24 febrero 2014

CIRCULATION. Valvular Heart Disease. Postprocedural Aortic Regurgitation in Balloon-Expandable and Self-Expandable Transcatheter Aortic Valve Replacement Procedures. Analysis of Predictors and Impact on Long-Term Mortality: Insights From the FRANCE2 Registry

Eric Van Belle, MD, PhD; Françis Juthier, MD; Sophie Susen, MD, PhD; André Vincentelli, MD, PhD; Bernard Iung, MD; Jean Dallongeville, MD, PhD; Hélène Eltchaninoff, MD; Marc Laskar, MD; Pascal Leprince, MD; Michel Lievre, MD, PhD; Carlo Banfi, MD, PhD; Jean-Luc Auffray, MD; Cedric Delhaye, MD; Patrick Donzeau-Gouge, MD; Karine Chevreul, MD, PhD; Jean Fajadet, MD; Alain Leguerrier, MD; Alain Prat, MD; Martine Gilard, MD; Emmanuel Teiger, MD, PhD; for the FRANCE 2 Investigators

Background: Significant postprocedural aortic regurgitation (AR) is observed in 10% to 20% of cases after transcatheter aortic valve replacement (TAVR). The prognostic value and the predictors of such a complication in balloon-expandable (BE) and self-expandable (SE) TAVR remain unclear.

10 febrero 2014

CIRCULATION. Coronary Heart Disease. Trends in Cause of Death After Percutaneous Coronary Intervention

Daniel B. Spoon, MD; Peter J. Psaltis, MBBS, PhD; Mandeep Singh, MD, MPH; David R. Holmes Jr, MD; Bernard J. Gersh, MBChB, DPhil; Charanjit S. Rihal, MD, MBA; Ryan J. Lennon, MS; Issam D. Moussa, MD; Robert D. Simari, MD; Rajiv Gulati, MD, PhD

Background: The impact of changing demographics on causes of long-term death after percutaneous coronary intervention (PCI) remains incompletely defined.

07 enero 2014

CIRCULATION. Epidemiology and Prevention. Increased Risk of Acute Myocardial Infarction and Stroke During Hemorrhagic Fever With Renal Syndrome. A Self-Controlled Case Series Study

Anne-Marie Connolly-Andersen, PhD; Edvin Hammargren, MD; Heather Whitaker, PhD; Mats Eliasson, Prof; Lars Holmgren, MPH; Jonas Klingström, PhD; Clas Ahlm, Prof

Background: We recently observed that cardiovascular causes of death are common in patients with hemorrhagic fever with renal syndrome (HFRS), which is caused by hantaviruses. However, it is not known whether HFRS is a risk factor for the acute cardiovascular events of acute myocardial infarction (AMI) and stroke.

22 enero 2014

CIRCULATION. Epidemiology and Prevention. Warfarin Use and the Risk for Stroke and Bleeding in Patients With Atrial Fibrillation Undergoing Dialysis

Mitesh Shah, MBBS MSc; Meytal Avgil Tsadok, PhD; Cynthia A. Jackevicius, PharmD, MSc; Vidal Essebag, MD, PhD; Mark J. Eisenberg, MD, MPH; Elham Rahme, PhD; Karin H. Humphries, DSc; Jack V. Tu, MD, PhD; Hassan Behlouli, PhD; Helen Guo, MSc; Louise Pilote, MD, PhD

Background: Current observational studies on warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation (AF) undergoing dialysis found conflicting results.

03 enero 2014

CIRCULATION. Interventional Cardiology. ST-Elevation Myocardial Infarction Diagnosed After Hospital Admission

Ross F. Garberich, MS; Jay H. Traverse, MD; Michael T. Claussen, BS; Gabriel Rodriguez, BS; Anil K. Poulose, MD; Ivan J. Chavez, MD; Stephanie Rutten-Ramos, DVM, PhD; David A. Hildebrandt, RN; Timothy D. Henry, MD

Background: Treatment times for ST-elevation myocardial infarction (STEMI) patients presenting to percutaneous coronary intervention hospitals have improved dramatically over the past 10 years, particularly for patients using emergency medical services. Limited data exist regarding treatment times and outcomes for patients who develop STEMI after hospital admission.

