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ESTUDIOS


01 noviembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Mechanisms of Very Late Bioresorbable Scaffold Thrombosis: The INVEST Registry

Kyohei Yamaji, Yasushi Ueki, Geraud Souteyrand, Joost Daemen, Jens Wiebe, Holger Nef, Tom Adriaenssens, Joshua P. Loh, Benoit Lattuca, Joanna J. Wykrzykowska, Josep Gomez-Lara, Leo Timmers, Pascal Motreff, Petra Hoppmann, Mohamed Abdel-Wahab, Robert A. Byrne, Felix Meincke, Niklas Boeder, Benjamin Honton, Crochan J. O’Sullivan, Alfonso Ielasi, Nicolas Delarche, Günter Christ, Joe K.T. Lee, Michael Lee, Nicolas Amabile, Alexios Karagiannis, Stephan Windecker and Lorenz Räber

Background: Very late scaffold thrombosis (VLScT) occurs more frequently after bioresorbable scaffold (Absorb BVS 1.1, Abbott Vascular, Santa Clara, California) implantation than with metallic everolimus-eluting stents.

01 noviembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Double Kissing Crush Versus Provisional Stenting for Left Main Distal Bifurcation Lesions

Shao-Liang Chen, Jue-Jie Zhang, Yaling Han, Jing Kan, Lianglong Chen, Chunguang Qiu, Tiemin Jiang, Ling Tao, Hesong Zeng, Li Li, Yong Xia, Chuanyu Gao, Teguh Santoso, Chootopol Paiboon, Yan Wang, Tak W. Kwan, Fei Ye, Nailiang Tian, Zhizhong Liu, Song Lin, Chengzhi Lu, Shangyu Wen, Lang Hong, Qi Zhang, Imad Sheiban, Yawei Xu, Lefeng Wang, Tanveer S. Rab, Zhanquan Li, Guanchang Cheng, Lianqun Cui, Martin B. Leon and Gregg W. Stone

Background: Provisional stenting (PS) is the most common technique used to treat distal left main (LM) bifurcation lesions in patients with unprotected LM coronary artery disease undergoing percutaneous coronary intervention. The double kissing (DK) crush planned 2-stent technique has been shown to improve clinical outcomes in non-LM bifurcations compared with PS, and in LM bifurcations compared with culotte stenting, but has never been compared with PS in LM bifurcation lesions.

01 diciembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 3-Year Clinical Outcomes With Everolimus-Eluting Bioresorbable Coronary Scaffolds: The ABSORB III Trial

Dean J. Kereiakes, Stephen G. Ellis, Christopher Metzger, Ronald P. Caputo, David G. Rizik, Paul S. Teirstein, Marc R. Litt, Annapoorna Kini, Ameer Kabour, Steven O. Marx, Jeffrey J. Popma, Robert McGreevy, Zhen Zhang, Charles Simonton, Gregg W. Stone and for the ABSORB III Investigators

Background: The Absorb everolimus-eluting poly-L-lactic acid–based bioresorbable vascular scaffold (BVS) provides early drug delivery and mechanical support functions similar to metallic drug-eluting stents (DES), followed by complete bioresorption in approximately 3 years with recovery of vascular structure and function. The ABSORB III trial demonstrated noninferior rates of target lesion failure (cardiac death, target vessel myocardial infarction [TVMI], or ischemia-driven target lesion revascularization) at 1 year in 2,008 patients with coronary artery disease randomized to BVS versus cobalt-chromium everolimus-eluting stents (EES).

01 diciembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Effect of Technique on Outcomes Following Bioresorbable Vascular Scaffold Implantation: Analysis From the ABSORB Trials

Gregg W. Stone, Alexandre Abizaid, Yoshinobu Onuma, Ashok Seth, Runlin Gao, John Ormiston, Takeshi Kimura, Bernard Chevalier, Ori Ben-Yehuda, Ovidiu Dressler, Tom McAndrew, Stephen G. Ellis, Dean J. Kereiakes and Patrick W. Serruys

Background: Procedural technique may affect clinical outcomes after bioresorbable vascular scaffold (BVS) implantation. Prior studies suggesting such a relationship have not adjusted for baseline patient and lesion characteristics that may have influenced operator choice of technique and outcomes.

