25 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis

Daisuke Nakamura, MD*, Guilherme F. Attizzani, MD*, Catalin Toma, MD, Tej Sheth, MD, Wei Wang, PhD, Mohamad Soud, MD, Reem Aoun, MD, Ramyashree Tummala, MD, Milana Leygerman, MS, Anas Fares, MD, Emile Mehanna, MD, Setsu Nishino, MD, PhD, Anthony Fung, MD, Marco A. Costa, MD, PhD and Hiram G. Bezerra, MD, PhD

Background: There are few clinical studies on the pathophysiological mechanisms of very late stent thrombosis (VLST). We report optical coherence tomography findings in patients with VLST and compare the findings between bare-metal stents (BMS) and drug-eluting stents (DES).

09 agosto 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Physiologic Assessment and Imaging. Coronary Plaque Characteristics Associated With Reduced TIMI (Thrombolysis in Myocardial Infarction) Flow Grade in Patients With ST-Segment–Elevation Myocardial Infarction. A Combined Optical Coherence Tomography and Intravascular Ultrasound Study

Takumi Higuma, MD, PhD*, Tsunenari Soeda, MD, PhD*, Masahiro Yamada, MD, PhD, Takashi Yokota, MD, PhD, Hiroaki Yokoyama, MD, PhD, Fumie Nishizaki, MD, PhD, Lei Xing, MD, PhD, Erika Yamamoto, MD, PhD, Krzysztof Bryniarski, MD, Jiannan Dai, MD, Hang Lee, PhD, Ken Okumura, MD, PhD and Ik-Kyung Jang, MD, PhD

Background: Previous studies reported that reduced TIMI (Thrombolysis in Myocardial Infarction) flow grade before procedure was associated with worse clinical outcomes in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention. The aim of this study was to identify specific morphological characteristics of the culprit plaque associated with poor TIMI flow grade at baseline in patients with ST-segment–elevation myocardial infarction using both optical coherence tomography and intravascular ultrasound.

25 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Physiologic Assessment and Imaging. Diastolic Backward-Traveling Decompression (Suction) Wave Correlates With Simultaneously Acquired Indices of Diastolic Function and Is Reduced in Left Ventricular Stunning

Andrew Ladwiniec, MBBS, MRCP, Paul A. White, PhD, Sukhjinder S. Nijjer, PhD, MRCP, Michael O’Sullivan, PhD, FRCP, Nick E.J. West, MD, FRCP, Justin E. Davies, PhD, FRCP and Stephen P. Hoole, DM, FRCP

Background: Wave intensity analysis can distinguish proximal (propulsion) and distal (suction) influences on coronary blood flow and is purported to reflect myocardial performance and microvascular function. Quantifying the amplitude of the peak, backwards expansion wave (BEW) may have clinical utility. However, simultaneously acquired wave intensity analysis and left ventricular (LV) pressure–volume loop data, confirming the origin and effect of myocardial function on the BEW in humans, have not been previously reported.

02 agosto 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Myocardial Infarction. Pharmacoinvasive Strategy Versus Primary Percutaneous Coronary Intervention in Patients With ST-Segment–Elevation Myocardial Infarction. A Propensity Score–Matched Analysis

Doo Sun Sim, MD, PhD, Myung Ho Jeong, MD, PhD, Youngkeun Ahn, MD, PhD, Young Jo Kim, MD, PhD, Shung Chull Chae, MD, PhD, Taek Jong Hong, MD, PhD, In Whan Seong, MD, PhD, Jei Keon Chae, MD, PhD, Chong Jin Kim, MD, PhD, Myeong Chan Cho, MD, PhD, Seung-Woon Rha, MD, PhD, Jang Ho Bae, MD, PhD, Ki Bae Seung, MD, PhD and Seung Jung Park, MD, PhD; on behalf of the Korea Acute Myocardial Infarction Registry (KAMIR) Investigators

Background: The Strategic Reperfusion Early After Myocardial Infarction trial and the French Registry of Acute ST-elevation or Non-ST-elevation Myocardial Infarction 2015 suggested that pharmacoinvasive strategy compares favorably with primary percutaneous coronary intervention (PPCI). We sought to assess the clinical impact of pharmacoinvasive strategy compared with PPCI in real-world patients with ST-segment–elevation myocardial infarction.

