of Virtual Histology Intravascular Ultrasound and Optical Coherence Tomography

Kenya Nasu, MD; Mitsuyasu Terashima, MD, PhD; Maoto Habara, MD; Euihong Ko, MD; Tsuyoshi Ito, MD; Daisuke Yokota, MD; Shuichi Ishizuka, MD; Tairo Kurita, MD; Masashi Kimura, MD; Yoshihisa Kinoshita, MD; Yasushi Asakura, MD; Etsuo Tsuchikane, MD, PhD; Osamu Katoh, MD; Takahiko Suzuki, MD, PhD

Objectives The aim of this study was to evaluate the relationship between cholesterol metabolism and coronary plaque vulnerability.

08 agosto 2013

HEART FAILURE REVIEWS. Clinical utility of antigen carbohydrate 125 in heart failure

Julio Núñez, Gema Miñana, Eduardo Núñez, Francisco J. Chorro, Vicent Bodí & Juan Sanchis

Abstract: In recent years, there has been a proliferation of new biomarkers with potential prognostic implication in heart failure (HF). Nevertheless, most of them do not fulfill the required criteria for being used in daily clinical practice. Tumor marker antigen carbohydrate 125 (CA125), a glycoprotein widely used for ovarian cancer monitoring, is synthesized by epithelial serous cells in response to fluid accumulation and/or cytokine stimuli. This glycoprotein has been emerged as a potential biomarker in HF. Plasma CA125 correlates with clinical, hemodynamic, and echocardiographic parameters related to the severity of the disease. High levels have shown to be present in the majority of acutely decompensated patients, and in this setting, it has shown to be independently related to mortality or subsequent admission for acute HF. In addition, certain characteristics such as wide availability and the close correlation between plasma changes with disease severity and clinical outcomes have increased the interest of researchers about the potential of this glycoprotein for monitoring and guiding therapy in HF. In this article, we have reviewed the available evidence supporting the potential role of CA125 as a biomarker in HF.

01 julio 2013

RADIOLOGY. Use of Carotid Plaque Neovascularization at Contrast-enhanced US to Predict Coronary Events in Patients with Coronary Artery Disease

Ying Zhu, MD, You-Bin Deng, MD, Ya-Ni Liu, MD, Xiao-Jun Bi, MD, Jie Sun, MD, Qiao-Ying Tang, MD and Qi Deng, MD

Purpose: To determine whether carotid plaque neovascularization as assessed with contrast-enhanced ultrasonography (US) can help predict future coronary events in patients with stable coronary artery disease (CAD).

01 junio 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Long-Term Outcome After Drug-Eluting Versus Bare-Metal Stent Implantation in Patients With ST-Segment Elevation Myocardial Infarction. 5 Years Follow-Up From the Randomized DEDICATION Trial (Drug Elution and Distal Protection in Acute Myocardial Infarction)

Lene Holmvang, MD; Henning Kelbæk, MD; Anne Kaltoft, MD; Leif Thuesen, MD; Jens Flensted Lassen, MD; Peter Clemmensen, MD; Lene Kløvgaard, RN; Thomas Engstrøm, MD; Hans E. Bøtker, MD; Kari Saunamäki, MD; Lars R. Krusell, MD; Erik Jørgensen, MD; Hans-Henrik Tilsted, MD; Evald H. Christiansen, MD; Jan Ravkilde, MD; Lars Køber, MD; Klaus Fuglsang Kofoed, MD; Christian J. Terkelsen, MD; Steffen Helqvist, MD

Objectives: This study sought to compare the long-term effects of drug-eluting stent (DES) compared with bare-metal stent (BMS) implantation in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention.

01 junio 2013

JACC: CARDIOVASCULAR INTERVENTIONS. The Long-Term Clinical Outcome of T-Stenting and Small Protrusion Technique for Coronary Bifurcation Lesions

Toru Naganuma, MD; Azeem Latib, MD; Sandeep Basavarajaiah, MD; Alaide Chieffo, MD; Filippo Figini, MD; Mauro Carlino, MD; Matteo Montorfano, MD; Cosmo Godino, MD; Santo Ferrarello, MD; Tasuku Hasegawa, MD; Masanori Kawaguchi, MD; Sunao Nakamura, MD; Antonio Colombo, MD

Objectives: This study sought to report long-term clinical outcomes in patients treated with the provisional T-stenting and small protrusion (TAP) technique.

01 junio 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Serial Morphological and Functional Assessment of Drug-Eluting Balloon for In-Stent Restenotic Lesions. Mechanisms of Action Evaluated With Angiography, Optical Coherence Tomography, and Fractional Flow Reserve

Pierfrancesco Agostoni, MD, PhD; Anouar Belkacemi, MD; Michiel Voskuil, MD, PhD; Hendrik M. Nathoe, MD, PhD; Pieter A. Doevendans, MD, PhD; Pieter R. Stella, MD, PhD

Objectives: This study sought to elucidate the underlying mechanism through which drug-eluting balloons (DEB) restore coronary blood flow, by assessing the coronary vessel before, immediately after, and at 6-month follow-up with angiography, optical coherence tomography (OCT), and fractional flow reserve (FFR).

01 junio 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Transapical Implantation of a Second-Generation Transcatheter Heart Valve in Patients With Noncalcified Aortic Regurgitation

Moritz Seiffert, MD; Patrick Diemert, MD; Dietmar Koschyk, MD; Johannes Schirmer, MD; Lenard Conradi, MD; Renate Schnabel, MD, MSc; Stefan Blankenberg, MD; Hermann Reichenspurner, MD, PhD; Stephan Baldus, MD; Hendrik Treede, MD

Objectives: This study sought to report on the feasibility and early results of transcatheter aortic valve implantation employing a second-generation device in a series of patients with pure aortic regurgitation.

01 junio 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Transvenous, Antegrade Melody Valve-in-Valve Implantation for Bioprosthetic Mitral and Tricuspid Valve Dysfunction. A Case Series in Children and Adults

Michael W. Cullen, MD; Allison K. Cabalka, MD; Oluseun O. Alli, MBBS; Sorin V. Pislaru, MD, PhD; Paul Sorajja, MD; Vuyisile T. Nkomo, MD, MPH; Joseph F. Malouf, MD; Frank Cetta, MD; Donald J. Hagler, MD; Charanjit S. Rihal, MD, MBA

Objectives: The purpose of this study was to report the results of percutaneous valve-in-valve therapy using the Melody valve (Medtronic, Minneapolis, Minnesota) for patients with degenerated mitral and tricuspid bioprosthetic valves.