01 junio 2011

CIRCULATION. Optical Coherence Tomographic Analysis of In-Stent Neoatherosclerosis After Drug–Eluting Stent Implantation

Soo-Jin Kang, MD; Gary S. Mintz, MD; Takashi Akasaka, MD, PhD; Duk-Woo Park, MD, PhD; Jong-Young Lee, MD; Won-Jang Kim, MD; Seung-Whan Lee, MD, PhD; Young-Hak Kim, MD, PhD; Cheol Whan Lee, MD, PhD; Seong-Wook Park, MD, PhD; Seung-Jung Park, MD, PhD

Background—We report findings from optical coherence tomography (OCT) of in-stent neoatherosclerosis as a cause of drug-eluting stent (DES) failure. Circulation. 2011; 123: 2954-2963 Published online before print June 6, 2011, doi: 10.1161. Copyright © 2011 American Heart Association, Inc. All rights reserved. Print ISSN: 0009-7322. Online ISSN: 1524-4539.

01 junio 2011

JACC: CARDIOVASCULAR INTERVENTIONS. Total Ischemic Time: The Correct Focus of Attention for Optimal ST-Segment Elevation Myocardial Infarction Care

Ali E. Denktas, MD, H. Vernon Anderson, MD, James McCarthy, MD, Richard W. Smalling, MD, PhD

Currently accepted standards for gauging quality of care in the treatment of ST-segment elevation myocardial infarction (STEMI) mainly focus on shortening the time to treatment after the patient arrives at the hospital. But this narrow focus fails to consider the substantial duration of myocardial ischemia that exists prior to hospital arrival, and the large number of deaths that occur during the pre-hospital period. The time from symptom onset until reperfusion occurs is one estimate of total ischemic time. Several experimental studies and now human clinical studies have confirmed that infarct size and mortality are strongly correlated with the total ischemic time, and much less so with its subintervals like door-to-balloon time. This review will discuss the importance of total ischemic time in STEMI. JACC: CARDIOVASCULAR INTERVENTIONS VOL. 4, NO. 6, 2011. Copyright © 2011 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798/$36.00. PUBLISHED BY ELSEVIER INC. DOI: 10.1016/j.jcin.2011.02.012.

19 marzo 2012

CARDIOVASCULAR DISORDERS. Clinical outcomes after treatment of multiple lesions with zotarolimus-eluting versus sirolimuseluting coronary stents (a SORT OUT III substudy)

Troels Thim, Michael Maeng, Jens Flensted Lassen, Anne Kaltoft, Lisette Okkels Jensen, Jan Ravkilde, Per Thayssen, Søren Galatius, Evald Høj Christiansen and Thomas Engstrøm, et al.

Data on clinical outcomes among patients treated with the zotarolimus-eluting Endeavor™ stent versus the sirolimus-eluting Cypher™ stent favor the sirolimus-eluting stent. However, a separate comparison of clinical outcome among patients treated for multiple lesions with these stents is lacking. We performed this comparison within the SORT OUT III trial data set. BMC Cardiovascular Disorders Volume 12, Number 1 (2012), 18, DOI: 10.1186/1471-2261-12-18. Copyright © 2012 Thim et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

01 febrero 2012

JOURNAL OF INTERVENTIONAL CARDIOLOGY. Percutaneous Balloon Atrioseptostomy for Left Heart Discharge in Extracorporeal Life Support Patients with Persistent Pulmonary Edema

MATHIEU BIGNON M.D., VINCENT ROULE M.D., ZIAD DAHDOUH M.D., RÉMI SABATIER M.D., THÉRÈSE LOGNONÉ M.D., GUILLAUME MALCOR M.D., MOUSSA IDALI M.D., CALIN IVASCAU M.D., MASSIMO MASSETTI M.D. and GILLES GROLLIER M.D.

Aims: In severe myocardial dysfunction, extracorporeal life support (ECLS) can preserve organ perfusion. Occasionally, the high resulting afterload can lead to refractory pulmonary edema. We report our experience with percutaneous balloon atrioseptostomy used in this circumstance to discharge the left heart and prevent worsening pulmonary congestion. You have free access to this content Journal of Interventional CardiologyVolume 25, Issue 1, Article first published online: 4 NOV 2011. Copyright © 2012, Wiley Periodicals, Inc. DOI: 10.1111/j.1540-8183.2011.00681.x.

