18 marzo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain? The RIPCORD Study

Nick Curzen, BM, PhD, Omar Rana, MD, Zoe Nicholas, BSc, Peter Golledge, MD, Azfar Zaman, MD, Keith Oldroyd, MD, Colm Hanratty, MD, Adrian Banning, MD, Stephen Wheatcroft, MD, Alex Hobson, MD, Kam Chitkara, MBBS, David Hildick-Smith, MD, Dan McKenzie, MBBS, Alison Calver, MD, Borislav D. Dimitrov, MD, PhD and Simon Corbett, MB BChir, PhD

Background: The use of coronary angiography (CA) for diagnosis and management of chest pain (CP) has several flaws. The assessment of coronary artery disease using fractional flow reserve (FFR) is a well-validated technique for describing lesion-level ischemia and improves clinical outcome in the context of percutaneous coronary intervention. The impact of routine FFR at the time of diagnostic CA on patient management has not been determined.

25 febrero 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Congenital Heart Disease. Feasibility and Short-Term Outcomes of Percutaneous Transcatheter Pulmonary Valve Replacement in Small (<30 kg) Children With Dysfunctional Right Ventricular Outflow Tract Conduits

Darren P. Berman, MD, Doff B. McElhinney, MD, Julie A. Vincent, MD, William E. Hellenbrand, MD and Evan M. Zahn, MD

Background: In 2010, the Melody transcatheter pulmonary valve (TPV) received Food and Drug Administration approval for treatment of dysfunctional right ventricular outflow tract conduits in patients ≥30 kg. Limited data are available regarding use of this device in smaller patients.

01 marzo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Comparison of early and late outcomes of TAVI alone compared to TAVI plus PCI in aortic stenosis patients with and without coronary artery disease

Yigal Abramowitz MD1,2,*, Shmuel Banai MD1,2, Guy Katz MD1,2, Arie Steinvil MD MHA1,2, Yaron Arbel MD1,2, Ofer Havakuk MD1,2, Amir Halkin MD1,2, Yanai Ben-Gal MD2,3, Gad Keren MD1,2 andAriel Finkelstein MD1,2

Objectives: To assess the safety and effectiveness of performing percutaneous coronary intervention (PCI) before transcatheter aortic valve implantation (TAVI).

15 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Five-year clinical follow-up of a randomized comparison of a polymer-free sirolimus-eluting stent versus a polymer-based paclitaxel-eluting stent in patients with diabetes mellitus (LIPSIA Yukon trial)

Thomas Stiermaier MD1,*, Anja Heinz1, Denis Schloma MD1, Klaus Kleinertz MD2, Wilfried Dänschel MD2, Sandra Erbs MD1, Axel Linke MD1, Enno Boudriot MD1, Bernward Lauer MD3, Gerhard Schuler MD1, Holger Thiele MD1 andSteffen Desch MD1

Objectives: The long-term performance of polymer-free stent systems in patients with diabetes mellitus has not been investigated extensively. This study reports long-term results of the LIPSIA Yukon trial which compared the polymer-free sirolimus-eluting Yukon Choice stent with the polymer-based paclitaxel-eluting Taxus Liberté stent in this subpopulation. At 9 months, the Yukon Choice stent failed to show non-inferiority in terms of the primary end point late lumen loss, while no significant difference in clinical outcome was detected.

15 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. First report of a novel polymer-free dual-drug eluting stent in de novo coronary artery disease: Results of the first in human BICARE trial

Mengyue Yu MD1,†, Bo Xu MBBS1,†, David E. Kandzari MD2, Yongjian Wu MD1, Hongbing Yan MD1, Jue Chen MD1, Jie Qian MD1, Shubin Qiao MD1, Yuejin Yang MD1 andRun-Lin Gao MD1,*

Background: Persistence of stent polymer coating has been associated with incomplete endothelialization, expansive vessel remodeling, neoatherosclerosis, and delayed healing associated with inflammation that may contribute to late adverse events.

15 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Patent foramen ovale closure with the gore septal occluder

John D. Thomson MD1,*, David Hildick-Smith MD2, Paul Clift MD3, Gareth Morgan MD4, Matthew Daniels PhD5,6, Robert Henderson MD7, Mark S. Spence MD8, Vaikom S. Mahadevan MD9, David Crossland MRCPCH10 andOliver Ormerod MD5

Objectives: To report procedural outcome and short-term follow-up data for the Gore septal occluder (GSO), a new device for closure of patent foramen ovale (PFO).

01 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Outcomes of small coronary artery stenting with bare-metal stents versus drug-eluting stents: Results from the NHLBI dynamic registry

Shailja V. Parikh MD1,*, Michael Luna MD1, Faith Selzer PhD2, Oscar C. Marroquin MD3, Suresh R. Mulukutla MD4, J. Dawn Abbott MD5 andElizabeth M. Holper MD, MPH1

Objectives: Examine 1-year outcomes of patients with small coronary arteries in the National Heart, Lung, and Blood Institute Dynamic Registry (NHLBI) undergoing drug-eluting stent (DES) vs. bare-metal stent (BMS) placement.

