01 abril 2013

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. Safety and efficacy of everolimus-eluting stents versus paclitaxel-eluting stents in a diabetic population

Ana Laynez MD, Gabriel Sardi MD, Camille Hauville MD, PhD, Israel M. Barbash MD, Rajbabu Pakala PhD, Rebecca Torguson MPH, Zhenyi Xue MS, Lowell F. Satler MD, Augusto D. Pichard MD, Ron Waksman MD

Objectives: This study aimed to analyze the use of everolimus-eluting stents (EES) and paclitaxel-eluting stents (PES) in an unrestricted diabetic population and to compare the performance of these two drug-eluting stents.

01 abril 2012

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Prediction of Optimal Deployment Projection for Transcatheter Aortic Valve Replacement. Angiographic 3-Dimensional Reconstruction of the Aortic Root Versus Multidetector Computed Tomography

Ronald K. Binder, MD, Jonathon Leipsic, MD, David Wood, MD, Teri Moore, Stefan Toggweiler, MD, Alex Willson, MBBS, Ronen Gurvitch, MBBS, Melanie Freeman, MBBS and John G. Webb, MD

Background—Identifying the optimal fluoroscopic projection of the aortic valve is important for successful transcatheter aortic valve replacement (TAVR). Various imaging modalities, including multidetector computed tomography (MDCT), have been proposed for prediction of the optimal deployment projection. We evaluated a method that provides 3-dimensional angiographic reconstructions (3DA) of the aortic root for prediction of the optimal deployment angle and compared it with MDCT.

01 marzo 2012

CIRCULATION. Giant Aorto–Right Ventricular Fistula With Single Coronary Artery

Sudhanshu Kumar Dwivedi, MD, DM; Sudarshan Kumar Vijay, MD; Sharad Chandra, MD, DM; Naveed Ahmad, MD; Ram Kirti Saran, MD, DM; Sushil Kumar Singh, MS, MCh

A 15-year-old boy with symptoms of dyspnea and fatigue since early childhood was referred to our institution for evaluation. Physical examination of the patient showed long, slender extremities and a pectus carinatum deformity of the chest (Figure 1A). His arm span–to-height ratio was 1.03, and his upper segment–to–lower segment ratio was 0.82. He had blood pressure of 126/70 mm Hg, with a heart rate of 96 bpm; a grade 4/6 continuous murmur was present in the right lower parasternal area. A 12-lead ECG showed right bundle-branch block (Figure 2), and chest radiography (posteroanterior view) revealed mild cardiomegaly. Radiography of the thoracolumbar spine of the patient disclosed a mild degree of scoliosis (inset, Figure 1A).

01 marzo 2013

JACC. FIRST: Fractional Flow Reserve and Intravascular Ultrasound Relationship Study

Ron Waksman, MD; Jacek Legutko, MD; Jasvindar Singh, MD; Quentin Orlando, DO; Steven Marso, MD; Timothy Schloss, MD; John Tugaoen, MD; James DeVries, MD; Nicholas Palmer, MD; Michael Haude, MD; Stacy Swymelar, BS; Rebecca Torguson, MPH

Objectives FIRST (Fractional Flow Reserve and Intravascular Ultrasound Relationship Study) aimed to determine the optimal minimum lumen area (MLA) by intravascular ultrasound (IVUS) that correlates with fractional flow reserve (FFR) and to assess the correlation between virtual histology IVUS and FFR for intermediate coronary lesions.

01 abril 2013

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Transcatheter Aortic Valve Implantation in Patients With Severe Left Ventricular Dysfunction. Immediate and Mid-Term Results, A Multicenter Study

Chiara Fraccaro, MD, Rasha Al-Lamee, MA, MRCP, Giuseppe Tarantini, MD, PhD, Francesco Maisano, MD, Massimo Napodano, MD, Matteo Montorfano, MD, Anna Chiara Frigo, MSc, Sabino Iliceto, MD, Gino Gerosa, MD, Giambattista Isabella, MD and Antonio Colombo, MD

Background—Few data exist about transcatheter aortic valve implantation (TAVI) in patients with low ejection fraction. The aim of the study was to analyze safety, feasibility, and efficacy of TAVI in patients with severe left ventricular dysfunction.

01 marzo 2012

CIRCULATION. Validation of the Bleeding Academic Research Consortium Definition of Bleeding in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention

Gjin Ndrepepa, MD; Tibor Schuster, PhD; Martin Hadamitzky, MD; Robert A. Byrne, MB, BCh; Julinda Mehilli, MD; Franz-Josef Neumann, MD; Gert Richardt, MD; Stefanie Schulz, MD; Karl-Ludwig Laugwitz, MD; Steffen Massberg, MD; Albert Schömig, MD; Adnan Kastrati, MD

Background—The Bleeding Academic Research Consortium (BARC) has recently proposed a unified definition of bleeding in patients receiving antithrombotic therapy. We investigated the relationship between bleeding events as defined by BARC and 1-year mortality in patients undergoing percutaneous coronary intervention (PCI) and assessed whether the BARC bleeding definition is superior to existing bleeding definitions in regard to mortality prediction in patients after PCI procedures.

