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ESTUDIOS


27 junio 2013

CIRCULATION. Valvular Heart Disease. Impact of Aortic Valve Replacement on Outcome of Symptomatic Patients With Severe Aortic Stenosis With Low Gradient and Preserved Left Ventricular Ejection Fraction

Alper Ozkan, MD; Rory Hachamovitch, MD, MS; Samir R. Kapadia, MD; E. Murat Tuzcu, MD; Thomas H. Marwick, MD, PhD, MPH

Background: The optimal management of low-gradient “severe” aortic stenosis (mean gradient <40 mm Hg, indexed aortic valve area ≤0.6 cm2/m2) with preserved left ventricular ejection fraction remains controversial because gradients may be similar after aortic valve replacement (AVR). We compared outcomes of low-gradient severe aortic stenosis with AVR or medical therapy.

15 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Renal Function–Adjusted Contrast Volume Redefines the Baseline Estimation of Contrast-Induced Acute Kidney Injury Risk in Patients Undergoing Primary Percutaneous Coronary Intervention

Giuseppe Andò, MD, PhD, Cesare de Gregorio, MD, Gaetano Morabito, MD, Olimpia Trio, MD, PhD, Francesco Saporito, MD and Giuseppe Oreto, MD

Background: Age, estimated glomerular renal function (eGFR), and ejection fraction are preprocedural predictors of contrast-induced acute kidney injury (CI-AKI) after primary percutaneous coronary intervention. The effect of renal function–adjusted contrast volume (CV) remains not totally explored, and a threshold has not yet been established.

29 julio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Artery Disease. Incidence and Outcome of Surgical Procedures After Coronary Artery Bypass Grafting Compared With Those After Percutaneous Coronary Intervention

Akihiro Tokushige, MD, Hiroki Shiomi, MD, Takeshi Morimoto, MD, Koh Ono, MD, Yutaka Furukawa, MD, Yoshihisa Nakagawa, MD, Kazushige Kadota, MD, Kenji Ando, MD, Satoshi Shizuta, MD, Tomohisa Tada, MD, Junichi Tazaki, MD, Yoshihiro Kato, MD, Mamoru Hayano, MD, Mitsuru Abe, MD, Shuichi Hamasaki, MD, Mitsuru Ohishi, MD, Hitoshi Nakashima, MD, Kazuaki Mitsudo, MD, Masakiyo Nobuyoshi, MD, Toru Kita, MD, Yutaka Imoto, MD, Ryuzo Sakata, MD, Hitoshi Okabayashi, MD, Michiya Hanyu, MD, Mitsuomi Shimamoto, MD, Noboru Nishiwaki, MD, Tatsuhiko Komiya, MD and Takeshi Kimura, MD; on behalf of the CREDO-Kyoto PCI/CABG Registry Cohort-2 Investigators

Background: Noncardiac surgery after percutaneous coronary intervention (PCI) has been reported to be carrying high risk for both ischemic and bleeding complications. However, there has been no report comparing the incidence and outcomes of surgical procedures after coronary artery bypass grafting (CABG) with those after PCI.

17 junio 2014

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Outcomes With Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Intervention for Patients With Diabetes Mellitus

Sripal Bangalore, MD, MHA, Bora Toklu, MD and Frederick Feit, MD

Background: Coronary artery bypass graft surgery (CABG) compared with percutaneous coronary intervention (PCI) reduces mortality in patients with diabetes mellitus. However, prior trials compared CABG with balloon angioplasty or older generation stents, and it is not known if the gap between CABG and PCI can be reduced by newer generation drug-eluting stents.

11 julio 2014

CIRCULATION. Coronary Computed Tomographic Angiography and Incidental Pulmonary Nodules

David A. Bluemke, MD, PhD

Incidental findings are an important topic in diagnostic imaging. Because of the comprehensive nature of computed tomography (CT) scanning, incidental findings are seemingly found on almost every CT scan performed for a wide variety of reasons in a radiology department. Many of these incidental findings such as a liver cyst are benign and immediately dismissed. Other findings require more extensive interpretation and management. In regard to coronary CT angiography (CCTA), a similar problem exists. Even though we have a primary interest in the heart, the CT scanner delivers radiation to all tissues of the chest such as the bones, lung parenchyma, and breast tissue. Extracardiac findings are reported to occur in 15% to 67% of CCTA examinations and the vast majority (≈80%) represent pulmonary nodules.

