01 julio 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Safety of Prasugrel Loading Doses in Patients Pre-Loaded With Clopidogrel in the Setting of Primary Percutaneous Coronary Intervention. Results of a Nonrandomized Observational Study

Lorenz Räber, MD, PhD∗; Roland Klingenberg, MD†; Dik Heg, PhD‡; Henning Kelbæk, MD§; Marco Roffi, MD‖; David Tüller, MD¶; Andreas Baumbach, MD#; Thomas Zanchin, MD∗; David Carballo, MD‖; Miodrag Ostojic, MD, PhD∗∗; Giulio G. Stefanini, MD, PhD∗; Nicolas Rodondi, MD††; Clemens von Birgelen, MD, PhD‡‡; Aris Moschovitis, MD∗; Thomas Engstrøm, MD§; Baris Gencer, MD‖; Reto Auer, MD§§; Bernhard Meier, MD∗; Francois Mach, MD‖; Thomas F. Lüscher, MD∗; Peter Jüni, MD‡; Christian M. Matter, MD†; Stephan Windecker, MD∗

Objectives: The aim of this study was to assess the safety of the concurrent administration of a clopidogrel and prasugrel loading dose in patients undergoing primary percutaneous coronary intervention.

01 julio 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Pharmacodynamic Effects of Ticagrelor Dosing Regimens in Patients on Maintenance Ticagrelor Therapy. Results From a Prospective, Randomized, Double-Blind Investigation

Jung Rae Cho, MD; Fabiana Rollini, MD; Francesco Franchi, MD; Christopher DeGroat, MD; Mona Bhatti, MD; Elizabeth C. Dunn, RN; Elisabetta Ferrante, PhD; Ana Muniz-Lozano, MD; Siva Suryadevara, MD; Martin M. Zenni, MD; Luis A. Guzman, MD; Theodore A. Bass, MD; Dominick J. Angiolillo, MD, PhD

Objectives: The aim of this study was to assess the impact of ticagrelor dosing regimens on pharmacodynamic (PD) profiles in patients on maintenance ticagrelor therapy.

01 julio 2015

JACC: CARDIOVASCULAR INTERVENTIONS. 5-Year Outcomes After Transcatheter Aortic Valve Implantation With CoreValve Prosthesis

Marco Barbanti, MD∗; Anna Sonia Petronio, MD‡; Federica Ettori, MD§; Azeem Latib, MD‖; Francesco Bedogni, MD¶; Federico De Marco, MD#; Arnaldo Poli, MD∗∗; Carla Boschetti, MD††; Marco De Carlo, MD‡; Claudia Fiorina, MD§; Antonio Colombo, MD‖; Nedy Brambilla, MD¶; Giuseppe Bruschi, MD#; Paola Martina, MD∗∗; Claudia Pandolfi, MD††; Cristina Giannini, MD‡; Salvatore Curello, MD§; Carmelo Sgroi, MD∗; Simona Gulino, MD∗; Martina Patanè, MD∗; Yohei Ohno, MD∗; Claudia Tamburino, MD∗; Guilherme F. Attizzani, MD∗; Sebastiano Immè, MD∗; Alessandra Gentili, MS‡‡; Corrado Tamburino, MD, PhD∗

Objectives: The purpose of this analysis was to assess 5-year outcomes of transcatheter aortic valve implantation (TAVI) using the current technology of the self-expanding CoreValve prosthesis (Medtronic Inc., Minneapolis, Minnesota).

01 julio 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Treatment of Heart Failure With Associated Functional Mitral Regurgitation Using the ARTO System. Initial Results of the First-in-Human MAVERIC Trial (Mitral Valve Repair Clinical Trial)

Jason H. Rogers, MD∗; Martyn Thomas, MD†; Marie-Claude Morice, MD‡; Inga Narbute, MD§; Milana Zabunova, MD§; Thomas Hovasse, MD‡; Mathieu Poupineau, MD‖; Ainars Rudzitis, MD§; Ginta Kamzola, MD§; Ligita Zvaigzne, MD§; Samantha Greene, BA¶; Andrejs Erglis, MD§

Objectives: MAVERIC (Mitral Valve Repair Clinical Trial) reports the safety and efficacy of the ARTO system in patients with symptomatic heart failure and functional mitral regurgitation (FMR).

01 septiembre 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Physiologic Assessment and Imaging. Comparison of Intracoronary Versus Intravenous Administration of Adenosine for Measurement of Coronary Fractional Flow Reserve

Christian Schlundt, MD, Christian Bietau, MD, Lutz Klinghammer, MD, Ricarda Wiedemann, Harald Rittger, MD, Josef Ludwig, MD and Stephan Achenbach, MD

Background: Measurement of fractional flow reserve (FFR) constitutes the current gold standard to evaluate the hemodynamic significance of coronary stenoses. Limited data validate the intracoronary application of adenosine against standard intravenous infusion. We systematically compared FFR measurements during intracoronary and intravenous application of adenosine about agreement and reproducibility.

