01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Incidence and Predictors of Debris Embolizing to the Brain During Transcatheter Aortic Valve Implantation

Nicolas M. Van Mieghem, MD, PhD∗; Nahid El Faquir, BSc∗; Zouhair Rahhab, BSc∗; Ramón Rodríguez-Olivares, MD∗; Jeroen Wilschut, MD∗; Mohamed Ouhlous, MD, PhD†; Tjebbe W. Galema, MD, PhD∗; Marcel L. Geleijnse, MD, PhD∗; Arie-Pieter Kappetein, MD, PhD‡; Marguerite E.I. Schipper, MD, PhD§; Peter P. de Jaegere, MD, PhD∗

Objectives: The aim of this study was to identify variables associated with tissue fragment embolization during transcatheter aortic valve replacement (TAVR).

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Clinical Outcomes and Revascularization Strategies in Patients With Low-Flow, Low-Gradient Severe Aortic Valve Stenosis According to the Assigned Treatment Modality

Crochan J. O’Sullivan, MD∗; Lars Englberger, MD‡; Nicola Hosek, MS∗; Dik Heg, PhD§; Davide Cao, MD∗; Giulio G. Stefanini, MD∗; Stefan Stortecky, MD∗; Steffen Gloekler, MD∗; Ernest Spitzer, MD∗; David Tüller, MD†; Christoph Huber, MD‡; Thomas Pilgrim, MD∗; Fabien Praz, MD∗; Lutz Buellesfeld, MD∗; Ahmed A. Khattab, MD∗; Thierry Carrel, MD‡; Bernhard Meier, MD∗; Stephan Windecker, MD∗; Peter Wenaweser, MD∗

Objectives: This study compared clinical outcomes and revascularization strategies among patients presenting with low ejection fraction, low-gradient (LEF-LG) severe aortic stenosis (AS) according to the assigned treatment modality.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Treatment of Acquired von Willebrand Syndrome in Aortic Stenosis With Transcatheter Aortic Valve Replacement

Tobias Spangenberg, MD∗; Ulrich Budde, MD†; Dimitry Schewel, MD∗; Christian Frerker, MD∗; Thomas Thielsen, MD∗; Karl-Heinz Kuck, MD∗; Ulrich Schäfer, MD∗

Objectives: This study sought to investigate the prevalence of abnormal von Willebrand multimers (AbM) in patients undergoing transcatheter aortic valve replacement (TAVR) and the impact of TAVR on the underlying factor variances.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Long-Term Outcomes of Percutaneous Paravalvular Regurgitation Closure After Transcatheter Aortic Valve Replacement

Francesco Saia, MD, PhD∗; Claudia Martinez, MD†; Sameer Gafoor, MD‡; Vikas Singh, MD†; Cristina Ciuca, MD∗; Ilona Hofmann, MD‡; Cinzia Marrozzini, MD∗; John Tan, MD§; John Webb, MD§; Horst Sievert, MD, PhD‡; Antonio Marzocchi, MD∗; William W. O’Neill, MD‖

Objectives: This study sought to evaluate acute and long-term outcomes of percutaneous paravalvular regurgitation (PVR) closure after transcatheter aortic valve replacement (TAVR).

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Surgical Sutureless and Transcatheter Aortic Valves. Hemodynamic Performance and Clinical Outcomes in Propensity Score-Matched High-Risk Populations With Severe Aortic Stenosis

Vasileios Kamperidis, MD, MSc, PhD∗; Philippe J. van Rosendael, MD∗; Arend de Weger, MD‡; Spyridon Katsanos, MD, PhD∗; Madelien Regeer, MD∗; Frank van der Kley, MD∗; Bart Mertens, PhD§; Georgios Sianos, MD, PhD†; Nina Ajmone Marsan, MD, PhD∗; Jeroen J. Bax, MD, PhD∗; Victoria Delgado, MD, PhD∗

Objectives: In propensity score–matched patients with severe aortic stenosis treated with surgical aortic valve replacement (AVR) with the 3f Enable sutureless prosthesis (Medtronic, Minneapolis, Minnesota) or transcatheter aortic valve replacement (TAVR), the hemodynamic performance of both valves and mid-term survival of patients were evaluated.

