01 mayo 2014

JACC. The Year in Valvular Heart Disease

Shahbudin H. Rahimtoola, MB, FRCP, DSc (Hon)

A total of 46 pages and 241 references. Of the 66 recommendations, none had Level of Evidence: A. There were 28 Class I recommendations with Level of Evidence: B in 6 and C in 22. There were 31 Class IIa recommendations with Level of Evidence: B in 1 and C in 30. There are 7 Class IIb recommendations; all were with Level of Evidence: C.

01 mayo 2014

JACC. Release and Capture of Bioactive Oxidized Phospholipids and Oxidized Cholesteryl Esters During Percutaneous Coronary and Peripheral Arterial Interventions in Humans

Amir Ravandi, MD, PhD∗; Gregor Leibundgut, MD†; Ming-Yow Hung, MD†; Mitul Patel, MD†; Patrick M. Hutchins, PhD¶; Robert C. Murphy, PhD¶; Anand Prasad, MD†; Ehtisham Mahmud, MD†; Yury I. Miller, MD, PhD†; Edward A. Dennis, PhD∗∗; Joseph L. Witztum, MD†; Sotirios Tsimikas, MD†

Objectives: This study sought to assess whether oxidized lipids are released downstream from obstructive plaques after percutaneous coronary and peripheral interventions using distal protection devices.

01 mayo 2014

JACC. Transcatheter Aortic Valve Replacement Using a Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis at Extreme Risk for Surgery

Jeffrey J. Popma, MD∗; David H. Adams, MD†; Michael J. Reardon, MD‡; Steven J. Yakubov, MD§; Neal S. Kleiman, MD‡; David Heimansohn, MD‖; James Hermiller, MD‖; G. Chad Hughes, MD¶; J. Kevin Harrison, MD¶; Joseph Coselli, MD#; Jose Diez, MD#; Ali Kafi, MD∗∗; Theodore Schreiber, MD∗∗; Thomas G. Gleason, MD††; John Conte, MD‡‡; Maurice Buchbinder, MD§§; G. Michael Deeb, MD‖‖; Blasé Carabello, MD¶¶; Patrick W. Serruys, MD, PhD##; Sharla Chenoweth, MS∗∗∗; Jae K. Oh, MD†††

Objectives: This study sought to evaluate the safety and efficacy of the CoreValve transcatheter heart valve (THV) for the treatment of severe aortic stenosis in patients at extreme risk for surgery.

01 mayo 2014

JACC. Coronary Computed Tomography Angiography for the Detection of Cardiac Allograft Vasculopathy

Omar Wever-Pinzon, MD∗; Jorge Romero, MD†; Iosif Kelesidis, MD†; James Wever-Pinzon, MD∗; Carlos Manrique, MD†; Deborah Budge, MD∗; Stavros G. Drakos, MD, PhD∗; Ileana L. Piña, MD, MPH†; Abdallah G. Kfoury, MD∗; Mario J. Garcia, MD†; Josef Stehlik, MD, MPH∗

Objectives : This study aimed to evaluate the diagnostic accuracy of coronary computed tomography angiography (CCTA) for detecting cardiac allograft vasculopathy (CAV) in comparison with conventional coronary angiography (CCAG) alone or with intravascular ultrasound (IVUS).

01 mayo 2014

JACC. Influence of Transcatheter Aortic Valve Replacement Strategy and Valve Design on Stroke After Transcatheter Aortic Valve Replacement

Ganesh Athappan, MD∗; R. Dilip Gajulapalli, MD†; Prasanna Sengodan, MD∗; Anju Bhardwaj, MD∗; Stephen G. Ellis, MD†; Lars Svensson, MD, PhD†; Emin Murat Tuzcu, MD†; Samir R. Kapadia, MD†

Objectives: The study undertook a systematic review to establish and compare the risk of stroke between the 2 widely used approaches (transfemoral [TF] vs. transapical [TA]) and valve designs (CoreValve, Medtronic, Minneapolis, Minnesota vs. Edwards Valve, Edwards Lifesciences, Irvine, California) for transcatheter aortic valve replacement (TAVR).

