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ESTUDIOS


01 enero 2015

ENDOVASCULAR TODAY. Vascular Healing After Arterial Access: A Histopathological Comparison of Standard Seldinger Versus a Novel Access Technology

Rahul S. Patel, MD; Renu Virmani, MD; Frank D. Kolodgie, PhD; Debra Cogan, RN; and Zoltan Turi, MD

With the introduction of percutaneous arterial access by Seldinger in 1953, the need for surgical arteriotomy was eliminated.1 However, potential trauma to the artery from needle puncture, the introduction of multiple catheters, and the process of closure was recognized early and has, to some degree, remained unresolved for 60 years. Manual compression is generally effective for closure, but it has a number of undesirable features, including discomfort, risks associated with stasis in the artery and adjacent vein during vessel occlusion, and the substantial inflammatory response associated with arteries subjected to manual compression.2 A number of alternatives to manual compression have been introduced. Unfortunately, despite several generations of device development, the most recent studies of these devices still demonstrate that the optimal solution for arterial closure has not been achieved by the deposition of clips, plugs, or sutures into the arterial tract. Acute arterial complications, as well as the histopathological sequelae caused by closure device debris left behind in the arterial system and tissue tract, have been well documented.3 In general, review of the literature and the FDA MAUDE (Manufacturer and User Facility Device Experience) database demonstrates that vascular closure device (VCD) use exposes patients to risks of bleeding, infection, and vessel obstruction among others.

01 enero 2015

ENDOVASCULAR TODAY. Behind the BEST-CLI Trial

Principal Investigators Alik Farber, MD; Matthew T. Menard, MD; and Kenneth Rosenfield, MD, discuss the structure and origins of this study comparing best endovascular and surgical options for critical limb ischemia.

In fall 2014, investigators began enrolling patients in BEST-CLI, a prospective, multicenter, randomized trial comparing “best endovascular” versus “best surgical” options for treating critical limb ischemia (CLI). The trial is funded by the National Institutes of Health and aims to enroll 2,100 patients at 120 centers in North America over the next 4 years.

01 enero 2015

ENDOVASCULAR TODAY. A Brief Discussion of the Midterm Results Using Onyx™ Liquid Embolic System in Treating Persistent Type II Endoleaks After EVAR

Michel Bosiers, MD; Arne Schwindt, MD; Konstantinos P. Donas, MD, PhD; Giovanni Torsello, MD, PhD

We retrospectively reviewed our prospectively maintained database in search of patients who, until December 2011, had persistent type II endoleaks, with growth of their aneurysm diameter of > 5 mm and were treated with Onyx™ liquid embolic system.

01 enero 2015

ENDOVASCULAR TODAY. Reduction of CT Beam Hardening Artifacts of Ethylene-Vinyl Alcohol Copolymer by Variation of the Tantalum Content

Marcus Treitl, MD

As Onyx™ was initially approved for embolization of intracranial pathologies, its high tantalum content (TC) ensured fluoroscopic contrast despite the high x-ray absorption of the braincase. Tantalum, however, causes relevant beam hardening artifacts in CT examinations that might limit diagnostic information of any follow-up imaging. We developed an aortic phantom to simulate treatment and follow-up imaging of endoleaks, and assessed the diagnostic performance of Onyx™ liquid embolic system formulations with different, reduced TCs in order to determine a tantalum dosage that interferes less with diagnostic CT imaging, but still enables fluoroscopic visualization during embolization.

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