01 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Low profile vascular plugs for paravalvular leaks after TAVR

Ted Feldman MD, FESC, FACC, FSCAI*, Michael H. Salinger MD, FACC, FSCAI, Justin P. Levisay MD, FACC, FSCAI andSteven Smart MD, FACC

Background: Paravalvular leak (PVL) after transcatheter aortic valve replacement (TAVR) is associated with less good outcomes. The use of percutaneous plugs is among the strategies to treat PVL after TAVR. Plugs have been limited by the need to pass 4–6 F delivery sheaths between the TAVR stent frame and the native valve leaflets.

01 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Incidence and prognostic value of bleeding after percutaneous coronary intervention in patients older than 75 years of age

Gjin Ndrepepa MD1,*, Franz-Josef Neumann MD2, Stefanie Schulz MD1, Massimiliano Fusaro MD1, Salvatore Cassese MD1, Robert A. Byrne MBBCh1, Gert Richardt MD3, Karl-Ludwig Laugwitz MD4,5 andAdnan Kastrati MD1,5

Objectives: We aimed to assess the impact of bleeding after percutaneous coronary intervention (PCI) on the outcome of patients >75 years of age

15 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Relationship between intravascular ultrasound parameters and fractional flow reserve in intermediate coronary artery stenosis of left anterior descending artery: Intravascular ultrasound volumetric analysis

Hyoung-Mo Yang MD, Seung-Jea Tahk MD, PHD*, Hong-Seok Lim MD, PHD, Myeong-Ho Yoon MD, PHD, So-Yeon Choi MD, PHD, Byoung-Joo Choi MD, Xiong Jie Jin MD, Gyo-Seung Hwang MD, PHD, Jin-Sun Park MD andJoon-Han Shin MD

Objectives: The objective of this study was to assess the relationship between intravascular ultrasound (IVUS) parameters, including volumetric analysis, and fractional flow reserve (FFR).

15 febrero 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Long-term impact of balloon postdilatation on neointimal formation: An experimental comparative study between second-generation self-expanding versus balloon-expandable stent technologies

Michael S. Aboodi MD, Krzysztof Milewski MD, PhD, Armando Tellez MD, Yanping Cheng MD, Geng-Hua Yi MD, Greg L. Kaluza MD, PhD andJuan F. Granada MD*

Background: Self-expanding stents (SES) are reemerging as therapeutic alternatives to treat coronary artery disease. It has been proposed that SES can improve clinical outcomes by inducing less injury at implantation and achieving better vessel wall apposition. To date, little data exists comparing the vascular response to both methods of deployment in a controlled experimental setting.

01 marzo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Functional and morphological assessment of side branch after left main coronary artery bifurcation stenting with cross-over technique

Soo-Jin Kang MD, PhD, Jung-Min Ahn MD, Won-Jang Kim MD, Jong-Young Lee MD, Duk-Woo Park MD, PhD, Seung-Whan Lee MD, PhD, Young-Hak Kim MD, PhD, Cheol Whan Lee MD, PhD, Seong-Wook Park MD, PhD andSeung-Jung Park MD, PhD*

Background: In left main coronary artery (LMCA) bifurcation lesions, hemodynamic and geometrical change in left circumflex artery (LCX) ostium after main branch (MB) stenting has not been known. This study evaluated how accurately intravascular ultrasound (IVUS) predicts the functional compromise of the sidebranch.

01 marzo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Angiographic fate of side branch dissections in bifurcation lesions treated with a provisional single stenting strategy: A post-hoc analysis of the international multicenter randomized DEBIUT study

Anouar Belkacemi MD, PhD1, Pieter R. Stella MD, PhD1, Shao Chunlai MD1,2, Marcelle Uiterwijk MD1, Danish Ali MD1 andPierfrancesco Agostoni MD, PhD1,*

Background: The provisional single stenting strategy is currently the preferred treatment strategy in bifurcation lesions. However, in case of nonflow limiting side branch (SB) dissections, it is not clear whether outcomes may be inferior to coronaries without a SB dissection, whether it can be safe to leave a SB dissection untreated, and whether bail-out SB stenting provides benefits over conservative treatment.

01 marzo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Long-term clinical outcomes following drug-eluting stent implantation for unprotected distal trifurcation left main disease: The Milan-New Tokyo (MITO) registry

Alfonso Ielasi MD1, Kensuke Takagi MD1,2,3, Azeem Latib MD1,2, Sandeep Basavarajaiah MD1,2, Filippo Figini MD1,2, Mauro Carlino MD1, Matteo Montorfano MD1, Alaide Chieffo MD1, Sunao Nakamura MD3 andAntonio Colombo MD1,2,*

Background: Unprotected distal left main trifurcation (ULMT) lesion represents a challenge for interventional cardiologists with the potential for peri-procedural complications and adverse events at follow-up especially when the main branch and the side branches are concomitantly diseased.

01 marzo 2014

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Prolonged high-pressure is required for optimal stent deployment as assessed by optical coherence tomography

Jeffrey R. Cook MD, Ajay Mhatre MD, Fen Wei Wang MD, PhD andBarry F. Uretsky MD*

Aims: Optimizing stent deployment is important for both acute- and long-term outcomes. High-pressure balloon inflation is the standard for coronary stent implantation. However, there is no standardized inflation protocol. We hypothesized that prolonged high-pressure balloon inflation until stabilization of inflation pressure is superior to a rapid inflation/deflation sequence for both stent expansion and strut apposition.