01 mayo 2014

JACC. Impact of Coronary Lesion Complexity on Drug-Eluting Stent Outcomes in Patients With and Without Diabetes Mellitus

Elvin Kedhi, MD, PhD∗; Philippe Généreux, MD†; Tullio Palmerini, MD‖; Thomas C. McAndrew, MS‡; Helen Parise, ScD‡; Roxana Mehran, MD‡; George D. Dangas, MD, PhD‡; Gregg W. Stone, MD†

Objectives: The aim of this study was to investigate whether baseline lesion complexity affects drug-eluting stent (DES) outcomes according to diabetic status.

01 mayo 2014

JACC. A Randomized Trial of Deferred Stenting Versus Immediate Stenting to Prevent No- or Slow-Reflow in Acute ST-Segment Elevation Myocardial Infarction (DEFER-STEMI)

David Carrick, BMedSci, MBChB∗; Keith G. Oldroyd, MBChB, MD∗; Margaret McEntegart, MBChB, PhD†; Caroline Haig, PhD‡; Mark C. Petrie, MBChB, MD∗; Hany Eteiba, MBChB, MD∗; Stuart Hood, MBChB, MD∗; Colum Owens, MBChB, MD∗; Stuart Watkins, MBChB, PhD∗; Jamie Layland, MBChB∗; Mitchell Lindsay, MBChB, MD∗; Eileen Peat, MBChB, MD∗; Alan Rae, MBChB, MD†; Miles Behan, MBChB, MD§; Arvind Sood, MBChB, MD‖; W. Stewart Hillis, MBChB, MD∗; Ify Mordi, MBChB∗; Ahmed Mahrous, MSc†; Nadeem Ahmed, MBChB∗; Rebekah Wilson, BMedSci∗; Laura Lasalle, MPH¶; Philippe Généreux, MD¶; Ian Ford, PhD‡; Colin Berry, MBChB, PhD∗

Objectives: The aim of this study was to assess whether deferred stenting might reduce no-reflow and salvage myocardium in primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI).

01 mayo 2014

JACC. Percutaneous Approaches to Valve Repair for Mitral Regurgitation

Ted Feldman, MD; Amelia Young, MD

Percutaneous therapy has emerged as an option for treatment of mitral regurgitation for selected, predominantly high-risk patients. Most of the percutaneous approaches are modifications of existing surgical approaches. Catheter-based devices mimic these surgical approaches with less procedural risk, due to their less-invasive nature. Percutaneous annuloplasty can be achieved indirectly via the coronary sinus or directly from retrograde left ventricular access. Catheter-based leaflet repair with the MitraClip (Abbott Laboratories, Abbott Park, Illinois) is accomplished with an implantable clip to mimic the surgical edge-to-edge leaflet repair technique. A large experience with MitraClip has been reported, and several other percutaneous approaches have been successfully used in smaller numbers of patients to demonstrate proof of concept, whereas others have failed and are no longer under development. There is increasing experience in both trials and practice to begin to define the clinical utility of percutaneous leaflet repair, and annuloplasty approaches are undergoing significant development. Transcatheter mitral valve replacement is still in early development.

01 mayo 2014

JACC. Outcomes of Acute Type A Dissection Repair Before and After Implementation of a Multidisciplinary Thoracic Aortic Surgery Program

Nicholas D. Andersen, MD; Asvin M. Ganapathi, MD; Jennifer M. Hanna, MD, MBA; Judson B. Williams, MD, MHS; Jeffrey G. Gaca, MD; G. Chad Hughes, MD

Objectives: The purpose of this study was to compare the results of acute type A aortic dissection (ATAAD) repair before and after implementation of a multidisciplinary thoracic aortic surgery program (TASP) at our institution, with dedicated high-volume thoracic aortic surgeons, a multidisciplinary approach to thoracic aortic disease management, and a standardized protocol for ATAAD repair.

13 diciembre 2013

EUROPEAN HEART JOURNAL. Fixed low-dose ultrasound-assisted catheter-directed thrombolysis for intermediate and high-risk pulmonary embolism

Rolf P. Engelberger , Aris Moschovitis , Jennifer Fahrni , Torsten Willenberg , Frederic Baumann , Nicolas Diehm , Do-Dai Do , Iris Baumgartner , Nils Kucher

Aims: No standardized local thrombolysis regimen exists for the treatment of pulmonary embolism (PE). We retrospectively investigated efficacy and safety of fixed low-dose ultrasound-assisted catheter-directed thrombolysis (USAT) for intermediate- and high-risk PE.

