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ESTUDIOS


14 mayo 2021

1-Year Results From the RANGER II SFA Randomized Trial of the Ranger Drug-Coated Balloon

Ravish Sachar, Yoshimitsu Soga, Mohammad M. Ansari, Amane Kozuki, Louis Lopez, Marianne Brodmann, Herman Schroë, Vijay S. Ramanath, Juan Diaz-Cartelle, Thomas Zeller, and on behalf of the RANGER II SFA Investigators

This study sought to evaluate the safety and effectiveness of the Ranger drug-coated balloon (DCB) (paclitaxel dose density 2 μg/mm2) for treating superficial femoral artery or proximal popliteal artery lesions.

14 mayo 2021

Clinical Impact of Stent Graft Thrombosis in Femoropopliteal Arterial Lesions

Shigeo Ichihashi, Mitsuyoshi Takahara, Osamu Iida, Kenji Suzuki, Terutoshi Yamaoka, Koji Maeda, Kazuki Tobita, Taira Kobayashi, Tatsuya Nakama, Masami Shingaki, Shunsuke Ozaki, Daisuke Akagi, Yoshimitsu Soga, Shinichi Iwakoshi, Naoki Fujimura, and Kimihiko Kichikawa

This study sought to elucidate the clinical impact and prognosis of stent graft (SG) thrombosis.

14 mayo 2021

Transcatheter Versus Surgical Aortic Valve Replacement in Young, Low-Risk Patients With Severe Aortic Stenosis

Charan Yerasi, Toby Rogers, Brian J. Forrestal, Brian C. Case, Jaffar M. Khan, Itsik Ben-Dor, Lowell F. Satler, Hector M. Garcia-Garcia, Jeffrey E. Cohen, Hiroto Kitahara, Christian Shults, and Ron Waksman

Transcatheter aortic valve replacement (TAVR) is approved for all patient risk profiles and is an option for all patients irrespective of age. However, patients enrolled in the low- and intermediate-risk trials were in their 70s, and those in the high-risk trials were in their 80s. TAVR has never been systematically tested in young (<65 years), low-risk patients. Unanswered questions remain, including the safety and effectiveness of TAVR in patients with bicuspid aortic valves; future coronary access; durability of transcatheter heart valves; technical considerations for surgical transcatheter heart valve explantation; management of concomitant conditions such as aortopathy, mitral valve disease, and coronary artery disease; and the safety and feasibility of future TAVR-in-TAVR. The authors predict that balancing these questions with patients’ clear preference for less invasive treatment will become common. In this paper, the authors consider each of these questions and discuss risks and benefits of theoretical treatment strategies in the lifetime management of young patients with severe aortic stenosis.

15 julio 2021

Effect of Transcatheter Aortic Valve Replacement on Concomitant Mitral Regurgitation and Its Impact on Mortality

Guy Witberg, Pablo Codner, Uri Landes, Shmuel Schwartzenberg, Marco Barbanti, Roberto Valvo, Ole De Backer, Joris F. Ooms, Fabian Islas, Luis Marroquin, Alexander Sedaghat, Atsushi Sugiura, Giulia Masiero, Paul Werner, Xavier Armario, Claudia Fiorina, Dabit Arzamendi, Sandra Santos-Martinez, Felipe Fernández-Vázquez, Jose A. Baz, Klemen Steblovnik, Victor Mauri, Matti Adam, Ilan Merdler, Manuel Hein, Philipp Ruile, Carmelo Grasso, Luca Branca, Rodrigo Estévez-Loureiro, Tomás Benito-González, Ignacio J. Amat-Santos, Darren Mylotte, Martin Andreas, Matjaz Bunc, Giuseppe Tarantini, Jan-Malte Sinning, Luis Nombela-Franco, Lars Søndergaard, Nicolas M. Van Mieghem, Ariel Finkelstein, and Ran Kornowski

The purpose of this study was to examine the impact of residual mitral regurgitation (MR) on mortality in patients undergoing transcatheter aortic valve replacement (TAVR).