27 abril 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Insights Into Timing, Risk Factors, and Outcomes of Stroke and Transient Ischemic Attack After Transcatheter Aortic Valve Replacement in the PARTNER Trial (Placement of Aortic Transcatheter Valves)

Samir Kapadia, MD, Shikhar Agarwal, MD, D. Craig Miller, MD, John G. Webb, MD, Michael Mack, MD, Stephen Ellis, MD, Howard C. Herrmann, MD, Augusto D. Pichard, MD, E. Murat Tuzcu, MD, Lars G. Svensson, MD, PhD, Craig R. Smith, MD, Jeevanantham Rajeswaran, PhD, John Ehrlinger, PhD, Susheel Kodali, MD, Raj Makkar, MD, Vinod H. Thourani, MD, Eugene H. Blackstone, MD and Martin B. Leon, MD

Background: Prior studies of stroke and transient ischemic attack (TIA) after transcatheter aortic valve replacement (TAVR) are limited by reporting and follow-up variability. This is a comprehensive analysis of time-related incidence, risk factors, and outcomes of these events.

15 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Neurological Events Following Transcatheter Aortic Valve Replacement and Their Predictors. A Report From the CoreValve Trials

Neal S. Kleiman, MD, Brijeshwar J. Maini, MD, Michael J. Reardon, MD, John Conte, MD, Stanley Katz, MD, Vivek Rajagopal, MD, James Kauten, MD, Alan Hartman, MD, Raymond McKay, MD, Robert Hagberg, MD, Jian Huang, MD, Jeffrey Popma, MD, for the CoreValve Investigators

Background: The risk for stroke after transcatheter aortic valve replacement (TAVR) is an important concern. Identification of predictors for stroke is likely to be a critical factor aiding patient selection and management as TAVR use becomes widespread.

20 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Propensity Score–Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale. The IPSYS Registry (Italian Project on Stroke in Young Adults)

Alessandro Pezzini, MD, Mario Grassi, PhD, Corrado Lodigiani, MD, PhD, Rosalba Patella, MD, Carlo Gandolfo, MD, Andrea Zini, MD, Maria Luisa DeLodovici, MD, Maurizio Paciaroni, MD, Massimo Del Sette, MD, Antonella Toriello, MD, Rossella Musolino, MD, Rocco Salvatore Calabrò, MD, Paolo Bovi, MD, Alessandro Adami, MD, Giorgio Silvestrelli, MD, Maria Sessa, MD, Anna Cavallini, MD, Simona Marcheselli, MD, Domenico Marco Bonifati, MD, Nicoletta Checcarelli, MD, Lucia Tancredi, MD, Alberto Chiti, MD, Elisabetta Del Zotto, MD, PhD, Giampaolo Tomelleri, MD, Alessandra Spalloni, MD, Elisa Giorli, MD, Paolo Costa, MD, Giacomo Giacalone, MD, Paola Ferrazzi, MD, Loris Poli, MD, Andrea Morotti, MD, Valeria Piras, MD, Maurizia Rasura, MD, Anna Maria Simone, MD, Massimo Gamba, MD, Paolo Cerrato, MD, Maria Luisa Zedde, MD, Giuseppe Micieli, MD, Maurizio Melis, MD, Davide Massucco, MD, Davide Guido, PhD, Valeria De Giuli, MD, Silvia Bonaiti, MD, Cataldo D’Amore, MD, Sara La Starza, MD, Licia Iacoviello, MD, PhD and Alessandro Padovani, MD, PhD; on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators

Background: We sought to compare the benefit of percutaneous closure to that of medical therapy alone for the secondary prevention of embolism in patients with patent foramen ovale (PFO) and otherwise unexplained ischemic stroke, in a propensity scored study.