01 diciembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. National Trends and Outcomes in Isolated Tricuspid Valve Surgery

Chad J. Zack, Erin A. Fender, Pranav Chandrashekar, Yogesh N.V. Reddy, Courtney E. Bennett, John M. Stulak, Virginia M. Miller and Rick A. Nishimura

Background: Severe isolated disease of the tricuspid valve (TV) is increasing and results in intractable right heart failure. However, isolated TV surgery is rarely performed, and there are little data describing surgical outcomes.

01 diciembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Surgical Versus Percutaneous Coronary Revascularization in Patients With Diabetes and Acute Coronary Syndromes

Krishnan Ramanathan, James G. Abel, Julie E. Park, Anthony Fung, Verghese Mathew, Carolyn M. Taylor, G.B. John Mancini, Min Gao, Lillian Ding, Subodh Verma, Karin H. Humphries and Michael E. Farkouh

Background: Randomized trial data support the superiority of coronary artery bypass grafting (CABG) surgery over percutaneous coronary intervention (PCI) in diabetic patients with multivessel coronary artery disease (MV-CAD). However, whether this benefit is seen in a real-world population among subjects with stable ischemic heart disease (SIHD) and acute coronary syndromes (ACS) is unknown.

01 diciembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Quality-of-Life After Everolimus-Eluting Stents or Bypass Surgery for Left-Main Disease: Results From the EXCEL Trial

Suzanne J. Baron, Khaja Chinnakondepalli, Elizabeth A. Magnuson, David E. Kandzari, John D. Puskas, Ori Ben-Yehuda, Gerrit-Anne van Es, David P. Taggart, Marie-Claude Morice, Nicholas J. Lembo, W. Morris Brown III, Adrian Banning, Charles A. Simonton, A. Pieter Kappetein, Joseph F. Sabik, Patrick W. Serruys, Gregg W. Stone, David J. Cohen and on behalf of the EXCEL Investigators

Background: The EXCEL (Evaluation of Xience Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) trial compared outcomes in patients with unprotected left main coronary artery disease (LMCAD) treated with coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) using everolimus-eluting stents. Whereas rates of death, stroke, and myocardial infarction were similar at 36 months, event timing and repeat revascularization rates differed by treatment group.

01 diciembre 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Self-Expanding Transcatheter Aortic Valve System for Symptomatic High-Risk Patients With Severe Aortic Stenosis

Hermann Reichenspurner, Andreas Schaefer, Ulrich Schäfer, Didier Tchétché, Axel Linke, Mark S. Spence, Lars Søndergaard, Hervé LeBreton, Gerhard Schymik, Mohamed Abdel-Wahab, Jonathon Leipsic, Darren L. Walters, Stephen Worthley, Markus Kasel and Stephan Windecker

Background: The CENTERA transcatheter heart valve (THV) is a low-profile, self-expanding nitinol valve made from bovine pericardial tissue that is 14-F compatible with a motorized delivery system allowing for repositionability.

01 enero 2018

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Left Atrial Appendage Closure and Systemic Homeostasis: The LAA HOMEOSTASIS Study

Dhanunjaya Lakkireddy, Mohit Turagam, Muhammad Rizwan Afzal, Johnson Rajasingh, Donita Atkins, Buddhadeb Dawn, Luigi Di Biase, Krzysztof Bartus, Saibal Kar, Andrea Natale and David J. Holmes Jr.

Background: The impact of left atrial appendage (LAA) exclusion, comparing an epicardial LAA or an endocardial LAA device, on systemic homeostasis remains unknown.

01 agosto 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study

Jonathan Afilalo, Sandra Lauck, Dae H. Kim, Thierry Lefèvre, Nicolo Piazza, Kevin Lachapelle, Giuseppe Martucci, Andre Lamy, Marino Labinaz, Mark D. Peterson, Rakesh C. Arora, Nicolas Noiseux, Andrew Rassi, Igor F. Palacios, Philippe Généreux, Brian R. Lindman, Anita W. Asgar, Caroline A. Kim, Amanda Trnkus, José A. Morais, Yves Langlois, Lawrence G. Rudski, Jean-Francois Morin, Jeffrey J. Popma, John G. Webb and Louis P. Perrault

Background: Frailty is a geriatric syndrome that diminishes the potential for functional recovery after a transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) procedure; however, its integration in clinical practice has been limited by a lack of consensus on how to measure it.