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Outcomes With Cangrelor Versus Clopidogrel on a Background of Bivalirudin. Insights From the CHAMPION PHOENIX (A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI])

Harvey D. White, DSc∗; Deepak L. Bhatt, MD, MPH†; C. Michael Gibson, MD‡; Christian W. Hamm, MD§; Kenneth W. Mahaffey, MD‖; Matthew J. Price, MD¶; Ph. Gabriel Steg, MD#; Gregg W. Stone, MD§§; Bernardo Cortese, MD‖‖; Michael Wilensky, MD¶¶; Efthymios N. Deliargyris, MD##; Tiepu Liu, MD, PhD##; Jayne Prats, PhD##; Robert A. Harrington, MD‖

Objectives: The aim of this study was to examine the efficacy and bleeding outcomes of cangrelor in patients in the CHAMPION PHOENIX (A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI]) who underwent percutaneous coronary intervention with bivalirudin.

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Blood Transfusion After Percutaneous Coronary Intervention and Risk of Subsequent Adverse Outcomes. A Systematic Review and Meta-Analysis

Chun Shing Kwok, MBBS∗; Matthew W. Sherwood, MD†; Sarah M. Watson, MBChB‡; Samina B. Nasir, MBChB‡; Matt Sperrin, PhD§; Jim Nolan, MD‖; Tim Kinnaird, MBBCh¶; Songsak Kiatchoosakun, MD#; Peter F. Ludman, MD∗∗; Mark A. de Belder, MD††; Sunil V. Rao, MD†; Mamas A. Mamas, BM BCh, DPhil∗

Objectives: This study sought to define the prevalence and prognostic impact of blood transfusions in contemporary percutaneous coronary intervention (PCI) practice.

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Persistence of Iatrogenic Atrial Septal Defect After Interventional Mitral Valve Repair With the MitraClip System

Robert Schueler, MD∗; Can Öztürk, MD∗; Jan Arne Wedekind, MD†; Nikos Werner, MD∗; Florian Stöckigt, MD∗; Fritz Mellert, MD‡; Georg Nickenig, MD∗; Christoph Hammerstingl, MD∗

Objectives: The purpose of this study was to investigate the persistence rates of iatrogenic atrial septal defect (iASD) after interventional edge-to-edge repair with serial transesophageal echocardiography examinations and close clinical follow-up (FU).

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Incidence and Severity of Paravalvular Aortic Regurgitation With Multidetector Computed Tomography Nominal Area Oversizing or Undersizing After Transcatheter Heart Valve Replacement With the Sapien 3

Tae-Hyun Yang, MD∗; John G. Webb, MD∗; Philipp Blanke, MD∗; Danny Dvir, MD∗; Nicolaj C. Hansson, MD‡; Bjarne L. Nørgaard, MD‡; Christopher R. Thompson, MD∗; Martyn Thomas, MD§; Olaf Wendler, MD‖; Alec Vahanian, MD¶; Dominique Himbert, MD¶; Susheel K. Kodali, MD#; Rebecca T. Hahn, MD#; Vinod H. Thourani, MD∗∗; Gerhard Schymik, MD††; Bruce Precious, MD∗; Adam Berger, MD∗; David A. Wood, MD∗; Philippe Pibarot, MD‡‡; Josep Rodés-Cabau, MD‡‡; Wael A. Jaber, MD§§; Martin B. Leon, MD#; Thomas Walther, MD‖‖; Jonathon Leipsic, MD∗

Objectives: This study sought to compare the influence of the extent of multidetector computed tomography (MDCT) area oversizing on the incidence of paravalvular aortic regurgitation (PAR) between the Sapien 3 and the Sapien XT transcatheter heart valve (THV) to define a new MDCT sizing guideline suitable for the Sapien 3 platform.

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Comparison Among Drug-Eluting Balloon, Drug-Eluting Stent, and Plain Balloon Angioplasty for the Treatment of In-Stent Restenosis. A Network Meta-Analysis of 11 Randomized, Controlled Trials

Joo Myung Lee, MD, MPH∗; Jonghanne Park, MD∗; Jeehoon Kang, MD∗; Ki-Hyun Jeon, MD∗; Ji-hyun Jung, MD∗; Sang Eun Lee, MD, PhD∗; Jung-Kyu Han, MD, PhD∗; Hack-Lyoung Kim, MD, PhD†; Han-Mo Yang, MD, PhD∗; Kyung Woo Park, MD, PhD∗; Hyun-Jae Kang, MD, PhD∗; Bon-Kwon Koo, MD, PhD∗; Hyo-Soo Kim, MD, PhD∗

Objectives: A Bayesian network meta-analysis was performed comparing the efficacy and safety of drug-eluting balloons (DEB), drug-eluting stents (DES), or plain old balloon angioplasty (POBA) for treatment of in-stent restenosis (ISR).