15 julio 2021

Development and Validation of a Practical Model to Identify Patients at Risk of Bleeding After TAVR

Eliano Pio Navarese, Zhongheng Zhang, Jacek Kubica, Felicita Andreotti, Antonella Farinaccio, Antonio L. Bartorelli, Francesco Bedogni, Manali Rupji, Fabrizio Tomai, Arturo Giordano, Bernard Reimers, Carmen Spaccarotella, Krzysztof Wilczek, Janina Stepinska, Adam Witkowski, Marek Grygier, Tomasz Kukulski, Wojciech Wanha, Wojciech Wojakowski, Maciej Lesiak, Dariusz Dudek, Michal O. Zembala, Sergio Berti, and a Joint Effort of the Italian and Polish Cardiac Interventional Societies

No standardized algorithm exists to identify patients at risk of bleeding after transcatheter aortic valve replacement (TAVR). The aim of this study was to generate and validate a useful predictive model.

15 junio 2021

The Impact of Aortic Angulation on Contemporary Transcatheter Aortic Valve Replacement Outcomes

Giorgio A. Medranda, Anees Musallam, Cheng Zhang, Hank Rappaport, Paige E. Gallino, Brian C. Case, Lowell F. Satler, Itsik Ben-Dor, Toby Rogers, and Ron Waksman

Objectives The aim of this study was to investigate whether the degree of aortic angulation (AA) affects outcomes after transcatheter aortic valve replacement (TAVR) using newer-generation transcatheter heart valves (THVs).

15 junio 2021

Predictors and Clinical Impact of Prosthesis-Patient Mismatch After Self-Expandable TAVR in Small Annuli

Pier Pasquale Leone, Damiano Regazzoli, Matteo Pagnesi, Jorge Sanz-Sanchez, Mauro Chiarito, Francesco Cannata, Nicolas M. Van Mieghem, Marco Barbanti, Corrado Tamburino, Rui Teles, Marianna Adamo, Mizuki Miura, Francesco Maisano, Won-Keun Kim, Francesco Bedogni, Giulio Stefanini, Antonio Mangieri, Francesco Giannini, Antonio Colombo, Bernhard Reimers, Azeem Latib, and on behalf of the TAVI-SMALL Investigators

Objectives The aim of this study was to define predictors of prosthesis-patient mismatch (PPM) and its impact on mortality after transcatheter aortic valve replacement (TAVR) with self-expandable valves (SEVs) in patients with small annuli.

15 junio 2021

Short-Term Clinical Outcomes of Transcatheter Tricuspid Valve Repair With the Third-Generation MitraClip XTR System

Tobias Friedrich Ruf, Rebecca T. Hahn, Felix Kreidel, Andres Beiras-Fernandez, Michaela Hell, Patrick Gerdes, Jaqueline Grace da Roche e Silva, Markus Vosseler, Martin Geyer, Alexander Tamm, Thomas Münzel, and Ralph Stephan von Bardeleben

Objectives The aim of this study was to assess 30-day outcomes of transcatheter edge-to-edge repair with the MitraClip XTR for significant tricuspid regurgitation (TR), relative to baseline coaptation gap sizes (CGS).

15 junio 2021

Impact of Residual Mitral Regurgitation on Survival After Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation

Satoshi Higuchi, Mathias Orban, Lukas Stolz, Nicole Karam, Fabien Praz, Daniel Kalbacher, Sebastian Ludwig, Daniel Braun, Michael Näbauer, Mirjam G. Wild, Michael Neuss, Christian Butter, Mohammad Kassar, Aniela Petrescu, Roman Pfister, Christos Iliadis, Matthias Unterhuber, Sang-Don Park, Holger Thiele, Stephan Baldus, Stephan von Bardeleben, Niklas Schofer, Steffen Massberg, Stephan Windecker, Philipp Lurz, and Jörg Hausleiter

Objectives The aim of this study was to assess the impact of residual mitral regurgitation (resMR) on mortality with respect to left ventricular dilatation (LV-Dil) or right ventricular dysfunction (RV-Dys) in patients with secondary mitral regurgitation (SMR) who underwent mitral valve transcatheter edge-to-edge repair (TEER).