01 junio 2012

CLINICAL CARDIOLOGY. Cannabinoids and Atherosclerotic Coronary Heart Disease

Sandeep Singla MD, Rajesh Sachdeva MD and Jawahar L. Mehta MD, PhD

Marijuana is the most abused recreational drug in the United States. Cannabinoids, the active ingredients of marijuana, affect multiple organ systems in the human body. The pharmacologic effects of marijuana, based on stimulation of cannabinoid receptors CB1 and CB2, which are widely distributed in the cardiovascular system, have been well described. Activation of these receptors modulates the function of various cellular elements of the vessel wall, and may contribute to the pathogenesis of atherosclerosis. Clinically, there are reports linking marijuana smoking to the precipitation of angina and acute coronary syndromes. Recently, large published clinical trials with CB1 antagonist rimonabant did not show any significant benefit of this agent in preventing progression of atherosclerosis. In light of these findings and emerging data on multiple pathways linking cannabinoids to atherosclerosis, we discuss the literature on the role of cannabinoids in the pathophysiology of atherosclerosis. We also propose a marijuana paradox, which implies that inhalation of marijuana may be linked to precipitation of acute coronary syndromes, but modulation of the endocannabinoid system by a noninhalation route may have a salutary effect on the development of atherosclerosis. Clinical Cardiology. Volume 35, Issue 6, pages 329–335, June 2012. Article first published online: 25 JAN 2012. DOI: 10.1002/clc.21962. Copyright © 2012 Wiley Periodicals, Inc.

01 junio 2011

JACC: CARDIOVASCULAR INTERVENTIONS. Impact of Bleeding on Mortality After Percutaneous Coronary Intervention

Roxana Mehran, MD, Stuart Pocock, PhD, Eugenia Nikolsky, MD, PhD, George D. Dangas, MD, PhD, Tim Clayton, MSc, Bimmer E. Claessen, MD, Adriano Caixeta, MD, PhD, Frederick Feit, MD, Steven V. Manoukian, MD, Harvey White, MD, Michel Bertrand, MD, E. Magnus Ohman, MD, Helen Parise, PhD, Alexandra J. Lansky, MD, A. Michael Lincoff, MD, Gregg W. Stone, MD

Results From a Patient-Level Pooled Analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trials. JACC: CARDIOVASCULAR INTERVENTIONS VOL. 4, NO. 6, 2011. Copyright © 2011 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798/$36.00. PUBLISHED BY ELSEVIER INC. DOI: 10.1016/j.jcin.2011.02.011.

01 febrero 2012

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Comparison of in vivo eccentricity and symmetry indices between metallic stents and bioresorbable vascular scaffolds: Insights from the ABSORB and SPIRIT trials

Salvatore Brugaletta MD, Josep Gomez-Lara MD, Roberto Diletti MD, Vasim Farooq MBChB, MRCP, Robert Jan van Geuns MD, Bernard de Bruyne MD, Dariusz Dudek MD, Hector M. Garcia-Garcia MD, PhD, John A. Ormiston MBChB, PhD and Patrick W. Serruys MD, PhD

Objective: To compare the geometrical parameters of a bioresorbable vascular scaffold (BVS) with a standard metallic stent. Background: The introduction of polymeric bioresorbable materials in the design of novel coronary scaffolds may affect some geometrical parameters, such as eccentricity and symmetry indices, previously introduced as IVUS criteria for optimal metallic stent deployment. Catheterization and Cardiovascular Interventions. Volume 79, Issue 2, pages 219–228, 1 February 2012. Article first published online: 11 MAY 2011. DOI: 10.1002/ccd.22996. Copyright © 2011 Wiley Periodicals, Inc.

