21 junio 2016

STROKE. Brief Report. Predictors of Restenosis Following Carotid Angioplasty and Stenting

Elena Zapata-Arriaza, MD; Francisco Moniche, MD, PhD; Alejandro González, MD, PhD; Alejandro Bustamante, MD; Irene Escudero-Martínez, MD; Francisco Javier De la Torre Laviana, MD; María Prieto, MD; Fernando Mancha, PhD; Joan Montaner, MD, PhD

Background and Purpose: Restenosis after carotid angioplasty (with or without stent) is associated with increased rate of stroke and death. Our aim was to determine risk and predictive factors related to carotid restenosis post carotid angioplasty and its association to recurrent cerebrovascular events.

21 junio 2016

STROKE. Brief Report. Influence of Distance to Scene on Time to Thrombolysis in a Specialized Stroke Ambulance

Peter M. Koch, MD; Alexander Kunz, MD; Martin Ebinger, MD; Frederik Geisler, MD; Michal Rozanski, MD; Carolin Waldschmidt, MD; Joachim E. Weber, MD; Matthias Wendt, MD; Benjamin Winter, MD; Katja Zieschang, MD; Kerstin Bollweg, PhD; Sabina Kaczmarek; Matthias Endres, MD; Heinrich J. Audebert, MD

Background and Purpose: Specialized computed tomography–equipped stroke ambulances shorten time to intravenous thrombolysis in acute ischemic stroke by starting treatment before hospital arrival. Because of longer travel-time-to-scene, time benefits of this concept are expected to diminish with longer distances from base station to scene.

12 julio 2016

STROKE. Clinical Sciences. Family History and Risk of Recurrent Stroke

Jong-Won Chung, MD, MSc; Beom Joon Kim, MD, PhD; Moon-Ku Han, MD, PhD; Kyusik Kang, MD, PhD; Jong-Moo Park, MD, PhD; Sang-Soon Park, MD, PhD; Tai Hwan Park, MD, PhD; Yong-Jin Cho, MD, PhD; Keun-Sik Hong, MD, PhD; Kyung Bok Lee, MD, PhD; Jae Guk Kim, MD, PhD; Youngchai Ko, MD, PhD; SooJoo Lee, MD, PhD; Hyun-Wook Nah, MD, PhD; Dae-Hyun Kim, MD, PhD; Jae-Kwan Cha, MD, PhD; Mi-Sun Oh, MD, PhD; Kyung-Ho Yu, MD, PhD; Byung-Chul Lee, MD, PhD; Myung Suk Jang, AS; Ji Sung Lee, PhD; Juneyoung Lee, PhD; Hee-Joon Bae, MD, PhD; on behalf of the CRCS-5 Investigators

Background and Purpose: The association between family history of stroke and stroke recurrence remains unclear.

01 julio 2016

THE LANCET. Neurology. Dementia risk after spontaneous intracerebral haemorrhage: a prospective cohort study

Solène Moulin, MD, Julien Labreuche, Bst, Stéphanie Bombois, PhD, Costanza Rossi, PhD, Gregoire Boulouis, MD, Hilde Hénon, PhD, Prof Alain Duhamel, PhD, Prof Didier Leys, PhD, Prof Charlotte Cordonnier, PhD

Background: Dementia occurs in at least 10% of patients within 1 year after stroke. However, the risk of dementia after spontaneous intracerebral haemorrhage that accounts for about 15% of all strokes has not been investigated in prospective studies. We aimed to determine the incidence of dementia and risk factors after an intracerebral haemorrhage.

01 junio 2016

THE LANCET. Neurology. Effect of baseline Alberta Stroke Program Early CT Score on safety and efficacy of intra-arterial treatment: a subgroup analysis of a randomised phase 3 trial (MR CLEAN)

Dr Albert J Yoo, MD, Olvert A Berkhemer, MD*, Puck S S Fransen, MD, Lucie A van den Berg, MD, Debbie Beumer, MD, Hester F Lingsma, PhD, Wouter J Schonewille, MD, Marieke E S Sprengers, MD, René van den Berg, MD, Marianne A A van Walderveen, MD, Ludo F M Beenen, MD, Marieke J H Wermer, MD, Geert J Lycklama à Nijeholt, MD, Jelis Boiten, MD, Sjoerd F M Jenniskens, MD, Joseph C J Bot, MD, Anna M M Boers, MSc, Henk A Marquering, PhD, Prof Yvo B W E M Roos, MD†, Prof Robert J van Oostenbrugge, MD†, Prof Diederik W J Dippel, MD†, Prof Aad van der Lugt, MD†, Wim H van Zwam, MD†, Prof Charles B L M Majoie, MD† for the MR CLEAN investigators

Background: Whether infarct size modifies intra-arterial treatment effect is not certain, particularly in patients with large infarcts. We examined the effect of the baseline Alberta Stroke Program Early CT Score (ASPECTS) on the safety and efficacy of intra-arterial treatment in a subgroup analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN).

01 junio 2016

THE LANCET. Neurology. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium the Stroke Genetics Network (SiGN) and the International Stroke Genetics Consortium (ISGC)†

Background: Genetic determinants of stroke, the leading neurological cause of death and disability, are poorly understood and have seldom been explored in the general population. Our aim was to identify additional loci for stroke by doing a meta-analysis of genome-wide association studies.

07 junio 2016

STROKE. Clinical Sciences. Hemorrhagic Reversible Cerebral Vasoconstriction Syndrome. Features and Mechanisms

Mehmet A. Topcuoglu, MD; Aneesh B. Singhal, MD

Background and Purpose: To compare hemorrhagic and nonhemorrhagic reversible cerebral vasoconstriction syndromes (RCVS) with a view to understand mechanisms.

