01 octubre 2015

AMERICAN HEART JOURNAL. Improved outcomes of elderly patients treated with drug-eluting versus bare metal stents in large coronary arteries: Results from the BAsel Stent Kosten-Effektivitäts Trial PROspective Validation Examination randomized trial

David J. Kurz, MD, Alain M. Bernheim, MD, David Tüller, MD, Rainer Zbinden, MD, Raban Jeger, MD, Christoph Kaiser, MD, Soeren Galatius, MD, Kim W. Hansen, MD, Hannes Alber, MD, Matthias Pfisterer, MD, Franz R. Eberli, MD

Background: Drug-eluting stents (DES) improve outcomes in elderly patients with small coronary artery disease compared with bare-metal stents (BMS), but randomized data in elderly patients in need of large coronary stents are not available.

01 octubre 2015

AMERICAN HEART JOURNAL. Relationship between stent type and quality of life after percutaneous coronary intervention for acute myocardial infarction

Adnan K. Chhatriwalla, MD, Lakshmi Venkitachalam, PhD, Kevin F. Kennedy, MS, Joshua M. Stolker, MD, Philip G. Jones, MS, David J. Cohen, MD, MSc, John A. Spertus, MD, MPH

Background: Drug-eluting stents (DES) reduce restenosis, as compared with bare-metal stents (BMS); however, the relationship between stent type and health status is unknown. We examined whether stent type was associated with health status outcomes in patients undergoing percutaneous coronary intervention (PCI).

01 octubre 2015

AMERICAN HEART JOURNAL. Impact of lung diseases on morbidity and mortality after transcatheter aortic valve implantation: Insights from spirometry and body plethysmography

Michael Gotzmann, MD, Heiko Knoop, MD, Aydan Ewers, MD, Andreas Mügge, MD, Jörg W. Walther, MD

Background: The study aims to determine the impact of different lung diseases on morbidity and mortality after transcatheter aortic valve implantation (TAVI).

01 noviembre 2015

AMERICAN HEART JOURNAL. The MitraClip and survival in patients with mitral regurgitation at high risk for surgery: A propensity-matched comparison

Eric J. Velazquez, MD, Zainab Samad, MD, MHS, Hussein R. Al-Khalidi, PhD, Chithra Sangli, MA, Paul A. Grayburn, MD, Joseph M. Massaro, PhD, Susanna R. Stevens, MS, Ted E. Feldman, MD, Mitchell W. Krucoff, MD

Background: We compared 30-day and 1-year survival among high-risk mitral regurgitation (MR) patients treated with the MitraClip (Abbott Vascular, Abbott Park, IL) with matched non-surgically treated patients from the Duke Echocardiography Laboratory Database (DELD).

01 noviembre 2015

AMERICAN HEART JOURNAL. A cluster randomized trial of objective risk assessment versus standard care for acute coronary syndromes: Rationale and design of the Australian GRACE Risk score Intervention Study (AGRIS)

Derek P. Chew, MBBS, MPH, Carolyn M. Astley, RN, DrPH, Heather Luker, MPH, Bernadette Alprandi-Costa, RN, Graham Hillis, MBBS, PhD, Clara K. Chow, MBBS, PhD, Steve Quinn, PhD, Andrew T. Yan, MD, Chris P. Gale, PhD, Shaun Goodman, MD, Keith A.A. Fox, MBBS, David Brieger, MBBS, PhD

Background: Assessing risk and weighing the potential benefits from evidence-based therapies are essential in the clinical decision making process of optimizing care and outcomes for patients presenting with acute coronary syndromes (ACS). Such practices are advocated in international clinical guidelines of ACS care. While the GRACE risk score (GRS) is a guideline advocated, well-validated risk stratification tool, its utility in improving care and outcomes remains unproven, and its application has been limited in routine clinical practice.

01 noviembre 2015

AMERICAN HEART JOURNAL. Lifestyle modification for resistant hypertension: The TRIUMPH randomized clinical trial

James A. Blumenthal, PhD, Andrew Sherwood, PhD, Patrick J. Smith, PhD, Stephanie Mabe, MS, Lana Watkins, PhD, Pao-Hwa Lin, PhD, Linda W. Craighead, PhD, Michael Babyak, PhD, Crystal Tyson, MD, Kenlyn Young, RD, Megan Ashworth, MS, William Kraus, MD, Lawrence Liao, MD, Alan Hinderliter, MD

Background: Resistant hypertension (RH) is a growing health burden in this country affecting as many as 1 in 5 adults being treated for hypertension. Resistant hypertension is associated with increased risk of adverse cardiovascular disease (CVD) events and all-cause mortality. Strategies to reduce blood pressure (BP) in this high-risk population are a national priority.

01 diciembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Do You See What I See? Time for a Standardized Approach to Angiography-Based Decision Making

Eric A. Osborn, MD, PhD and Donald E. Cutlip, MD

The relative merit of percutaneous coronary intervention (PCI) for the treatment of stable ischemic heart disease remains a debated issue. Clinical trials that have relied mostly on a visual estimate of angiographic stenosis severity for subject selection have failed to demonstrate a clinical benefit for PCI when compared with guideline-directed medical therapy alone.

01 diciembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Transcatheter Aortic Valve Replacement: Does It Work and Can We Afford It?

Christopher Cao, MBBS, BSc, Hugh Wolfenden, MBBS and Tristan D. Yan, MBBS, MD, PhD

Since the first procedure was performed just over a decade ago, transcatheter aortic valve replacement (TAVR) has emerged as one of the most significant innovations in cardiovascular medicine since the introduction of percutaneous coronary intervention.

