10 junio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Everolimus-Eluting Stents Improve Vascular Response in a Diabetic Animal Model

Anwer Habib, MD, Vinit Karmali, MA, Michael C. John, MPH, Rohini Polavarapu, BA, Gaku Nakazawa, MD, Kim Pachura, BS, Talina Davis, Frank D. Kolodgie, PhD, Renu Virmani, MD and Aloke V. Finn, MD

Background: Preclinical evaluation of the vascular response of drug-eluting stents is limited especially in the setting of diabetes mellitus preventing the evaluation of changes in drug-eluting stent design and eluted drugs after clinical use.

17 junio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Outcomes With Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention for Patients With Diabetes Mellitus

Sripal Bangalore, MD, MHA, Bora Toklu, MD and Frederick Feit, MD

Background: Coronary artery bypass graft surgery (CABG) compared with percutaneous coronary intervention (PCI) reduces mortality in patients with diabetes mellitus. However, prior trials compared CABG with balloon angioplasty or older generation stents, and it is not known if the gap between CABG and PCI can be reduced by newer generation drug-eluting stents.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Geometrical and Stress Analysis of Factors Associated With Stent Fracture After Melody Percutaneous Pulmonary Valve Implantation

Daria Cosentino, PhD, Michael A. Quail, MBChB, MRCPCH, MSc, Giancarlo Pennati, PhD, Claudio Capelli, PhD, Philipp Bonhoeffer, MD, Vanessa Díaz-Zuccarini, PhD, Andrew M. Taylor, MD, FRCP, FRCR and Silvia Schievano, PhD

Background: Patients treated with the Melody device (Medtronic) for percutaneous pulmonary valve implantation experience stent fractures in ≈25% of the cases. The aim of this study is to identify the risk factors associated with fracture using 3-dimensional (3D) analyses.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Association of Glycemic Control With Mortality in Patients With Diabetes Mellitus Undergoing Percutaneous Coronary Intervention

Praneet K. Sharma, MD, Shikhar Agarwal, MD, MPH, Stephen G. Ellis, MD, Sachin S. Goel, MD, Leslie Cho, MD, E. Murat Tuzcu, MD, A. Michael Lincoff, MD and Samir R. Kapadia, MD

Background: Diabetes mellitus adversely affects outcomes in patients undergoing percutaneous coronary intervention. The association of baseline hemoglobin A1c (HbA1c) at the time of percutaneous coronary intervention with long-term mortality is unknown.

01 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Hemodynamics. Baseline Instantaneous Wave-Free Ratio as a Pressure-Only Estimation of Underlying Coronary Flow Reserve. Results of the JUSTIFY-CFR Study (Joined Coronary Pressure and Flow Analysis to Determine Diagnostic Characteristics of Basal and Hyperemic Indices of Functional Lesion Severity–Coronary Flow Reserve)

Ricardo Petraco, MD, Tim P. van de Hoef, MD, Sukhjinder Nijjer, MBChB, Sayan Sen, MBBS, Martijn A. van Lavieren, MSc, Rodney A. Foale, MD, Martijn Meuwissen, MD, PhD, Christopher Broyd, MBBS, Mauro Echavarria-Pinto, MD, Nicolas Foin, PhD, Iqbal S. Malik, MBBS, PhD, Ghada W. Mikhail, MBBS, MD, Alun D. Hughes, MBBS, PhD, Darrel P. Francis, MB BChir, MA, MD, Jamil Mayet, MBChB, MD, MBA, Carlo Di Mario, MD, PhD, Javier Escaned, MD, PhD, Jan J. Piek, MD, PhD and Justin E. Davies, MBBS, PhD

Background: Coronary flow reserve has extensive validation as a prognostic marker in coronary disease. Although pressure-only fractional flow reserve (FFR) improves outcomes compared with angiography when guiding percutaneous coronary intervention, it disagrees with coronary flow reserve classification 30% of the time. We evaluated whether baseline instantaneous wave-free ratio (iFR) could provide an improved pressure-only estimation of underlying coronary flow reserve.