13 junio 2014

EUROPEAN HEART JOURNAL. Influence of coronary vessel dominance on short- and long-term outcome in patients after ST-segment elevation myocardial infarction

Caroline E. Veltman , Bas L. van der Hoeven , Georgette E. Hoogslag , Helèn Boden , Rohit K. Kharbanda , Michiel A. de Graaf , Victoria Delgado , Erik W. van Zwet , Martin J. Schalij , Jeroen J. Bax , Arthur J.H.A. Scholte

Aims: Prognostic importance of coronary vessel dominance in patients with ST-elevation myocardial infarction (STEMI) remains uncertain. The aim of this study was to assess influence of coronary vessel dominance on the short- and long-term outcome after STEMI.

09 febrero 2015

EUROPEAN HEART JOURNAL. Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography

Rine Nakanishi , Daniel S. Berman , Matthew J. Budoff , Heidi Gransar , Stephan Achenbach , Mouaz Al-Mallah , Daniele Andreini , Filippo Cademartiri , Tracy Q. Callister , Hyuk-Jae Chang , Victor Y. Cheng , Kavitha Chinnaiyan , Benjamin J.W. Chow , Ricardo Cury , Augustin Delago , Martin Hadamitzky , Jörg Hausleiter , Gudrun Feuchtner , Yong-Jin Kim , Philipp A. Kaufmann , Jonathon Leipsic , Fay Y. Lin , Erica Maffei , Gianluca Pontone , Gilbert Raff , Leslee J. Shaw , Todd C. Villines , Allison Dunning , James K. Min

Aims: We evaluated coronary artery disease (CAD) extent, severity, and major adverse cardiac events (MACEs) in never, past, and current smokers undergoing coronary CT angiography (CCTA).

01 febrero 2015

EUROPEAN HEART JOURNAL. A bi-directional assessment of spontaneous coronary artery dissection by three-dimensional flythrough rendering of optical coherence tomography images

Ji Bak Kim , Hyeong Soo Nam , Hongki Yoo , Jin Won Kim

A 71-year-old woman was admitted to our hospital due to unstable chest pain. Coronary angiography demonstrated a complex eccentric lesion with 80% narrowing of the right coronary arterial lumen (Panel A). Intravascular optical coherence tomography (IV-OCT) revealed typical characteristics of spontaneous coronary artery

01 marzo 2015

CATHETERIZATION & CARDIOVASCULAR INTERVENTIONS. Rationale, development, implementation, and initial results of a fast track protocol for transfemoral transcatheter aortic valve replacement (TAVR)

Rebecca Marcantuono MSN, CRNP, Jacob Gutsche MD, Maureen Burke-Julien MSN, CRNP, Saif Anwaruddin MD, FSCAI, John G. Augoustides MD, David Jones MSN, CRNP, Lisa Mangino – Blanchard MSN, CRNP, Nicole Hoke MSN, RN, Stephanie Houseman RN, Robert Li MD, FSCAI, Prakash Patel MD, Robert Stetson MHA, Elizabeth Walsh RN, Wilson Y. Szeto MD andHoward C. Herrmann MD, FSCAI*

Background: The care pathway for patients undergoing transcatheter aortic valve replacement (TAVR), particularly in the US, was initially based on open surgical techniques and often includes general anesthesia, transesophageal echocardiographic monitoring, and cardiothoracic intensive care unit (ICU) stays. Whether a subgroup of patients could benefit from early extubation, fewer days in the ICU, and early ambulation in terms of both cost and effectiveness is unknown.

01 abril 2015

CATHETERIZATION & CARDIOVASCULAR INTERVENTIONS. Comparison of procedural complications and in-hospital clinical outcomes between patients with successful and failed percutaneous intervention of coronary chronic total occlusions: A Meta-Analysis of Observational Studies

Muhammad F. Khan MD, FACP1,2,*, Emmanouil S. Brilakis MD, PhD, FACC, FSCAI3,4, Christopher S. Wendel MS1 andHoang Thai MD, FACC, FSCAI5,6

Background: Multiple attempts to pass guidewires and balloons across totally occluded segments may result in significant mechanical trauma and higher rates of coronary complications in patients undergoing PCI (percutaneous coronary intervention) for CTOs (chronic total occlusion). It is unknown whether these procedural complications affect short-term survival and in-hospital clinical outcomes after the PCI. The goal of this analysis was to clarify this issue by comparing the rates of adverse in-hospital clinical outcomes between successful and failed CTO-PCI groups.