03 agosto 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Outcomes of Redo Transcatheter Aortic Valve Replacement for the Treatment of Postprocedural and Late Occurrence of Paravalvular Regurgitation and Transcatheter Valve Failure

Marco Barbanti, MD, John G. Webb, MD, Claudia Tamburino, MD, Nicolas M. Van Mieghem, MD, PhD, Raj R. Makkar, MD, Nicolò Piazza, MD, Azeem Latib, MD, Jan-Malte Sinning, MD, Kim Won-Keun, MD, Sabine Bleiziffer, MD, Francesco Bedogni, MD, Samir Kapadia, MD, Didier Tchetche, MD, Josep Rodés-Cabau, MD, Claudia Fiorina, MD, Luis Nombela-Franco, MD, Federico De Marco, MD, Peter P. de Jaegere, MD, PhD, Tarun Chakravarty, MD, Beatriz Vaquerizo, MD, Antonio Colombo, MD, Lars Svensson, MD, Rüdiger Lange, MD, Georg Nickenig, MD, Helge Möllmann, MD, Thomas Walther, MD, Francesco Della Rosa, MD, Yacine Elhmidi, MD, Danny Dvir, MD, Nedy Brambilla, MD, Sebastiano Immè, MD, Carmelo Sgroi, MD, Simona Gulino, MD, Denise Todaro, MD, Gerlando Pilato, MD, Anna Sonia Petronio, MD and Corrado Tamburino, MD, PhD

Background: Transcatheter aortic valves can degenerate in a manner similar to surgical bioprostheses.

15 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Cardiac Catheterization. Very Long–Term (10 to 14 Year) Outcomes After Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Multivessel Coronary Artery Disease in the Bare-Metal Stent Era

Hiroki Shiomi, MD, Kyohei Yamaji, MD, Takeshi Morimoto, MD, Satoshi Shizuta, MD, Kenji Nakatsuma, MD, Hirooki Higami, MD, Yutaka Furukawa, MD, Yoshihisa Nakagawa, MD, Kazushige Kadota, MD, Kenji Ando, MD, Ryuzo Sakata, MD, Hitoshi Okabayashi, MD, Michiya Hanyu, MD, Mitsuomi Shimamoto, MD, Noboru Nishiwaki, MD, Tatsuhiko Komiya, MD and Takeshi Kimura, MD

Background: Many of the previous randomized trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel coronary artery disease reported equivalent or better survival with CABG as compared with PCI at 5-year follow-up. However, 5-year follow-up might be too short to evaluate the true differences in long-term clinical outcomes between PCI and CABG.

15 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Interventions. Absorb Bioresorbable Vascular Scaffold in Complex Coronary Bifurcation Interventions. Insights From an In Vivo Multimodality Imaging Study

Johan Bennett, MB BCh, MD, Maarten Vanhaverbeke, MD, Nina Vanden Driessche, BSc, Tom Adriaenssens, MD, PhD, Nick Hiltrop, MD, Walter Desmet, MD, PhD, Peter Sinnaeve, MD, PhD and Christophe Dubois, MD, PhD

Background: Although bioresorbable scaffolds offer potential advantages compared with metallic drug-eluting stents in the treatment of complex coronary bifurcation lesions, there are concerns that the polymeric scaffold integrity may be compromised. This in vivo study sought to provide insights about the feasibility of performing complex bifurcation stenting with Absorb bioresorbable vascular scaffolds (Abbott Vascular, Santa Clara, CA).

15 julio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Coronary Physiologic Assessment and Imaging. Assessing Computational Fractional Flow Reserve From Optical Coherence Tomography in Patients With Intermediate Coronary Stenosis in the Left Anterior Descending Artery

Jinyong Ha, PhD*, Jung-Sun Kim, MD*, Jaeyeong Lim, BS, Gihoon Kim, BS, Seungwan Lee, MS, Joon Sang Lee, PhD, Dong-Ho Shin, MD, Byeong-Keuk Kim, MD, Young-Guk Ko, MD, Donghoon Choi, MD, Yangsoo Jang, MD and Myeong-Ki Hong, MD

Background: Intravascular optical coherence tomography (OCT) imaging provides limited information on the functional assessment of coronary stenosis. We evaluated a new approach to OCT image–based computation modeling, which can be used to estimate the fractional flow reserve (FFR) in patients with intermediate coronary stenosis.