14 junio 2016

STROKE. Clinical Sciences. Interaction of Recanalization, Intracerebral Hemorrhage, and Cerebral Edema After Intravenous Thrombolysis

Bharath Kumar Cheripelli, MRCP; Xuya Huang, MRCP; Rachael MacIsaac, PhD; Keith W. Muir, MD, FRCP

Background and Purpose: Both intracerebral hemorrhage (ICH) and brain edema have been attributed to reperfusion after intravenous thrombolysis. We explored the interaction of recanalization and core size for imaging outcomes (ICH and vasogenic brain edema).

12 mayo 2016

STROKE. Clinical Sciences. Impact of Target Arterial Residual Stenosis on Outcome After Endovascular Revascularization

Yang-Ha Hwang, MD, PhD; Yong-Won Kim, MD; Dong-Hun Kang, MD; Yong-Sun Kim, MD, PhD; David S. Liebeskind, MD

Background and Purpose: Acute intracranial occlusion can be associated with in situ thrombo-occlusion in relation to preexisting intracranial atherosclerotic disease. We aimed to assess residual stenosis at the site of a target arterial lesion (TAL) to determine whether residual stenosis at the TAL is associated with underlying intracranial atherosclerotic disease.

19 mayo 2016

STROKE. Endovascular Hypothermia in Acute Ischemic Stroke. Pilot Study of Selective Intra-Arterial Cold Saline Infusion

Jian Chen, MD*; Liqiang Liu, MD*; Hongqi Zhang, MD; Xiaokun Geng, MD; Liqun Jiao, MD; Guilin Li, MD; Jonathan M. Coutinho, MD; Yuchuan Ding, MD, PhD; David S. Liebeskind, MD; Xunming Ji, MD

Background and Purpose: We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke.

26 abril 2016

STROKE. Clinical Sciences. Recanalization Modulates Association Between Blood Pressure and Functional Outcome in Acute Ischemic Stroke

Ana Inês Martins, MD; João Sargento-Freitas, MD; Fernando Silva, MD; Joana Jesus-Ribeiro, MD; Inês Correia, MD; João Pedro Gomes, MD; Mariana Aguiar-Gonçalves, MD; Leila Cardoso, MD; Cristina Machado, MD; Bruno Rodrigues, MD; Gustavo C. Santo, MD; Luís Cunha, MD, PhD

Background and Purpose: Historical stroke cohorts reported a U- or J-shaped relationship between blood pressure (BP) and clinical outcome. However, these studies predated current revascularization strategies, disregarding the recanalization state of the affected arterial territory. We aimed to investigate the relationship between BP in the first 24 hours after ischemic stroke and clinical outcome in patients submitted to intravenous or intra-arterial recanalization treatments.

05 mayo 2016

STROKE. Clinical Sciences. Outcome After Thrombectomy and Intravenous Thrombolysis in Patients With Acute Ischemic Stroke. A Prospective Observational Study

Jens Minnerup, MD*; Heike Wersching, MD, MSc*; Anja Teuber, MSc; Jürgen Wellmann, PhD; Jens Eyding, MD; Ralph Weber, MD; Gernot Reimann, MD; Werner Weber, MD; Lars Udo Krause, MD; Tobias Kurth, MD, ScD; Klaus Berger, MD, MPH, MSc, for the REVASK Investigators†

Background and Purpose: In patients with ischemic stroke, randomized trials showed a better functional outcome after endovascular therapy with new-generation thrombectomy devices compared with medical treatment, including intravenous thrombolysis. However, effects on mortality and the generalizability of results to routine clinical practice are uncertain.

28 abril 2016

STROKE. Basic Sciences. Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage

Shenglong Cao, MD; Mingzhe Zheng, MD, PhD; Ya Hua, MD; Gao Chen, MD, PhD; Richard F. Keep, PhD; Guohua Xi, MD

Background and Purpose: Hematoma clearance occurs in the days after intracerebral hemorrhage (ICH) and has not been well studied. In the current study, we examined changes in the hematoma in a piglet ICH model. The effect of deferoxamine on hematoma was also examined.

05 mayo 2016

STROKE. Carotid Atherosclerosis and Stroke in Atrial Fibrillation. The Atherosclerosis Risk in Communities Study

Wobo Bekwelem, MD, MPH; Paul N. Jensen, PhD, MPH; Faye L. Norby, MS, MPH; Elsayed Z. Soliman, MD, MSc, MS; Sunil K. Agarwal, MD, MPH, PhD; Gregory Y.H. Lip, MD; Wei Pan, PhD; Aaron R. Folsom, MD, MPH; W.T. Longstreth Jr, MD; Alvaro Alonso, MD, PhD; Susan R. Heckbert, MD, PhD; Lin Y. Chen, MD, MS

Background and Purpose: Whether consideration of carotid intima-media thickness (cIMT) and carotid plaque would improve risk prediction of ischemic stroke in persons with atrial fibrillation (AF) is unknown. The purpose of this study was to assess the improvement in risk prediction of stroke by adding cIMT and carotid plaque to the CHA2DS2-VASc (variables age, heart failure, hypertension, diabetes mellitus, myocardial infarction, and peripheral arterial disease) score.

19 abril 2016

STROKE. Mechanical Thrombectomy Improves Functional Outcomes Independent of Pretreatment With Intravenous Thrombolysis

Georgios Tsivgoulis, MD; Aristeidis H. Katsanos, MD; Dimitris Mavridis, PhD; Georgios Magoufis, ΜD; Adam Arthur, MD, MPH; Andrei V. Alexandrov, MD

Background and Purpose: Endovascular intervention for emergent large-vessel occlusion (ELVO) has evolved rapidly during the past decade. The question of whether pretreatment with intravenous thrombolysis (IVT) has a significant impact on the functional outcome of patients with ELVO still remains unanswered.