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ESTUDIOS


08 noviembre 2011

JACC. Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis

Neil E. Moat, MBBS, MS, Peter Ludman, MA, MD, Mark A. de Belder, MA, MD, Ben Bridgewater, PHD, Andrew D. Cunningham, PHD, Christopher P. Young, MD, Martyn Thomas, MD, Jan Kovac, MD, Tom Spyt, MD, Philip A. MacCarthy, BS, PHD, Olaf Wendler, MD, PHD, David Hildick-Smith, MD, Simon W. Davies, MBBS, MD, Uday Trivedi, MBBS, Daniel J. Blackman, MD, Richard D. Levy, MD, Stephen J. D. Brecker, MD, Andreas Baumbach, MD, Tim Daniel, MB, CHB, Huon Gray, MD, Michael J. Mullen, MBBS, MD

The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term. Journal of the American College of Cardiology Vol. 58, No. 20, 2011. Copyright © 2011 by the American College of Cardiology Foundation ISSN 0735-1097. Published by Elsevier Inc.

01 septiembre 2009

JACC: CARDIOVASCULAR INTERVENTIONS. Impact of Vessel Size on Angiographic and Clinical Outcomes of Revascularization With Biolimus-Eluting Stent With Biodegradable Polymer and Sirolimus-Eluting Stent With Durable Polymer

Joanna J. Wykrzykowska, MD; Patrick W. Serruys, MD, PhD; Yoshinobu Onuma, MD; Ton de Vries, MA; Gerrit-Anne van Es, PhD; Pawel Buszman, MD; Axel Linke, MD; Thomas Ischinger, MD; Volker Klauss, MD; Roberto Corti, MD; Franz Eberli, MD, PhD; William Wijns, MD; Marie-Claude Morice, MD; Carlo di Mario, MD, PhD; Robert Jan van Geuns, MD, PhD; Peter Juni, MD, PhD; Stephan Windecker, MD, PhD

Objectives: We assessed the impact of vessel size on outcomes of stenting with biolimus-eluting degradable polymer stent (BES) and sirolimus-eluting permanent polymer stent (SES) within a randomized multicenter trial (LEADERS).

01 noviembre 2011

LANCET: Long-term clinical outcomes of biodegradable polymer biolimus-eluting stents versus durable polymer sirolimus-eluting stents in patients with coronary artery disease (LEADERS): 4 year follow-up of a randomised non-inferiority trial

Giulio G Stefanini, Bindu Kalesan, Patrick W Serruys, Dik Heg, Pawel Buszman, Axel Linke, Thomas Ischinger, Volker Klauss, Franz Eberli, William Wijns, Marie-Claude Morice, Carlo Di Mario, Roberto Corti, Diethmar Antoni, Hae Y Sohn, Pedro Eerdmans, Gerrit-Anne van Es, Bernhard Meier, Stephan Windecker, Peter Jüni

Background: The eff ectiveness of durable polymer drug-eluting stents comes at the expense of delayed arterial healing and subsequent late adverse events such as stent thrombosis (ST). We report the 4 year follow-up of an assessment of biodegradable polymer-based drug-eluting stents, which aim to improve safety by avoiding the persistent infl ammatory stimulus of durable polymers

26 enero 2012

WJC. Clinical and prognostic implications of atrial fibrillation in patients undergoing transcatheter aortic valve implantation

Pablo Salinas, Raúl Moreno, Luis Calvo, Santiago Jiménez-Valero, Guillermo Galeote, Angel Sánchez-Recalde, Teresa López-Fernández, Sergio Garcia-Blas, Diego Iglesias, Luis Riera, Isidro Moreno-Gómez, Jose María Mesa, Ignacio Plaza, Rocio Ayala, Rosa Gonzalez, José-Luis López-Sendón

AIM: To study a cohort of consecutive patients undergoing transcatheter aortic valve implantation (TAVI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (SR). World J Cardiol. January 26, 2012. Volume 4. Copyright © 2012 Baishideng. All rights reserved.