26 diciembre 2013

CIRCULATION. Interventional Cardiology. Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation. Impact on Late Clinical Outcomes and Left Ventricular Function

Marina Urena, MD; John G. Webb, MD; Corrado Tamburino, MD; Antonio J. Muñoz-García, MD, PhD; Asim Cheema, MD; Antonio E. Dager, MD; Vicenç Serra, MD; Ignacio J. Amat-Santos, MD; Marco Barbanti, MD; Sebastiano Immè, MD; Juan H. Alonso Briales, MD; Luis Miguel Benitez, MD; Hatim Al Lawati, MD; Angela Maria Cucalon, MD; Bruno García del Blanco, MD; Javier López, MD, PhD; Eric Dumont, MD; Robert DeLarochellière, MD; Henrique B. Ribeiro, MD; Luis Nombela-Franco, MD; François Philippon, MD, FRCPC, FHRS; Josep Rodés-Cabau, MD

Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients.

21 marzo 2014

CIRCULATION. Coronary Heart Disease. Five-Year Survival in Patients With ST-Segment–Elevation Myocardial Infarction According to Modalities of Reperfusion Therapy

Nicolas Danchin, MD, PhD; Etienne Puymirat, MD, PhD; Philippe Gabriel Steg, MD, PhD; Patrick Goldstein, MD; François Schiele, MD, PhD; Loïc Belle, MD; Yves Cottin, MD, PhD; Jean Fajadet, MD; Khalife Khalife, MD; Pierre Coste, MD, PhD; Jean Ferrières, MD, PhD; Tabassome Simon, MD, PhD; on behalf of the FAST-MI 2005 Investigators

Background: Although primary percutaneous coronary intervention (pPCI) is the preferred reperfusion method for ST-segment–elevation myocardial infarction, it remains difficult to implement in many areas, and fibrinolytic therapy is still widely used.

03 marzo 2014

CIRCULATION. Congenital Heart Disease. Specialized Adult Congenital Heart Disease Care. The Impact of Policy on Mortality

Darren Mylotte, MD; Louise Pilote, MD, MPH, PhD; Raluca Ionescu-Ittu, PhD; Michal Abrahamowicz, PhD; Paul Khairy, MD, PhD; Judith Therrien, MD; Andrew S. Mackie, MD, SM; Ariane Marelli, MD, MPH

Background: Clinical guidelines recommend specialized care for adult congenital heart disease (ACHD) patients. In reality, few patients receive such dedicated care. We sought to examine the impact of specialized care on ACHD patient mortality.

18 marzo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Incomplete Stent Apposition Causes High Shear Flow Disturbances and Delay in Neointimal Coverage as a Function of Strut to Wall Detachment Distance. Implications for the Management of Incomplete Stent Apposition

Nicolas Foin, MSc, PhD*, Juan Luis Gutiérrez-Chico, MD, PhD*, Shimpei Nakatani, MD*, Ryo Torii, MSc, PhD*, Christos V. Bourantas, MD, PhD, Sayan Sen, MD, PhD, Sukhjinder Nijjer, MD, Ricardo Petraco, MD, Chrysa Kousera, MSc, Matteo Ghione, MD, Yoshinobu Onuma, MD, Hector M. Garcia-Garcia, MD, PhD, Darrel P. Francis, MD, PhD, Philip Wong, MD, Carlo Di Mario, MD, PhD, Justin E. Davies, MD, PhD and Patrick W. Serruys, MD, PhD

Background: Lack of re-endothelialization and neointimal coverage on stent struts has been put forward as the main underlying mechanism leading to late stent thrombosis. Incomplete stent apposition (ISA) has been observed frequently in patients with very late stent thrombosis after drug eluting stent implantation, suggesting a role of ISA in the pathogenesis of this adverse event. The aim of this study was to evaluate the impact of different degrees of ISA severity on abnormal shear rate and healing response with coverage, because of its potential implications for stent optimization in clinical practice.

25 febrero 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Risk of Acute Kidney Injury After Percutaneous Coronary Interventions Using Radial Versus Femoral Vascular Access. Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium

Judith Kooiman, MSc, Milan Seth, MS, Simon Dixon, MD, David Wohns, MD, Thomas LaLonde, MD, Sunil V. Rao, MD and Hitinder S. Gurm, MD

Background: Transradial percutaneous coronary intervention (PCI [TRI]) does not involve catheter manipulation in the descending aorta, whereas transfemoral PCI (TFI) does. Therefore, the risk of acute kidney injury (AKI) after PCI might be influenced by vascular access site. We compared risks of AKI and nephropathy requiring dialysis (NRD) among patients treated with TRI and TFI.

