14 enero 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Outcomes. Incidences, Predictors, and Clinical Outcomes of Acute and Late Stent Malapposition Detected by Optical Coherence Tomography After Drug-Eluting Stent Implantation

Eui Im, MD*, Byeong-Keuk Kim, MD*, Young-Guk Ko, MD, Dong-Ho Shin, MD, Jung-Sun Kim, MD, Donghoon Choi, MD, Yangsoo Jang, MD and Myeong-Ki Hong, MD, PhD

Background: We investigated the incidences, predictors, and clinical outcomes of acute and late stent malapposition detected by optical coherence tomography (OCT) after drug-eluting stent implantation.

14 enero 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Outcomes. Causes of Short-Term Readmission After Percutaneous Coronary Intervention

Jason H. Wasfy, MD, MPhil, Jordan B. Strom, MD, Cashel O’Brien, BA, Adrian H. Zai, MD, PhD, MPH, Jennifer Luttrell, MBA, Kevin F. Kennedy, MS, John A. Spertus, MD, MPH, Katya Zelevinsky, BA, Sharon-Lise T. Normand, PhD, Laura Mauri, MD, MSc and Robert W. Yeh, MD, MSc

Background: Rehospitalization within 30 days after an admission for percutaneous coronary intervention (PCI) is common, costly, and a future target for Medicare penalties. Causes of readmission after PCI are largely unknown.

21 enero 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Pharmacology. Administration of a Loading Dose Has No Additive Effect on Platelet Aggregation During the Switch From Ongoing Clopidogrel Treatment to Ticagrelor in Patients With Acute Coronary Syndrome

Gianluca Caiazzo, MD, PhD*, Salvatore De Rosa, MD, PhD*, Daniele Torella, MD, PhD, Carmen Spaccarotella, MD, Annalisa Mongiardo, MD, Salvatore Giampà, MD, Mariella Micieli, PharmD, MD, Eleonora Palella, MD, Elio Gulletta, MD and Ciro Indolfi, MD

Background: Ticagrelor outperforms clopidogrel in preventing cardiovascular events in acute coronary syndrome. Despite the inclusion of a loading dose in the Platelet Inhibition and Patient Outcomes (PLATO) trial for all patients randomized to ticagrelor, it may not be necessary in patients receiving ongoing clopidogrel therapy. The aim of the present study was to assess whether a ticagrelor loading dose is associated with a further platelet inhibition during the switch from clopidogrel to ticagrelor in patients with acute coronary syndrome receiving ongoing antiplatelet treatment.

04 noviembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Stent Coverage and Neointimal Proliferation in Bare Metal Stents Postdilated With a Paclitaxel-Eluting Balloon Versus Everolimus-Eluting Stents

Tudor C. Poerner, MD*, Sylvia Otto, MD*, Johannes Gassdorf, Kristina Nitsche, Florian Janiak, Bruno Scheller, MD, Björn Goebel, MD, Christian Jung, MD and Hans R. Figulla, MD

Background: In this randomized trial, strut coverage and neointimal proliferation of a therapy of bare metal stents (BMSs) postdilated with the paclitaxel drug-eluting balloon (DEB) was compared with everolimus drug-eluting stents (DESs) at 6-month follow-up using optical coherence tomography. We hypothesized sufficient stent coverage at follow-up.

01 marzo 2014

AMERICAN JOURNAL OF ROENTGENOLOGY. Cardiac CT Angiography in the Emergency Department

Maya Galperin-Aizenberg, Tessa S. Cook, Judd E. Hollander and Harold I. Litt

OBJECTIVE. Nearly 8 million patients present annually to emergency departments (EDs) in the United States with acute chest pain. Identifying those with a sufficiently low risk of acute coronary syndrome (ACS) remains challenging. Early imaging is important for risk stratification of these individuals. The objective of this article is to discuss the role of cardiac CT angiography (CTA) as a safe, efficient, and cost-effective tool in this setting and review state-of-the-art technology, protocols, advantages, and limitations from the perspective of our institution s 10-year experience.