29 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Artery Disease. Incidence and Outcome of Surgical Procedures After Coronary Artery Bypass Grafting Compared With Those After Percutaneous Coronary Intervention. A Report From the Coronary Revascularization Demonstrating Outcome Study in Kyoto PCI/CABG Registry Cohort-2

Akihiro Tokushige, MD, Hiroki Shiomi, MD, Takeshi Morimoto, MD, Koh Ono, MD, Yutaka Furukawa, MD, Yoshihisa Nakagawa, MD, Kazushige Kadota, MD, Kenji Ando, MD, Satoshi Shizuta, MD, Tomohisa Tada, MD, Junichi Tazaki, MD, Yoshihiro Kato, MD, Mamoru Hayano, MD, Mitsuru Abe, MD, Shuichi Hamasaki, MD, Mitsuru Ohishi, MD, Hitoshi Nakashima, MD, Kazuaki Mitsudo, MD, Masakiyo Nobuyoshi, MD, Toru Kita, MD, Yutaka Imoto, MD, Ryuzo Sakata, MD, Hitoshi Okabayashi, MD, Michiya Hanyu, MD, Mitsuomi Shimamoto, MD, Noboru Nishiwaki, MD, Tatsuhiko Komiya, MD and Takeshi Kimura, MD; on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators

Background: Noncardiac surgery after percutaneous coronary intervention (PCI) has been reported to be carrying high risk for both ischemic and bleeding complications. However, there has been no report comparing the incidence and outcomes of surgical procedures after coronary artery bypass grafting (CABG) with those after PCI.

05 agosto 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Congenital Heart Disease. Trial Occlusion to Assess the Risk of Persistent Pulmonary Arterial Hypertension After Closure of a Large Patent Ductus Arteriosus in Adolescents and Adults With Elevated Pulmonary Artery Pressure

Duan-zhen Zhang, MD, Xian-yang Zhu, MD, Bei Lv, MD, Chun-sheng Cui, MD, Xiu-min Han, MD, Xiao-tang Sheng, MD, Qi-guang Wang, MD and Po Zhang, MD

Background: No method is available to predict whether patients with patent ductus arteriosus (PDA) and severe pulmonary arterial hypertension (PAH) will show persistent postprocedural PAH (PP-PAH) after PDA closure. This study evaluated the usefulness of trial occlusion for predicting PP-PAH after transcatheter PDA closure in patients with severe PAH.

15 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Renal Function–Adjusted Contrast Volume Redefines the Baseline Estimation of Contrast-Induced Acute Kidney Injury Risk in Patients Undergoing Primary Percutaneous Coronary Intervention

Giuseppe Andò, MD, PhD, Cesare de Gregorio, MD, Gaetano Morabito, MD, Olimpia Trio, MD, PhD, Francesco Saporito, MD and Giuseppe Oreto, MD

Background: Age, estimated glomerular renal function (eGFR), and ejection fraction are preprocedural predictors of contrast-induced acute kidney injury (CI-AKI) after primary percutaneous coronary intervention. The effect of renal function–adjusted contrast volume (CV) remains not totally explored, and a threshold has not yet been established.

24 junio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Radial Versus Femoral Access Is Associated With Reduced Complications and Mortality in Patients With Non–ST-Segment–Elevation Myocardial Infarction

M. Bilal Iqbal, MD, Aruna Arujuna, MD, Charles Ilsley, MD, Andrew Archbold, MD, Tom Crake, MD, Sam Firoozi, MD, Sundeep Kalra, MD, Charles Knight, MD, Pitt Lim, MD, Iqbal S. Malik, MD, Anthony Mathur, MD, Pascal Meier, MD, Roby D. Rakhit, MD, Simon Redwood, MD, Mark Whitbread, BSc, Dan Bromage, MD, Krishna Rathod, MD, Andrew Wragg, MD, Philip MacCarthy, MD and Miles Dalby, MD; From the London Heart Attack Centre (HAC) Group Investigators

Background: Compared with transfemoral access, transradial access (TRA) for percutaneous coronary intervention is associated with reduced risk of bleeding and vascular complications. Studies suggest that TRA may reduce mortality in patients with ST-segment–elevation myocardial infarction. However, there are few data on the effect of TRA on mortality, specifically, in patients with non–ST-segment–elevation myocardial infarction.

01 agosto 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Acute Coronary Syndromes Without Obstructive Coronary Atherosclerosis. The Tiles of a Complex Puzzle

Gaetano A. Lanza, MD and Filippo Crea, MD

The large prevalence at autopsy studies, as well as at coronary angiography, of obstructive coronary atherosclerosis in patients presenting cardiac ischemic pain led to the dominant concept, in the past century, that flow-limiting coronary artery stenoses were the only cause of ischemic heart disease (IHD).

20 mayo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Prognosis of Patients With Non–ST-Segment–Elevation Myocardial Infarction and Nonobstructive Coronary Artery Disease

David Planer, MD, MSc, Roxana Mehran, MD, E. Magnus Ohman, MD, Harvey D. White, DSc, Jonathan D. Newman, MD, MPH, Ke Xu, PhD and Gregg W. Stone, MD

Background: Troponin elevation is a risk factor for mortality in patients with non–ST-segment–elevation acute coronary syndromes. However, the prognosis of patients with troponin elevation and nonobstructive coronary artery disease (CAD) is unknown. Our objective was therefore to evaluate the impact of nonobstructive CAD in patients with non–ST-segment–elevation acute coronary syndromes and troponin elevation enrolled in the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial.