01 abril 2012

CIRCULATION. Very Late Coronary Stent Thrombosis of a Newer-Generation Everolimus-Eluting Stent Compared With Early-Generation Drug-Eluting Stents

Lorenz Räber, MD; Michael Magro, MD; Giulio G. Stefanini, MD; Bindu Kalesan, MSc; Ron T. van Domburg, PhD; Yoshinobu Onuma, MD; Peter Wenaweser, MD; Joost Daemen, MD, PhD; Bernhard Meier, MD; Peter Jüni, MD; Patrick W. Serruys, MD, PhD; Stephan Windecker, MD

Background—Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring >1 year after stent implantation. It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents (EES).

01 febrero 2013

JACC. First-Generation Drug-Eluting Stents for Chronic Total OcclusionIn. Danger of Extinction?

Joachim Schofer, MD

An attempt to recanalize a chronic total occlusion (CTO) is only made in one-half of the patients presenting with an occluded vessel during angiography (1). Possible reasons for hesitating to perform a percutaneous coronary intervention (PCI) for a CTO may be the length and complexity of the procedure and the accordingly lower procedural success rate (2). Hence, patients with CTO are, in case of single-vessel disease, often managed medically or, in case of multivessel disease, are likely scheduled for bypass graft surgery even if the remaining lesions are suitable for PCI. In 2 randomized trials comparing coronary artery bypass surgery with PCI, CTO remains the strongest predictor of referral to bypass surgery rather than randomization ((3),4).

01 marzo 2013

JACC. Intravascular Ultrasound and Fractional Flow Reserve in Assessment of the Intermediate Coronary Stenosis

Goran Stankovic, MD, PhD; Milan Dobric, MD

Fractional flow reserve (FFR) may be regarded as a gold standard for the evaluation of the physiological significance of coronary stenosis in the catheterization laboratory with extensive validation in randomized, controlled trials (1). The beauty of FFR lies in its consistent ischemic threshold value that is valid for varying complexities of geometry and hemodynamics and provides us with the highly reproducible index on which we could base our clinical decisions (2).

01 abril 2012

EUROPEAN HEART JOURNAL. Comparison of drug-eluting stents with bare metal stents in patients with ST-segment elevation myocardial infarction

Bindu Kalesan, Thomas Pilgrim, Katja Heinimann, Lorenz Räber, Giulio G. Stefanini, Marco Valgimigli, Bruno R. da Costa, François Mach, Thomas F. Lüscher, Bernhard Meier, Stephan Windecker and Peter Jüni

Aims: To evaluate safety and effectiveness of early generation drug-eluting stents (DES) compared with bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), and to determine whether benefits and risks vary over time.

01 marzo 2013

AMERICAN HEART JOURNAL. Dynamic modeling of 90-day mortality in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention

Cynthia M. Westerhout, PhD , Karen S. Pieper, MS , Stefan K. James, MD, PhD , Kenneth W. Mahaffey, MD , Frans Van de Werf, MD, PhD , Robert M. Califf, MD, MACC , Christopher B. Granger, MD , Paul W. Armstrong, MD

Aims: Dynamic risk models update the risk profile of ST-elevation myocardial infarction (STEMI) patients over the acute period following the event and have implications to clinical practice and research.

01 marzo 2013

AMERICAN HEART JOURNAL. Comparison of costs between transradial and transfemoral percutaneous coronary intervention: A cohort analysis from the Premier research database

David M. Safley, MD , Amit P. Amin, MD, MSc , John A. House, MS , Dmitri Baklanov, MD , Rebecca Mills, MSM , Helmut Giersiefen, PhD , Andreas Bremer, PhD , Steven P. Marso, MD

Background: Transradial intervention (TRI) for percutaneous coronary intervention (PCI) is associated with shorter length of stay, fewer bleeding complications, and higher patient satisfaction. Less is known about the economic implications of TRI in contemporary practice.

01 marzo 2013

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS. A “modified crossover technique” for vascular access management in high-risk patients undergoing transfemoral transcatheter aortic valve implantation

Gill Louise Buchanan MBChB, Alaide Chieffo MD, Matteo Montorfano MD, Davide Maccagni RT, Francesco Maisano MD, Azeem Latib MD, Remo Daniel Covello MD, Antonio Grimaldi MD, Ottavio Alfieri MD, Antonio Colombo MD

Objectives: To describe results from our “modified crossover technique” for vascular access management during transcatheter aortic valve implantation (TAVI).

28 diciembre 2011

JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH. The Twelve-Month Outcome of Biolimus Eluting Stent with Biodegradable Polymer Compared With an Everolimus Eluting Stent with Durable Polymer

Ahmad Separham, Bahram Sohrabi, Naser Aslanabadi, Samad Ghaffari

Introduction: Drug-eluting stents (DES) have significantly decreased the need for repeat coronary revascularization but concerns remain regarding the safety of first and second generation DES. We compared the safety and efficacy of a biolimus-eluting stent (with biodegradable polymer) with an everolimus-eluting stent (with durable polymer) one

01 febrero 2012

EUROPEAN HEART JOURNAL. Prognostic impact of a chronic total occlusion in a non-infarct-related artery in patients with ST-segment elevation myocardial infarction: 3-year results from the HORIZONS-AMI trial

Bimmer E. Claessen, George D. Dangas, Giora Weisz, Bernhard Witzenbichler, Giulio Guagliumi, Martin Möckel, Sorin J. Brener, Ke Xu, José P.S. Henriques, Roxana Mehran and Gregg W. Stone

Aims: We sought to investigate the impact of multivessel disease (MVD) with and without a chronic total occlusion (CTO) in a non-infarct-related artery (IRA) on mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).