01 diciembre 2014

AMERICAN HEART JOURNAL. Multidisciplinary rehabilitation program in recently hospitalized patients with heart failure and preserved ejection fraction: Rationale and design of a randomized controlled trial

Edward Koifman, MD, Ehud Grossman, MD, Avishay Elis, MD, Dror Dicker, MD, Bella Koifman, MD, Morris Mosseri, MD, Rafael Kuperstein, MD, Ilan Goldenberg, MD, Tamir Kamerman, MSc, Nava Levine-Tiefenbrun, PhD, Robert Klempfner, MD

Background: Heart failure with preserved ejection fraction (HFpEF) comprises a large portion of heart failure patients and portends poor prognosis with similar outcome to heart failure with reduced ejection fraction (HFrEF). Thus far, no medical therapy has been shown to improve clinical outcome in this common condition.

01 octubre 2014

AMERICAN HEART JOURNAL. Prognostic implications of creatine kinase–MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention

Akshay Bagai, MD, MHS, Phillip J. Schulte, PhD, Christopher B. Granger, MD, Kenneth W. Mahaffey, MD, Robert H. Christenson, PhD, Gregory Bell, MD, Renato D. Lopes, MD, MHS, PhD, Cynthia L. Green, PhD, A. Michael Lincoff, MD, Paul W. Armstrong, MD, Matthew T. Roe, MD, MHS

Background: Peak creatine kinase (CK)–MB concentration is related to reperfusion success and clinical outcomes after fibrinolytic therapy for acute myocardial infarction. However, prognostic implications of CK-MB measurements after primary percutaneous coronary intervention (PCI), which provides more predictable and consistent reperfusion, are unknown.

01 octubre 2014

AMERICAN HEART JOURNAL. Design and rationale of the ANALYZE ST study: A prospective, nonrandomized, multicenter ST monitoring study to detect acute coronary syndrome events in implantable cardioverter-defibrillator patients

C. Michael Gibson, MS, MD, Mitchell Krucoff, MD, Ajay J. Kirtane, MD, SM, Sunil V. Rao, MD, Judith A. Mackall, MD, Ray Matthews, MD, Samir Saba, MD, Ron Waksman, MD, David Holmes, MD

Background: In the setting of ST-segment elevation myocardial infarction, timely restoration of normal blood flow is associated with improved myocardial salvage and survival. Despite improvements in door-to-needle and door-to-balloon times, there remains an unmet need with respect to improved symptom-to-door times. A prior report of an implanted device to monitor ST-segment deviation demonstrated very short times to reperfusion among patients with an acute coronary syndrome (ACS) with documented thrombotic occlusion. The goal of the ANALYZE ST study is to evaluate the safety and effectiveness of a novel ST-segment monitoring feature using an existing implantable cardioverter-defibrillator (ICD) among patients with known coronary artery disease.

01 octubre 2014

AMERICAN HEART JOURNAL. Unique device identifiers for coronary stent postmarket surveillance and research: A report from the Food and Drug Administration Medical Device Epidemiology Network Unique Device Identifier Demonstration

James E. Tcheng, MD, Jay Crowley, MSi, Madris Tomes, MBAi, Terrie L. Reed, MSi, Joseph M. Dudas, MBA, Kweli P. Thompson, MD, Kirk N. Garratt, MD, Joseph P. Drozda Jr., MD on behalf of the MDEpiNet UDI Demonstration Expert Workgroup

Background: Although electronic product identification in the consumer sector is ubiquitous, unique identification of medical devices is just being implemented in 2014. To evaluate unique device identifiers (UDIs) in health care, the US Food and Drug Administration (FDA) funded the Medical Device Epidemiology Network initiative, including a demonstration of the implementation of coronary stent UDI data in the information systems of a multihospital system (Mercy Health). This report describes the first phase of the demonstration.

01 septiembre 2014

AMERICAN HEART JOURNAL. Spironolactone lowers the rate of repeat revascularization in acute myocardial infarction patients treated with percutaneous coronary intervention

Pil Sang Song, MDd, Dong-Kie Kim, MDd, Guang-Won Seo, MD, Ki-Hun Kim, MD, Sang-Hoon Seol, MD, PhD, Jeong Hoon Yang, MD, Joo-Yong Hahn, MD, PhD, Seung-Hyuk Choi, MD, PhD, Jin-Ho Choi, MD, PhD, Hyeon-Cheol Gwon, MD, PhD, Youngkeun Ahn, MD, PhD, Myung Ho Jeong, MD, PhD, Young Bin Song, MD, PhD, Doo-Il Kim, MD, PhD, Other Korea Acute Myocardial Infarction Registry Investigators

Background: We sought to assess the effect of the aldosterone receptor blocker, spironolactone, on 1-year clinical outcomes in all-comers with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention.