15 junio 2021

Randomized Comparison Between Radial and Femoral Large-Bore Access for Complex Percutaneous Coronary Intervention

Thomas A. Meijers, Adel Aminian, Marleen van Wely, Koen Teeuwen, Thomas Schmitz, Maurits T. Dirksen, Sudhir Rathore, René J. van der Schaaf, Paul Knaapen, Joseph Dens, Juan F. Iglesias, Pierfrancesco Agostoni, Vincent Roolvink, Renicus S. Hermanides, Niels van Royen, and Maarten A.H. van Leeuwen S

Objectives The aim of this study was to investigate whether transradial (TR) percutaneous coronary intervention (PCI) is superior to transfemoral (TF) PCI in complex coronary lesions with large-bore guiding catheters with respect to clinically relevant access site–related bleeding or vascular complications.

15 junio 2021

Principles of Intravascular Lithotripsy for Calcific Plaque Modification

Dean J. Kereiakes, Renu Virmani, Jason Y. Hokama, Uday Illindala, Carlos Mena-Hurtado, Andrew Holden, Jonathan M. Hill, Sean P. Lyden, and Ziad A. Ali

A significant proportion of lesions treated with transcatheter interventions in the coronary and peripheral vascular beds exhibit moderate to severe calcific plaques known to portend lower procedural success rates, increased peri-procedural adverse events, and unfavorable clinical outcomes compared with noncalcific plaques. Adapted from lithotripsy technology used for treatment of ureterorenal calculi, intravascular lithotripsy (IVL) is a novel technique for the treatment of severely calcific plaque lesions that uses acoustic shockwaves in a balloon-based delivery system. Shockwaves induce calcium fractures, which facilitate stent expansion and luminal gain. In this review, the authors summarize the physics, preclinical and clinical data on IVL use in the coronary and peripheral vasculature, and future directions of IVL in transcatheter cardiovascular therapies.

15 marzo 2021

Tip-to-Base LAMPOON for Transcatheter Mitral Valve Replacement With a Protected Mitral Annulus

John C. Lisko, Vasilis C. Babaliaros, Jaffar M. Khan, Norihiko Kamioka, Patrick T. Gleason, Gaetano Paone, Isida Byku, Jasleen Tiwana, James M. McCabe, Krishna Cherukuri, Ramzi Khalil, David Lasorda, Sachin S. Goel, Neal S. Kleiman, Michael J. Reardon, David V. Daniels, Christian Spies, Paul Mahoney, Brian C. Case, Brian K. Whisenant, Pradeep K. Yadav, Jose F. Condado, Rachel Koch, Kendra J. Grubb, Christopher G. Bruce, Toby Rogers, Robert J. Lederman, and Adam B. Greenbaum

Objectives The purpose of this study was to evaluate tip-to-base intentional laceration of the anterior mitral leaflet to prevent left ventricular outflow tract obstruction (LAMPOON) in patients undergoing transcatheter mitral valve replacement (TMVR) in annuloplasty rings or surgical mitral valves.

15 marzo 2021

Balloon-Assisted BASILICA to Facilitate Redo TAVR

Adam B. Greenbaum, Norihiko Kamioka, John P. Vavalle, John C. Lisko, Patrick T. Gleason, Gaetano Paone, Kendra J. Grubb, Christopher G. Bruce, Robert J. Lederman, and Vasilis C. Babaliaros

Introduction BASILICA (bioprosthetic aortic scallop intentional laceration to prevent coronary artery obstruction) can prevent coronary obstruction following transcatheter aortic valve replacement (TAVR) (1). Transcatheter aortic valve (TAV)–in–TAV may pose the highest risk for obstruction because of narrow residual sinuses, tall leaflets, and supra-annular designs. Bench testing suggests that certain TAV devices exhibit inadequate leaflet “splay” following traditional BASILICA (2). In cases risking inadequate splay (heavily calcified leaflets, very small valve-to-coronary distance, TAV-in-TAV), we have performed balloon-assisted BASILICA. This expands the traversal point outward by inflating a balloon across the leaflet(s) prior to laceration and increases leaflet splay (Figure 1A). Herein, we describe the first reported case.

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