01 mayo 2011

JACC: CARDIOVASCULAR INTERVENTIONS. Long-Term Safety and Efficacy of Paclitaxel-Eluting Stents. Final 5-Year Analysis From the TAXUS Clinical Trial Program

Gregg W. Stone, MD, Stephen G. Ellis, MD, Antonio Colombo, MD, Eberhard Grube, MD, Jeffrey J. Popma, MD, Takahiro Uchida, MD, PhD, Jill S. Bleuit, PhD, Keith D. Dawkins, MD, Mary E. Russell, MD, PhD

Objectives: These studies sought to evaluate the clinical outcomes of the slow-release Taxus paclitaxel-eluting stent (PES) versus an otherwise identical bare-metal stent (BMS). Background: Prior studies were not individually powered to generate reliable estimates of low-frequency safety endpoints or to characterize the long-term safety and efficacy profile of PES. JACC: CARDIOVASCULAR INTERVENTIONS VOL. 4, NO. 5, 2011. © 2011 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798/$36.00. PUBLISHED BY ELSEVIER INC. DOI: 10.1016/j.jcin.2011.03.005.

01 junio 2011

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Impact of Polymer Formulations on Neointimal Proliferation After Zotarolimus-Eluting Stent With Different Polymers

Katsuhisa Waseda, MD, PhD, Junya Ako, MD, PhD, Masao Yamasaki, MD, PhD, Tomomi Koizumi, MD, PhD, Ryota Sakurai, MD, Yoichiro Hongo, MD, Bon-Kwon Koo, MD, PhD, John Ormiston, MBChB, Stephen G. Worthley, MBBS, PhD, Robert J. Whitbourn, MBBS, Darren L. Walters, MBBS, MPhil, Ian T. Meredith, MBBS, PhD, Peter J. Fitzgerald, MD, PhD and Yasuhiro Honda, MD

Background—Polymer formulation may affect the efficacy of drug-eluting stents. Resolute, Endeavor, and ZoMaxx are zotarolimus-eluting stents with different stent platforms and different polymer coatings and have been tested in clinical trials. The aim of this analysis was to compare the efficacy of zotarolimus-eluting stents with different polymers. Circulation: Cardiovascular Interventions. 2011; 4: 248-255 Published online before print May 17, 2011, doi: 10.1161. Print ISSN: 1941-7640. Online ISSN: 1941-7632 Copyright © American Heart Association. All rights reserved.

01 junio 2011

CIRCULATION. Cost-Effectiveness of Dabigatran for Stroke Prophylaxis in Atrial Fibrillation

Shimoli V. Shah, MD; Brian F. Gage, MD, MSc

Background—Recent studies have investigated alternatives to warfarin for stroke prophylaxis in patients with atrial fibrillation (AF), but whether these alternatives are cost-effective is unknown. Circulation. 2011; 123: 2562-2570 Published online before print May 23, 2011, doi: 10.1161. Copyright © 2011 American Heart Association, Inc. All rights reserved. Print ISSN: 0009-7322. Online ISSN: 1524-4539.

13 febrero 2012

JOURNAL OF CARDIOTHORACIC SURGERY. Transauricular embolization of the rabbit coronary artery for experimental myocardial infarction: comparison of a minimally invasive closed-chest model with open-chest surgery

Konstantinos Katsanos, Sofoklis Mitsos, Efstratios Koletsis, Vassiliki Bravou, Dimitris Karnabatidis, Fevronia Kolonitsiou, Athanassios Diamantopoulos, Dimitrios Dougenis and Dimitris Siablis

To date, most animal studies of myocardial ischemia have used open-chest models with direct surgical coronary artery ligation. We aimed to develop a novel, percutaneous, minimally-invasive, closed-chest model of experimental myocardial infarction (EMI) in the New Zealand White rabbit and compare it with the standard open-chest surgical model in order to minimize local and systemic side-effects of major surgery. Journal of Cardiothoracic Surgery 2012, 7:16 http://www.cardiothoracicsurgery.org/content/7/1/16. Copiryght © 2012 Katsanos et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License

01 junio 2011

JACC: CARDIOVASCULAR INTERVENTIONS. Randomized Comparison of Pre-Hospital–Initiated Facilitated Percutaneous Coronary Intervention Versus Primary Percutaneous Coronary Intervention in Acute Myocardial Infarction Very Early After Symptom Onset