25 noviembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Effect of a Real-Time Radiation Monitoring Device on Operator Radiation Exposure During Cardiac Catheterization. The Radiation Reduction During Cardiac Catheterization Using Real-Time Monitoring Study

Georgios Christopoulos, MD, Aristotelis C. Papayannis, MD, Mohammed Alomar, MD, Anna Kotsia, MD, Tesfaldet T. Michael, MD, Bavana V. Rangan, BDS, MPH, Michele Roesle, RN, BSN, Deborah Shorrock, Lorenza Makke, RCIS, Ronald Layne, BS, Rebecca Grabarkewitz, BS, Donald Haagen, RCIS, Spyros Maragkoudakis, MD, Atif Mohammad, MD, Karan Sarode, MA, Daisha J. Cipher, PhD, Charles E. Chambers, MD, Subhash Banerjee, MD and Emmanouil S. Brilakis, MD, PhD

Background: The Radiation Reduction During Cardiac Catheterization Using Real-Time Monitoring study sought to examine the effect of a radiation detection device that provides real-time operator dose reporting through auditory feedback (Bleeper Sv; Vertec Scientific Ltd; Berkshire, UK) on patient dose and operator exposure during cardiac catheterization.

21 octubre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Revascularization Decisions in Patients With Stable Angina and Intermediate Lesions. Results of the International Survey on Interventional Strategy

Gabor G. Toth, MD, Balint Toth, MS, Nils P. Johnson, MD, MS, Frederic De Vroey, MD, Luigi Di Serafino, MD, PhD, Stylianos Pyxaras, MD, Dan Rusinaru, MD, Giuseppe Di Gioia, MD, Mariano Pellicano, MD, Emanuele Barbato, MD, PhD, Carlos Van Mieghem, MD, PhD, Guy R. Heyndrickx, MD, PhD, Bernard De Bruyne, MD, PhD and William Wijns, MD, PhD

Background: Fractional flow reserve (FFR) measurement of intermediate coronary stenoses is recommended by guidelines when demonstration of ischemia by noninvasive testing is unavailable. The study aims to evaluate the penetration of this recommendation into current thinking about revascularization strategies for stable coronary artery disease.

18 noviembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Prevention of Neointimal Formation After Angioplasty Using Nuclear Factor-κB Decoy Oligodeoxynucleotide-Coated Balloon Catheter in Rabbit Model

Takashi Miyake, MD, PhD, Shinya Ihara, MSc, Tetsuo Miyake, MD, Yusuke Tsukada, BSc, Hajime Watanabe, BSc, Hiroaki Matsuda, BSc, Hideki Kiguchi, MSc, Hiroyuki Tsujimoto, PhD, Hironori Nakagami, MD, PhD and Ryuichi Morishita, MD, PhD

Background: Despite the advent of drug-eluting stents, restenosis after endovascular intervention is still a major limitation in the treatment of cardiovascular disease. To regulate the multiple biological mechanisms underlying restenosis, we focused on inhibition of an important transcription factor, nuclear factor-kappaB (NFκB), using a decoy strategy.

28 octubre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Intracoronary Delivery of Injectable Bioabsorbable Scaffold (IK-5001) to Treat Left Ventricular Remodeling After ST-Elevation Myocardial Infarction

Norbert Frey, MD, Axel Linke, MD, Tim Süselbeck, MD, Jochen Müller-Ehmsen, MD, Paul Vermeersch, MD, Danny Schoors, MD, Mark Rosenberg, MD, Florian Bea, MD, Shmuel Tuvia, PhD and Jonathan Leor, MD, FESC

Background: We aimed to test, for the first time, the feasibility of intracoronary delivery of an innovative, injectable bioabsorbable scaffold (IK-5001), to prevent or reverse adverse left ventricular remodeling and dysfunction in patients after ST-segment–elevation myocardial infarction.

25 noviembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Transcatheter Closure of Large Atrial Septal Defects. Feasibility and Safety in a Large Adult and Pediatric Population

Alban-Elouen Baruteau, MD, Jérôme Petit, MD, Virginie Lambert, MD, PhD, Marielle Gouton, MD, Dominique Piot, MD, Philippe Brenot, MD, Claude-Yves Angel, MD, Lucile Houyel, MD, Emmanuel Le Bret, MD, PhD, Régine Roussin, MD, Mohamedou Ly, MD, André Capderou, MD, PhD and Emre Belli, MD

Background: Data are needed on the safety and efficacy of device closure of large atrial septal defects.

11 noviembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Pericardial Endoscopy–Guided Left Atrial Appendage Ligation. A Pilot Study in a Canine Model

Takehiro Kimura, MD, PhD, Seiji Takatsuki, MD, PhD, Shunichiro Miyoshi, MD, PhD, Yoshinori Katsumata, MD, PhD, Takahiko Nishiyama, MD, PhD, Nobuhiro Nishiyama, MD, PhD, Yoko Tanimoto, MD, PhD, Yoshiyasu Aizawa, MD, PhD, Masahiro Jinzaki, MD, PhD and Keiichi Fukuda, MD, PhD

Background: Approaches for closing the left atrial appendage (LAA) have been developed for stroke prevention. However, the prevailing maneuvers require an open-chest surgery, intravascular access, or transseptal puncture. We evaluated the feasibility and safety of pericardial endoscopy-guided LAA ligation in a canine model.

01 diciembre 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Spontaneous Coronary Artery Dissection. Novel Diagnostic Insights From Large Series of Patients

Fernando Alfonso, MD, PhD and Teresa Bastante, MD

Spontaneous coronary artery dissection (SCAD) is a rare clinical entity of unknown cause that classically is thought to occur in young women without traditional coronary risk factors.