11 julio 2014

CIRCULATION. Health Services and Outcomes Research. Cost-Effectiveness of Follow-Up of Pulmonary Nodules Incidentally Detected on Cardiac Computed Tomographic Angiography in Patients With Suspected Coronary Artery Disease

Alexander Goehler, MD, PhD, MSc, MPH; Pamela M. McMahon, PhD; Heidi S. Lumish, BS; Carol C. Wu, MD; Vidit Munshi, BS; Michael Gilmore, MBA; Jonathan H. Chung, MD; Brian B. Ghoshhajra, MD, MBA; Daniel Mark, MD; Quynh A. Truong, MD, MPH; G. Scott Gazelle, MD, MPH, PHD; Udo Hoffmann, MD, MPH

Background: Pulmonary nodules (PNs) are often detected incidentally during coronary computed tomographic (CT) angiography, which is increasingly being used to evaluate patients with chest pain symptoms. However, the efficiency of following up on incidentally detected PN is unknown.

23 julio 2014

CIRCULATION. Cardiovascular Surgery. Practice Patterns and Clinical Outcomes After Hybrid Coronary Revascularization in the United States An Analysis From the Society of Thoracic Surgeons Adult Cardiac Database

Ralf E. Harskamp, MD; J. Matthew Brennan, MD, MPH; Ying Xian, MD, PhD; Michael E. Halkos, MD, MS; John D. Puskas, MD, MS; Vinod H. Thourani, MD; James S. Gammie, MD; Bradley S. Taylor, MD; Robbert J. de Winter, MD, PhD; Sunghee Kim, PhD; Sean O’Brien, PhD; Eric D. Peterson, MD, MPH; Jeffrey G. Gaca, MD

Background: Hybrid coronary revascularization (HCR) involves a combination of surgical and percutaneous techniques, which in selected patients may present an alternative to conventional coronary artery bypass grafting (CABG).

30 septiembre 2014

CIRCULATION. Coronary Revascularization in the Diabetic Patient

Johanne Silvain, MD, PhD; Jean-Baptiste Vignalou, MD; Olivier Barthélémy, MD; Mathieu Kerneis, MD; Jean-Philippe Collet, MD, PhD; Gilles Montalescot, MD, PhD

Background: Diabetes Mellitus and Coronary Artery Disease. Cardiovascular disease is the leading cause of morbidity and mortality in people with diabetes mellitus. Patients with diabetes mellitus have a 2- to 4-fold increase in risk of developing cardiovascular disease than those without diabetes mellitus, and also a 2- to 5-fold increase in mortality attributable to cardiovascular disease when compared with age- and sex-matched nondiabetic persons.1 Accelerated atherogenesis, blood abnormalities (altered platelet function, inflammation, hypofibrinolysis, and hypercoagulability), and myocardial vulnerability in diabetic patients are now considered as the causative factors for life-threatening cardiovascular events.

25 agosto 2014

CIRCULATION. An Aspirin a Day to Keep the Clots Away. Can Aspirin Prevent Recurrent Thrombosis in Extended Treatment for Venous Thromboembolism?

Thomas W. Wakefield, MD; Andrea T. Obi, MD; Peter K. Henke, MD

Patients presenting with deep vein thrombosis (DVT) in the absence of any identifiable risk factors are said to have an unprovoked or idiopathic DVT. Recurrent events are much more common in these patients (10% versus ≤ 3% at 1 year) compared with patients with a DVT provoked by a reversible risk factor, and such events represent a major healthcare problem.1 Three months of anticoagulation is sufficient to decrease the risk of recurrent thrombosis related to the initial DVT. However, once therapy is discontinued, the risk for recurrence rises dramatically. It has been suggested that 30% to 50% of patients experience a recurrence at 10 years.2,3 Factors associated with a higher likelihood of recurrence are male sex, elevated D dimer, incomplete resolution of DVT, body mass index ≥30, and post-thrombotic syndrome.4 In fact, a number of tools have been developed to determine the risk of recurrence after DVT.

25 agosto 2014

CIRCULATION. Vascular Medicine. Aspirin for the Prevention of Recurrent Venous Thromboembolism

John Simes, MD; Cecilia Becattini, MD; Giancarlo Agnelli, MD; John W. Eikelboom, MB, BS; Adrienne C. Kirby, MSc; Rebecca Mister, MSc; Paolo Prandoni, MD; Timothy A. Brighton, MB, BS; for the INSPIRE Study Investigators* (International Collaboration of Aspirin Trials for Recurrent Venous Thromboembolism)

Background: In patients with a first unprovoked venous thromboembolism (VTE) the risk of recurrent VTE remains high after anticoagulant treatment is discontinued. The Aspirin for the Prevention of Recurrent Venous Thromboembolism (the Warfarin and Aspirin [WARFASA]) and the Aspirin to Prevent Recurrent Venous Thromboembolism (ASPIRE) trials showed that aspirin reduces this risk, but they were not individually powered to detect treatment effects for particular outcomes or subgroups.