08 abril 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Optical Coherence Tomographic Evaluation of Transplant Coronary Artery Vasculopathy With Correlation to Cellular Rejection

Liang Dong, MD, Akiko Maehara, MD, Tamim M. Nazif, MD, Ari T. Pollack, MD, Shigeo Saito, MD, LeRoy E. Rabbani, MD, Mark A. Apfelbaum, MD, Kate Dalton, MS, RD, Jeffrey W. Moses, MD, Ulrich P. Jorde, MD, Ke Xu, PhD, Gary S. Mintz, MD, Donna M. Mancini, MD and Giora Weisz, MD

Background: Cardiac allograft vasculopathy is an accelerated fibroproliferative process that affects the coronary arteries of transplanted hearts. Intracoronary imaging with optical coherence tomography enables detection of subangiographic cardiac allograft vasculopathy.

01 abril 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Safety and Efficacy of a Potential Treatment Algorithm by Using Manual Compression Repair and Ultrasound-Guided Thrombin Injection for the Management of Iatrogenic Femoral Artery Pseudoaneurysm in a Large Patient Cohort

Marijana Dzijan-Horn, MD, Nicolas Langwieser, MD, Philipp Groha, MD, Christian Bradaric, MD, Maryam Linhardt, MD, Corinna Böttiger, MD, Robert A. Byrne, MB BCh, PhD, Birgit Steppich, MD, Tobias Koppara, MD, Julia Gödel, MD, Martin Hadamitzky, MD, Ilka Ott, MD, Nicolas von Beckerath, MD, Adnan Kastrati, MD, Karl-Ludwig Laugwitz, MD and Tareq Ibrahim, MD

Background: Because of the risk of associated complications, femoral pseudoaneurysm (PSA) formation implies further treatment. Ultrasound-guided thrombin injection (UGTI) is becoming the accepted gold standard, but manual compression (MC) represents an established treatment option including PSAs not feasible for UGTI. This study aims to assess our experience in PSA treatment using MC or UGTI according to a potential algorithm based on morphological properties in a large patient cohort.

01 abril 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Remote Ischemic Postconditioning During Percutaneous Coronary Interventions. Remote Ischemic Postconditioning–Percutaneous Coronary Intervention Randomized Trial

Shahar Lavi, MD, Sabrina D’Alfonso, MSc, Pantelis Diamantouros, MD, Anthony Camuglia, MD, Pallav Garg, MD, Patrick Teefy, MD, George Jablonsky, MD, Kumar Sridhar, MD and Ronit Lavi, MD

Background: Remote ischemic preconditioning may result in reduction in infarct size during percutaneous coronary intervention (PCI). It is unclear whether remote ischemic postconditioning (RIPost) will reduce the incidence of myocardial injury after PCI, and whether ischemic conditioning of a larger remote organ (thigh versus arm) would provide further myocardial protection.

25 marzo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Pharmacology. Onset of Antiplatelet Action With High (100 mg) Versus Standard (60 mg) Loading Dose of Prasugrel in Patients With ST-Segment–Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Pharmacodynamic Study

Dimitrios Alexopoulos, MD, George Makris, MD, Ioanna Xanthopoulou, MD, Sotirios Patsilinakos, MD, Spyridon Deftereos, MD, Vassilios Gkizas, MD, Angelos Perperis, MD, Stavros Karanikas, MD, Christos Angelidis, MD, Grigorios Tsigkas, MD, Nikolaos Koutsogiannis, MD, George Hahalis, MD and Periklis Davlouros, MD

Background: In patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention, a suboptimal degree of platelet inhibition for the first 2 hours after the standard 60 mg loading dose of prasugrel has been described.

25 febrero 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Prognostic Implications of Pulmonary Hypertension in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation. Study From the FRANCE 2 Registry

Adrien Luçon, MD, Emmanuel Oger, MD, PhD, Marc Bedossa, MD, Dominique Boulmier, MD, Jean Philippe Verhoye, MD, PhD, Hélène Eltchaninoff, MD, PhD, Bernard Iung, MD, Alain Leguerrier, MD, PhD, Marc Laskar, MD, Pascal Leprince, MD, PhD, Martine Gilard, MD, PhD and Hervé Le Breton, MD, PhD

Background: Pulmonary hypertension (PH) is associated with poor prognosis in patients with severe aortic stenosis. The aim of this multicenter study was to describe clinical outcome after transcatheter aortic valve implantation