29 marzo 2011

JACC. Arterial Stiffening Relates to Arterial Calcification But Not to Noncalcified Atheroma in Women

Marina Cecelja, BSC, Benyu Jiang, PHD, Lisa Bevan, RGN, Michelle L. Frost, PHD, Tim D. Spector, MD, Phil J. Chowienczyk

Our aim was to examine the relationship of arterial stiffness to measures of atherosclerosis, arterial calcification, and bone mineral density (BMD); the heritability of these measures; and the degree to which they are explained by common genetic influences. Journal of the American College of Cardiology. Vol. 57, No. 13, 2011. Copyright © 2011 by the American College of Cardiology Foundation. Published by Elsevier Inc. ISSN 0735-1097.

01 noviembre 2010

JACC: CARDIOVASCULAR INTERVENTIONS. The Global Experience With Percutaneous Aortic Valve Replacement

Martyn Thomas, MD London, United Kingdom

Transcatheter aortic valve replacement is now a viable option in the treatment of high-risk severe symptomatic aortic stenosis. This review describes the current data with this technology and also the potential for the future role of the technology, including potential ways to yet further improve the short- and longer-term results. JACC: CARDIOVASCULAR INTERVENTIONS VOL. 3, NO. 11, 2010. Copyright © 2010 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798. PUBLISHED BY ELSEVIER INC.

01 septiembre 2008

LANCET: Biolimus-eluting stent with biodegradable polymer versus sirolimus-eluting stent with durable polymer for coronary revascularisation (LEADERS): a randomised non-inferiority trial

Stephan Windecker, Patrick W Serruys, Simon Wandel, Pawel Buszman, Stanislaw Trznadel, Axel Linke, Karsten Lenk, Thomas Ischinger, Volker Klauss, Franz Eberli, Roberto Corti, William Wijns, Marie-Claude Morice, Carlo di Mario, Simon Davies, Robert-Jan van Geuns, Pedro Eerdmans, Gerrit-Anne van Es, Bernhard Meier, Peter Jüni

Background: A novel stent platform eluting biolimus, a sirolimus analogue, from a biodegradable polymer showed promising results in preliminary studies. We compared the safety and effi cacy of a biolimus-eluting stent (with biodegradable polymer) with a sirolimus-eluting stent (with durable polymer).

28 junio 2011

JACC. 2-Year Follow-Up of a Randomized Controlled Trial of Everolimus- and Paclitaxel-Eluting Stents for Coronary Revascularization in Daily Practice

Pieter C. Smits, MD, PHD, Elvin Kedhi, MD, Kees-Jan Royaards, MD, Kaiyum Sheik Joesoef, MD, Jochem Wassing, MD, Tessa A. M. Rademaker-Havinga, MSC, Eugene McFadden, MD

The purpose of this study was to compare the safety and efficacy of the Xience V (Abbott Vascular, Santa Clara, California) everolimus-eluting stent (EES) with the Taxus Liberté (Boston Scientific, Natick, Massachusetts) paclitaxel-eluting stent (PES) at 2-year follow-up. Journal of the American College of Cardiology. Vol. 58, No. 1, 2011. Copyright © 2011 by the American College of Cardiology Foundation. Published by Elsevier Inc. ISSN 0735-1097.

01 abril 2010

INTERNATIONAL JOURNAL STROKE. Prevention of stroke in patients with patent foramen ovale

H. P. Mattle, B. Meier and K. Nedeltchev

Patent foramen ovale is found in 24% of healthy adults and 38% of patients with cryptogenic stroke. This ratio and case reports indicate that patent foramen ovale and stroke are associated, probably because of paradoxical embolism. In healthy people with patent foramen ovale, embolic events are not more frequent than in controls, and therefore no primary prevention is needed. However, once ischaemic events occur, the risk of recurrence is substantial and prevention becomes an issue. Acetylsalicylic acid and warfarin reduce this risk to the same level as in patients without patent foramen ovale. Patent foramen ovale with a coinciding atrial septal aneurysm, spontaneous or large right-to-left shunt, or multiple ischaemic events potentiates the risk of recurrence. Transcatheter device closure has therefore become an intriguing addition to medical treatment, but its therapeutic value still needs to be confirmed by randomised-controlled trials. Copyright 2010 The Authors. Journal compilation. Copyright 2010 World Stroke Organization International Journal of Stroke Vol 5, April 2010, 92–102

29 febrero 2012

JACC. A Randomized, Multicenter, Single-Blinded Trial Comparing Paclitaxel-Coated Balloon Angioplasty With Plain Balloon Angioplasty in Drug-Eluting Stent Restenosis: The PEPCAD-DES Study