Holger Thiele, MD, Ingo Eitel, MD, Claudia Meinberg, BSc, Steffen Desch, MD, Anja Leuschner, BSc, Dietrich Pfeiffer, MD, Andreas Hartmann, MD, Ulrich Lotze, MD, Wolfgang Strauß, MD, Gerhard Schuler, MD LIPSIA-STEMI Trial Group

Objectives: This multicenter trial sought to assess the merits of facilitated percutaneous coronary intervention (PCI) versus primary PCI in an ST-segment elevation myocardial infarction (STEMI) network with long transfer distances in patients presenting early after symptom onset. Background: Facilitated PCI with fibrinolysis might be beneficial in specific high-risk STEMI situations to prevent myocardial necrosis expansion. JACC: CARDIOVASCULAR INTERVENTIONS VOL. 4, NO. 6, 2011. Copyright © 2011 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798/$36.00. PUBLISHED BY ELSEVIER INC. DOI: 10.1016/j.jcin.2011.01.013.

01 mayo 2011

JACC: CARDIOVASCULAR INTERVENTIONS. Late-Term Clinical Outcomes With Zotarolimus- and Sirolimus-Eluting Stents

David E. Kandzari, MD, Laura Mauri, MD, MSc, Jeffrey J. Popma, MD, Mark A. Turco, MD, Paul A. Gurbel, MD, Peter J. Fitzgerald, MD, Martin B. Leon, MD

5-Year Follow-Up of the ENDEAVOR III (A Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). JACC: CARDIOVASCULAR INTERVENTIONS VOL. 4, NO. 5, 2011. Copyright © 2011 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION ISSN 1936-8798/$36.00. PUBLISHED BY ELSEVIER INC. DOI: 10.1016/j.jcin.2010.12.014.

14 abril 2011

STROKE. Improving Stroke Risk Stratification Using the CHADS2 and CHA2DS2-VASc Risk Scores in Patients With Paroxysmal Atrial Fibrillation by Continuous Arrhythmia Burden Monitoring

Giuseppe Boriani, MD, PhD; Giovanni Luca Botto, MD; Luigi Padeletti, MD; Massimo Santini, MD; Alessandro Capucci, MD; Michele Gulizia, MD; Renato Ricci, MD; Mauro Biffi, MD; Tiziana De Santo, BS; Giorgio Corbucci, PhD; Gregory Y.H. Lip, MD; for the Italian AT-500 Registry Investigators

Background and Purpose—In patients with atrial fibrillation (AF), stroke risk stratification schema do not consider AF parameters. The aim of the study is to assess the impact of combining risk factors with continuous AF burden monitoring. Stroke. 2011; 42: 1768-1770 Published online before print April 14, 2011. Copyright © 2011 American Heart Association, Inc. All rights reserved. Print ISSN: 0039-2499. Online ISSN: 1524-4628

01 febrero 2012

JOURNAL OF INTERVENTIONAL CARDIOLOGY. Treatment of a Giant Coronary Artery Aneurysm: Intravascular Ultrasound and Optical Coherence Tomography Findings

JAIME DUTARY M.D., BRIAN ZAKHEM M.B.B.S., F.R.A.C.P., CAMINO BAÑUELOS DE LUCAS M.D., MANUEL PAULO M.D., NIEVES GONZALO M.D., Ph.D., FERNANDO ALFONSO M.D., Ph.D., F.E.S.C.

A giant coronary aneurysm (GCA) partially thrombosed was demonstrated in a 77-year-old patient evaluated for an inferior myocardial infarction. Primary angioplasty (balloon only) with suboptimal result was initially obtained. After triple antiplatelet and anticoagulation therapy (4 days), a new angiography was performed and a fusiform GCA was clearly delineated. A second percutaneous intervention was performed using a “scaffolding technique” with conventional stent and subsequent implantation of 2 polytetrafluoroethylene-covered stents to successfully exclude the aneurysm. This case demonstrates a novel technique to treat long GCA. (J Interven Cardiol 2012;25:82–85) You have free access to this content Journal of Interventional CardiologyVolume 25, Issue 1, Article first published online: 22 MAY 2011. Copyright © 2012, Wiley Periodicals, Inc. DOI: 10.1111/j.1540-8183.2011.00659.x.