27 mayo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Optimization in Stent Implantation by Manual Thrombus Aspiration in ST-Segment–Elevation Myocardial Infarction

Diego Fernández-Rodríguez, MD, Ander Regueiro, MD, Salvatore Brugaletta, MD, PhD, Victoria Martín-Yuste, MD, PhD, Mónica Masotti, MD, PhD, Angel Cequier, MD, PhD, Andrés Iñíguez, MD, PhD, Antonio Serra, MD, PhD, Rosana Hernández-Antolín, MD, PhD, Vicente Mainar, MD, PhD, Marco Valgimigli, MD, PhD, Maurizio Tespili, MD, PhD, Pieter den Heijer, MD, PhD, Armando Bethencourt, MD, PhD, Nicolás Vázquez, MD, PhD, Patrick W. Serruys, MD, PhD and Manel Sabaté, MD, PhD on behalf of the EXAMINATION investigators

Background: Manual thrombus aspiration (TA) is effective to reduce the thrombus burden during primary percutaneous coronary intervention for ST-elevation myocardial infarction. The objective of this study is to assess the impact of manual TA on stent implantation during primary percutaneous coronary intervention.

29 abril 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Hemodynamics. Physiological Basis and Long-Term Clinical Outcome of Discordance Between Fractional Flow Reserve and Coronary Flow Velocity Reserve in Coronary Stenoses of Intermediate Severity

Tim P. van de Hoef, MD, Martijn A. van Lavieren, MSc, Peter Damman, MD, PhD, Ronak Delewi, MD, Martijn A. Piek, Steven A.J. Chamuleau, MD, PhD, Michiel Voskuil, MD, PhD, José P.S. Henriques, MD, PhD, Karel T. Koch, MD, PhD, Robbert J. de Winter, MD, PhD, Jos A.E. Spaan, PhD, Maria Siebes, PhD, Jan G.P. Tijssen, PhD, Martijn Meuwissen, MD, PhD and Jan J. Piek, MD, PhD

Background: Discordance between fractional flow reserve (FFR) and coronary flow velocity reserve (CFVR) may reflect important coronary pathophysiology but usually remains unnoticed in clinical practice. We evaluated the physiological basis and clinical outcome associated with FFR/CFVR discordance.

06 mayo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Randomized Comparison Between Polymer-Free Versus Polymer-Based Paclitaxel-Eluting Stent

Yoshitaka Shiratori, MD, Clarissa Cola, MD, Salvatore Brugaletta, MD, PhD, Luis Alvarez-Contreras, MD, Victoria Martín-Yuste, MD, PhD, Bruno García del Blanco, MD, Rafael Ruiz-Salmeron, MD, Jose Díaz, MD, Eduardo Pinar, MD, Vicens Martí, MD, PhD, Juan García-Picart, MD and Manel Sabaté, MD, PhD

Background: Most drug-eluting stents currently in use are coated with a polymer carrying the drug that is released for several weeks. However, a durable polymer may provoke hypersensitive reaction, delayed artery healing, and eventually stent thrombosis. The aim of this study was to investigate the safety and efficacy of a polymer-free paclitaxel-eluting stent (PF-PES) versus a polymer-based PES (PB-PES).

13 mayo 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Comparison of Biolimus A9–Eluting (Nobori) and Everolimus-Eluting (Promus Element) Stents in Patients With De Novo Native Long Coronary Artery Lesions

Jong-Young Lee, MD, PhD, Duk-Woo Park, MD, PhD, Young-Hak Kim, MD, PhD, Jung-Min Ahn, MD, Won-Jang Kim, MD, PhD, Soo-Jin Kang, MD, PhD, Seung-Whan Lee, MD, PhD, Cheol Whan Lee, MD, PhD, Seong-Wook Park, MD, PhD, Sung-Cheol Yun, PhD, Tae-Hyun Yang, MD, PhD, Bong-Ki Lee, MD, PhD, Nae-Hee Lee, MD, PhD, Joo-Young Yang, MD, PhD, Won-Yong Shin, MD, PhD, Hun Sik Park, MD, PhD, Kee-Sik Kim, MD, PhD, Seung Ho Hur, MD, PhD, Sung Yun Lee, MD, PhD, Jong-Seon Park, MD, PhD, Yun Seok Choi, MD, PhD, Seung Uk Lee, MD, PhD, Sung-Ho Her, MD, PhD and Seung-Jung Park, MD, PhD

Background: Procedural and clinical outcomes still remain unfavorable for patients with long coronary lesions who undergo percutaneous coronary intervention. The current study, therefore, evaluated 2 innovative drug-eluting stents for the management of long-lesion coronary artery disease.