01 diciembre 2013

JACC: CARDIOVASCULAR INTERVENTIONS. 5-Year Results of a Randomized Comparison of XIENCE V Everolimus-Eluting and TAXUS Paclitaxel-Eluting Stents. Final Results From the SPIRIT III Trial (Clinical Evaluation of the XIENCE V Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions)

Hemal Gada, MD, MBA∗; Ajay J. Kirtane, MD, SM∗; William Newman, MD†; Mark Sanz, MD‡; James B. Hermiller, MD§; Kenneth W. Mahaffey, MD‖; Donald E. Cutlip, MD¶; Krishnankutty Sudhir, MD, PhD#; Liming Hou, PhD#; Kai Koo, PhD#; Gregg W. Stone, MD

Objectives: This study sought to evaluate the long-term safety and efficacy of everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) in patients with obstructive coronary artery disease.

01 diciembre 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Risk of Stent Thrombosis Among Bare-Metal Stents, First-Generation Drug-Eluting Stents, and Second-Generation Drug-Eluting Stents. Results From a Registry of 18,334 Patients

Tomohisa Tada, MD∗; Robert A. Byrne, MB BCh, PhD∗; Iva Simunovic, MD∗; Lamin A. King, MS∗; Salvatore Cassese, MD∗; Michael Joner, MD∗; Massimiliano Fusaro, MD∗; Simon Schneider, MD†; Stefanie Schulz, MD∗; Tareq Ibrahim, MD†; Ilka Ott, MD∗; Steffen Massberg, MD‡; Karl-Ludwig Laugwitz, MD†; Adnan Kastrati, MD∗

Objectives: This study sought to compare the risk of stent thrombosis among patients treated with bare-metal stents (BMS), first-generation drug-eluting stents (G1-DES), and second-generation drug-eluting stents (G2-DES) for a period of 3 years.

01 diciembre 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Concomitant Administration of Clopidogrel With Statins or Calcium-Channel Blockers. Insights From the TRITON–TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis In Myocardial Infarction 38)

Objectives: This study sought to evaluate the clinical relevance of potential clopidogrel drug–drug interactions.

01 diciembre 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Device Closure of Patent Foramen Ovale Versus Medical Therapy in Cryptogenic Stroke. A Systematic Review and Meta-Analysis

Abdur R. Khan, MD∗; Aref A. Bin Abdulhak, MD†; Mujeeb A. Sheikh, MD∗; Sobia Khan, MBBS∗; Patricia J. Erwin, MLS‡; Imad Tleyjeh, MD§; Sadik Khuder, PhD#; Ehab A. Eltahawy, MD∗

Objectives: This study sought to perform a meta-analysis of randomized controlled trials comparing device closure with medical therapy in the prevention of recurrent neurological events in patients with cryptogenic stroke and patent foramen ovale.

01 diciembre 2013

JACC: CARDIOVASCULAR INTERVENTIONS. Frequency-Domain Optical Coherence Tomography Assessment of Unfavorable Kissing-Balloon Result in Unprotected Left Main Intervention

Yusuke Fujino, MD∗; Guilherme F. Attizzani, MD†; Satoko Tahara, MD, PhD∗; Kensuke Takagi, MD∗; Hiram G. Bezerra, MD, PhD†; Sunao Nakamura, MD, PhD∗; Marco A. Costa, MD, PhD†

A 67-year-old man with a history of hypertension and dyslipidemia was admitted because of angina symptoms. Coronary angiography (CAG) showed an eccentric lesion of the distal unprotected left main coronary artery (ULMCA) involving the ostium of the left anterior descending coronary artery (LAD). ULMCA/LAD crossover stent implantation was conducted with a 3.5 × 18-mm everolimus-eluting stent (EES) (XIENCE PRIME, Abbott Vascular, Santa Clara, California) at 12 atm, followed by the kissing-balloon technique (KBT). Despite a favorable CAG result, frequency-domain optical coherence tomography (FD-OCT) revealed stent strut deformation towards the LAD, leading to a large area of malapposition, mainly because of balloon inflation over an inadequate guidewire position (i.e., behind the stent struts) in the left circumflex coronary artery (LCX). Information provided by FD-OCT ultimately oriented the guidewire removal and repositioning in the LCX, as well as additional intrastent post-dilation in the ULMCA–LAD with a noncompliant balloon (3.5 × 12 mm) at 22 atm. Marked reduction in stent strut malapposition and adequate stent expansion were demonstrated

01 febrero 2014

JACC. Normal Coronary Rates for Elective Angiography in the Veterans Affairs Healthcare System. Insights From the VA CART Program (Veterans Affairs Clinical Assessment Reporting and Tracking)

Steven M. Bradley, MD, MPH∗; Thomas M. Maddox, MD, MSc∗; Maggie A. Stanislawski, MS∗; Colin I. O’Donnell, MS∗; Gary K. Grunwald, PhD∗; Thomas T. Tsai, MD, MSc∗; P. Michael Ho, MD, PhD∗; Eric D. Peterson, MD, MPH§; John S. Rumsfeld, MD, PhD∗

Objectives: This study sought to determine if an integrated healthcare system is selective and consistent in the use of angiography, as reflected by normal coronary rates.