01 septiembre 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Reperfusion Times for Radial Versus Femoral Access in Patients With ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Warren J. Cantor, MD, Dennis T. Ko, MD, MSc, Madhu K. Natarajan, MD, MSc, Vladimír Džavík, MD, Harindra C. Wijeysundera, MD, PhD, Julie T. Wang, MSc, Kori J. Kingsbury, MPA, MSN, James L. Velianou, MD, Eric A. Cohen, MD, Michel R. Le May, MD and Jack V. Tu, MD, PhD

Background: Radial access is associated with less bleeding and vascular complications. However, it may delay reperfusion during primary percutaneous coronary intervention for ST-segment–elevation myocardial infarction.

01 septiembre 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Nationwide Analysis of Patients With ST-Segment–Elevation Myocardial Infarction Transferred for Primary Percutaneous Intervention

Harold L. Dauerman, MD, Eric R. Bates, MD, Michael C. Kontos, MD, Shuang Li, MS, J. Lee Garvey, MD, Timothy D. Henry, MD, Steven V. Manoukian, MD and Matthew T. Roe, MD, MHS

Background: Current American College of Cardiology/American Heart Association guidelines recommend transfer and primary percutaneous coronary intervention (PCI) for ST-segment–elevation myocardial infarction (STEMI) patients within the time limit of first contact to device ≤120 minutes. We determined the hospital-level, patient-level, and process characteristics of timely versus delayed primary PCI for a diverse national sample of transfer patients confined to a travel distance that facilitates the process.

01 septiembre 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Peripheral Vascular Disease. Wire-Interwoven Nitinol Stent Outcome in the Superficial Femoral and Proximal Popliteal Arteries

Lawrence Garcia , MD, Michael R. Jaff , DO, Christopher Metzger , MD, Gino Sedillo , MD;, Ashish Pershad , MD, Frank Zidar , MD, Raghotham Patlola , MD, Robert G. Wilkins , MD, Andrey Espinoza , MD, Ayman Iskander , MD, George S. Khammar , MD, Yazan Khatib , MD, Robert Beasley , MD, Satyaprakash Makam , MD, Richard Kovach , MD, Suraj Kamat , MD, Luis R. Leon Jr , MD, William Britton Eaves , MD, Jeffrey J. Popma , MD, Laura Mauri , MD, MSc, Dennis Donohoe , MD, Carol C. Base , RN, MS; and Kenneth Rosenfield , MD, MHCDS; for the SUPERB Trial Investigators*

Background: Stent-based therapy in the superficial femoral and popliteal arteries in patients with peripheral artery disease is compromised by restenosis and risk of stent fracture or distortion. A novel self-expanding nitinol stent was developed that incorporates an interwoven-wire design (Supera stent, IDEV Technologies, Inc, Webster, TX) to confer greater radial strength, flexibility, and fracture resistance.

01 septiembre 2015

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Peripheral Vascular Disease. Neuromatous Regeneration as a Nerve Response After Catheter-Based Renal Denervation Therapy in a Large Animal Model

Serge D. Rousselle, DVM, Irena K. Brants, DVM, Atsushi Sakaoka, MS, Brad Hubbard, DVM, Nicolette D. Jackson, DVM, Joan R. Wicks, DVM, PhD, Krista N. Dillon, L.A. Naiche, PhD, Randy Hart, BS, Javier A. Garza, MD and Armando Tellez, MD

Background: Renal denervation (RDN) emerged as a therapeutic option for resistant hypertension. Nerve regrowth after RDN has been questioned. We aimed to characterize the nerve response after RDN.

01 agosto 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Long-Term Clinical Outcomes of Final Kissing Ballooning in Coronary Bifurcation Lesions Treated With the 1-Stent Technique. Results From the COBIS II Registry (Korean Coronary Bifurcation Stenting Registry)

Cheol Woong Yu, MD∗; Jeong Hoon Yang, MD†; Young Bin Song, MD†; Joo-Yong Hahn, MD†; Seung-Hyuk Choi, MD†; Jin-Ho Choi, MD†; Hyun Jong Lee, MD‡; Ju Hyeon Oh, MD§; Bon-Kwon Koo, MD‖; Seung Woon Rha, MD¶; Jin-Ok Jeong, MD#; Myung-Ho Jeong, MD∗∗; Jung Han Yoon, MD††; Yangsoo Jang, MD‡‡; Seung-Jea Tahk, MD§§; Hyo-Soo Kim, MD‖; Hyeon-Cheol Gwon, MD†

Objectives: This study investigated the impact of final kissing ballooning (FKB) after main vessel (MV) stenting on outcomes in patients with coronary bifurcation lesions after application of the 1-stent technique.