23 junio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Routine Endovascular Treatment With a Stent Graft for Access-Site and Access-Related Vascular Injury in Transfemoral Transcatheter Aortic Valve Implantation

Alexander Sedaghat, MD, Nils Neumann, MD, Nadjib Schahab, MD, Jan-Malte Sinning, MD, Christoph Hammerstingl, MD, Simon Pingel, MD, Christian Schaefer, MD, Fritz Mellert, MD, Wolfgang Schiller, MD, Armin Welz, MD, Eberhard Grube, MD, Georg Nickenig, MD and Nikos Werner, MD

Background: Access-site and access-related vascular injury (ASARVI) is still a major limiting factor in transcatheter aortic valve implantation and affects the outcome of patients. Management strategies for ASARVI include manual compression, stent grafts, and vascular surgery. We hypothesized that the standard use of a self-expanding stent graft for the management of ASARVI is feasible and safe.

23 junio 2016

CIRCULATION: CARDIOVASCULAR INTERVENTIONS. Structural Heart Disease. Direct Transcatheter Heart Valve Implantation Versus Implantation With Balloon Predilatation. Insights From the Brazilian Transcatheter Aortic Valve Replacement Registry

Fernando L.M. Bernardi, MD, Henrique B. Ribeiro, MD, PhD, Luiz A. Carvalho, MD, Rogerio Sarmento-Leite, MD, José A. Mangione, MD, PhD, Pedro A. Lemos, MD, PhD, Alexandre Abizaid, MD, PhD, Eberhard Grube, MD, Josep Rodés-Cabau, MD and Fábio S. de Brito Jr, MD, PhD

Background: Direct transcatheter aortic valve replacement (TAVR) is regarded as having potential advantages over TAVR with balloon aortic valve predilatation (BAVP) in reducing procedural complications, but there are few data to support this approach.

01 junio 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Pharmacodynamic Effects of Switching From Prasugrel to Ticagrelor. Results of the Prospective, Randomized SWAP-3 Study

Francesco Franchi, MD; Gabriel Todd Faz, MD; Fabiana Rollini, MD; Yongwhi Park, MD; Jung Rae Cho, MD; Estela Thano, MD; Jenny Hu, MD; Megha Kureti, MD; Niti Aggarwal, MD; Ashwin Durairaj, MD; Latonya Been, AAS; Martin M. Zenni, MD; Luis A. Guzman, MD; Siva Suryadevara, MD; Patrick Antoun, MD; Theodore A. Bass, MD; Dominick J. Angiolillo, MD, PhD

Objectives: This study sought to assess the pharmacodynamic (PD) effects of switching to ticagrelor patients who were treated with prasugrel after undergoing percutaneous coronary intervention in the setting of an acute coronary syndrome.

01 junio 2016

JACC: CARDIOVASCULAR INTERVENTIONS. Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Interventions in Patients With Unprotected Left Main Coronary Artery Disease

Zhe Zheng, MD, PhDa,b; Bo Xu, MBBSa,c; Heng Zhang, MD, PhDa,b; Changdong Guan, MSca,c; Ying Xian, MD, PhDd; Yanyan Zhao, BSa,e; Hongyang Fan, MD, PhDa,b; Yuejin Yang, MD, PhDa,c; Wei Wang, MD, PhDa,b; Runlin Gao, MD, PhDa,c; Shengshou Hu, MD, PhDa,b

Objectives: This study sought to investigate long-term clinical outcomes following coronary artery bypass graft (CABG) and percutaneous coronary intervention (PCI) in patients with unprotected left main disease (ULMD).