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. The Impact of Downstream Coronary Stenosis on Fractional Flow Reserve Assessment of Intermediate Left Main Coronary Artery Disease

William F. Fearon, MD∗; Andy S. Yong, MBBS, PhD∗; Guy Lenders, MD†; Gabor G. Toth, MD‡; Catherine Dao, MD∗; David V. Daniels, MD∗; Nico H.J. Pijls, MD, PhD†; Bernard De Bruyne, MD, PhD‡

Objectives: The aim of this study was to determine the impact of downstream coronary stenosis in the left anterior descending coronary artery (LAD) or left circumflex coronary artery (LCx) on the assessment of fractional flow reserve (FFR) across an intermediate left main coronary artery (LMCA) stenosis in humans with the pressure wire positioned in the nondiseased downstream vessel.

01 marzo 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Thrombotic Complications Associated With Early and Late Nonadherence to Dual Antiplatelet Therapy

Donald E. Cutlip, MD∗; Dean J. Kereiakes, MD‡; Laura Mauri, MD, MSc†; Robert Stoler, MD‖; Harold L. Dauerman, MD¶

Objectives: This study sought to assess the frequency and clinical impact of dual antiplatelet therapy (DAPT) nonadherence.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Provisional T-Stenting With Bioresorbable Vascular Scaffolds In Vivo. Insights From Optical Frequency Domain Imaging

Toru Naganuma, MD∗; Hisaaki Ishiguro, MD†; Kensuke Takagi, MD†; Yusuke Fujino, MD†; Satoru Mitomo, MD†; Shotaro Nakamura, MD†; Sunao Nakamura, MD†; Antonio Colombo, MD∗

Provisional single-stenting is the preferred strategy for the treatment of coronary bifurcation lesions (1). In cases where the side branch (SB) suffers from flow compromise following main-branch (MB) stenting, stent implantation in the SB ought to be considered (2). Currently, the use of bioresorbable vascular scaffolds (BVS) (Abbott Vascular, Santa Clara, California) is expanding from simple to complex lesions including those at bifurcation sites. Bench testing has suggested that dilation with a small balloon toward the SB through the MB BVS is acceptable, although in vivo data are limited (3). We report the optical frequency domain imaging (Terumo Corp., Tokyo, Japan) of BVS implantation in vivo obtained at each step of the provisional T-stenting technique.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Long-Term Outcome After Transcatheter Closure of Atrial Septal Defect in Older Patients

Yoichi Takaya, MD∗; Teiji Akagi, MD†; Yasufumi Kijima, MD∗; Koji Nakagawa, MD∗; Shunji Sano, MD‡; Hiroshi Ito, MD∗

Objectives: This study assessed long-term outcome after transcatheter atrial septal defect (ASD) closure in older patients, especially those older than 75 years of age.

01 abril 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Tricuspid Regurgitation Is Associated With Increased Risk of Mortality in Patients With Low-Flow Low-Gradient Aortic Stenosis and Reduced Ejection Fraction

Abdellaziz Dahou, MD, MSc∗; Julien Magne, PhD†; Marie-Annick Clavel, DVM, PhD∗; Romain Capoulade, PhD∗; Philipp Emanuel Bartko, MD, PhD§; Jutta Bergler-Klein, MD§; Mario Sénéchal, MD∗; Gerald Mundigler, MD§; Ian Burwash, MD‖; Henrique B. Ribeiro, MD∗; Kim O’Connor, MD∗; Patrick Mathieu, MD∗; Helmut Baumgartner, MD¶; Jean G. Dumesnil, MD∗; Raphael Rosenhek, MD§; Eric Larose, MD∗; Josep Rodés-Cabau, MD∗; Philippe Pibarot, DVM, PhD∗

Objectives: This study sought to examine the impact of tricuspid regurgitation (TR) on mortality in patients with low-flow, low-gradient (LF-LG) aortic stenosis (AS) and reduced left ventricular ejection fraction (LVEF).