01 agosto 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Comparative Analysis of Sequential Proximal Optimizing Technique Versus Kissing Balloon Inflation Technique in Provisional Bifurcation Stenting

Gérard Finet, MD, PhD∗; François Derimay, MD, MSc∗; Pascal Motreff, MD, PhD†; Patrice Guerin, MD, PhD‡; Paul Pilet, B Eng‡; Jacques Ohayon, PhD§; Olivier Darremont, MD‖; Gilles Rioufol, MD, PhD∗

Objectives: This study used a fractal bifurcation bench model to compare 6 optimization sequences for coronary bifurcation provisional stenting, including 1 novel sequence without kissing balloon inflation (KBI), comprising initial proximal optimizing technique (POT) + side-branch inflation (SBI) + final POT, called “re-POT.”

01 agosto 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Differential Prognostic Effect Between First- and Second-Generation Drug-Eluting Stents in Coronary Bifurcation Lesions. Patient-Level Analysis of the Korean Bifurcation Pooled Cohorts

Joo Myung Lee, MD, MPH∗; Joo-Yong Hahn, MD, PhD†; Jeehoon Kang, MD∗; Kyung Woo Park, MD, PhD∗; Woo Jung Chun, MD, PhD‡; Seung Woon Rha, MD, PhD§; Cheol Woong Yu, MD, PhD‖; Jin-Ok Jeong, MD, PhD¶; Myung-Ho Jeong, MD, PhD#; Jung Han Yoon, MD, PhD∗∗; Yangsoo Jang, MD, PhD††; Seung-Jea Tahk, MD, PhD‡‡; Hyeon-Cheol Gwon, MD, PhD†; Bon-Kwon Koo, MD, PhD∗; Hyo-Soo Kim, MD, PhD∗

Objectives: The purpose of this study was to investigate the differential clinical outcomes after percutaneous coronary intervention (PCI) for coronary bifurcation lesions with 1- or 2-stenting techniques using first- or second-generation drug-eluting stents (DES).

01 agosto 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Clinical Outcome After DK Crush Versus Culotte Stenting of Distal Left Main Bifurcation Lesions. The 3-Year Follow-Up Results of the DKCRUSH-III Study

Shao-Liang Chen, MD∗; Bo Xu, MBBS†; Ya-Ling Han, MD‡; Imad Sheiban, MD§; Jun-Jie Zhang, MD∗; Fei Ye, MD∗; Tak W. Kwan, MD‖; Chitprapai Paiboon, MD¶; Yu-Jie Zhou, MD#; Shu-Zheng Lv, MD#; George D. Dangas, MD∗∗; Ya-Wei Xu, MD††; Shang-Yu Wen, MD‡‡; Lang Hong, MD§§; Rui-Yan Zhang, MD‖‖; Hai-Chang Wang, MD¶¶; Tie-Ming Jiang, MD##; Yan Wang, MD∗∗∗; Teguh Sansoto, MD†††; Fang Chen, MD#; Zu-Yi Yuan, MD‡‡‡; Wei-Min Li, MD§§§; Martin B. Leon, MD‖‖‖

Objectives: The present study aimed to investigate the difference in major adverse cardiac events (MACE) at 3 years after double-kissing (DK) crush versus culotte stenting for unprotected left main distal bifurcation lesions (LMDBLs).

01 agosto 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Baseline Characteristics and Prognostic Implications of Pre-Existing and New-Onset Atrial Fibrillation After Transcatheter Aortic Valve Implantation

Romain Chopard, MD, PhD∗; Emmanuel Teiger, MD, PhD†; Nicolas Meneveau, MD, PhD∗; Sidney Chocron, MD, PhD‡; Martine Gilard, MD§; Marc Laskar, MD‖; Hélène Eltchaninoff, MD¶; Bernard Iung, MD#; Pascal Leprince, MD∗∗; Karine Chevreul, MD††; Alain Prat, MD‡‡; Michel Lievre, PhD§§; Alain Leguerrier, MD‖‖; Patrick Donzeau-Gouge, MD, PhD¶¶; Jean Fajadet, MD##; Gauthier Mouillet, MD†; Francois Schiele, MD, PhD∗

Objectives: The aim of this study was to determine baseline characteristics and clinical outcomes of patients with pre-existing atrial fibrillation (AF) and of patients who presented with new-onset AF after transcatheter aortic valve implantation (TAVI).

01 agosto 2015

JACC: CARDIOVASCULAR INTERVENTIONS. Treatment of Symptomatic Severe Aortic Stenosis With a Novel Resheathable Supra-Annular Self-Expanding Transcatheter Aortic Valve System

Ganesh Manoharan, MBBCh, MD∗; Antony S. Walton, MBBS†; Stephen J. Brecker, MBBS, MD‡; Sanjeevan Pasupati, MBChB§; Daniel J. Blackman, MD‖; Hongyan Qiao, PhD¶; Ian T. Meredith, AM, MBBS, PhD#

Objectives: The purpose of this study was to prospectively evaluate the safety and clinical performance of the CoreValve Evolut R transcatheter aortic valve replacement (TAVR) system (Medtronic, Inc., Minneapolis, Minnesota) in a single-arm, multicenter pivotal study in high- or extreme-risk patients with symptomatic aortic valve stenosis.