14 agosto 2013

CIRCULATION. Interventional Cardiology. Cost-Effectiveness of Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease and Abnormal Fractional Flow Reserve

William F. Fearon, MD; David Shilane, PhD; Nico H.J. Pijls, MD, PhD; Derek B. Boothroyd, PhD; Pim A.L. Tonino, MD, PhD; Emanuele Barbato, MD, PhD; Peter Jüni, MD; Bernard De Bruyne, MD, PhD; Mark A. Hlatky, MD; on behalf of the Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 2 (FAME 2) Investigators

Background: The Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) 2 trial demonstrated a significant reduction in subsequent coronary revascularization among patients with stable angina and at least 1 coronary lesion with a fractional flow reserve ≤0.80 who were randomized to percutaneous coronary intervention (PCI) compared with best medical therapy. The economic and quality-of-life implications of PCI in the setting of an abnormal fractional flow reserve are unknown.

30 septiembre 2014

CIRCULATION. Surgery for Valvular Heart Disease. Outcome and Impact of Surgery in Paradoxical Low-Flow, Low-Gradient Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction. A Cardiac Catheterization Study

Dania Mohty, MD, PhD; Julien Magne, PhD; Mathieu Deltreuil, MD; Victor Aboyans, MD, PhD; Najmeddine Echahidi, MD; Claude Cassat, MD; Philippe Pibarot, DvM, PhD; Marc Laskar, MD; Patrice Virot, MD

Background: The clinical relevance and management of paradoxical low-flow, low-gradient aortic stenosis (LFLG-AS) with preserved left ventricular ejection fraction remain debated. The aim of this study is to determine the features and outcome of LFLG-AS assessed using cardiac catheterization.

14 agosto 2013

CIRCULATION. Health Services and Outcomes Research. Association of Early Physician Follow-Up and 30-Day Readmission After Non–ST-Segment–Elevation Myocardial Infarction Among Older Patients

Connie N. Hess, MD, MHS; Bimal R. Shah, MD, MBA; S. Andrew Peng, MS; Laine Thomas, PhD; Matthew T. Roe, MD, MHS; Eric D. Peterson, MD, MPH

Background: Hospital readmission rates within 30 days after acute myocardial infarction are a national performance metric. Previous data suggest that early physician follow-up after heart failure hospitalizations can reduce readmissions; whether these results can be extended to acute myocardial infarction is unclear.

30 septiembre 2014

CIRCULATION. Contemporary Reviews in Cardiovascular Medicine. Characterization of Coronary Atherosclerosis by Magnetic Resonance Imaging

Marcus R. Makowski, MD, PhD; Markus Henningsson, PhD; Elmar Spuentrup, MD; W. Yong Kim, MD; David Maintz, MD; Warren J. Manning, MD; René M. Botnar, PhD

Introduction: Coronary atherosclerosis remains the major cause of mortality in industrialized and developing nations.1 Clinical risk-scoring systems do not allow satisfactory identification of individuals with subclinical disease and at high risk for coronary events.2 Novel approaches to more reliably identify asymptomatic individuals at high risk for future cardiovascular events are therefore urgently needed.

27 agosto 2014

WORLD JOURNAL OF RADIOLOGY. Coronary venous system in cardiac computer tomography: Visualization, classification and role

Rafal Mlynarski, Agnieszka Mlynarska and Maciej Sosnowski.

The role of the coronary venous system was underestimated for many years. In the last 20 years, a few percutaneous cardiology techniques in which the anatomy of the coronary venous system was significant were developed and are in use. The most important seems to be cardiac resynchronization therapy, which is an invasive method for the treatment of heart failure. Unfortunately, one of the major problems is the significant anatomical variability of the coronary venous system. The description of the selected anatomical structures is only useful in selected cases such as, for example, the obstruction of selected vessels, a huge Thebesian valve, etc. The 3D images can add significant value; however, their usefulness is limited due to the different points of view that are obtained during intra-operational fluoroscopy. After summarizing all of the articles and guidelines, it can be recommended that the visualization of the coronary venous system be performed in certain patients before cardiac resynchronization. The best option is to use tomography with retrospective gating with the optimal reconstruction of cardiac veins that occurs during the diastolic phases.

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