01 febrero 2014

JACC. Polypill Therapy, Subclinical Atherosclerosis, and Cardiovascular Events—Implications for the Use of Preventive Pharmacotherapy. MESA (Multi-Ethnic Study of Atherosclerosis)

Márcio Sommer Bittencourt, MD∗; Michael J. Blaha, MD, MPH†; Ron Blankstein, MD∗; Matthew Budoff, MD‡; Jose D. Vargas, MD§; Roger S. Blumenthal, MD†; Arthur S. Agatston, MD¶; Khurram Nasir, MD, MPH†

Objectives: This study examines whether the coronary artery calcium (CAC) score can be used to define the target population to treat with a polypill.

01 febrero 2014

JACC. Clinical Outcomes With Bioabsorbable Polymer- Versus Durable Polymer-Based Drug-Eluting and Bare-Metal Stents. Evidence From a Comprehensive Network Meta-Analysis

Objectives: This study sought to investigate the relative safety and efficacy of bioabsorbable polymer (BP)-based biolimus-eluting stents (BES) versus durable-polymer (DP)-drug-eluting stents (DES) and bare-metal stents (BMS) by means of a network meta-analysis.

01 febrero 2014

JACC. The Impact of Renal Artery Stenosis on Outcomes After Open-Heart Surgery

Femi Philip, MD∗; Heather L. Gornik, MD∗; Jeevanantham Rajeswaran, PhD†; Eugene H. Blackstone, MD∗; Mehdi H. Shishehbor, DO, MPH, PhD∗

Objectives: The aim of this study was to assess the impact of atherosclerotic renal artery stenosis (ARAS) on outcomes after open-heart surgery (OHS).

01 febrero 2014

JACC. The Effect of Dabigatran Plasma Concentrations and Patient Characteristics on the Frequency of Ischemic Stroke and Major Bleeding in Atrial Fibrillation Patients. The RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy)

Paul A. Reilly, PhD∗; Thorsten Lehr, PhD†; Sebastian Haertter, PhD†; Stuart J. Connolly, MD§; Salim Yusuf, MD, DPhil§; John W. Eikelboom, MB BS§; Michael D. Ezekowitz, MD, PhD‖; Gerhard Nehmiz, PhD†; Susan Wang, PhD∗; Lars Wallentin, MD, PhD¶

Objectives: The goal of this study was to analyze the impact of dabigatran plasma concentrations, patient demographics, and aspirin (ASA) use on frequencies of ischemic strokes/systemic emboli and major bleeds in atrial fibrillation patients.

01 enero 2014

JACC. Outcomes of Patients With Chronic Lung Disease and Severe Aortic Stenosis Treated With Transcatheter Versus Surgical Aortic Valve Replacement or Standard Therapy. Insights From the PARTNER Trial (Placement of AoRTic TraNscathetER Valve)

Objectives: The study aimed to evaluate the impact of chronic lung disease (CLD) on outcomes of severe aortic stenosis patients across all treatment modalities.

01 enero 2014

JACC. Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction. Evidence of Therapeutic Regeneration in the Final 1-Year Results of the CADUCEUS Trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction)

Konstantinos Malliaras, MD∗; Raj R. Makkar, MD∗; Rachel R. Smith, PhD∗; Ke Cheng, PhD∗; Edwin Wu, MD†; Robert O. Bonow, MD†; Linda Marbán, PhD∗; Adam Mendizabal, MS‡; Eugenio Cingolani, MD∗; Peter V. Johnston, MD§; Gary Gerstenblith, MD§; Karl H. Schuleri, MD§; Albert C. Lardo, PhD§; Eduardo Marbán, MD, PhD∗

Objectives: This study sought to report full 1-year results, detailed magnetic resonance imaging analysis, and determinants of efficacy in the prospective, randomized, controlled CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial.

01 enero 2014

JACC. Discharge Aspirin Dose and Clinical Outcomes in Patients With Acute Coronary Syndromes Treated With Prasugrel Versus Clopidogrel. An Analysis From the TRITON–TIMI 38 Study (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis In Myocardial Infarction 38)

Payal Kohli, MD∗; Jacob A. Udell, MD, MPH†; Sabina A. Murphy, MPH†; Christopher P. Cannon, MD†; Elliott M. Antman, MD†; Eugene Braunwald, MD†; Stephen D. Wiviott, MD†

Objectives: The goal of this study was to determine whether there is a relationship between aspirin dose and the potent antiplatelet agent prasugrel in the TRITON–TIMI 38 (Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis In Myocardial Infarction 38) study.

12 noviembre 2013

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Adventitial Nab-Rapamycin Injection Reduces Porcine Femoral Artery Luminal Stenosis Induced by Balloon Angioplasty via Inhibition of Medial Proliferation and Adventitial Inflammation

Warren J. Gasper, MD, Cynthia A. Jimenez, MD, Joy Walker, MD, Michael S. Conte, MD, Kirk Seward, PhD and Christopher D. Owens, MD

Background: Endovascular interventions on peripheral arteries are limited by high rates of restenosis. Our hypothesis was that adventitial injection of rapamycin nanoparticles would be safe and reduce luminal stenosis in a porcine femoral artery balloon angioplasty model.

03 diciembre 2013

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Congenital Heart Disease. Impact of Transcatheter Pulmonary Valve Replacement on Biventricular Strain and Synchrony Assessed by Cardiac Magnetic Resonance Feature Tracking

David M. Harrild, MD, PhD, Edward Marcus, MS, Babar Hasan, MD, Mark E. Alexander, MD, Andrew J. Powell, MD, Tal Geva, MD and Doff B. McElhinney, MD

Background: Transcatheter pulmonary valve (TPV) replacement is an emerging therapy intended to restore pulmonary valve function in patients with right ventricular outflow tract conduit dysfunction; the impact of this technique on ventricular strain and synchrony is not known.