01 septiembre 2014

AMERICAN HEART JOURNAL. Safety and clinical outcome of erythropoiesis-stimulating agents in patients with ST-elevation myocardial infarction: A meta-analysis of individual patient data

Marieke L. Fokkema, MD, PhD, Peter van der Meer, MD, PhD, Sunil V. Rao, MD, Anne M. Belonje, MD, PhD, Maurizio Ferrario, MD, Hans L. Hillege, PhD, Stuart D. Katz, MD, MS, Erik Lipšic, MD, PhD, Andrew J. Ludman, MRCP, MD, Ilka Ott, MD, PhD, Fabrice Prunier, MD, PhD, Dong-Ju Choi, MD, PhD, Ken Toba, MD, PhD, Dirk J. van Veldhuisen, MD, PhD, Adriaan A. Voors, MD, PhD

Background: Erythropoiesis-stimulating agents (ESAs) have been investigated in small studies in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Erythropoiesis-stimulating agents did not show a clear effect on left ventricular function or clinical outcome, but some studies suggested an increased risk of thromboembolic events.

01 septiembre 2014

AMERICAN HEART JOURNAL. Temporal trends in the use of intraaortic balloon pump associated with percutaneous coronary intervention in the United States, 1998-2008

Hiren Patel, MD, Anupama Shivaraju, MD, Gregg C. Fonarow, MD, Hui Xie, PhD, Weihua Gao, PhD, Adhir R. Shroff, MD, Mladen I. Vidovich, MD

Background: With conflicting evidence regarding the usefulness of intraaortic balloon pump (IABP), reports of IABP use in the United States have been inconsistent. Our objective was to examine trends in IABP usage in percutaneous coronary intervention (PCI) in the United States and to evaluate the association of IABP use with mortality.

01 agosto 2014

AMERICAN HEART JOURNAL. A critical review of hemodynamic changes and left ventricular remodeling after surgical aortic valve replacement and percutaneous aortic valve replacement

Shin-Jae Kim, MD, Zainab Samad, MD, Gerald S. Bloomfield, MD, MPH, Pamela S. Douglas, MD

Background: The introduction of transcatheter aortic valve replacement (TAVR) in clinical practice has widened options for symptomatic patients at high surgical risk; however, it is not known whether TAVR has equivalent or prolonged benefits in terms of left ventricular (LV) remodeling.

01 agosto 2014

AMERICAN HEART JOURNAL. Does optical coherence tomography optimize results of stenting? Rationale and study design

Nicolas Meneveau, MD, PhD, Fiona Ecarnot, MSc, Geraud Souteyrand, MD, Pascal Motreff, MD, PhD, Christophe Caussin, MD, Eric Van Belle, MD, PhD, Patrick Ohlmann, MD, PhD, Olivier Morel, MD, PhD, Alain Grentzinger, MD, Michael Angioi, MD, Romain Chopard, MD, François Schiele, MD, PhD

Background: To date, no randomized study has investigated the value of optical coherence tomography (OCT) in optimizing the results of coronary angioplasty for non–ST-segment elevation acute coronary syndromes.

01 agosto 2014

AMERICAN HEART JOURNAL. Prevalence, characteristics, and predictors of early termination of cardiovascular clinical trials due to low recruitment: Insights from the ClinicalTrials.gov registry

Sabrina Bernardez-Pereira, MD, MS, Renato D. Lopes, MD, PhD, Maria Julia Machline Carrion, MD, MS, Eliana Vieira Santucci, MS, Rafael Marques Soares, MS, Matheus de Oliveira Abreu, MS, Ligia Nasi Laranjeira, MS, Dimas T. Ikeoka, MD, PhD, Ana Denise Zazula, MD, Frederico Rafael Moreira, MS, Alexandre Biasi Cavalcanti, MD, PhD, Evandro Tinoco Mesquita, MD, PhD, Eric D. Peterson, MD, MPH, Robert M. Califf, MD, Otavio Berwanger, MD, PhD on behalf of the Methodological Evaluation of clinical TriAls (META) Study Group

Background: Early termination of clinical trials due to low recruitment represents an understudied challenge for clinical research. We aimed to describe characteristics of cardiovascular trials terminated because of low recruitment and identify the major predictors of such early termination.