Background: Significant paravalvular leak (PVL) occurs in up to 13% of patients after transcatheter aortic valve replacement (TAVR) with a balloon‐expandable bioprosthesis. Transcatheter PVL repair has emerged as a less invasive alternative for this problem.
Objectives: This study aims to evaluate the safety and performance of the new embolic deflection device TriGuard™HDH in patients undergoing TAVR.
Introduction: Patent foramen ovale (PFO) closure is a widely performed procedure. Understanding the anatomy is mandatory in order to perform the procedure successfully. The degree of overlap between the septum primum and secundum is called the tunnel. In particular, long and stiff tunnels may prevent the correct positioning of devices that have a fixed distance between the right and left atrial discs.
Objectives: This study aimed at assessing the feasibility and long‐term efficacy of left atrial appendage occlusion (LAAO) in a “real world” setting.
Background: There are limited data to guide the optimum approach to patients presenting with angina after coronary artery bypass grafting (CABG). Although often referred for invasive angiography, the effectiveness of this is unknown; angina may also result from diffuse distal or micro‐vascular coronary disease and it is not known how often targets for intervention are identified.
Background: Guidelines recommend routine monitoring of unfractionated heparin (UFH) with activated clotting time (ACT) during percutaneous coronary intervention (PCI). However, the optimal ACT for patients undergoing PCI is unclear.
Background: Patients with ST‐segment elevation myocardial infarction (STEMI) undergoing drug‐eluting stent (DES) implantation are at increased risk of late adverse events, partly explained by an exaggerated inflammatory reaction to durable‐polymer stent coatings.
Objectives: The aims of this study were to evaluate clinical outcomes following PCI using SeQuent Please paclitaxel‐coated balloons (PCB) of ISR and denovo lesions (DNL), in all‐comer patients at Liverpool Hospital, Sydney, Australia.
Objective: To assess safety and feasibility of autologous adipose‐derived regenerative cells (ADRCs), for treatment of chronic ischemic cardiomyopathy patients.
Background: Whether the efficacy and safety of dual antiplatelet therapy (DAPT) are uniform between sexes is unclear. We sought to compare clinical outcomes between short‐ (≤6 months) versus long‐term (≥1 year) DAPT after drug‐eluting stent (DES) placement in women and men.
Objective: To examine the influence of smoking on the antiplatelet effect of clopidogrel following percutaneous coronary intervention (PCI).
Objectives: To construct a model to predict long‐term bleeding events following percutaneous coronary intervention (PCI).
Background: Atrial fibrillation (AF), with a prevalence of 1% to 2%, is the most common cardiac arrhythmia. Without antithrombotic treatment, the annual risk of a cardioembolic event is 5% to 6%. The source of a cardioembolic event is a thrombus, which is usually formed in the left atrial appendage (LAA). Prevention of cardioembolic events involves treatment with anticoagulant drugs: either vitamin K antagonists or, recently, novel oral anticoagulants (NOAC). The other (nonpharmacologic) option for the prevention of a cardioembolic event involves interventional occlusion of the LAA.
Objectives: The objective was to assess whether total stent length (TSL) after cobalt‐chromium everolimus‐eluting stent (CoCr‐EES) implantation was associated with long‐term clinical outcomes.
Objectives: The aim of this study was to explore the effect of one stenosis in a daughter artery on the fractional flow reserve (FFR) of another stenosis parallels in side branch. Background: The impact of one stenosis on the FFR of another parallel stenosis has not been evaluated. Methods: The proximal segments of the left anterior descending (LAD) and left circumflex (LCX) arteries were exposed and encircled with a Teflon pledget complex in seven swine (55–70 kg). Five degrees of stenosis (to approximate angiographic diameter stenoses of 0%, 25%, 50%, 75%, and 100%) were made by tightening the pledgets. FFR was evaluated simultaneously in the LAD and the LCX with two pressure wires in each coronary artery. A mixed‐effects linear model was used to evaluate the association between the FFR values. Results: A total of 115 paired FFR values were obtained. The FFR of the LAD and LCX were not significantly associated with each other (F = 0.237 and P = 0.627 for the LCX FFR to predict the LAD FFR; F = 0.541 and P = 0.463 for the LAD FFR to predict the LCX FFR). Conclusions: The individual FFR values of each parallel stenosis in the LAD and the LCX were not significantly influenced by each other. This relationship was independent of the mean aortic pressure and heart rate.
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