01 agosto 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. First-in-Human Closed-Chest Transcatheter Superior Cavopulmonary Anastomosis

Kanishka Ratnayaka, John W. Moore, Rodrigo Rios, Robert J. Lederman, Sanjeet R. Hegde and Howaida G. El-Said

Background: In the care of patients with congenital heart disease, percutaneous interventional treatments have supplanted many surgical approaches for simple lesions, such as atrial septal defect. By contrast, complex congenital heart defects continue to require open-heart surgery. In single-ventricle patients, a staged approach is employed, which requires multiple open-heart surgeries and significant attendant morbidity and mortality. A nonsurgical transcatheter alternative would be attractive.

01 agosto 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Clinical Outcomes With a Repositionable Self-Expanding Transcatheter Aortic Valve Prosthesis: The International FORWARD Study

Eberhard Grube, Nicolas M. Van Mieghem, Sabine Bleiziffer, Thomas Modine, Johan Bosmans, Ganesh Manoharan, Axel Linke, Werner Scholtz, Didier Tchétché, Ariel Finkelstein, Ramiro Trillo, Claudia Fiorina, Antony Walton, Christopher J. Malkin, Jae K. Oh, Hongyan Qiao, Stephan Windecker, FORWARD Study Investigators, Eberhard Grube, Stephan Windecker, Johan Bosmans, Sabine Bleiziffer, Ganesh Manoharan, Thomas Modine, Nicolas Van Mieghem, Ajay Sinhal, Robert Gooley, Tony Walton, Gerald Yong, Johan Bosmans, John Webb, Michael Chu, Sam Radhakrishnan, Antonio Dager, Marian Branny, Didier Tchetche, Thomas Modine, Emmanuel Teiger, Bernard Chevalier, Dominique Himbert, Gerhard Schymik, Tobias Zeus, Christoph Jensen, Tienush Rassaf, Stephan Fichtlscherer, Georg Nickenig, Axel Linke, Sabine Bleiziffer, Jörg Kempfert, Werner Scholtz, Axel Harnath, Ruth Strasser, Christian Frerker, Konstantinos Spargias, Béla Peter Merkely, Ariel Finkelstein, Corrado Tamburino, Antonio Colombo, Anna Sonia Petronio, Claudia Fiorina, Francesco Bedogni, Giovanni Amoroso, Jan van der Heijden, Nicolas Van Mieghem, Pim Tonino, Pedro Echeverria Beliz, Adam Witkowski, Vasco Gama Ribeiro, Moheeb Al Abdullah, Hellmuth Weich, Ramiro Trillo, José Maria Hernández García, Cesar Moris, Anders Lars Jönsson, Christopher J. Malkin, Saib Khogali, David Hildick-Smith and Ganesh Manoharan

Background: Clinical outcomes in large patient populations from real-world clinical practice with a next-generation self-expanding transcatheter aortic valve are lacking.

01 agosto 2017

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. Transcatheter Mitral Valve Replacement for Degenerated Bioprosthetic Valves and Failed Annuloplasty Rings

Sung-Han Yoon, Brian K. Whisenant, Sabine Bleiziffer, Victoria Delgado, Niklas Schofer, Lena Eschenbach, Buntaro Fujita, Rahul Sharma, Marco Ancona, Ermela Yzeiraj, Stefano Cannata, Colin Barker, James E. Davies, Antonio H. Frangieh, Florian Deuschl, Tomaz Podlesnikar, Masahiko Asami, Abhijeet Dhoble, Anthony Chyou, Jean-Bernard Masson, Harindra C. Wijeysundera, Daniel J. Blackman, Rajiv Rampat, Maurizio Taramasso, Enrique Gutierrez-Ibanes, Tarun Chakravarty, Guiherme F. Attizzani, Tsuyoshi Kaneko, S. Chiu Wong, Horst Sievert, Fabian Nietlispach, David Hildick-Smith, Luis Nombela-Franco, Lenard Conradi, Christian Hengstenberg, Michael J. Reardon, Albert Markus Kasel, Simon Redwood, Antonio Colombo, Saibal Kar, Francesco Maisano, Stephan Windecker, Thomas Pilgrim, Stephan M. Ensminger, Bernard D. Prendergast, Joachim Schofer, Ulrich Schaefer, Jeroen J. Bax, Azeem Latib and Raj R. Makkar

Background: Limited data exist regarding transcatheter mitral valve replacement (TMVR) for patients with failed mitral valve replacement and repair.

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