Harald Rittger, Johannes Brachmann, Anil-M. Sinha, Matthias Waliszewski, Marc Ohlow, Andreas Brugger, Holger Thiele, Ralf Birkemeyer, Volkhard Kurowski, Ole-A. Breithardt, Martin. Schmidt, Stefan Zimmermann, Sandra Lonke, Moritz von Cranach, The-Vinh Nguyen, Werner G. Daniel, and Jochen Wöhrle

The authors sought to define the impact of paclitaxel-coated balloon angioplasty for treatment of drug-eluting stent restenosis compared with uncoated balloon angioplasty alone. Journal of the American College of Cardiology Vol. 59, No. 15, 2012 © 2012 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc.

26 febrero 2012

WJC. Percutaneous panvascular intervention in an unusual case of extensive atherosclerotic disease

Rajesh Vijayvergiya, Dheeraj Garg, Saroj K Sinha

Atherosclerosis is a systemic disease, which can have varied clinical presentation with involvement of multiple vascular beds. It is common to come across patients with concomitant coronary artery disease (CAD) and peripheral arterial disease (PAD), in whom panvascular revascularization is required. As they are high-risk patients with poor clinical outcome, their management requires a comprehensive multi-specialty approach. Following improvement in technical skills and hardware for percutaneous interventions in recent years, more complex lesions with adverse clinical situations can undergo intervention by a cardiologist/vascular interventionist. We hereby report a case with CAD and PAD, who underwent successful complex coronary and multiple peripheral interventions for his symptomatic disease. World J Cardiol 2012 February 26; 4(2): 48-53. Copyright © 2012 Baishideng. All rights reserved.

30 noviembre 2011

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Embolization of an Amplatzer mVSD Occluder Device Used for Percutaneous Closure of an Ascending Aortic Pseudoaneurysm: Case Report and Literature Review

Stéphane Noble, MD and Réda Ibrahim MD

Pseudoaneurysm of the ascending aorta is a rare, but potentially dangerous condition. The high morbidity and mortality rate associated with its surgical management has led to the development of transcatheter approaches. We report a case of percutaneous closure of an ascending aortic pseudoaneurysm using an Amplatzer mVSD occluder device complicated by device embolization at day 27 and we review the literature of Amplatzer devices in this off-label use. Copyright 2011 Wiley Periodicals, Inc. Catheterization and Cardiovascular Interventions 79:334–338 (2012)

08 marzo 2011

JACC. Efficacy and Safety of Glycoprotein IIb/IIIa Inhibitors During Elective Coronary Revascularization A Meta-Analysis of Randomized Trials Performed in the Era of Stents and Thienopyridines

David E. Winchester, MD, Xuerong Wen, MPH, William D. Brearley, MD, Ki E. Park, MD, R. David Anderson, MD, Anthony A. Bavry, MD, MPH

The purpose of this study was to investigate the efficacy and safety of glycoprotein IIb/IIIa inhibitors (GPIs) during elective percutaneous coronary intervention (PCI). Journal of the American College of Cardiology. Vol. 57, No. 10, 2011. Copyright © 2011 by the American College of Cardiology Foundation. Published by Elsevier Inc. ISSN 0735-1097.

26 octubre 2011

JAMA. Clinical, Angiographic, and Genetic Factors Associated With Early Coronary Stent Thrombosis

Guillaume Cayla, MD, PhD Jean-Se´ bastien Hulot, MD, PhD Stephen A. O’Connor, MD Atul Pathak, MD, PhD Stuart A. Scott, PhD Yves Gruel, MD, PHD Johanne Silvain, MD, PhD Jean-Baptiste Vignalou, MD Yves Huerre, MD Axel de la Briolle, MD, PHD Fre´de´ rick Allanic Farzin Beygui, MD, PhD Olivier Barthe´le´ my, MD Gilles Montalescot, MD, PhD Jean-Philippe Collet, MD, PhD

Context: Despite dual antiplatelet therapy, stent thrombosis remains a devastating and unpredictable complication of percutaneous coronary intervention (PCI). Objective: To perform a sequential analysis of clinical and genetic factors associated with definite early stent thrombosis. Copyright ©2011 American Medical Association. All rights reserved. JAMA, October 26, 2011—Vol 306, No. 16

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